contraception in chronic medical conditions

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Contraception in Chronic Medical Conditions Pelin Batur, MD, FACP, NCMP Pelin Batur, MD, FACP, NCMP Education Director, Education Director, Primary Care Women’s Health Primary Care Women’s Health Deputy Editor, Deputy Editor, Cleveland Clinic Journal of Cleveland Clinic Journal of Medicine Medicine

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Contraception in Chronic Medical Conditions. Pelin Batur, MD, FACP, NCMP Education Director, Primary Care Women’s Health Deputy Editor, Cleveland Clinic Journal of Medicine. Why do I care?. Why wouldn’t you use it!??. GYNs might need our help - PowerPoint PPT Presentation

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Page 1: Contraception in  Chronic Medical Conditions

Contraception in Chronic Medical Conditions

Pelin Batur, MD, FACP, NCMPPelin Batur, MD, FACP, NCMP

Education Director, Education Director,

Primary Care Women’s HealthPrimary Care Women’s Health

Deputy Editor, Deputy Editor,

Cleveland Clinic Journal of MedicineCleveland Clinic Journal of Medicine

Page 2: Contraception in  Chronic Medical Conditions

Why do I care?

GYNs might need our helpGYNs might need our help

Help find answers to ‘annoying’ questionsHelp find answers to ‘annoying’ questions

You are using the most teratogenic medsYou are using the most teratogenic meds

Might need info in your personal life! Might need info in your personal life!

Why wouldn’t you use it!??

Page 3: Contraception in  Chronic Medical Conditions

Some fun facts…Some fun facts… 50% of pregnancies unintended50% of pregnancies unintended

4/10 of these lead to abortion4/10 of these lead to abortion 54% of those who had abortions54% of those who had abortions

had used a contraceptive that monthhad used a contraceptive that month 1/3 US servicewomen can’t access before deployment1/3 US servicewomen can’t access before deployment

Most effective methods discouraged or unavailableMost effective methods discouraged or unavailable 41% hard time getting refills41% hard time getting refills

Not so funny

Finer et al. Contraception 2011; 84:478–485Grindlay et al. Contraception 2013; 87:162-169

Page 4: Contraception in  Chronic Medical Conditions

Conditions that may make unintended pregnancy an unacceptable health risk

Breast cancer Complicated valvular heart

disease Diabetes with vascular

complications Endometrial or ovarian cancer Epilepsy Bariatric surgery within 2 years HIV/AIDS Ischemic heart disease Malignant liver tumors

Peripartum cardiomyopathy Schistosomiasis with liver

fibrosis Severe cirrhosis Sickle cell disease Solid organ transplant within 2

years Stroke SLE Thrombogenic mutations Tuberculosis

Page 5: Contraception in  Chronic Medical Conditions

Female Condom Sponge

Diaphragm Cervical cap

Page 6: Contraception in  Chronic Medical Conditions

Long Acting Reversible Contraceptives (LARCs)

The contraceptive CHOICE project Prospective study: what happens if cost is

not an issue? LARCs chosen by 75% of women LARCs 20x more effective than CHC 2008-2010 abortions ↓ by 20.6% Teen birth-rate ↓ 6.3/1000 (national av is 34.3)

Peipert JF et al. Obs Gynecol Oct 2012Winner B, et al. NEJM May 2012

Page 7: Contraception in  Chronic Medical Conditions

Contraception & Health Care Policy

Page 8: Contraception in  Chronic Medical Conditions

ACA Women’s Preventive Services:Contraception

Health Plans must Health Plans must cover:cover:

FDA-approved FDA-approved contraception contraception methodsmethods

SterilizationSterilization Patient ed and Patient ed and

counselingcounseling No deductibles and No deductibles and

co-pays. co-pays.

Page 9: Contraception in  Chronic Medical Conditions

Does it save us money?

