connected medical devices market and business models 2017 report by yole developpement

39
From Technologies to Market Connected Medical Devices Market and Business Models 2017 Sample September 2017

Upload: yole-developpement

Post on 21-Jan-2018

1.477 views

Category:

Technology


0 download

TRANSCRIPT

Page 1: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

From Technologies to Market

Connected

Medical Devices

Market and Business

Models 2017

SampleSeptember 2017

Page 2: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

2

OBJECTIVES OF THE REPORT

• This report introduces the concept of IoMT and related medical devices in an increasingly connected World

• It describes how the healthcare organization is changing with new business models, and new value creation fromgenerated data

• It evaluates the market of connected devices, gives penetration rates compared to non-connected devices andanalyzes the dynamics

• It identifies the medical device and assistance device main players, giving an overview of the main products anddevelopments.

• The report gives a selected list of technology drivers and trends

• It informs on regulation, connectivity protocols and security for data exchanges

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 3: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

3

WHO SHOULD BE INTERESTED IN THE REPORT

o Pharmaceutical and medical device companies

• Understand the new challenges of IoT in medical /healthcare field

• Understand the benefits of connectivity and data generated

• Access market data and dynamics of connected medicaldevices and related sensors

• Identify standard supply chain, major players

• Get a list of selected connected medical devices on themarket and under development

• Identify new business models and innovative structurationof the healthcare industry regarding Internet of things

• Obtain information on connectivity and choice depending

• Get access to the latest information on regulations andsecurity of data sharing

o Sensor and assembly companies

• Better understand dynamic of connected medical devicemarket

• Identify the key criteria challenges linked to hardware andespecially sensors.

o IT and Connectivity players

• Get an overview of healthcare field in the context ofInternet of Things

• Better understand industry requirements

• Obtain information on regulation in medical field

o R&D players

• Understand the challenges related to Internet of MedicalThings industry

• Anticipate needs of medical device manufacturers and keydrivers

o Financial and strategic investors

• Get an overview of a changing field: market dynamic, newbusiness models, new generation of value,…

• Understand key players and innovative start-ups

o Healthcare & governmental organizations:

• Assess the benefits of innovative business models usingconnected medical devices

• Identify the key players and related products

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 4: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

4

TABLE OF CONTENT

1. Executive Summary p5

2. Introduction p35Definition

Report Scope

IoT Promises: the 4th industrial revolution

IoT and IoT medical (IoMT): History & context

Connected medical device drivers

Information and data value

Devices & sensors

Typical IT architecture

3. Connected medical device market forecast p72Segmentation of the Connected medical device market

Global connected medical device market

Sensor market

4. Connected device segmentation p93Implantable device for patient monitoring

Self-quantified patient monitoring

Professional patient monitoring

Assistance for lack of autonomy

5. Sensor technology trendsp194

Needs of miniaturization

Low power consumption and energy storage

Sensors for IoMT

Packaging trends

Sensor players

6. Business models p212

Identifying value proposition

Who pay?

7. Players and supply chain p231

Key players

Value chain

Data and interoperability players

8. IoMT Connectivity p240

Wireless sensor module and connectivity

Connectivity model

Connected medical device connectivity breadkdown

Connectivity roadmap

9. Regulation and market access p251

7. Conclusions p276

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 5: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

5

Biography & contactABOUT THE AUTHORS

Asma Siari, Technology & Market Analyst

As a Technology & Market Analyst in the Medical Technologies (MedTech) business unit at Yole Développement (Yole), Asma Siari isinvolved in the development of technology & market reports as well as the production of custom consulting projects. After a Master’sdegree in Biotechnologies, Diagnostic Therapeutics & Management, Asma serves as Research Assistant at the Moores Cancer Center (SanDiego, CA). She is a coauthor in two scientific publications published in the Molecular Cancer Research Journal. In addition to her missionatYole,Asma prepares today her Advanced Master’s degree in International Strategy & Marketing BtoB (EM Lyon Business School, France).

Email: [email protected]

Jérome Mouly, Technology & Market Analyst

Jerôme Mouly serves as a Technology & Market Analyst specialized in microtechnologies for biomedical & medical imagingapplications at Yole Développement, the “More than Moore” market research and strategy consulting company. Since 2000,Jérôme has participated in more than 100 marketing and technological analyses for industrial groups, start-ups and institutesrelated to semiconductor & medical technologies industry. Jérôme holds a Master of Physics from the University of Lyon.

Email: [email protected]

Sébastien Clerc, Technology & Market Analyst

Sébastien Clerc is a Medical Technologies Analyst at Yole Développement, the "More than Moore" market research and strategyconsulting company. After graduating from Grenoble Institute of Technology with a master’s degree in Biomedical Technologies, hecompleted his training with a master’s of Innovation and Technology Management, during which he oversaw strategy and marketing.

Email: [email protected]

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 6: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

6

3M, Abbott, Adherium, Adobe Creative Cloud, Advanced MD, Alere, AMS, Analog Devices, Amazon Web Services, Apple, ARM, Aryballe Technologies, Astra Zeneca, AT&T, Atonomics, Atonomics, BAM Labs,

Becton Dickinson, BioSerenity, Biotronik, Bosch, CardioMEMS, Cepheid, Chrono Therapeutics, Cleardata, Cognizant, Cohero Health, Common Sensing, Companion Medical, Daktari Diagnostics,

Danaher Corporation, Dexcom, GlySens, EBR Systems, Eko Devices, Empatica, Endotronix, Endevco, EPFL, Epson, Facebook, Food and Drug Administration, Gecko Health, Given Imaging, , General Electric (GE), Glaxosmithkline (GSK), Global Kinetics, GlySens, Glucovista, GN ReSound, Google Cloud, Health Care Originals, Hero Health, Hocoma, HP Enterprise, IBM, iHealth, Innothéra , Inspiro Medical, InSync,

