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International Congress of Scientifi c Iridology

Monday 21 September 2015 - IFSH - 65 Rue d’Amiral Mouchez - 75013 Paris

NEW MODERN IRIDOLOGY FINDINGS FOR PRACTICAL APPLICATION IN THE CLINIC

NEW IRIS SIGNS & INFORMATION

WITH JOHN ANDREWS (England)

©JOHN ANDREWS 2015johnandrewsiridology@hotmail.com

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Overview of Modern Iridology FindingsPNEI & Modern IridologyJohn Andrews (UK)

The Future

of Iridology...

Now!

The scientifi c integration of mind/body medicine for the hormonal, immune, limbic &

nervous systems with how the patient has acquired or inherited stress-related mechanisms,

basically; how stress & emotions impact these systems and vice versa

Modern Iridology & PNEI• Each iris is perfect for that individual - it

shows how the individual can retain or fi nd

homeostasis

• Remember that Iridology should be not be a

judgement on the patient (Px)

• It should be a positive & empowering

experience (PNEI pathways infl uence).

Remember the impact words can have on

a person & PNEI pathways in both negative

& positive terms - the emotional connects

with the physical

• Many signs are genetic in the iris, so may not

relate to the individual - iris shows inherent

talents & abilities for the Px - many signs

relate to our grandparents (recent genetic

studies)

Modern Iridology• Modern Iridology helps us to direct the

right clinical questions for the patient

& practitioner

• When we are faced with thousands of

iris and associated signs in other tissues

Modern Iridology helps the iridologist to

prioritize the many signs, so we have a both

a genetic & individual priority

• Look for co-signs or an amalgamation of

evidence in the iris - utilize the different

systems. This work on both the physical &

emotional/psychological levels

• Modern Iridology uses the Collarette

Structure & Diameter to determine the

“dominant iris” to help with prioritizing

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PNEI Approaches - Mind Body Medicine• PNEI is an abbreviation for Psycho-neuro-endocrino-immunology. PNEI is a scientifi c approach

that recognizes the interaction and interdependence for homeostasis of the organism depends on the correct biological communication between and within the immune, hormonal, neurological, limbic an other systems of the body

• It is the scientifi c validation of mind-body medicine and demonstrates that the emotional or psychological states infl uence the physical and vice versa

The Microbiota-gut Interplay Serves many Functions

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Psycho-neuro-endocrino- immunology - PNEI• Developing science

• Clinical & experimental psychoneuroimmunology “studies to date confi rm the long-standing

belief that the immune system does not function completely autonomously”from Basic Clinical

Immunology, 7th Edition, USA, 1991 by Stiles

• The immune & endocrine systems can be referred to as a brain or brains in a fl uid state

• Scientifi c validation of the mind-body approach

• Recognizes the diverse & profound infl uence stress has on the individual

• Recognizes the emotional epigenetic impact & inheritance from previous generations (exactly

what we see with modern Iridology

• Shows the central importance to all function of the limbic system (emotional centres of the

brain) & the PNEI via the hypothalamus

PAX6 gene can be infl uenced by emotions & stress

Symptoms are the tip of

the iceberg - the end result

of various pathways or

triggers. The iris shows

the foundation - the body

of the iceberg hidden

under the surface - which

contributes to the formation

of the tip.

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• Based on new research & fi ndings in relation to the iris, inner pupillary border, the cells, genetics & the human body

• New systems of analysis involving: • New interpretation of many established iris

signs due to advances in ocular embryology, development of iris signs, human physiology, genetics & technological developments over the last 10-15 years

• The identifi cation of new signs, iris topographies (maps/charts) & new iris with inner pupillary border combinations combinations

• Indentifi cation of the Maternal/Paternal DNA predominance

• Flexible systems with an emphasis on the collarette, Pupillary Zone & Inner Pupillary Border

• The future of iridology... now• It is an extension & enhancement of classical

approaches - Modern Iridology does not replace classical approaches, but is an signifi cant & profound addition

• For example in my own practice I use 1% to 5% of the material from classical approaches, on average 2 %, such is the wealth of resources in modern iridology

• Modern Iridology is expanding because iridology is compelled to develop & progress

• Modern Iridology provides fl exible systems of analysis. These are interchangeable, depending on what is required at the time which validate & enhance each other