Cost of unintended pregnancy in the US = 4.6 billion/yr

Including LARCs: If 10% of women age 20-29 changed to LARCs, savings $288

million/year

Extending coverage to low income Americans for 5 yrs 72 prevented pregnancies per 1000 women Saves $489 per woman enrolled

Doesn’t include cost of • Decreased productivity• Ob complications• Health of children• Undocumented immigrants

Trussel et al. Contraception 2013; 87:154Burlone et al. Contraception 2013; 87:143

Page 10: Contraception in  Chronic Medical Conditions

Is there really an access issue?Counterfeit and illegal sales

o Can buy contraception without rxo Facebook, Twitter, Slideshare, Flickr

Liange B et al. Contraception 86 (2012): 551Martinez G. Vital Health Stat 2011; 23:1

Page 11: Contraception in  Chronic Medical Conditions

Is there really an access issue?Counterfeit and illegal sales

o Health care providers buying from these sites!

Liange B et al. Contraception 86 (2012): 551Martinez G. Vital Health Stat 2011; 23:1

Page 12: Contraception in  Chronic Medical Conditions

Intrauterine Contraception: IUD

ParaGard

Silver identifier

Mirena Skyla

Copper, 10 yrsNo hormones

5 yrs 3 yrs Both with local progestin

Page 13: Contraception in  Chronic Medical Conditions

Progestin Only Contraception: Implanon Nexplanon

Lasts 3 yrsLasts 3 yrs 99% effective unless99% effective unless

meds that induce liver enzymesmeds that induce liver enzymes 30-40% amenorrhea at 1 yr30-40% amenorrhea at 1 yr

_____________

Page 14: Contraception in  Chronic Medical Conditions

Arm pain and numbness in a Nexplanon user

Implant

Medial cutaneous nerve (forearm)

Brown M et al. Contraception 2012; 86:591

Page 15: Contraception in  Chronic Medical Conditions

Intrauterine Contraception: Essure

Local anesthesia, 10 minutesLocal anesthesia, 10 minutes

Back-up method needed for first 3 monthsBack-up method needed for first 3 months

Page 16: Contraception in  Chronic Medical Conditions
Page 17: Contraception in  Chronic Medical Conditions

MRI Safety

MR SafeMR Safe MirenaMirena NexplanonNexplanon

MR ConditionalMR Conditional Safe if scanner <3 TSafe if scanner <3 T

EssureEssure Copper IUDCopper IUD SkylaSkyla

MR UnsafeMR Unsafe

Page 18: Contraception in  Chronic Medical Conditions

Progestin Only Contraception: Depo-Provera

Failure rate 0.0-0.7%Failure rate 0.0-0.7% Side Effects:Side Effects:

Menorrhagia, amenorrheaMenorrhagia, amenorrhea Weight gain (1-3 kg)Weight gain (1-3 kg) HypoestrogenicHypoestrogenic Higher insulin and FBSHigher insulin and FBS ↓ ↓ HDLHDL

Page 19: Contraception in  Chronic Medical Conditions

Bone Health: Depo-Provera

Black box warning: OsteopeniaBlack box warning: Osteopenia Studies on BMD mixedStudies on BMD mixed BMD BMD at 5 yrs vs controls at 5 yrs vs controls

-5.38% in LS ( -3.13% 2 yrs after dc)-5.38% in LS ( -3.13% 2 yrs after dc) -5.16% in TH ( -1.34%)-5.16% in TH ( -1.34%) -6.12% in FN ( -5.38%)-6.12% in FN ( -5.38%)

Decline is more pronounced in first 2 yrsDecline is more pronounced in first 2 yrs ACOG & WHO: Advantages of DMPA > risksACOG & WHO: Advantages of DMPA > risks

Can continue for decades!

Batur P, Joy S. Clinical Reviews of Bone and Mineral Metabolism; 3(2): 103-113, 2005

Page 20: Contraception in  Chronic Medical Conditions

Bone Health: Depo-Provera

Use of DMPA and incidence of bone fracture 312,395 women in UK, retrospectively followed 5 yrs

Fx incidence in 1000 women: 9.1 (Depo) vs 7.3 (non-Depo) Incidence RR 1.23 (95% CI 1.16-1.130)

Overall “message”: no significant increase DMPA cohort higher risk of fx at baseline Risk did not increase further after DMPA initiated Longer term users had lower fx risk than short term No excess risk of axial fx (hip, pelvis, vertebral)

Lanza L, et al. Obs Gynecol March 2013; 121 (3), 593

Page 21: Contraception in  Chronic Medical Conditions

Is a DXA scan needed?