Invensense, Ipatient care, Kaa, Knowles, Leman Microdevices, Lora, Measurement Specialties, Medimetrics, Medissimo, Medtronic, Melexis, Microsoft Azure, Murata, My Signal, Nonin, Nokia, OJBio,

OMRON, OnSemiconductor, Opko, Oracle, Orange, Oticon, Patient Pending, Philips Healthcare, PillDrill, PK Vitality, Praxis, Propeller Health, Proteus Digital Health, PWS, Q-Medic, Qardio, Qualcomm

Life, ResMed, Roche, Salesforce, Samsung, SAP, Senseonics, Sensimed, Sensirion, Sequana Medical, Sigfox,Silicon Microstructures, St. Jude Medical, Starkey, Stim Wave Technologies, STMicroelectronics, TATA Elxsi, TDK, Télécom Santé, Telefonica, Teva, Tronics Microsystems, Telekom, TytoCare, Valtronic,

Verily, Verizon, VitalConnect, Withings, Zigbee and many others…

LIST OF COMPANIES MENTIONED IN THIS REPORT

280+ slides of market analysis and business models overview

Information gathered through direct discussions with players all along the supply chain

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 7: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

7

SCOPE OF THE REPORT

What is in and what is out

• In our report we are only considering devices that are clinically approved (FDA approved, CE mark certified…) and assisting systems for peoplewith lack of autonomy/disability.

Connected assisting devices

Not in the report

In the report

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 8: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

8

INTERNET OF MEDICAL THINGS

At the crossroads of Medical devices, IT and Telecom

A global infrastructure

consisting of the collection of

medical devices and applications

that are interconnected

through information and communication

technologies

Medical devices Information Technology

Telecommunications

IoMT

Inhalers

Glucose monitoring

Insulin pen

Infusion pumps

Neural implants

ECG monitoring

RF

WIFIBluetooth

WLAN

Zigbee

LoRa

Software

Internet

Database

Cloud

Servers

Computers

Security

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 9: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

9

CONNECTED MEDICAL DEVICE TIMELINE

Medical device development around connectivity

2 major medical device developments benefitedfrom connectivity:

Existing medical devices moving to connectedmedical devices.

Products created on purpose of connectivity

Today 20222010

Evolution to connectivity

Creation thanks to connectivity

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 10: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

10

STANDARD IOMT SUPPLY CHAIN

Type of players involved

Homecare Body (anywhere) care Hospital / Caregivers

Home devicesRemote

consultation

Activity monitoring

Wearables

Portable devicesImplantable

devices

Emergency devicesPoint of Care

Augmented

Intelligence (AI)

Analytics

Storage

Data transfer

and security Interoperability

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 11: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

11

SEGMENTATION OF THE CONNECTED MEDICAL DEVICE MARKET

4 segments with different requirements and challenges front of connectivity

Lack of autonomy

patient assistanceImplanted patients

4Main segments

Self-quantified

patients

Professional

patient monitoring

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 12: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

12

CONNECTED MEDICAL DEVICE MARKET FORECAST

Total module market value

• The market forconnected medical devicewill grow from $9.6B in2016 to $23.7B in 2022with a CAGR2016-2022 of16.3%

• In 2017, more than 85%of these sales are part ofthe connected devices forchronic diseasemonitoring (Respiratory,diabetes,cardiovascular…)

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 13: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

13

CONTENT OF THE REPORT

Drivers and challenges

Introduction to connected medical devices and drivers to adoption

Challenges of connectivity and data generation

Patient centric model explanation

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 14: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

14

CONTENT OF THE REPORT

Market data and dynamics

Overview of the connected medical device market forecasts

MEMS and sensors for connected medical devices

Penetration of connected devices compared to non-connected devices and forecasts

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 15: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

15

CONTENT OF THE REPORT

Business models and players

Example of innovative business models in the context of digital health

Reimbursement rule changes: Who pay? Who benefit?

How health insurances deal with performance?

Presentation of the key players and supply chain

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 16: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

16

CONTENT OF THE REPORT

Connectivity and challenges

Overview of connectivity in healthcare applications

Analysis of connectivity and applications

Roadmap of the main platform used for connected medical devices

Presentation of platforms, interoperability and security of data sharing

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 17: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

17

CONTENT OF THE REPORT

Product overview

Presentation of connected products on the market or currently under development phase

Segmentation of products by medical device types (technical), and data destination (economical)

Information on sensors used and connectivity

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 18: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

18

CONTENT OF THE REPORT

Technology and connectivity overview

Description of the main technology drivers for connected medical devices

Description of sensor working principle, specifications, type of measurement

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 19: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

19

CONTENT OF THE REPORT

Regulation & market access

A set of slides to present regulation for medical devices with a specific focus on connected devices

An international overview with focus on USA (FDA), Europe (CE Mark), China (CFDA)

Information on ISO standards and requirements

Overview of data exchange security protocols (HIPAA)

©2017 | www.yole.fr | Connected medical devices 2017 | Sample

Page 21: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

Healthcare is facing one of its most major turning points in decades. After penetrating the consumer market, the digital revolution and its related concept of the Internet of Things (IoT) is rapidly changing health models. There are many reasons for this transformation. The population is growing and aging, and chronic diseases are exploding. More than 415 million people are living with diabetes worldwide and there are more than 1.5 billion people at risk of cardiovascular diseases. The number of doctors and nurses has stayed consistently flat, as health budgets are shrinking in many regions. Fortunately, connected devices and smartphones are now widespread. People are managing their lives through apps and clouds, and now can do the same with their health, from

hospital to home or even just walking in the street. This report analyzes the dynamics of the connected medical devices market and how its current $9B revenues will grow at a rate of 16% year-over-year through to 2022 to reach more than $23B. Healthcare is shifting to a patient-centric model with nearly 20% growth over the period to 2022 for the segment of self-quantified devices. This compares to single-digit growth for connected implantable devices, which face serious security issues. Preventive and predictive medicine and even participative medicine are on the way to supplement evidence-based approaches, using the large volumes of data generated by these connected medical devices.

