contentsannalsoftherheumaticdiseases january1986vol.45no. 1 contents page george frederic still e b...

Annals of the Rheumatic Diseases January 1986 Vol. 45 No. 1

Contents

PageGeorge Frederic Still E B D HAMILTON 1Rheumatoid arthritis, juvenile arthritis, iridocyclitis and the Epstein-Barr virus A J GEAR,

P J W VENABLES, J M B EDWARDS, R N MAINI, AND B M ANSELL 6

Cytidine deaminase activity as a measure of acute inflammation in rheumatoid arthritis P W THOMPSON,D D JONES AND H L F CURREY 9

Platelet releasing activity in sera of patients with rheumatoid vasculitis T J CUNNINGHAM, R L MEDCALF,J D MATHEWS, AND K D MUIRDEN 15

Relationship between iron deposits and tissue damage in the synovium: an ultrastructural studyC J MORRIS, D R BLAKE, A C WAINWRIGHT, AND M M STEVEN 21

Distribution of joint mobility in a normal population: results of the use of fixed torque measuringdevices ALAN J SILMAN, DORIAN HASKARD, AND SIMON DAY 27

Trichorhinophalangeal syndrome type I: symptoms and signs, radiology and genetics SVEN NOLTORPULF KRISTOFFERSSON, NILS MANDAHL, LEIF STIGSSON, BJORN SVENSSON, AND CARL-OLOF WERNER 31

Studies of the effect of D-penicillamine and sodium aurothiomalate therapy on superoxide anionproduction by monocytes from patients with rheumatoid arthritis: evidence for in vivo stimulationof monocytes N P HURST, A L BELL, AND G NUKI 37

Intracellular and extracellular sulphydryl levels in rheumatoid arthritis J F KOSTER, P BIEMOND,AND A J G SWAAK 44

Acute poststreptococcal polymyalgia NOAM HARATS, HANAN GUR, AND ALAN RUBINOW 47Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections

of killed bacteria A C HANGLOW, C J R WELSH, P CONN, J M PITrS, A RAMPLING, AND R R A COOMBS 50Restricted expression of anti-type II collagen antibody isotypes in mice suppressed for collagen-induced arthritis THOMAS F KRESINA AND CANDACE K FINEGAN 60

Studies on the chronic phase of adjuvant arthritis: effect of SR 41319, a new diphosphonateA BARBIER, J C BRELItRE, B REMANDET, AND R RONCUCCI 67

Facial rash with scarring due to granulomatous vasculitis in rheumatoid disease RAYMOND WHITE,ANNETrE WEGMAN, PETER BULPITT, GLENDA WOOD, AND ANTHONY FLEMING 75

Palindromic rheumatism with rheumatoid nodules: a case report with ultrastructural studiesSERGE SCHREIBER, H RALPH SCHUMACHER, AND P VARGHESE CHERIAN 78

Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treated withD-penicillamine A J WILLIAMS, J N FORDHAM, C G BARNES, AND F J GOODWIN 82

Correspondence 85

Clinical vignette 88Notes 88

ASTMS CODEN: ARDIAO 45 (1) 1-88 (1986) ISSN 0003-4967

British Medical Association Tavistock Square London WC1H 9JR

Published by British Medical Association, Tavistock Square, London WC1H 9JR, andprinted in England by The Devonshire Press Ltd., Torquay

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CONTENTS OF VOLUME 45

No. 1 JANUARY, 1986George Frederic Still

E B D Hamilton 1Rheumatoid arthritis, juvenile arthritis, iridocyclitis and the Epstein-Barr

virusA J Gear, P J W Venables, J M B Edwards, R N Maini, andB M Ansell 6

Cytidine deaminase activity as a measure of acute inflammation inrheumatoid arthritisP W Thompson, D D Jones, and H L F Currey 9

Platelet releasing activity in sera of patients with rheumatoid vasculitisTJ Cunningham, R L Medcalf, J D Mathews, and K D Muirden 1 5

Relationship between iron deposits and tissue damage in the synovium:an ultrastructural studyC J Morris, D R Blake, A C Wainwright, and M M Steven 21

Distribution of joint mobility in a normal population: results of the use offixed torque measuring devicesAlan J Silman, Dorian Haskard, and Simon Day 27

Trichorhinophalangeal syndrome type 1: symptoms and signs, radiologyand geneticsSven Noltorp, Ulf Kristoffersson, Nils Mandahl, Leif Stigsson,Bjorn Svensson, and Carl-Olof Werner 31