Use clinical judgment, depends on:Length of useRisk factorsInsurance coverage

Try dx code 256.39

Page 22: Contraception in  Chronic Medical Conditions

Progestin only pill"mini-pill”

For those who cannot tolerate estrogenFor those who cannot tolerate estrogen CAD, VTE, strokeCAD, VTE, stroke Migraine w/ auraMigraine w/ aura DM w/ vascular complicationDM w/ vascular complication <6 wks postpartum<6 wks postpartum Uncontrolled hypertensionUncontrolled hypertension

Main use in lactating womenMain use in lactating women Higher rates of breakthrough bleeding Higher rates of breakthrough bleeding Lower contraceptive efficacyLower contraceptive efficacy Back up method for 2 days if > 3hrs late w/ doseBack up method for 2 days if > 3hrs late w/ dose

Page 23: Contraception in  Chronic Medical Conditions

Combined Oral Contraceptives (COC)

Have been used ~ 50 years in the USHave been used ~ 50 years in the US Most popular contraceptive choice along with Most popular contraceptive choice along with

sterilization sterilization

NuvaRing Ortho Evra

Page 24: Contraception in  Chronic Medical Conditions

COC Metabolism

Contraceptive effectiveness Contraceptive effectiveness may be reducedmay be reduced when when

co-administered with:co-administered with: rifampin rifampin anticonvulsants (phenytoin, carbamazepine, anticonvulsants (phenytoin, carbamazepine,

topiramate, barbiturates)topiramate, barbiturates) anti-HIV protease inhibitorsanti-HIV protease inhibitors non-prescription/herbal products ( St. John's non-prescription/herbal products ( St. John's

wort)wort)

Page 25: Contraception in  Chronic Medical Conditions

COC Metabolism

EE EE increasedincreased when co-administered with: when co-administered with: atorvastatin (Lipitor), atorvastatin (Lipitor), ↑20%↑20%

rosuvastatin okrosuvastatin ok erythro/clarithromycinerythro/clarithromycin acetaminophenacetaminophen ascorbic acidascorbic acid itraconazole, ketoconazoleitraconazole, ketoconazole grapefruit juicegrapefruit juice

Page 26: Contraception in  Chronic Medical Conditions

Combined Oral Contraceptives: Progestin Formulations

First GenerationFirst Generation:: norethindrone norethindrone ethynodiol diacetateethynodiol diacetate

Seconds GenerationSeconds Generation:: norgestrel norgestrel levonorgestrellevonorgestrel

Third GenerationThird Generation:: norgestimate norgestimate desogestrel desogestrel ((RR VTE 1.7-19xRR VTE 1.7-19x))

Fourth GenerationFourth Generation:: drospirenone drospirenone ((RR VTE 0.9-3xRR VTE 0.9-3x)) dienogestdienogest

Page 27: Contraception in  Chronic Medical Conditions

Why are they so mean to Yasmin/Yaz?

Page 28: Contraception in  Chronic Medical Conditions

Letter to patients from Aetna…

Did you suffer any cardiovascular - or gallbladder - related injury or injuries during or after [the period when you used Yaz, Yasmin, or Ocella]?

Have you pursued, are you pursuing, or do you intend to pursue a personal injury claim related to your use of Yaz, Yasmin, or Ocella?

Have you hired or do you plan to hire an attorney to represent you in this claim?

Page 29: Contraception in  Chronic Medical Conditions

The aftermath…

~12,000 lawsuits to Bayer~12,000 lawsuits to Bayer settled 1,977 cases for $402.6 million, for settled 1,977 cases for $402.6 million, for

an average of $212,000 per case, while an average of $212,000 per case, while setting aside $610.5 million to settle the setting aside $610.5 million to settle the othersothers

Source: Bloomberg.com

Page 30: Contraception in  Chronic Medical Conditions

What does the data really show?