CONNECTED MEDICAL DEVICES MARKET AND BUSINESS MODELS 2017 Market & Technology report - September 2017

CONNECTED MEDICAL DEVICES: THE DIGITAL HEALTH REVOLUTION HAS STARTED

The Internet of Medical Things (IoMT) powers industry momentum in digital health and reinvents healthcare organization

KEY FEATURES OF THE REPORT Get the sample of the report on www.i-Micronews.com•Overviewofclinicallycertifiedconnectedmedicaldevicesanddevicesforpeople’sassistance

•Definitionofconnecteddevices,IoMTinthecontextofdigitalhealth

•IntroductionandtrendsforconnectivityandtypicalarchitectureforanIoMTproject

•Descriptionofthedriversfortheadoptionofconnectedmedicaldevicesanddevicesforassistance

•Segmentationofconnectedmedicaldevicesandassistancedevicesinfourcategories:Implanteddevices;self-monitoringdevices;professionallyorienteddevices;andassistancedevicesforpeoplelackingautonomy

•Marketforecastformajorconnectedmedicaldevices,assistancedevicesandassociatedMEMS sensors

•Technologydriversforconnectedmedicaldevices

•ExampleofnewbusinessmodelsinducedbyIoMT:Whopays?Whoprescribes?

•Themajorplayers,supplyandvaluechaininIoMT

•Regulationsandsecurityaspectsforconnectedmedicaldevices

2016-2022 Connected medical device market forecast

25

20

15

10

5

0

Rev

enue

s (U

S$B)

2016 2017 2018 2019 2020 2021 2022

Implanted devices Self monitored Professional oriented Assistance devices

CAGR2016-2022: 16.3%

(Yole Développement, September 2017)

Current changes in healthcare require innovative business models to be created, involving new players from different fields. The performance of these new models needs to be evaluated. The Internet of Medical Things is at the crossroads of medical devices, telecommunications and Information Technology (IT).

A whole infrastructure has to be set up, involving new players in the medical area. Patients receive data from their inhalers or insulin pens to manage their medication, doses and alerts. Physicians are able to follow their patients’ records and could see them only when needed, saving visit costs. Health insurance now pays for

INNOVATIVE MODELS AND NEW PLAYERS ARE RESHAPING HEALTHCARE ORGANIZATION

Page 22: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

CONNECTED MEDICAL DEVICES MARKET AND BUSINESS MODELS 2017

TECHNOLOGY OVERVIEW: FROM REUSING SENSOR INNOVATION TO DEDICATED DEVICES

Sensors are at the heart of connected medical devices to measure phenomena such as heart rate, blood glucose level and detection of people’s falls. This report covers the MEMS-based sensor market and trends within it. Portable, wearable and implantable connected medical devices are not dedicated to hospital and physician use any more.

They now need to be adapted to patient use with the smallest size possible, ease of use and the minimum number of constraints. The first step for medical device manufacturers is to connect their products to the telecommunication infrastructure and to patients’ smartphones and tablets. Significant efforts have been made at the software level to make systems safe and protect data. The hardware part represents 5%-10% of connected devices’ value when using sensors that are existing components taken from other applications, enabling smooth innovation. Connected consumer devices have largely contributed to the miniaturization of electronics using MEMS technologies and successful component design decreasing power consumption requirements. Dedicated sensors with high levels of accuracy and reliability should be the next wave of the IoMT innovation. Strong efforts will be made to provide vital medical grade measurements with less invasive devices. For example, thanks to the development of microneedle arrays, patches or smartwatches should replace painful glucometers. We expect the IoMT sensor wave to come after 2022 and increase the global value share that sensors will claim in hardware. Healthcare is a market changing slowly with regards to innovation and needs to use available approved devices. Technology descriptions and current developments will be the focus of a future report.

prescribed medication after a doctor’s diagnosis. Hospitalization costs to insurance companies are increasing year-over-year due to lack of monitoring or low patient adherence. Connected medical devices could allow “self-quantified” monitoring and could send alerts before patient crises or accidents. But demonstrating that better self-management of chronic disease and better medication adherence will cost less to insurance companies is not an easy task.

It means that when insurance companies reimburse connected medical devices they must include the cost of infrastructure including telecommunication and mobile apps. Prescribers and payers are also taking the IoMT opportunity with inventive new models. Additionally, the IoMT represents a huge opportunity for new players such as IBM and its Watson Augmented Intelligence system to enter the healthcare market and to bring computing power for predictive medicine, as well as the relevant infrastructure to operate connected devices from home, hospitals or anywhere data needs to be shared. Qualcomm Life’s 2net and Capsule Tech solutions are likewise dedicated to IoMT applications. These and several other examples are described in this report.

And what about Google, Apple and the other giants? The medical device market is far from their field of interest due to its low volumes, strict regulations, and long development time. Yes, the limits of consumer healthcare are well enough established today to escape the strong restrictions on medical data. But with monetization of data being key for giant companies, regulations on medical data are still more constraining compared to consumers’ private data. This situation creates opportunities for start-up companies to develop connected medical devices. Consolidation of the market and of the supply chain will occur later with series of mergers and acquisitions aiming to gather together the most innovative products and regroup solutions with high levels of synergy.