Studies of the effect of D-penicillamine and sodium aurothiomalatetherapy on superoxide anion production by monocytes from patientswith rheumatoid arthritis: evidence for in vivo stimulation ofmonocytesN P Hurst, A L Bell, and G Nuki 37

Intracellular and extracellular sulphydryl levels in rheumatoid arthritisJ F Koster, P Biemond, and A J G Swaak 44

Acute poststreptococcal polymyalgiaNoam Harats, Hanan Gur, and Alan Rubinow 47

Experimental induction of rheumatoid factor and joint lesions in rabbitsafter intravenous injections of killed bacteriaA C Hanglow, C J R Welsh, P Conn, J M Pitts, A Rampling, andRRA Coombs 50

Restricted expression of anti-type iI collagen antibody isotypes in micesuppressed for collagen-induced arthritisThomas F Kresina and Candace K Finegan 60

Studies on the chronic phase of adjuvant arthritis: effect of SR 41319, anew diphosphonateA Barbier, J C Breliere, B Remandet, and R Roncucci 67

Facial rash with scarring due to granulomatous vasculitis in rheumatoiddiseaseRaymond White, Annette Wegman, Peter Bulpitt, Glenda Wood,and Anthony Fleming 75

Palindromic rheumatism with rheumatoid nodules: a case report withultrastructural studiesSerge Schreiber, H Ralph Schumacher, and P Varghese Cherian 78


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Progressive proliferative glomerulonephritis in a patientwith rheumatoidarthritis treated with D-penicillamineA J Williams, J N Fordham, C G Barnes, and F J Goodwin 82

Correspondence 85Clinical vignette 88Notes 88

No. 2 FEBRUARY, 1986Constrictive pericarditis in rheumatoid arthritis

A K Thould 89Growth of human B cell colonies from peripheral blood of patients with

systemic lupus erythematosusAnne C Fay, Susan Price, A Trudgett, J D McCrea, Margaret Haire,M W J Boyd, and T A McNeill 95

Cultured human cells with high levels of gold-binding cytosolicmetallothionein are not resistant to the growth inhibitory effect ofsodium aurothiomalateA Glennas and H E Rugstad 101

Rubella-associated arthritis. 1. Comparative study of joint manifestationsassociated with natural rubella infection and RA 27/3 rubellaimmunisationAubrey J Tingle, Marilyn Allen, Ross E Petty, G Donald Kettyls,and Janet K Chantler 110

Rubella-associated arthritis. 11. Relationship between circulatingimmune complex levels and joint manifestations

Vijendra K Singh, Aubrey J Tingle, and Michael Schulzer 115T lymphocyte lines from arthritic synovial fluid: establishment and

functionC J Bishop, R A Hazelton, D J Moss, and J M Ryan 120

HLA haplotype sharing by siblings with rheumatoid arthritis: evidencefor genetic heterogeneity

David M Grennan, PaulA Sanders, Philip A Dyer, and Rodney Harris 126Limited joint mobility (LJM) of the hand in patients with diabetes mellitus:

relation to chronic complicationsHarold S Starkman, Ray E Gleason, Lawrence I Rand,Donald E Miller, and J Stuart Soeldner 130

Azathioprine in giant cell arteritis/polymyalgia rheumatica: adouble-blind studyM De Silva and B L Hazleman 136

Sulphasalazine in rheumatoid arthritis: desensitising the patient with askin rashD E Bax and R S Amos 139

HLA-B27 associated reactive spondyloarthropathies in a Dutch militaryhospitalR J Lionarons, M Van Zoeren, J N Verhagen, and H A Lammers 141

HLA-B27 associated cross-reactive marker on the cells of New Zealandpatients with ankylosing spondylitis

L E McGuigan, A F Geczy, J K Prendergast, J P Edmonds, H H Hart,and H V Bashir 144


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Bone metabolism in rheumatoid arthritis compared with postmenopausalosteoporosisRM Van Soesbergen, P Lips, A Van Den Ende, and J K Van Der Korst 149

Inability of rheumatologists to describe their true policies for assessingrheumatoid arthritisJ R Kirwan, D M Chaput De Saintonge, C R B Joyce, J Holmes,and H L F Currey 156

Comparison of urinary glycosaminoglycan excretion in rheumatoidarthritis, osteoarthritis, myocardial infarction, and controlsAlexis J Chuck, John Murphy, Jacqueline B Weiss, andDavid M Grennan 162

Systemic lupus erythematosus and nodular regenerative hyperplasia ofthe liverP Klemp, A H Timme, and G M Sayers 167