Page 31: Contraception in  Chronic Medical Conditions

Summary of VTE: absolute risks

Condition Rate of VTE (per 10,000 women per year)

Reproductive Aged(baseline-no pill)

1-5

Pill users 3-10(*rates vary by progestins)

Pregnancy 10-29

Postpartum 65-400

Page 32: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery disease Coronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

Page 33: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

Fertil Steril 2006; 85(5):1425? Protective effect

NEJM 2012; 366:225730-40 mcg EE RR ↑ 1.3-2.320 mcg EE RR ↑ 0.0-1.6Ortho Evra RR 0.0Nuvaring ↑ 2.1

Page 34: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease

Fertil Steril 2006; 85(5):1425? Protective effect

NEJM 2012; 366:225730-40 mcg EE RR ↑ 1.3-2.320 mcg EE RR ↑ 0.0-1.6Ortho Evra RR 0.0Nuvaring ↑ 2.1

Page 35: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

Page 36: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

Stroke 2009; 40(4):1050No increased risk

NEJM 2012; 366:225730-40 mcg EE RR ↑ 1.5-2.220 mcg EE RR ↑ 0.9-1.7Ortho Evra ↑ 3.2Nuvaring ↑ 2.5

ACOG Risk is small but catastrophic

Page 37: Contraception in  Chronic Medical Conditions

COC Risks

StrokeStroke Stroke 2009; 40(4):1050No increased risk

NEJM 2012; 366:225730-40 mcg EE RR ↑ 1.5-2.220 mcg EE RR ↑ 0.9-1.7Ortho Evra ↑ 3.2Nuvaring ↑ 2.5

ACOG Risk is small but catastrophic

Page 38: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

No ↑ risk•Contraception 2012; 85: p342•NEJM 1986; 315:p405•JAMA 2000;284: p1791 •NEJM 2002; 346: p2025

↑ risk•Lancet 1996; 347: p1713•Br J Cancer 2003;88: p50•Can Epid Prev 2010; 19: p2496•Mayo Clin Proc 2006;81: p1287

Page 39: Contraception in  Chronic Medical Conditions

COC Risks

Breast cancerBreast cancer

BRCA carriers: •↓ovarian cancer RR 0.50 (CI 0.33-0.75)•No association with breast cancer

• Formulations before 1975 ↑risk • RR 1.47 (1.06-2.04)

Eur J Cancer 2010: 46(12): 2275

Page 40: Contraception in  Chronic Medical Conditions

COC Risks

Coronary artery diseaseCoronary artery disease HypertensionHypertension StrokeStroke Breast cancerBreast cancer Lung cancerLung cancer

Page 41: Contraception in  Chronic Medical Conditions

CDC: US medical eligibility criteria for contraceptive use, 2010

1 = condition with no restriction

2 = condition where advantage > risk

3 = condition where advantage < risk

4 = condition represents unacceptable health risk if that method is used

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr59e0528a13.htm

Page 42: Contraception in  Chronic Medical Conditions

Contraception for diabetics

Don’t worry about: gestational diabetesworsening control of DM

Page 43: Contraception in  Chronic Medical Conditions

Special Considerations:

Bariatric Surgery Gastric bypass Gastric bypass

COC category 3COC category 3All other methods category 1All other methods category 1

Restrictive (lap band) Restrictive (lap band) All category 1All category 1

Page 44: Contraception in  Chronic Medical Conditions

Headache…

Page 45: Contraception in  Chronic Medical Conditions

Seizure Disorder Decreased contraceptive efficacyDecreased contraceptive efficacy

Use doses >50 mcg EEUse doses >50 mcg EE Barbiturates, carbamazepine, oxcarbazepine, felbamate, topiramate levels Barbiturates, carbamazepine, oxcarbazepine, felbamate, topiramate levels

reducedreduced Levetiracetam, valproic okLevetiracetam, valproic ok

lamotrigine (lamotrigine (LamictalLamictal) ) COCs decrease the lamotrigine levels by 50%COCs decrease the lamotrigine levels by 50% Toxic levels in placebo weekToxic levels in placebo week

DMPA, IUDDMPA, IUD

Cochrane Rev Abstract 2007

Page 46: Contraception in  Chronic Medical Conditions

Sickle cell disease

No proof COC contributes to extra VTE riskNo proof COC contributes to extra VTE risk No studies looking at this directlyNo studies looking at this directly

No effect on number of crisisNo effect on number of crisis Fair-poor quality studiesFair-poor quality studies