Connected medical device technology trends

(Yole Développement, September 2017)

Sensitivity

Accuracy

Reliability

Integrated connectivity

Storage

Data exploitation

2010 2016 2022 2030

Connectivity and software wave

Sensor

wave

Innovation is at connectivity and software level Medical devices integrate connectivity first

Sensors are those developed for consumer market…but not specific : • Miniaturized • Low-cost • Low power consumption

Innovation is at sensor level New sensors are specifically developed:

• Less invasive • Highly integrated • Biocompatible

58 millions of sensors

> 320 millions of sensors

Sensor innovation expected to be the next wave

Connected medical device market: business models

(Yole Développement, September 2017)

Symptoms Consultation Evidence

based medication

Cure

Monitoring – early detection Consultation

Medication support based

on records Cure

Reimbursement at this stage

Reimbursement at this stage

Evaluation based on performance: Is cost of preventing lower than cost of curing?

2016

2022

Page 23: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

Find more details about

this report here:

MARKET & TECHNOLOGY REPORT

Executive summary 5

Introduction 35

> Definition> Report scope> IoT Promises: The fourth industrial revolution> IoT and medical IoT (IoMT): History and context> Connected medical device drivers> Information and data value> Devices and sensors> Typical IT architecture

Connected medical device market forecast 72

> Segmentation of the connected medical device market

> Global connected medical device market> Sensor market

Connected device segmentation 93

> Implantable devices for patient monitoring> Self-quantified patient monitoring> Professional patient monitoring> Assistance for lack of autonomy

Sensor technology trends 194

> Needs for miniaturization> Low power consumption and energy storage> Sensors for IoMT> Packaging trends> Sensor players

Business models 212

> Identifying value propositions> Who pays?

Players and supply chain 231

> Key players> Value chain> Data and interoperability players

IoMT Connectivity 240

> Wireless sensor module and connectivity> Connectivity model> Connected medical device connectivity breakdown> Connectivity roadmap

Regulation and market access 251Conclusions 276

TABLE OF CONTENTS (complete content on i-Micronews.com)

COMPANIES CITED IN THE REPORT (non exhaustive list)3M, Abbott, Adherium, Adobe Creative Cloud, Advanced MD, Alere, AMS, Analog Devices, Amazon Web Services, Apple, ARM, Aryballe Technologies, Astra Zeneca, AT&T, Atonomics, BAM Labs, Becton Dickinson, BioSerenity, Biotronik, Bosch, CardioMEMS, Cepheid, Chrono Therapeutics, Cleardata, Cognizant, Cohero Health, Common Sensing, Companion Medical, Daktari Diagnostics, Danaher Corporation, Dexcom, GlySens, EBR Systems, Eko Devices, Empatica, Endotronix, Endevco, EPFL, Epson, Facebook, Food and Drug Administration, Gecko Health, Given Imaging, General Electric (GE), GlaxoSmithKline (GSK), Global Kinetics, GlySens, Glucovista, GN ReSound, Google Cloud, Health Care Originals, Hero Health, Hocoma, HP Enterprise, IBM, iHealth, Innothéra , Inspiro Medical, InSync, Invensense, Ipatient care, Kaa, Knowles, Leman Microdevices, Lora, Measurement Specialties, Medimetrics, Medissimo, Medtronic, Melexis, Microsoft Azure, Murata, My Signal, Nonin, Nokia, OJBio, OMRON, OnSemiconductor, Opko, Oracle, Orange, Oticon, Patient Pending, Philips Healthcare, PillDrill, PK Vitality, Praxis, Propeller Health, Proteus Digital Health, PWS, Q-Medic, Qardio, Qualcomm Life, ResMed, Roche, Salesforce, Samsung, SAP, Senseonics, Sensimed, Sensirion, Sequana Medical, Sigfox,Silicon Microstructures, St. Jude Medical, Starkey, Stim Wave Technologies, STMicroelectronics, TATA Elxsi, TDK, Télécom Santé, Telefonica, Teva, Tronics Microsystems, Telekom, TytoCare, Valtronic, Verily, Verizon, VitalConnect, Withings, Zigbee and many others…

•Artificialorgans2017•StatusoftheMEMSindustry2017•MaximIntegratedMAX30102Optical

Heart-Rate Sensor•Point-of-NeedTesting:ApplicationofMicrofluidicTechnologies2016

Findallourreportson www.i-micronews.com

RELATED REPORTSBenef it from our Bundle & Annual Subscription offers and access our analyses at the bestavailablepriceandwithgreatadvantages

AUTHORSJerôme Mouly servesasaTechnology& Market Analys t specia l i zed inmicrotechnologies for biomedical & medical imaging applications at YoleDéveloppement, the“More thanMoore”market research and strategy consultingcompany. S ince 2000 , Jérôme hasparticipated in more than 100 marketingand technological analyses for industrialgroups, start-upsand institutes related tosemiconductor & medical technologiesindustry.JérômeholdsaMasterofPhysicsfrom the University of Lyon.

Sébastien Clerc isaMedicalTechnologiesAnalystatYoleDéveloppement, the“MorethanMoore”marketresearchandstrategyconsulting company. Af ter graduatingfrom Grenoble INP with a BiomedicalTechnologiesMasterdegree,hecompletedhistrainingwithaMasterdegreeinInnovationandTechnologyManagement,duringwhichheoversawstrategyandmarketing.

AsaTechnology&MarketAnalyst in theMedicalTechnologies (MedTech)businessunitatYoleDéveloppement(Yole),Asma Siari is involved in the development oftechnology&marketreportsaswellastheproductionofcustomconsultingprojects.AfteraMaster’sdegreeinBiotechnologies,Diagnostic Therapeutics & Management,Asma serves as Research Assistant at the Moores Cancer Center (San Diego,CA). She is a coauthor in two scientificpublications published in the MolecularCancerResearchJournal.InadditiontohermissionatYole,AsmapreparestodayherAdvancedMaster’sdegreeinInternationalStrategy & Marketing BtoB (EM LyonBusinessSchool,France).

REPORT OBJECTIVES•ThisreportintroducestheconceptofIoMTandrelatedmedicaldevicesinanincreasinglyconnectedworld.