Corticosteroids in rheumatoid arthritis: Is a trial of their 'diseasemodifying' potential feasible?Margaret A Byron and John R Kirwan 171

Correspondence 174Book reviews 175Notes 176Correction 176

No. 3 MARCH, 1986Association of different HLA antigens with various toxic effects of gold

salts in rheumatoid arthritisM Hakala, A H W Van Assendelft, J Ilonen, S Jalava, andA Tiilikainen 177

Differential effects of therapeutic regimens on specific classes ofrheumatoid factorRichard M Pope, James Lessard, and Eugene Nunnery 183

Ankylosing spondylitis, HLA-B27, and klebsiella: a study of lymphocytereactivity of anti-klebsiella seraB Singh, J D Milton, and J C Woodrow 190

Doctor-patient communication in rheumatology: studies of visual andverbal perception using educational booklets and other graphicmaterialJ M H Moll 198

Urinary monoclonal free light chains in primary Sjogren's syndrome: anaid to the diagnosis of malignant lymphomaM T Walters, FK Stevenson, A Herbert, M I D Cawley, and J L Smith 210

2', 5'-Oligoadenylate synthetase induction in lymphocytes of patientswith connective tissue diseasesWinsome Hylton, Jane Cayley, Caroline Dore, and A M Denman 220

Structural consequences of traumatising articular cartilageN D Broom 225

Metabolic activity of erosions in rheumatoid arthritisPauline Pitt, H Berry, M Clarke, H Foley, J Barratt, and V Parsons 235

Amyloid in intervertebral discs: a histopathological investigation ofsurgical material from 100 consecutive operations on herniateddiscsChr Ladefoged, Ole Fedders, and Ole Fritz Petersen 239


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Antioxidant action of antimalarialsYoshiki Miyachi, Akira Yoshioka, Sadao Imamura, and Yukie Niwa 244

Superoxide production by polymorphonuclear leucocytes in rheumatoidarthritis and osteoarthritis: in vivo inhibition by the antirheumaticdrug piroxicam due to interference with the activation of theNADPH-oxidaseP Biemond, A J G Swaak, J M A Penders, C M Beindorff, andJ F Koster 249

Brucellar arthritis in children and its successful treatment withtrimethoprim-sulphamethoxazole (co-trimoxazole)

Francisco J Gomez-Reino, Isabel Mateo, Antonio Fuertes, andJuan J Gomez-Reino 256

Correspondence 259Notes 264

No. 4 APRIL, 1986Genetic analysis of families of patients with Behqet's syndrome: data

incompatible with autosomal recessive inheritanceJ A Bird Stewart 265

Genetic variants of complement component 3 (C3) in DR4 positive andDR4 negative rheumatoid arthritisW Thomson, P A Dyer, P A Sanders, and D M Grennan 269

A reappraisal of 'analgesic hip'Michael Doherty, Mary Holt, Philip MacMillan, lain Watt, andPaul Dieppe 272

Assessment of inflammation in the rheumatoid knee joint: correlationbetween clinical, radioisotopic, and thermographic methodsM De Silva, V Kyle, B Hazleman, R Salisbury, P Page Thomas, andP Wraight 277

Atypical erosive osteoarthritis and Sjogren's syndromeRhonda Shuckett, M Lynn Russell, and Dafna D Gladman 281

Biochemical and histological changes in osteoarthritic synovialmembrane0 Gedikoglu, M T Bayliss, S Y Ali, and I Tuncer 289

Functional capacity and treatment data from a community based studyof patients with rheumatoid arthritisSusan G Owen, William T Friesen, Michael S Roberts,Hilton Francis, and William Flux 293

Dupuytren's contracture and alcoholAnthony Bradlow and Alastair G Mowat 304

Hyperlipoproteinaemia in primary gout: hyperlipoproteinaemicphenotype and influence of alcohol intake and obesity in JapanSheng Jiao, Kaoru Kameda, Yuji Matsuzawa, and Seiichiro Tarui 308

Complement fixation by anti-dsDNA antibodies in SLE: measurementby radioimmunoassay and relationship with disease activityC G Mackworth-Young, J K H Chan, C C Bunn, G R V Hughes,and A E Gharavi 314

Thrombotic thrombocytopenic purpura and systemic lupus erythematosusDavid A Fox, James D Faix, Jon Coblyn, Patricia Fraser,Brian Smith, and Michael E Weinblatt 319


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Occurrence of autoimmune diseases and autoantibodies in multicaserheumatoid arthritis familiesD J Walker, M Griffiths, and / D Griffiths 323