• With Modern Iridology & PNEI the Limbic system (the emotional regions of the brain) with the Amygdala, Hippocampus & Hypothalamus are fundamental in this approach and how they impact the gastrointestinal system, nutritional & metabolics, endocrine balance, immune function, cellular potential & neurotransmitters. Modern Iridology can be related to all of these

• It is robust & valid• It is a combination of science & intuition• Modern Iridology provides many other

possibilities and can improve the confi dence & professional competence for the Iridologist

• If we face any limitations or a silent iris - you can look towards Modern Iridology

• Modern Iridology enables the practitioner to prioritize the thousands of potential signs & combination of signs in the iris & IPB

• Non-invasive & inexpensive• The foundation of Modern Iridology is the

understanding & extrapolation of the psycho-neuro-endocrino-immunology pathways or PNEI Network pathways in combination with iris & IPB markers

• The beauty of Modern Iridology is that it can be applied to all forms of clinical & therapeutic approaches

Modern Iridology Summary

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• New Dysglycemia (Blood sugar tendency) Systems with 1830 Px

• 462 Chronic Fatigue Syndrome Px

• 368 Citric acid cycle imbalance Px (Cellular Topography)

• New autoimmune profi les with 1214 autoimmune Px

• 701Progesterone Ratio Px

• 162 Hyperprolactinemia (HPRL - elevated prolactin)

• 107 Px with reduced zinc (shadow ring (iris) & Tubes (IPB)

Modern Iridology utilising new technologies has identifi ed many new PNEI & related Signs/Co-Signs Examples

Iris melanocytes

• New research & clarifi cation with the Pure Brown Iris - vast expansion of knowledge. With the pure brown iris the importance of the pupillary zone, collarette & IPB are amplifi ed. Previous iridology texts have small % brown iris, yet 80% of global population have pure brown irises

• Neurotransmitters, Immune Cells & hormonal interaction tendencies identifi cation via the IPB & iris

• The potential of the Cell for the Px• Nutritional markers including with tyrosine,

zinc, selenium, manganese, chromium, magnesium & others

• The profound signifi cance of the pupillary zone hypothalamus sign

Modern Iridology Developments

Pure Brown Iris - Achromia = Dysglycemia & <

Chromium Tendency + Hypertrophy IPB = Immuno-

Metabolic Network Pro-Infl ammatory cascades

Modern Iridology fi ndings - Rectangular melanin pigment equates

to a spleen PNEI Network Tendency. Px requires further spleen

support - with both Physical & emotional Levels. 62/83 Px had

spleen dysfunction or genetic spleen-related conditions. Topolabile

- Signifi cant for what it is - independent of location

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• Modern Iridology Chart

• Immune Cell Collarette Chart

• Cellular Iridology

(Citric Acid Cycle Iris Chart)

• Emotional Dynamics of the Collarette

• Pupillary Zone Topography

• Immune System Pupillary Zone Chart

• Endocrine System Pupillary Zone Chart

• Emotional Anatomy Chart

• Individual Chronobiology Iris Chart

• PNEI Collarette Chart, Neurotransmitter

& New IPB Charts to be published 2016

Modern Iridology New Topographies developed Andrews 1993 - 2015

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Pupillary Zone Endocrine Hypothalamus Topography. If the sign is located or reaches to zone 4 = hypothalamus.

Zone 5 = hypothalamus & hippocampus. Zone 6 = hypothalamus & amygdalaindependent of location

Hypothalamus

New PZ Hypothalamus Sign 360º

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• Chronobiological clock resides in the suprachiasmatic nucleus of the hypothalamus

• The Hypothalamus has central importance for all approaches in medicine, health &

Iridology

• It regulates the varied interactions of Psychoneuroendocrinoimmunology (PNEI) - this

verifi es the mind-body connection in medicine

• By the 5th week of gestation the hypothalamus has formed and the limbic system

(emotional responses) is in place. The hypothalamus is helping to control the endocrine

system from this time, including the anterior pituitary

• The hypothalamus is directly connected to the iris, pupil & IPB through micro neural

pathways to and from the lateral geniculate bodies in the thalami

• Blood sugar, blood pressure, body temperature, pain, infl ammation, immune function,

hormonal balance, stress, intestinal peristalsis, etc are all regulated by the hypothalamus.