•Itdescribeshowthehealthorganizationischangingwithnewbusinessmodelstocreate,andnewvaluecreationfromgenerateddata.

•Itevaluatesthemarketofconnecteddevices,givespenetrationratescomparedtonon-connecteddevicesandanalyzesthedynamics.

•Itidentifiesthemedicaldeviceandassistancedevicemainplayers,givinganoverviewofthemainproductsanddevelopments.

•Thereportgivesaselectedlistoftechnologydriversandtrends.•Itinformsreadersaboutregulations,connectivityprotocolsandsecurityfordataexchanges.

Page 24: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

ORDER FORMConnected Medical Devices Market and Business Models 2017

SHIPPING CONTACT

First Name:

Email:

Last Name:

Phone:

PAYMENT

BY CREDIT CARD Visa Mastercard Amex

Name of the Card Holder:

Credit Card Number:

Card Verification Value (3 digits except AMEX: 4 digits):

Expiration date:

BY BANK TRANSFERBANK INFO: HSBC, 1 place de la Bourse, F-69002 Lyon, France, Bank code: 30056, Branch code: 00170Account No: 0170 200 1565 87, SWIFT or BIC code: CCFRFRPP, IBAN: FR76 3005 6001 7001 7020 0156 587

RETURN ORDER BY • FAX: +33 (0)472 83 01 83• MAIL: YOLE DÉVELOPPEMENT, Le Quartz,

75 Cours Emile Zola, 69100 Villeurbanne/Lyon - France

SALES CONTACTS • North America - Steve Laferriere: +13106 008 267

[email protected] • Europe & RoW - Lizzie Levenez: + 49 15 123 544 182

[email protected]• Japan & Rest of Asia - Takashi Onozawa: +81 3 6869 6970

[email protected] • Greater China - Mavis Wang: +886 979 336 809

[email protected]• Specific inquiries: +33 472 830 180 – [email protected]

(1) Our Terms and Conditions of Sale are available at www.yole.fr/Terms_and_Conditions_of_Sale.aspx The present document is valid 24 months after its publishing date: September 5 ,2017

/

ABOUT YOLE DEVELOPPEMENT

BILL TO

Name (Mr/Ms/Dr/Pr):

Job Title:

Company:

Address:

City:

State:

Postcode/Zip:

Country*:

*VAT ID Number for EU members:

Tel:

Email:

Date:

PRODUCT ORDER - Ref YDMT17034Please enter my order for above named report: One user license*: Euro 5,490 Multi user license: Euro 6,490- The report will be ready for delivery from September 15, 2017- For price in dollars, please use the day’s exchange rate. All reports are

delivered electronically at payment reception. For French customers, add 20% for VAT

I hereby accept Yole Développement’s Terms and Conditions of Sale(1)

Signature:

*One user license means only one person at the company can use the report.

Founded in 1998, Yole Développement has grown to become a group of companies providing marketing, technology and strategy consulting, media and corporate finance services. With a strong focus on emerging applications using silicon and/or micro manufacturing, the Yole Développement group has expanded to include more than 50 collaborators worldwide covering MEMS, Compound Semiconductors, LED, Displays, Image Sensors, Optoelectronics, Microfluidics & Medical, Advanced Packaging, Manufacturing, Nanomaterials, Power Electronics and Batteries & Energy Management.The “More than Moore” company Yole and its partners System Plus Consulting, Blumorpho, KnowMade and PISEO support industrial companies, investors and R&D organizations worldwide to help them understand markets and follow technology trends to develop their business.

MEDIA & EVENTS• i-Micronews.com, online disruptive technologies website• @Micronews, weekly e-newsletter• Communication & webcasts services• Events: Yole Seminars, Market Briefings…More information on www.i-micronews.com

CONTACTSFor more information about :• Consulting Services: Jean-Christophe Eloy ([email protected])• Financial Services: Jean-Christophe Eloy ([email protected])• Report Business: Fayçal Khamassi ([email protected])• Press relations: Sandrine Leroy ([email protected])

CONSULTING• Market data & research, marketing analysis• Technology analysis• Reverse engineering & costing services• Strategy consulting• Patent analysisMore information on www.yole.fr

REPORTS• Collection of technology & market reports• Manufacturing cost simulation tools• Component reverse engineering & costing

analysis• Patent investigationMore information on www.i-micronews.com/reports

FINANCIAL SERVICES• Mergers & Acquisitions• Due diligence• FundraisingMore information on Jean-Christophe Eloy ([email protected])

Page 25: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

© 2017

Yole Développement

FromTechnologies to Market

Source: Wikimedia Commons

Page 26: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

22©2017 | www.yole.fr | About Yole Développement

FIELDS OF EXPERTISE

Yole Développement’s 35+ analysts operate in the following areas

MEMS & Sensors

Compound

Semi.

Imaging

Photonics

MedTech

Manufacturing

Advanced

Packaging

Batteries / Energy Management

Power Electronics

Displays

RF

Devices &

Techno.

Advanced

Substrates

Solid State

Lighting(LED, OLED, …)

Page 27: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

23©2017 | www.yole.fr | About Yole Développement

4 BUSINESS MODELS

o Consulting and Analysis

• Market data & research, marketing analysis

• Technology analysis

• Strategy consulting

• Reverse engineering & costing

• Patent analysis

www.yole.fr

o Reports

• Market & technology reports

• Patent investigation and patent infringement risk analysis

• Teardowns & reverse costing analysis

• Cost simulation tool

www.i-Micronews.com/reports

o Financial services

• Due diligence

• Fundraising

• Maturation of companies

• IP portfolio management & optimization

www.yole.fr

www.bmorpho.com

o Media

• i-Micronews.com website

• @Micronews e-newsletter

• Communication & webcast services

• Events

www.i-Micronews.com

Page 28: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

24©2017 | www.yole.fr | About Yole Développement

A GROUP OF COMPANIES

Market, technology

and strategy

consulting

www.yole.fr

Due diligences

www.yole.fr

Manufacturing costs analysis

Teardown and reverse engineering

Cost simulation tools

www.systemplus.fr

IP analysis

Patent assessment

www.knowmade.fr

Innovation and business maker

www.bmorpho.com

Test lab

Expertise

Research & innovationwww.piseo.fr

Page 29: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

25©2017 | www.yole.fr | About Yole Développement

OUR GLOBAL ACTIVITY

30%of our business

40%of our business 30%

of our business

Yole Inc.