Small joint involvement: a systematic roentgenographic study inrheumatoid arthritisJames T Halla, Sohrab Fallahi, and Joe G Hardin 327

Synovitis associated with serum IgM rheumatoid factor arisingspontaneously in 'Old English' rabbitsA C Hanglow, CJ R Welsh, P Conn, D S Thomas, and R RA Coombs 331

Effects of cyclosporin on collagen induced arthritis in miceKenji Takagishi, Nobuhiro Kaibara, Takao Hotokebuchi,Chikafumi Arita, Masahiro Morinaga, and Ken Arai 339

Manubriosternal joint dislocation in rheumatoid arthritis: the role ofthoracic kyphosisM C Kelly, N D Hopkinson, and G C Zaphiropoulos 345

Correspondence 349Book reviews 351Note 352

No. 5 MAY, 1986The SL autoantibody-antigen system: clinical and biochemical studies

Robert M Bernstein, Stephen H Morgan, Christopher C Bunn,Richard C Gainey, Graham R V Hughes, and Michael B Mathews 353

Predictive value of complement profiles and anti-dsDNA in systemiclupus erythematosusA J G Swaak, J Groenwold, and W Bronsveld 359

Relationships between C3b receptor (CR1) activity of erythrocytes andpositive Coombs' tests

Yoritaro Inada, Mikio Kamiyama, Tsuneyoshi Kanemitsu,William S Clark, and Yoshiyuki Asai 367

Long term progression of joint damage in rheumatoid arthritisD L Scott, B L Coulton, and A J Popert 373

Quantitative microfocal radiography accurately detects joint changes inrheumatoid arthritisJ C Buckland-Wright, / Carmichael, and S R Walker 379

Regressive systemic sclerosisCarol Black, Paul Dieppe, Ted Huskisson, and Frank Dudley Hart 384

Cultured human cells can acquire resistance to the antiproliferativeeffect of sodium aurothiomalateA Glennas and H E Rugstad 389

Sulphasalazine in ankylosing spondylitisNils Feltelius and Roger Hal/gren 396

IgG subclass serum levels in juvenile chronic arthritisAlberto Martini, Alessandro Plebani, Angelo Ravelli,Maria A Avanzini, Roy Jefferis, Laura Zonta, Luigi D Notarangelo,Alberto G Ugazio, and Roberto Burgio 400

Immunoglobulin classes in plasma cells of the synovial membrane inchronic inflammatory joint disease

Peter A Revell and Vivien Mayston 405


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Sister chromatid exchange frequencies in patients with scleroderma andtheir relativesR G Palmer, R S Pereira, C J Dore, and A M Denman 409

HLA antigens in Italian patients with primary Sjogren's syndromeC Vitali, A Tavoni, G Rizzo, R Neri, A D'ascanio, R Christofani,and S Bombardieri 412

Wegener's granulomatosis in two sistersMiguelA Muniain, Jose C Moreno, and Ricardo Gonzalez Campora 417

Effects of heparin, histamine, and salmon calcitonin on mouse calvarialbone resorptionA J Crisp, J K Wright, and B L Hazelman 422

Heterozygous C2 deficiency associated with angioedema, myastheniagravis, and systemic lupus erythematosusJ Efthimiou, D D'cruz, P Kaplan, and D Isenberg 428

Arthritis and antinuclear antibodies (ANA) with inherited deficiency ofthe sixth component of complement (C6)

Elizabeth Reinitz, Marissa Lawrence, Betty Diamond, Harold Keiser,and Chester Alper 431

Budd-Chiari syndrome as the major thrombotic complication of systemiclupus erythematosus with the lupus anticoagulantMordechai Averbuch and Yoram Levo 435

Correspondence 438Book reviews 440Correction 440

No. 6 JUNE, 1986Mechanism of action of intradiscal chymopapain in the treatment of

sciatica: a clinical, biochemical, and radiological studyJ R Jenner, David J Buttle, and A K Dixon 441

a, Antitrypsin (PI) allotypes in rheumatoid arthritisP A Sanders, W Thomson, D A Browne, P A Dyer, andD M Grennan 450

Improved method of isolating bacteria from joint fluids by the use ofblood culture bottlesRobert Von Essen and Aira Holtta 454

Bacterial arthritis in an English health district: a 10 year reviewC Cooper and M I D Cawley 458

Genetic susceptibility to early onset pauciarticular juvenile chronicarthritis: a study of HLA and complement markers in 158 BritishpatientsP J Hall, S J Burman, M R Laurent, D C Briggs, H E Venning,A M Leak, P A Bedford, and B M Ansell 464

