T H E J O U R N A L O F T H E A L Z H E I M E R ’ S A S S O C I A T I O N

Volume 10, Issue 2 March 2014

CONTENTS

Featured Articles

135 Microvascular network alterations in the retina

of patients with Alzheimer’s disease

Carol Yim-lui Cheung, Yi Ting Ong,

M. Kamran Ikram, Shin Yeu Ong, Xiang Li,

Saima Hilal, Joseree-Ann S. Catindig,

Narayanaswamy Venketasubramanian, Philip Yap,

Dennis Seow, Christopher P. Chen, Tien Yin Wong

143 Time course of brain volume changes in the

preclinical phase of Alzheimer’s disease

Charlotte Bernard, Catherine Helmer,

Bixente Dilharreguy, Helene Amieva,

Sophie Auriacombe, Jean-Francois Dartigues,

Michele Allard, Gwena€elle Catheline

152 Simulating effects of biomarker enrichment on

Alzheimer’s disease prevention trials:

Conceptual framework and example

Jeannie-Marie S. Leoutsakos, Alexandra L. Bartlett,

Sarah N. Forrester, Constantine G. Lyketsos

162 Global brain hypoperfusion and oxygenation in

amnestic mild cognitive impairment

Jie Liu, Yong-Sheng Zhu, Muhammad Ayaz Khan,

Estee Brunk, Kristin Martin-Cook,

Myron F. Weiner, C. Munro Cullum,

Hanzhang Lu, Benjamin D. Levine,

Ramon Diaz-Arrastia, Rong Zhang

171 Accounting for functional loss in Alzheimer’s

disease and dementia with Lewy bodies:

Beyond cognition

Joanne M. Hamilton, David P. Salmon,

RemaRaman, Lawrence A.Hansen, EliezerMasliah,

Guerry M. Peavy, Douglas Galasko

Alzheimer’s & Dementia (ISSN 1552-5260) is published bi-monthly by Elsevier, 360 Park

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179 Personality and risk of Alzheimer’s disease:

New data and meta-analysis

Antonio Terracciano, Angelina R. Sutin,

Yang An, Richard J. O’Brien, Luigi Ferrucci,

Alan B. Zonderman, Susan M. Resnick

187 Infantile exposure to lead and late-age cognitive

decline: Relevance to AD

Syed Waseem Bihaqi, Azadeh Bahmani,

Gehad M. Subaiea, Nasser H. Zawia

196 Increased risk of dementia in people with

previous exposure to general anesthesia: A

nationwide population-based case–control

study

Chia-Wen Chen, Che-Chen Lin, Kuen-Bao Chen,

Yu-Cheng Kuo, Chi-Yuan Li, Chi-Jung Chung

205 Evaluation of memory endophenotypes for

association with CLU, CR1, and PICALM

variants in black and white subjects

Otto Pedraza, Mariet Allen, Kyle Jennette,

Minerva Carrasquillo, Julia Crook, Daniel Serie,

V. Shane Pankratz, Ryan Palusak, Thuy Nguyen,

Kimberly Malphrus, Li Ma, Gina Bisceglio,

RosebudO. Roberts, John A. Lucas, Robert J. Ivnik,

Glenn E. Smith, Neill R. Graff-Radford,

Ronald C. Petersen, Steven G. Younkin,

Nil€ufer Ertekin-Taner

214 Implications of early treatment among

Medicaid patients with Alzheimer’s disease

David S. Geldmacher, Noam Y. Kirson,

Howard G. Birnbaum, Sara Eapen,

Evan Kantor, Alice Kate Cummings,

Vijay N. Joish

Contents continued on next page

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Contents continued

225 Diagnosing Alzheimer’s disease: A systematic

review of economic evaluations

Ron L.H. Handels, Claire A.G. Wolfs,

Pauline Aalten, Manuela A. Joore,

Frans R.J. Verhey, Johan L. Severens

238 ADO: A disease ontology representing the

domain knowledge specific to Alzheimer’s

disease

Ashutosh Malhotra, Erfan Younesi,

Michaela G€undel, Bernd M€uller,Michael T. Heneka, Martin Hofmann-Apitius

Perspectives

247 Rethinking the Food and Drug

Administration’s 2013 guidance on developing

drugs for early-stage Alzheimer’s disease

Lon S. Schneider

Review Article

251 Alzheimer’s disease in the human eye. Clinical

tests that identify ocular and visual information

processing deficit as biomarkers

Lily Y.L. Chang, Jennifer Lowe, Alvaro Ardiles,

Julie Lim, Angus C. Grey, Ken Robertson,

Helen Danesh-Meyer, Adrian G. Palacios,

Monica L. Acosta

Short Report

262 Microdosing of scopolamine as a

‘‘cognitive stress test’’: Rationale and

test of a very low dose in an at-risk

cohort of older adults

Peter J. Snyder, Yen Ying Lim,

Rachel Schindler, Brian R. Ott,

Stephen Salloway, Lori Daiello,

Christine Getter, Catherine M. Gordon,

Paul Maruff

Association Pages

268 Alzheimer’s Association Update

Online Exclusives

e27 Clinical characterization of a presenilin

1 mutation (F177S) in a family with very

early-onset Alzheimer’s disease in the

third decade of life

Lucrezia Hausner, Jakob A. Tsch€ape,Hans Peter Schmitt, Frank Hentschel,

Tobias Hartmann, Lutz Frolich

e40 Deaths in the United States among personswith

Alzheimer’s disease (2010–2050)

Jennifer Weuve, Liesi E. Hebert, Paul A. Scherr,

Denis A. Evans

e47 2014 Alzheimer’s disease facts and figures

Alzheimer’s Association

ISTAART Members and individual subscribers will have free access to two special online issues (February and October)

this year. Read the Journal (including these new, supplemental issues), register online, and sign up for alerts at www.

alzheimersanddementia.org.

Optic Disc

retinal opti

of both reti

disease pro

& Retinal Vasculature (Peter J. Snyder, 2013). Spalted box elder platter with pyrography, and superimposed

cal coherence tomography (OCT) image of artist’s (right eye) retinal vasculature and optic disc. OCT imaging

nal vasculature and neuron-containing cell layers may lead to new non-invasive biomarkers of early Alzheimer’s

gression.