Greater

China office

Yole Japan

HQ in Lyon

Nantes

Paris

Nice

Vénissieux

Europe office

Frankfurt

Hsinchu

Tokyo

Phoenix

Yole Korea

Seoul

Page 30: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

26©2017 | www.yole.fr | About Yole Développement

ANALYSIS SERVICES - CONTENT COMPARISON

Multi-

Customers

Action

Technology

and Market

Report

Leadership

Meeting

Q&A

Service

Depth of the analysis

Bre

adth

of th

e a

nal

ysis

Meet the

Analyst

Custom

Analysis

High

High

Low

Page 31: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

27©2017 | www.yole.fr | About Yole Développement

SERVING THE ENTIRE SUPPLY CHAIN

Our analysts provide market analysis,

technology evaluation,

and business plan along the entire

supply chain

Integrators and

end-users

Device

makers

Suppliers: material,

equipment, OSAT,

foundries…

Financial investors,

R&D centers

Page 32: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

28©2017 | www.yole.fr | About Yole Développement

SERVING MULTIPLE INDUSTRIAL FIELDS

We are workingacross

multiples industries to understand

the impact of More-than-

Moore technologies from deviceto system

From A to Z…

Transportation

makers

Mobile phone

and consumer

electronics

Automotive

Medical

systemsIndustrial and

defense

Energy

Page 33: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

29©2017 | www.yole.fr | About Yole Développement

o Yole Développement publishes a comprehensive collection of market & technology reports and patent analysis in:

• MEMS & Sensors

• RF devices & technologies

• Imaging

• Medical technologies (MedTech)

• Photonics

• Advanced packaging

• Manufacturing

• Advanced substrates

• Power electronics

• Batteries and energy management

• Compound semiconductors

• Solid state lighting

• Displays

o You are looking for:

• An analysis of your product market

• A review of your competitors evolution

• An understanding of your manufacturing and production costs

• An understanding of your industry technology roadmap and related IPs

• A clear view on the evolution of the supply chain

The combined team of 60+ experts (PhDs, MBAs, industry veterans…) from Yole Développement, System Plus Consulting and KnowMade, collect information, identifythe trends, the challenges, the emerging markets, the competitive environments and turn it into results to give you a complete picture of your industry landscape.

In the past 19 years, we worked on more than 2 000 projects, interacting with technology professional and high level opinion makers from the main players of theindustry.

o Every year, Yole Développement, System Plus Consulting and Knowmade publish +120 reports. Gain full benefit from our Bundle and Annual Subscription offers.

REPORTS COLLECTION

www.i-Micronews.com

Page 34: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

30©2017 | www.yole.fr | About Yole Développement

OUR 2017 REPORTS PLANNING (1/2)

MARKET AND TECHNOLOGY REPORTS by Yole Développement

o MEMS & SENSORS

− Acoustic MEMS and Audio Solutions 2017

− 3D Imaging & Sensing 2017

− Microspectrometers Markets and Applications 2017

− Status of the MEMS Industry 2017*

− MEMS & Sensors for Automotive 2017

− High End Inertial Sensors for Defense and Industrial Applications 2017*

− Magnetic Sensors Market and Technologies 2017

− Sensors and Sensing Modules for Smart Homes and Buildings 2017

− Sensing and Display for AR/VR/MR 2017

− MEMS Packaging 2017

− Fingerprint Sensor Applications and Technologies - Consumer Market Focus 2017

o RF DEVICES AND TECHNOLOGIES

− RF Front End Modules and Components for Cellphones 2017

− Advanced RF SiP for Cellphones 2017

− 5G and Beyond (Vol 1): Impact on RF Industry, from Infrastructure to Terminals

2017

− 5G and Beyond (Vol 2): RF Materials Platform, from Infrastructure to Terminals

2017

− RF Technologies for Automotive Applications 2017

− GaN and Si LDMOS Market and Technology Trends for RF Power 2017

o MANUFACTURING

− Glass Substrate Manufacturing 2017

− Equipment & Materials for Fan Out Technology 2017

− Equipment and Materials for 3D TSV Applications 2017

− Emerging Non Volatile Memories 2017*

o MEDTECH

− Status of the Microfluidics Industry 2017

− Solid State Medical Imaging 2017

− Connected Medical Devices: the Internet of Medical Things 2017

− Sensors for Medical Robotics 2017

− Artificial Organs: Market & Technology Analysis 2017

− Organs-on-a Chip 2017

o ADVANCED PACKAGING

− Advanced Substrates Overview 2017

− Status of the Advanced Packaging Industry 2017

− Fan Out Packaging: Market & Technology Trends 2017*

− 3D Business Update: Market & Technology Trends 2017*

− Advanced QFN: Market & Technology Trends 2017**

− Inspection and Metrology for Advanced Packaging Platform 2017**

− MEMS Packaging 2017

− Advanced Packaging for Memories 2017

− Advanced RF SiP for Cellphones 2017

− Power Packaging Market and Technology Trends 2017

− Embedded Die Packaging: Technologies and Markets Trends 2017

o IMAGING & OPTOELECTRONICS

− 3D Imaging & Sensing 2017

− Status of the CMOS Image Sensor Industry 2017*

− Camera Module for Consumer and Automotive Applications 2017*

− Uncooled Infrared Imaging Technology & Market Trends 2017*

− Solid State Medical Imaging 2017

o BATTERY AND ENERGY MANAGEMENT

− Status of Battery Industry for Stationary, Automotive and Consumer Applications