Gastrin, gastric acid secretion, and gastric microflora in patients withrheumatoid arthritisK Henriksson, K Uvnas-Moberg, C-E Nord, C Johansson, andR Gullberg 475

Serum osteocalcin in rheumatoid arthritis and other inflammatoryarthritides: relation between inflammatory activity and the effect ofglucocorticoids and remission inducing drugsEva Af Ekenstam, Sverker Ljunghall, and Roger Hallgren 484


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Therapeutic effects on cartilage metabolism in arthritis as measured byrelease of proteoglycan structures into the synovial fluid

Tore Saxne, Dick Heinegard, and Frank A Wollheim 491Idiopathic haemorrhagic rupture of the shoulder in destructive disease

of the elderlyAnthony D Woolf, Tim E Cawston, and Paul A Dieppe 498

A study of anti-poly(ADP-ribose) antibodies and an anti-DNA antibodyidiotype and other immunological abnormalities in lupus familymembersC Dudeney, Y Shoenfeld, J Rauch, M Jones, C Mackworth Young,M Tavassoli, S Shall, and D A Isenberg 502

Rheumatoid factor in rheumatoid arthritis associated renal disease andin lupus nephritisH Helin, M Korpela, J Mustonen, and A Pasternack 508

Connective tissue abnormalities in MRU1 miceJ C W Edwards, A Cooke, A R Moore, C Collins, F Hay, andD A Willoughby 512

Angio-immunoblastic lymphadenopathy with dysproteinaemia (AILD)and sicca syndromeY J Bignon, A Janin-Mercier, J J Dubost, J M Ristori, Y Fonck,J C Alphonse, and B J Sauvezie 519

Morphoea (localised scleroderma) in a patient with mixed connectivetissue diseaseD N Golding 523

Correspondence 526Book reviews 528Notes 528

No. 7 JULY, 1986New methods in arthroscopy: preliminary investigations

L Frizziero, F Zizzi, R Leghissa, and A Ferruzzi 529Immunogenetic heterogeneity of rheumatoid arthritis

M L Westedt, F C Breedveld, G M Th Schreuder, J D'amaro, A Cats,and R R P De Vries 534

Functional capacities of T lymphocyte subsets from synovial fluid andblood in rheumatoid arthritisJ0rgen Petersen 539

Cytotoxic mechanisms in vitro against Epstein-Barr virus infectedlymphoblastoid cell lines in rheumatoid arthritisMichael M McChesney and Arthur D Bankhurst 546

Defective Epstein-Barr virus specific suppressor T cell function inprogressive systemic sclerosisAlice Kahan, Andre Kahan, Charles J Menkes, and Bernard Amor 553

IgA-anti-yersinia antibodies in yersinia triggered reactive arthritisKaisa Granfors and Auli Toivanen 561

Significance of non-pathogenic cross reactive bowel flora in patientswith ankylosing spondylitis

L E McGuigan, J K Prendergast, A F Geczy, J P Edmonds, andH V Bashir 566


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A comparison of rheumatoid arthritis in Australia and ChinaHelen Moran, Shun-Le Chen, K D Muirden, Shao-Ji Jiang,Yue-Ying Gu, John Hopper, Pei-Lin Jiang, Gary Lawler, andRen-Biao Chen 572

Thyroid disorders in systemic lupus erythematosusK L Goh and F Wang 579

Immunocytology of synovial fluid cells may be of diagnostic andprognostic value in arthritis

L W Poulter, H A A Al-Shakarchi, E D R Campbell, A J Goldstein,and A T Richardson 584

Spontaneous and pokeweed mitogen induced production of rheumatoidfactor and immunoglobulins in type 11 essential mixedcryoglobulinaemiaR A Sinico, G Fiorini, A Fornasieri, P Bernasconi, S Benuzzi,M L Paracchini, and G D'amico 591

Serum ferritin as indicator of iron responsive anaemia in patients withrheumatoid arthritis

Troels M0rk Hansen and Niels Ebbe Hansen 596Patterns of radiographic abnormalities associated with basic calcium

phosphate and calcium pyrophosphate dihydrate crystal depositionin the kneePaul B Halverson and Daniel J McCarty 603

Response of acute cerebral lupus in childhood to pulsemethylprednisolone in reduced dosageOwen Hanmer and David Saltissi 606

Viewpoint: Is chronic synovitis an example of reperfusion injury?I Woodruff, D R Blake, J Freeman, F J Andrews, P Salt, andJ Lunec 608

Correspondence 612Book reviews 615Notes 616

No. 8 AUGUST, 198699mTc HMDP bone scanning in generalised nodal osteoarthritis.

