control of blood pressure outline short term control (baroreceptors) –location –types of...
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Control of blood pressure
Outline• Short term control (baroreceptors)
– Location– Types of baroreceptor– Baroreceptor reflex
• Other stretch receptors• Long-term control
– Renin/ angiotensin/ aldosterone system– Vasopressin– Atrial natiuretic peptide
• Response to blood loss (shock)
Control of blood pressure
• Mean blood pressure is controlled by changing total peripheral resistance and or cardiac output. P = CO x TPR (compare Ohm’s law)
– Cardiac output is controlled by sympathetic and para sympathetic nerves which effect:• heart rate• force of contraction
– TPR controlled by nervous and chemical means to effect constriction/dilatation of• arterioles and venules
Regulation of blood pressure
How is pressure “measured”?
• Short term– Baroreceptors
• Long term– Kidney via renin angiotensin system
http://www.cvphysiology.com/Blood Pressure/bp012 baroreceptor anat.gif
Location of barorecepto
rs•Baroreceptors sense stretch and rate of stretch by generating action potentials (voltage spikes)
•Located in highly distensible regions of the circulation to maximise sensitivity
Baroreceptor output(from single fibres)
Rapid decrease in mean pressure
From: Introduction to Cardiovascular physiology. J.R. Levick. Arnold 4th edition (2003)
Rapid increase in mean pressure
Response to pulse pressure
Two types of baroreceptor
• Type A– High sensitivity– High firing rate
• Type C– Lower sensitivity– Lower firing rate– Higher threshold (before firing starts)•Therefore can deal with higher pressures than type A which become “saturated” From “An Introduction to Cardiovascular Physiology”
J.R. Levick
Response of single baroreceptor fibre to change in pressure
From “An Introduction to Cardiovascular Physiology” J.R. Levick
Baroreceptor reflexBlood pressure
falls
Aortic archAortic arch Carotid sinusCarotid sinus
Constriction of veins &
arterioles
Constriction of veins &
arterioles
Increased stroke volume
Increased stroke volume
Increased heartrate
Increased heartrate
VasoconstrictionVasoconstriction Cardiac stimulationCardiac stimulation Cardiac inhibitionCardiac inhibition
Nucleus tractus solitariusNucleus tractus solitarius
Increased peripheral resistance
Increased cardiac output
Increased blood pressure
Neural integrationNeural integration
SensorsSensors
EffectorsEffectors
Baroreceptor reflex is afeedback loopfeedback loop
Read temperatur
e
Is temperaturetoo high?
No
Yes
Boiler on
Negative feedback
Example: central heating systemSet
temperature
Baroreceptor reflex is afeedback loopfeedback loop
“Read” pressure
Is pressuretoo high?
Two way negative feedback
Yes
Increase CO
Increase TPR
No
Reduce CO
Reduce TPR
Yes
No
Positive feedback loopPositive feedback loop
Read temperatur
e
Is temperaturetoo high?
Yes
No
Boiler on
Positive feedback
UnstableSet
temperature
Other stretch receptors
• Coronary artery baroreceptors– Respond to arterial pressure but more sensitive than carotid and aortic ones
• Veno-atrial mechanoreceptors– Respond to changes in central blood volume
• Lie down, lift your legs and cause peripheral vasodilatation
• Unmyelinated mechanoreceptors– Respond to distension of heart
• Ventricular ones during systole; atrial ones during inspiration
Location of receptors in and near the heart
From “An Introduction to Cardiovascular Physiology” J.R. Levick
Spinal cord
Baroreceptors in coronary arteries and aortic arch
Sympathetic afferents & unmyelinated nociceptors
Cardiac pain
Nucleus tractus solitarius
Cardiac vagal afferentsunmyelinatedmyelinated
Other receptors• Heart chemosensors
– Cause pain in response to ischaemia•K+, lactic acid, bradykinin, prostaglandins
• Arterial chemosensors– Stimulated in response to
•Hypoxaemia, hypercapnia*, acidosis, hyperkalaemia**
•Regulate breathing
• Lung stretch receptors– Cause tachycardia during inspiration
*too much CO2**too much K+
Overview of short-term control mechanisms
From: Introduction to Cardiovascular physiology. J.R. Levick. Arnold 4th edition (2003)
Long term control of blood pressure
• Involves control of blood volume/sodium balance by the kidneys– Hormonal control
•Renin-angiotensin-aldosterone system
•Antidiuretic hormone (vasopressin)•Atrial natiuretic peptide
– Pressure natriuresis
ArteriesArteries
VeinsVeins
Reduced renalblood flow
Reduced renalblood flow
Juxtaglomerularapparatus
Juxtaglomerularapparatus
ReninRenin
AngiotensinogenAngiotensinogen
Angiotensin IAngiotensin I
Angiotensin IIAngiotensin II
Increasedpre-loadIncreasedpre-load
Increasedafter-loadIncreasedafter-load
vasoconstrictionvasoconstriction
Increased aldosteronesecretion
Increased aldosteronesecretion
Sodium retentionSodium retention
Fluid re-absorptionFluid re-absorption
Increasedblood volumeIncreased
blood volume
Renin/angiotensin/ aldosterone system
LV filling pressure)
(LV pressurebeginning of systole)
Vasopressin
• Enhances water retention• Causes vasoconstriction• Secretion increased by unloading of aortic Baroreceptors and atrial sensors
http://www.cvphysiology.com/Blood%20Pressure/BP016.htm
Atrial natiuretic peptide
• Increases salt excretion via kidneys– By reducing water reabsorption in the
collecting ducts– relaxes renal arterioles– inhibits sodium reabsorption in the distal
tubule
• Released in response to stimulation of atrial receptors
Summary of long term BP control
• Cardiac output and BP depend on renal control of extra-cellular fluid volume via:– Pressure natriuresis, (increased renal filtration)
– Changes in:• Vasopressin• Aldosterone• Atrial natiuretic peptide
All under the control of altered cardiovascular receptor signaling
ShockDefinition:A pathophysiological disorder characterised by acute failure of the cardiovascular system to perfuse the tissues of the body adequately.
Levick J.R. “An Introduction to Cardiovascular Physiology”Symptoms– Cold, clammy skin– Muscular weakness– Rapid and shallow breathing– Rapid and weak pulse– Low pulse pressure (and sometimes mean pressure)
– Reduced urine output– Confusion
Types of shock
– Hypovolaemia•Caused by drop in blood (plasma) volume
– e.g. haemorrhage, diarrhoea, vomiting, injury
– Septic•Caused by bacterial endotoxins
– e.g. salmonella
– Cardiogenic•An acute interruption of of cardiac function– e.g. myocarditis (inflammation of the heart muscle) or myocardial infarction
– Anaphylactic•Caused by allergic reaction
Effect of blood loss
• less than 10%, no serious symptoms– e.g. blood transfusion
• 20 - 30% blood loss not usually life threatening
• greater than 30%, severe drop in BP and, often, death due to impaired cerebral and coronary perfusion
Response to moderate blood loss
(compensated haemorrhage)• Blood volume falls therefore pulse pressure and stroke volume fall. (Frank-Starling mechanism: reduced LV contractile force)
• Cardiopulmonary stretch receptor and baroreceptor activity falls
• Arterial chemoreceptor activity increases, due to hypoxia and acidosis rapid breathing release of vasoconstrictors
Vasopressin, angiotensin etc.
Response to moderate blood loss
More serious blood loss can be treated by transfusion to lessen the effects shown here
Uncompensated shock
If compensation is not sufficient, organ failure occurs due to inadequate perfusion
•Heart•Kidney•Brain