*2016 version still available / **To be confirmed

Page 35: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

31©2017 | www.yole.fr | About Yole Développement

OUR 2017 REPORTS PLANNING (2/2)o POWER ELECTRONICS

− Status of Power Electronics Industry 2017*

− Silicon Power Mosfet: Market and Technology Trends 2017

− IGBT Market and Technology Trends 2017

− Power Packaging Market and Technology Trends 2017

− Power SiC 2017: Materials, Devices, and Applications*

− Power GaN 2017: Materials, Devices, and Applications*

− Materials Market Opportunities for Cellphone Thermal Management (Battery

Cooling, Fast Charging, Data Processing, Battery Cooling, etc.) 2017

− Gate Driver Market and Technology Trends 2017

− Power Management ICs Market Quarterly Update 2017

− Power Electronics for Electrical Aircraft, Rail and Buses 2017**

− Thermal Management for LED and Power 2017

o COMPOUND SEMICONDUCTORS

− Power SiC 2017: Materials, Devices, and Applications*

− Power GaN 2017: Materials, Devices, and Applications*

− GaN and Si LDMOS Market and Technology Trends for RF Power 2017

− 5G and Beyond (Vol 2): RF Materials Platform, from Infrastructure to Terminals

2017

− Bulk GaN Substrate Market 2017

o DISPLAYS

− MicroLED Displays 2017

− Display for Augmented Reality, Virtual Reality and Mixed Reality 2017

− Quantum Dots for Display Applications 2017

− Phosphors & Quantum Dots 2017 - LED Downconverters for Lighting & Displays

− Organic Thin Film Transistor 2016: Flexible Displays and Other Applications

− Automotive Lighting 2017 - Technology, Industry and Market Trends

o SOLID STATE LIGHTING

− UV LEDs 2017 - Technology, Manufacturing and Application Trends*

− Horticultural Lighting 2017 - Technology, Industry and Market Trends

− Automotive Lighting 2017 - Technology, Industry and Market Trends*

− Active Imaging and Lidar 2017 (Vol 2) - IR Lighting**

− LED Lighting Module 2017 - Technology, Industry and Market Trends

− IR LEDs and Lasers - Technology Applications and Industry Trends 2017

− Phosphors & Quantum Dots 2017 - LED Downconverters for Lighting & Displays

− MicroLED Displays 2017

− CSP LED Lighting Module 2017

− LED Packaging 2017

− Thermal Management for LED and Power 2017

PATENT ANALYSIS by Knowmade

− Consumer Physics SCiO Molecular Sensor Patent-to-Product Mapping 2017

− Patent Licensing Companies in the Semiconductor Market - Patent Litigation

− Risk and Potential Targets 2017

− MEMS Microphone: Patent Landscape Analysis 2017

− MEMS Microphone: Knowles’ Patent Portfolio Analysis 2017

− Microbolometer: Patents Used in Products 2017

− Microfluidic Technologies for Diagnostic Applications Patent Landscape 2017

− Micropumps: Patent Landscape Analysis 2017

− GaN Technology: Top-100 IP Profiles 2017

− MicroLEDs: Patent Landscape Analysis 2017

− Consumer Physics SCiO Molecular Sensor Patent-to-Product Mapping 2017

− Uncooled Infrared Imaging: Patent Landscape Analysis 2017

− 3D Monolithic Memory: Patent Landscape Analysis 2017

TEARDOWN & REVERSE COSTING by System Plus Consulting More than 60 teardowns and reverse costing analysis and cost simulation tools to be

published in 2017.*2016 version still available / **To be confirmed

Page 36: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

32©2017 | www.yole.fr | About Yole Développement

OUR 2016 PUBLISHED REPORTS LIST (1/2)

MARKET AND TECHNOLOGY REPORTS by Yole Développement

o MEMS & SENSORS

− Gas Sensors Technology and Market 2016

− Status of the MEMs Industry 2016

− Sensors for Cellphones and Tablets 2016

− Market and Technology Trends of Inkjet Printheads 2016

− Sensors for Biometry and Recognition 2016

− Silicon Photonics 2016

o IMAGING & OPTOELECTRONICS

− Status of the CMOS Image Sensor Industry 2016

− Uncooled Infrared Imaging Technology & Market Trends 2016

− Imaging Technologies for Automotive 2016

− Sensors for Drones & Robots: Market Opportunities and Technology Evolution 2016