1. Comparison of the standard radiograph and four hour bone scanimage of the handC W Hutton, E R Higgs, P C Jackson, I Watt, and P A Dieppe 617

99mTc HMDP bone scanning in generalised nodal osteoarthritis. 11. Thefour hour bone scan image predicts radiographic changeC W Hutton, E R Higgs, P C Jackson, I Watt, and P A Dieppe 622

HLA and rheumatoid arthritis: a combined analysis of 440 British patientsD Jaraquemada, W Ollier, J Awad, A Young, A Silman, I M Roitt,M Corbett, F Hay, J A Cosh, R N Maini, P J Venables, B Ansell,J Holborow, J Reeback, H L F Currey, and H Festenstein 627

Gastrointestinal peptides in serum and synovial fluid from patients withinflammatory joint disease

I Lygren, M 0stensen, P G Burhol, and G Husby 637Systemic lupus erythematosus presenting as polymyalgia rheumatica in

the elderlyC W Hutton and P J Maddison 641


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Systemic lupus erythematosus in ZimbabweH G Taylor and C M Stein 645

Early treatment of avascular necrosis in systemic lupus erythematosusA A Kalla, / D Learmonth, and P Klemp 649

A placebo controlled, crossover study of azathioprine in Reiter'ssyndromeAndrei Calin 653

Association of bronchiolitis with connective tissue disordersMarkku Hakala, Paavo Paakko, Seppo Sutinen, Esko Huhti,Olli Koivisto, and Matti Tarkka 656

Mortality from amyloidosis and renal diseases in patients withrheumatoid arthritisMarkku Laakso, Olli Mutru, Heikki Isomaki, and Kalevi Koota 663

Amyloid deposits in the knee joint at autopsyChr Ladefoged 668

Lack of correlation between in vitro and in vivo effects of low densitylipoprotein on the inflammatory activity of monosodium uratecrystalsT P Gordon, P Clifton, M J James, and P J Roberts-Thomson 673

HLA-DR expression by labial minor salivary gland tissue in Sjogren'ssyndromeH M Moutsopoulos, J J Hooks, C C Chan, Y A Dalavanga,F N Skopouli and B Detrick 677

Rheumatoid factor tests in the diagnosis and prediction of rheumatoidarthritisD J Walker, J D Pound, / D Griffiths, and R J Powell 684

A population study on rheumatoid arthritis in Lesotho, southern AfricaJ D Moolenburgh, H A Valkenburg, and P B Fourie 691

Immune complexes and the pathogenesis of neutropenia in Felty'ssyndrui nleF C Breedveld, G J M Lafeber, E De Vries, J H J M Van Krieken, andA Cats 696

Correspondence 703Book review 704Clinical vignette 704

No. 9 SEPTEMBER, 1986A three year follow up of patients allocated to placebo, or oral or

injectable gold therapy for rheumatoid arthritisH A Capell, D Lewis, and J Carey 705

Binding of sodium aurothiomalate to human serum albumin in vitro atphysiological conditionsSusanne M0//er Pedersen 712

Pharmacodynamic effect of dipyridamole on thallium-201 myocardialperfusion in progressive systemic sclerosis with diffuse sclerodermaAndre Kahan, Jean Y Devaux, Bernard Amor, Charles J Menkes,Simon Weber, Jean M Foult, Alain Venot, Fran9ois Guerin,Michel Degeorges, and Jean C Roucayrol 718


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Cyclosporin treatment for rheumatoid arthritis: a placebo controlled,double blind, multicentre studyA WA M Van Rijthoven, BA C Dijkmans, H S Goei The, J Hermans,Z L M B Montnor-Beckers, P C L Jacobs, and A Cats 726

Cyclosporin A (CyA) in primary Sjogren's syndrome: a double blindstudyA A Drosos, F N Skopouli, J S Costopoulos, C S Papadimitriou,and H M Moutsopoulos 732

Pulmonary involvement in ankylosing spondylitisNils Feltelius, Hans Hedenstrom, Gunnar Hillerdal, andRoger Hallgren 736

Nailfold capillary microscopy in connective tissue disease: a quantitativemorphological analysisF Lefford and J C W Edwards 741

Osteogenesis imperfecta: a x ray fibre diffraction studyJ P Bradshaw and A Miller 750

Bone metabolism during methylprednisolone pulse therapy in rheumatoidarthritisJ W L Bijisma, S A Duursma, and 0 Huber-Bruning 757