In CR only 1 trial met criteria to be includedIn CR only 1 trial met criteria to be included 25 patients- Depo-Provera vs placebo25 patients- Depo-Provera vs placebo During DMPA use, less sickle During DMPA use, less sickle episodesepisodes

• OR 0.23 (95% CI 0.05-1.02)OR 0.23 (95% CI 0.05-1.02)

Cochrane Rev Abstract 2007Contraception 2012; 85: 527

Page 47: Contraception in  Chronic Medical Conditions

Systemic Lupus Erythematosus

Low likelihood of significant flare w/COC*Low likelihood of significant flare w/COC* Thrombosis risk not increasedThrombosis risk not increased Excluded those with mod-high ab levelsExcluded those with mod-high ab levels

Caution w/ drospirenone, DMPACaution w/ drospirenone, DMPA Severe thrombocytopenia: avoid ParaGard & DMPASevere thrombocytopenia: avoid ParaGard & DMPA Use of immunosuppressants does not affect choiceUse of immunosuppressants does not affect choice

*Petri M, et al. N Engl J Med. 2005;353:2550-2559 . *Sanchez-Guerrero J et al. N Engl J Med. 2005;353:2539-2950 .

Page 48: Contraception in  Chronic Medical Conditions

Rheumatoid arthritis

COC has no negative outcomes on RACOC has no negative outcomes on RA COC use > 5 yrs, RR of severe dz 0.1 COC use > 5 yrs, RR of severe dz 0.1 (95% CI 0.01-0.6)(95% CI 0.01-0.6)

DMARDs: methotrexate & leflunomide are DMARDs: methotrexate & leflunomide are pregnancy category Xpregnancy category X

Stop MTX 3 months & leflunomide 2 yrs prior to Stop MTX 3 months & leflunomide 2 yrs prior to conception conception

Ann Rheum Dis. 1996 February; 55(2): 94–98.J of Rheumatology. Vol 31: Supplement 69, March 2004

Page 49: Contraception in  Chronic Medical Conditions

Organ Transplant Amenorrhea/infertility common with hepato- renal diseaseAmenorrhea/infertility common with hepato- renal disease

1/20 transplant patients of childbearing get pregnant1/20 transplant patients of childbearing get pregnant

National transplantation pregnancy registry:National transplantation pregnancy registry: Live birth rate 50-86%Live birth rate 50-86%

Medicare:Medicare: Live birth rate 55%Live birth rate 55% Post transplant pregnancy 33/1000 womenPost transplant pregnancy 33/1000 women

Estimates don’t include abortionsEstimates don’t include abortions

Page 50: Contraception in  Chronic Medical Conditions

Organ Transplant Pregnancy risks post transplant:Pregnancy risks post transplant:

Graft rejectionGraft rejection Pregnancy complicationsPregnancy complications Most antirejection agents are pregnancy class DMost antirejection agents are pregnancy class D

Contraception should be discussed prior to transplantContraception should be discussed prior to transplant Women should wait 18-24 months before pregnancyWomen should wait 18-24 months before pregnancy IUD, hormonal options are category 2 IUD, hormonal options are category 2

• Unless graft failure, rejection, allograft vasculopathyUnless graft failure, rejection, allograft vasculopathy– COC category 4COC category 4– IUD category 3IUD category 3– Depo, POP category 2Depo, POP category 2

Page 51: Contraception in  Chronic Medical Conditions

HIV

CDC update 6/2012: All hormonal CDC update 6/2012: All hormonal contraception may be used in those with HIVcontraception may be used in those with HIV

? Increased risk of HIV acquisition? Increased risk of HIV acquisitionDepo HR 2.04 (CI 1.04-2.05)Depo HR 2.04 (CI 1.04-2.05)COC HR 1.8 (CI 0.55-5.82) COC HR 1.8 (CI 0.55-5.82)

MMWR 2012; 61(24):449Lancet Inf Dis 2012; 12(1): 19

Page 52: Contraception in  Chronic Medical Conditions

? Increased HIV acquisition

Should we shift away from DMPA to condoms or pills?