o MEDTECH

− BioMEMS 2016

− Point of Care Testing 2016: Application of Microfluidic Technologies

o ADVANCED PACKAGING

− Embedded Die Packaging: Technology and Market Trends 2017

− 2.5D & 3D IC TSV Interconnect for Advanced Packaging: Business Update 2016

− Fan-Out: Technologies and Market Trends 2016

− Fan-In Packaging: Business update 2016

− Status and Prospects for the Advanced Packaging Industry in China 2016

o MANUFACTURING

− Thin Wafer Processing and Dicing Equipment Market 2016

− Emerging Non Volatile Memories 2016

o COMPOUND SEMICONDUCTORS

− Power GaN 2016: Epitaxy and Devices, Applications and Technology Trends

− GaN RF Devices Market: Applications, Players, Technology and substrates 2016

− Sapphire Applications & Market 2016: from LED to Consumer Electronics

− Power SiC 2016: Materials, Devices, Modules, and Applications

o LED

− UV LED Technology, Manufacturing and Applications Trends 2016

− OLED for Lighting 2016 – Technology, Industry and Market Trends

− Automotive Lighting: Technology, Industry and Market Trends 2016

− Thermal Management Technology and Market Perspectives in Power Electronics and

LEDs 2017

− Organic Thin Film Transistor 2016: Flexible Displays and Other Applications

− Sapphire Applications & Market 2016: from LED to Consumer Electronics

− LED Packaging 2017: Market, Technology and Industry Landscape

o POWER ELECTRONICS

− Power Electronics for EV/HEV 2016: Market, Innovations and Trends

− Status of Power Electronics Industry 2016

− Passive Components Technologies and Market Trends for Power Electronics 2016

− Power SiC 2016: Materials, Devices, Modules, and Applications

− Power GaN 2016: Epitaxy and Devices, Applications, and Technology Trends

− Inverter Technologies Trends & Market Expectations 2016

− Opportunities for Power Electronics in Renewable Electricity Generation 2016

− Thermal Management Technology and Market Perspectives in Power Electronics and

LEDs 2017

− GaN RF Devices Market: Applications, Players, Technology and substrates 2016

o BATTERY AND ENERGY MANAGEMENT

− Beyond Li-ion Batteries: Present and Future Li-ion Technology Challengers 2016

− Stationary Storage and Automotive Li-ion Battery Packs 2016

− Opportunities for Power Electronics in Renewable Electricity Generation 2016

Page 37: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

33©2017 | www.yole.fr | About Yole Développement

OUR 2016 PUBLISHED REPORTS LIST (2/2)

PATENT ANALYSIS by Knowmade

− Microbattery Patent Landscape Analysis

− Miniaturized Gas Sensors Patent Landscape Analysis

− 3D Cell Culture Technologies Patent Landscape

− Phosphors and QDs for LED Applications Patent Landscape

− TSV Stacked Memory Patent Landscape

− Fan-Out Wafer Level Packaging Patent Landscape Analysis

TEARDOWN & REVERSE COSTING by System Plus Consulting More than 45 teardowns and reverse costing analysis and cost simulation tools published

in 2016.

MORE INFORMATION

o All the published reports from the Yole Group of Companies are available on our website

www.i-Micronews.com.

o Ask for our Bundle and Annual Subscription offers: With our bundle offer, you choose the

number of reports you are interested in and select the related offer. You then have up to 12

months to select the required reports from the Yole Développement, System Plus Consulting

and KnowMade offering. Pay once and receive the reports automatically (multi-user format).

Contact your sales team according to your location (see the last slide).

Page 38: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

34©2017 | www.yole.fr | About Yole Développement

MICRONEWS MEDIA

o About Micronews Media

To meet the growing demand for market,

technological and business information,

Micronews Media integrates several tools able

to reach each individual contact within its

network.We will ensure you benefit from this.

ONLINE ONSITE INPERSON

@Micronews e-newsletter

i-Micronews.com

i-Micronewsjp.com

FreeFullPDF.com

Events Webcasts

Unique, cost-effective ways

to reach global audiences.

Online display advertising

campaigns are great strategies

for improving your

product/brand visibility. They

are also an efficient way to

adapt with the demands of the

times and to evolve an effective

marketing plan and strategy.

Brand visibility, networking

opportunities

Today's technology makes it

easy for us to communicate

regularly, quickly, and

inexpensively – but when

understanding each other is

critical, there is no substitute

for meeting in-person. Events

are the best way to exchange

ideas with your customers,

partners, prospects while

increasing your brand/product

visibility.

Targeted audience

involvement equals clear,

concise perception of your

company’s message.

Webcasts are a smart,

innovative way of

communicating to a wider

targeted audience. Webcasts

create very useful, dynamic

reference material for

attendees and also for

absentees, thanks to the

recording technology.

Benefit from the i-Micronews.com

traffic generated by the 8,500+

monthly visitors, the 11,500+

weekly readers of @Micronews

e-newsletter

Seven main events planned for

2017 on different topics to

attract 140 attendees on average

Gain new leads for your business

from an average of 300

registrants per webcast

Contacts: Camille Veyrier ([email protected]) and Clotilde Fabre ([email protected]), Marketing & Communication Project Managers.

Page 39: Connected Medical Devices Market and Business Models 2017 Report by Yole Developpement

35©2017 | www.yole.fr | About Yole Développement

CONTACT INFORMATION

o CONSULTING AND SPECIFIC ANALYSIS

• North America: Steve LaFerriere, Director of Northern America Business DevelopmentEmail: [email protected] – +1 31 06 008 267

• Japan & Rest of Asia: Takashi Onozawa, General Manager, Asia Business DevelopmentEmail: [email protected] - +81 3 4405 9204

• Greater China: Mavis Wang, Director of Greater China Business DevelopmentEmail: [email protected] - +886 979 336 809

• RoW: Jean-Christophe Eloy, CEO & President, Yole DéveloppementEmail [email protected] - +33 4 72 83 01 80

o REPORT BUSINESS

• North America: Steve LaFerriere, Director of Northern America Business DevelopmentEmail: [email protected] – +1 31 06 008 267

• Europe: Lizzie Levenez, EMEA Business Development ManagerEmail: [email protected] - +49 15 123 544 182

• Rest of Asia: Takashi Onozawa, General Manager, Asia Business DevelopmentEmail: [email protected] - +81 3 4405 9204

• Japan & Asia: Miho Othake, Account ManagerEmail: [email protected] - +81 3 4405 9204

• Greater China: Mavis Wang, Director of Greater China Business DevelopmentEmail: [email protected] - +886 979 336 809

o FINANCIAL SERVICES

• Jean-Christophe Eloy, CEO & PresidentEmail: [email protected] - +33 4 72 83 01 80

o GENERAL

• Public Relations: [email protected] - +33 4 72 83 01 89

• Email: [email protected] - +33 4 72 83 01 80

Follow us on