Endocrine glands act on instruction from the hypothalamus

The Hypothalamus

Hypothalamus

The hypothalamus is of vital importance

in general, health, homeostasis,

psychoneuroendocrinoimmunology (PNEI)

& modern iridology

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Hypothalamus - Radial Sign

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Amygdala

Base section of the of pupillary

zone Hypothalamus Sign

(Number 6 in this diagram) - Rx

Amygdala - Rx (Dx)

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EFAs & Mg required for healthy cell membrane - also in blood sugar balance, detox and nerve functions

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Linear Pigment on the Collarette < Malic acid = hypothyroidism tendency

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Linear Pigment on Collarette - catalogue the colour & topography -

metabolic accumulation & < EFAs tendency

Irregular Pigment

Immune dysfunction consequence of CAC disruption

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24.2 Hour Individual Chronobiology Iris Map

La Cronobiologie

Adrenal Pigment/Indent

PNEI Network

SCN & La Chronobiologie

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This iris collarette topography

is applicable to both

the Dx/Rx & Gx/Lx

Pure Brown Iris

Immune Cell Chart (Neutropenia < Neutrophils)

M Sign IPB

Signifi cant blood sugar sign. Dysglycemia with

extreme symptoms & rapid development

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Globular IPB -

Serotonin Sign

(white arrow)

Claws Sign -

Progesterone

(black arrow)

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Every disease is a result of

reduced cell-to-cell & intracellular

communication - Modern Iridology can show this foundation• Immune cells, cytokines, hormones, peptides &

neurotransmitters all speak with each other in an

attempt to maintain homeostasis

• Research has found in many tumours you need

to stimulate Somatostatin. This can be considered

a new fundamental platform for any therapies.

Many tumours have increased Growth Hormone

(GH) in the cells. Increased somatostatin (mainly

produced from the hypothalamus) down-regulates

GH. Melatonin dow-regulates GH

Sections of DNA at the tip of chromosomes

They shorten every time cell replicates

Cells can maintain the length of their telomeres

with an enzyme telomerase - this adds genetic

material to the end of the DNA strand, thus

lengthening the number of times it can replicate

and prolong the cell life

Linked to IPB & pupillary zone topographies

Telomeres very prone to oxidative stress

Nutritional defi ciencies - vits C, D & E

Telomeres

Please refer to the following book >

and the chapter from page 135 on Classical Topographical

Questions in Modern Iridology

www.johnandrewsiridology.net

Modern Iridology approaches do not replace

existing methods, but enhances the iridology

experience for both Px and Pr - due to the abundance

of new and reliable information resources

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Striated/String Pigment -

107/138 Px = Initial: Cortisol

Reversal - Topolabile

Secondary: Intestinal Immune

Dysfunction & Dysbiosis

The Solitary sign - either

lacuna or pigment - on the

collarette is highlighted

in the modern iridology

approach

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In Modern iridology this

type of iris is not a “Weak”

constitution, etc. This is a

fl exible & absorbant person

that can endure a lot of

stress. with a distended

collarette there is a

dominance of the paternal

DNA

Restricted/Contracted Collarette

Vital immune indications

with ENT, HPA Axis, MALT,

zinc, vitamin C &maternal

DNA predominance

• Progesterone integral to the gastrointestinal mucosa

• Elevated & Multibridged collarette structure - “Progesterone Collarette” - Andrews,

Sao Paulo 2004

• New Hypothalamus Sign - Pupillary Zone topography - Andrews, Padova, 2004

• Claws’ morphologies on the Inner Pupillary Border - Andrews, Charlotte, 2006

• Partial atrophy on the IPB - Andrews, San Diego 2002

Main Iris Signs & Progesterone Tendency

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The Central Role of the Collarette in Iris

Analysis -The Progesterone Collarette

Claws IPB - Lower Progesterone Ratio

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• for the brain, blood & nervous system

• the fulcrum for mind-body medicine approach

• central to the limbic system

• PNEI dynamics

• direct connections to the iris & IPB tissues

• blood sugar regulation

• blood pressure control

• serotonin & other neurotransmitter

regulation

• sleep pattern regulation

• pain responses

The Hypothalamus is involved in the following:

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Macrophages

This iris collarette topography

is applicable to both the Rx & Lx

B Cells & Natural Killer Cells - reduced

potential Rx

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Nerve ending

Iris melanocytes

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Tyrosine/Dopamine

Linear Pigment on Collarette

catalogue the colour & topography

metabolic accumulation & < EFAs tendency

Shadow Ring< Reduced Zinc

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Another Shadow Ring sign

(see arrow)

Zinco & natural killer cells link established Andrews 1994 - 2015.