Neutropenia in patients with inflammatory arthritis treated withsulphasalazineM Farr, D P M Symmons, D R Blake, and P A Bacon 761

Significance of connective tissue proliferation in the breakdown ofcartilage: a novel in vivo modelF B De Brito, A R Moore, S Adhya, A YAI-Duaij, and DA Willoughby 765

Pulmonary hypertension in hydralazine induced systemic lupuserythematosus: association with C4 null alleleRonald A Asherson, Alastair G Benbow, Christopher J Speirs,N Jackson, and Graham R V Hughes 771

Idiopathic peripheral enthesopathy without spondylarthritisM Nishikai, M Sugimoto, A Sato, and H Takeuchi 774

Unusual radiographic features in a female patient with ankylosingspondylitisTimothy J Cunningham, Peter M Cumber, Gordon Evison, andPeter J Maddison 776

Spontaneous pneumomediastinum in adult dermatomyositisJohn D Bradley 780

Monarticular rheumatoid-like arthritis of seven years' duration followingfracture of the radial head

Jacqueline Currey, L H K Therkildsen, and E G L Bywaters 783Conference report 786Correspondence 788Note 792


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No. 10 OCTOBER, 1986Antinuclear antibodies in the relatives and spouses of patients with

systemic sclerosisP J Maddison, R P Skinner, R S Pereira, Carol M Black, B M Ansell,Malcolm I V Jayson, N R Rowell, and K I Welsh 793

Fluctuations in anti-nRNP levels in patients with mixed connective tissuedisease are related to disease activity as part of a polyclonal B cellresponseP M Houtman, C G M Kallenberg, P C Limburg, M A Van Leeuwen,M H Van Rijswijk, and T H The 800

Serum immune complexes containing IgA appear to predict erosivearthritis in a longitudinal study in rheumatoid arthritis

Marie-Louise Westedt, Mohamed R Daha, William M Baldwin Ill,Theo Stijnen, and Arnold Cats 809

Immune complexes in synovial fluid and serum from patients withdisseminated gonococcal infection: evidence for local immunecomplex formation within the joint

William C Shiel Jr, Brian S Andrews, George J Friou,Franc A Barada Jr, Eve Scopelitis, and David A Martin 816

Demonstration of antiglobulin activity in the synovial membrane ofpatients with rheumatoid arthritis and ankylosing spondylitis afterpepsin treatment: real or artefact?P G Davies, P A Revell, and V Mayston 821

Ankylosing spondylitis: a chronic inflammatory disease with ironoverload in granulocytes and platelets

Nils Feltelius, Ulf Lindh, Per Venge, and Roger Hallgren 827Human parvovirus infection in early rheumatoid and inflammatory

-arthritisB J Cohen, M M Buckley, J P Clewley, V E Jones, A H Puttick, andR K Jacoby 832

Early and late changes in sulphydryl group and copper proteinconcentrations and activities during drug treatment withaurothiomalate and auranofinK J Rae, C N N Mackay, C J McNeil, D H Brown, W E Smith,D Lewis, and H A Capell 839

Superoxide dismutase isoenzymes of the synovial fluid in rheumatoidarthritis and in reactive arthritidesS L Marklund, A Bjelle, and L G Elmqvist 847

Vertebral and peripheral bone mineral content and fracture incidence inpostmenopausal patients with rheumatoid arthritis: effect of lowdose corticosteroidsA Verstraeten and J Dequeker 852

Growth of monosodium urate monohydrate crystals: effect of cartilageand synovial fluid components on in vitro growth ratesHelen M Burt and Y C Dutt 858

Experimental cryo-irrigation of the knee jointS C Chen, B Helal, P A Revell, R Brocklehurst, and H L F Currey 865

Mast cells in newly formed lining tissue during acute inflammation: a sixday air pouch model in the mouseY M Sin, A D Sedgwick, E P Chea, and D A Willoughby 873

Correspondence 878Note 880Correction 880


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No. 11 NOVEMBER, 1986Genetic structure of the population with rheumatoid arthritis in north

east England: a genetic approach to define different subtypesS S Papiha, J S Lanchbury, and B Pal 881

Analysis of circulating immune complexes from patients withankylosing spondylitis by gel electrophoresis and immunoblottingusing antiserum against a psoriasis associated retrovirus-likeparticleEyvind R0dahl and Ole-Jan Iversen 892

Scanning electron microscopy of rheumatoid arthritis peripheral bloodpolymorphonuclear leucocytesD A McCarthy, C M Holburn, B K Pell, S R Moore, A P Kirk, andJ D Perry 899