600 additional unwanted births per 100 HIV infections averted

If no protection: 5400 unwanted births

Jain AK. Contraception 86 (2012): 645

Page 53: Contraception in  Chronic Medical Conditions

CHC Category 1 Medical Conditions

Family history of breast cancer Family history of breast cancer CirrhosisCirrhosis Endometrial cancer/hyperplasiaEndometrial cancer/hyperplasia Ovarian cancerOvarian cancer HIV HIV MalariaMalaria Viral hepatitisViral hepatitis Varicose veinsVaricose veins TBTB

Page 54: Contraception in  Chronic Medical Conditions

Category 1 Medical Conditionsassuming not…

CirrhosisCirrhosis notnot severe, decompensated severe, decompensated

HIVHIV watch drug interactionswatch drug interactions

Viral hepatitisViral hepatitis notnot acute or flare acute or flare

Page 55: Contraception in  Chronic Medical Conditions

CHC Category 2 Medical Conditions

Cervical cancerCervical cancer DVT family hx (1DVT family hx (1stst degree) degree) Superficial thrombophlebitisSuperficial thrombophlebitis Gallstones (asymptomatic)Gallstones (asymptomatic) Pregnancy related cholestasisPregnancy related cholestasis HTN during pregnancyHTN during pregnancy FNH liverFNH liver IBDIBD Valvular heart diseaseValvular heart disease

Page 56: Contraception in  Chronic Medical Conditions

Category 2 Medical Conditionsassuming not…

Preg related cholestasisPreg related cholestasis notnot COC related COC related

IBDIBD not extensive, dehydration, vitamin deficiency, surgery, not extensive, dehydration, vitamin deficiency, surgery, steroid use, immobilizationsteroid use, immobilization

Valvular heart dzValvular heart dz notnot complicated complicated

(pulm htn, htn, afib, SBE)(pulm htn, htn, afib, SBE)

Page 57: Contraception in  Chronic Medical Conditions

CHC Category 3 Medical Conditions

VTE/PEVTE/PE

Breast cancerBreast cancer

Peripartum cardiomyopathy >6 monthsPeripartum cardiomyopathy >6 months

Page 58: Contraception in  Chronic Medical Conditions

CHC Category 3 Medical Conditionsassuming:

VTE/PE VTE/PE anticoagulation for 3 months, low anticoagulation for 3 months, low risk for recurrencerisk for recurrence

Breast cancerBreast cancer disease free for 5 yearsdisease free for 5 years

Peripartum cardiomyopathyPeripartum cardiomyopathy >6 months >6 months & normal or mildly impaired cardiac function& normal or mildly impaired cardiac function

Page 59: Contraception in  Chronic Medical Conditions

Emergency Contraception

MethodMethod DoseDose EfficacyEfficacy

high dose estrogenhigh dose estrogen 5 mg EE qd x 55 mg EE qd x 5 75-80%75-80%

estrogen + progestinestrogen + progestin 100 ug EE + 0.5 mg 100 ug EE + 0.5 mg levonorgestrel po q12 hr x 2levonorgestrel po q12 hr x 2

56-89 % 56-89 %

levonorgestrellevonorgestrel

(Plan B)(Plan B) 0.75 mg q12 x 2 0.75 mg q12 x 2 (Plan B One-Step)(Plan B One-Step) 1.5 mg x1 1.5 mg x1 60-94 %60-94 %

ulipristal ulipristal (ella(ella™™)) 30 mg30 mg ~98.6%~98.6%

copper IUD Insert within 5 days 99%

Page 60: Contraception in  Chronic Medical Conditions

Emergency Contraception

MethodMethod DoseDose EfficacyEfficacy

levonorgestrellevonorgestrel

(Plan B)(Plan B) 0.75 mg q12 x 2 0.75 mg q12 x 2 (Plan B One-Step)(Plan B One-Step) 1.5 mg x1 1.5 mg x1 60-94 %60-94 %

ulipristal ulipristal (ella(ella™™)) 30 mg30 mg ~98.6%~98.6%

Page 61: Contraception in  Chronic Medical Conditions

Emergency Contraception

MethodMethod DoseDose EfficacyEfficacy

EC Hotline:

1-888-NOT-2- LATE

Page 62: Contraception in  Chronic Medical Conditions

Thank you!

[email protected]