Gx Clinical Case: Autoimmunity - Female Px

Note: Erratic/Missphapen Collarette Structure- AI Typical.

Autoimmune Systemic Lupus (SLE). < Reduced selenium tendency

Dx - Hypertrophy IPB

(protective/reactive immune system when in balance. Over/

hyperactive when Px imbalanced. Note Erratic Collarette

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Iris Co-signs

Pigment Indent

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New in 2008 - 270 page comprehensive iridology text book for

the practitioner, tutor, student or researcher

www.johnandrewsiridology.net

All information has been extensively revised &

updated from previous editions and over ten new

chapters have been produced. The book comes

complewte with 270 slide iris image gallery

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For Children/Teenagers & Adults:

• Plantago lanceolata folia

• Nux vomica Homaccord drops (liver & GI)

• Licorice root

• Triphala

• Emblica offi cinalis fruc (Amla Berry)

• Nervoheel (IBS & stress-related)

• Progesterone D6 (Mucosa support)

• Melatonin 4CH (Gastric mucosa)

• Mucosa Compositum

(GI immune support)

• Gastricumeel (Gastric balance)

• Spascupreel (Spasmodic conditions/IBS)

• Aletris farinosa

(progesterone up-regulation/adrenal

support)

• Prebiotics

• Probiotics

GI System Therapeutics

Magnolia cortex

• Ziziphus spinosa/Z.jujube fruc

(IBS & stress-induced GI conditions,

excessive BMs)

• Magnolia cortex (IBS, anxiety, etc)

• Mucuna pruriens (Velvet bean) -

GI/NTs support

• Arctium lappa radix -

GI & hepatic support

• Guacatonga - Caesaria sylvestris

(Gastric ulcers)

• Artemisia vulgaris folia

(CFS, GI immune support, IBS)

GI System Therapeutics

Artemisia vulgaris folia

• Nux vomica

• Galium-Heel

• Gastricumeel

Achylia gastrica

Ziziphus

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EFAs & Mg required for healthy cell membrane

- also in blood sugar balance, detox and nerve

functions

Achromia

in the pure brown iris

blood sugar/metabolic

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Ex - Peppercorn pigments distributed through

ciliary iris - modern fi ndings correlate with

chromium tendency. German iridology

1950/1960s linked to iron, but ten year study

only found 3 cases of anemia from 61 Px with

peppercorn pigments. However 48/63 had

lower chromium. 10 other Px had Diabetes in

genetics. 2 Px no links.

• Imunologia & Iridologia (em Portuguese)

• Chronobiology in Natural Medicine

• New Inner Pupillary Border Findings 2008 - 2015

• Pure Brown Iris in Modern Iridology Vol.2 2008-15

• Chronic Fatigue Syndrome & Natural Medicine

• Modern Iridology Introduction

• Cellular Iridology

& the New Citric Acid Cycle Topography

• For 2016/17 “PNEI & Modern Iridology”

1200 pages approx

New Publications Pending 2015-16

Irregular PigmentImmune dysfunction consequence

of CAC disruption

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• The crypt is a genetic or embryological sign

• Interestingly, despite the crypt’s reputation in classical iridology for deep-seated chronic

cases, this cellular CAC research found that the conditions with the crypt sign attached saw

greater levels of resolution of the condition - replicating what we see with the crypt within the

modern iridology PNEI & emotional approaches

Crypt

Grey Arrow - Crypts * Crypt formation like this suggests genetic

< vitamin D tendency - emphasis blood group A

Note white arrow: HPA/Stress Axis

NKC

Globular IPB Serotonin Sign (white arrow)Claws Sign -

Progesterone (black arrow)

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Striated/String Pigment 107/138 Px = Cortisol Reversal - Topolabile

Intestinal Immune Dysfunction & Dysbiosis

Mucuna pruriens

Linear Pigment on the Collarette metabolic accumulation/<EFAs

Pigmento Porquinho da India

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• Imunologia & Iridologia (em Portuguese)