Acute osteomyelitis in Nigerians with sickle cell diseaseWalton W Ebong 911

The costoclavicular syndrome: a 'new cause'M De Silva 916

Serum and synovial fluid levels of angiotensin converting enzyme inpolyarthritisJ R Lowe, J S Dixon, J A Guthrie, and P McWhinney 921

Lymphocytes bearing Fcy receptors in rheumatoid arthritis. IV. Increasednumbers and activation of Facb-R+ cells after immunisation of healthyindividualsN J Goulding, L-J Eales and N D Hall 925

The abnormal cytotoxic T cell response to Epstein-Barr virus inrheumatoid arthritis is correlated with disease activity and occurs inother arthropathiesJ S H Gaston, A B Rickinson, Q Y Yao, and M A Epstein -932

Serum alkaline ribonuclease derived from vascular endothelial cells israised in patients with rheumatoid vasculitisM Oribe, M Shingu, and M Nobunaga 937

Effect of treatment on erythrocyte phosphoribosyl pyrophosphatesynthetase and glutathione reductase activity in patients withprimary goutJ Braven, T R Hardwell, P Hickling, and M Whittaker 941

Prediction of progressive joint damage in patients with rheumatoidarthritis receiving gold or D-penicillamine therapyP T Dawes, P D Fowler, R Jackson, M Collins, M F Shadforth,R Stone, and D L Scott 945

Osteoporosis in rheumatoid arthritis: safety of low dose corticosteroidsP N Sambrook, J A Eisman, M G Yeates, N A Pocock, S Eberl,and G D Champion 950

Pilot study of phenytoin in rheumatoid arthritisDiana G Macfarlane, Beryl Clark, and Gabriel S Panayi 954

Autonomic neuropathy in systemic sclerosis: a case report andevaluation of six patientsC Sonnex, E Paice, and A G White 957

Behcet's disease with erosive arthritisA S M Jawad and C J Goodwill 961

Coronary arteritis complicating rheumatoid arthritisG A Van Albada-Kuipers, J A Bruijn, M-L Westedt, F C Breedveld,and F Eulderink 963

Correspondence 966Note 968


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No. 12 DECEMBER, 1986Measurement of the cross linking compound, pyridinoline, in urine as an

index of collagen degradation in joint diseaseSimon P Robins, Phyllis Stewart, Carol Astbury, and HowardA Bird 969

Deficient control of in vitro Epstein-Barr virus infection in patients withankylosing spondylitis

Stuart Robinson and Gabriel S Panayi 974Characterisation of nucleolar proteins as autoantigens using human

autoimmune seraJ Pfeifle, F A Anderer, and M Franke 978

Behqet's disease in Iraqi patientsZ S Al-Rawi, K E Sharquie, S J Khalifa, F M Al-Hadithi, andJ J Munir 987

Evidence for oligoclonal B cell expansion in the peripheral blood ofpatients with rheumatoid arthritisDavid A Fox and Brian R Smith 991

Collagenase production by human mononuclear cells in culture:inhibition by gold containing compounds and other antirheumaticagentsAkihide Ohta, James S Louie, and Jouni Uitto 996

Remarkably similar response to gold therapy in HLA identical sibs withrheumatoid arthritis

L B A Van De Putte, F Speerstra, P L C M Van Riel,A M Th Boerbooms, P J I Van't Pad Bosch, and P Reekers 1004

Carpal tunnel syndromecaused byamyloid containing 12 microglobulin: anew amyloid and a complication of long term haemodialysisJohn McClure, Carolyn J Bartley, and Peter Ackrill 1007

Low dose intravenous 3-amino-i-hydroxypropylidene-1,1-bisphosphonate(APD) for the treatment of Paget's disease of boneJ A Cantrill, H M Buckler, and D C Anderson 1012

Effects of dietary supplementation on autoimmunity in the MRUlprmouse: a preliminary investigationD G Godfrey, WH Stimson, J Watson, J F Belch, and RD Sturrock 1019

Experimental haemathrosis produces mild inflammation associatedwith intracellular Maltese crossesSung-Jae Choi, H Ralph Schumacher Jr, and Gilda Clayburne 1025

Vertebral osteomyelitis due to Staphylococcus warneriK T Karthigasu, R A Bowman, and D I Grove 1029

Is pregnancy a risk factor in the causation of rheumatoid arthritis?Alan J Silman 1031

Index 1035


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contentsannalsoftherheumaticdiseases january1986vol.45no. 1 contents page george frederic still e b...

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