• Chronobiology in Natural Medicine

• New Inner Pupillary Border Findings 2008 - 2015

• Pure Brown Iris in Modern Iridology Vol.2 2008-15

• Chronic Fatigue Syndrome & Natural Medicine

• Modern Iridology Introduction

• Cellular Iridology & the New Citric Acid Cycle Topography

• For 2016/17 “PNEI & Modern Iridology” 1200 pages approx

New Publications Pending 2015-16

Peak Mental Peformance 3 PM take Rhodiola, Eleuthero, Centella, Gingko, Guna-

Awareness, Cerebrum Compositum, Zincum, etc

between 1 & 3 PM

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• Adaptogen

• Rich in vitamin C, selenio, zinco,

polysaccharides, fl avanoids

• Requires average soil, good drainage

in full sun

• Modulates infl ammation, “superfood”

nutritional adaptogen, chemoprotective,

hepatoprotective, balances blood sugar

levels,

• Regular use helps to promote intestinal

symbiosis

• Can strengthen capillaries in the eyes as

well as veins & arteries through the system

• Can help with testosterone & sperm

counts & sperm motility

• Contraindications: Nightshade family

allergy & may cause diarrhea with

excessive use

• Manganese (Mn) should be routinely

tested but is not in the UK & many other

countries

• Mn important for neurological functions

(defi ciency linked to shizophrenia & anxiety

for example) & blood sugar level balance.

Mn helps convert phenylalanine into

tirosina & tirosina into dopamina

• 26 Px with Mn defi ciency (established via

blood test between 2002 & 2014) 24 has

multiple frontal radial furrows

• 64 Px with radial furrows - 24 had < Mn.

Lycium barbarum - Goji Berry WolfBerry

Manganese -The forgotten mineral

Lycium - Wolfberry

Manganese (Mn) & Frontal Radial

Furrows

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Superfood adaptogens

Pupil Ellipse - Bilateral note Pupillary zone Hypothalamus & orange pigment.

Overactive hypothalamic pathways

• Anger or resentment (Staphisagria?)

• Chronobiology (Timing of the therapies)

• Th 1/Th 2 (Which pathway is “rigid”?)

• Metabolic elements (Pancreas & Hepatic)

• Endocrine (Optimal HPA Axis function)

Infl ammation Regulation

Ex - Intestinal Transversal & Solitary

Pigment (baco/spleen) - amplify the TH2

immune rigidity in Ulcerative colitis

Solitary Pigment on collarette is signifi cant for all systems -

classical &/or modern

Vascular Transversal - very important ciliary iris sign.

Potential active infl ammation & immune

compromise (with pigment) - Note IPB &

Pupil too. HPA & adaptogen support

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Shadow Ring sign around pupil- >

Zinco, < natural killer cells - tendency to <

immunity. Also note Distended Collarette -

90%+ cance of paternal DNA dominance

Restricted Collarettematernal DNA dominance.Tendency to <

Zinco. In modern iridology smaller pigments

will be very signifi cant

Erratic collarette structure autoimmune tendency with lower selenium

Autoimmune diabetes

New Square Collarette tendency to “Therapy Resistance” involving

PNEI Network, requires extra detoxifi cation

& there is a blood sugar tendency with

Insulin Resistance too

Another Shadow Ring sign (see arrow). Zinco & natural killer cells link

established Andrews 1994 - 2015. * Note

also the pupillary zone pigments. Important

in classical iridology with GI tract (Russian,

South Korean & German authors), but also

in modern iridologia with previously released

cellular iridology, pupillary zone topography

(embryology) & pending neurotransmitters

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Hyperactive hypothalamus vertical ellipse pupil

Shadow Ring Sign

Progesterone Collarette refer to Progesterona PDF in your folder

Endocrine Axis

Adrenal Pigment/Indent -

PNEI Network

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Pure Brown Iris One or two signs on the external collarette are v.important. Observe PZ topographies

too & IPB, including cellular iridology. The collarette structure reveals a lot here: <

progesterone, Th 2 infl ammation (AI), < selenio & dyslycemia

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• Psychological hostility profi les have been linked to depression, cardiovascular disease,

metabolic syndrome, increased stress, autoimmunity, lower EFAS & infl ammation

• Niaru, et al (2000) found 1,081 had metabolic syndrome and hostility has infl ammatory

metabolic effects. Hostility and the metabolic syndrome in older males: The normative aging

study, Psychosomatic Medicine 62, 7-16

• Raikkonen et al, 2003, looked at 134 teens in a 3 year follow-up & found hostility increased

the risk of metabolic syndrome in adolescents. Hostility predicts metabolic risk factors in children and

adolescents, Health Psych, 22, 279-286

• A study of 6,814 healthy men & women found that individuals with higher levels of distrust,

cynicism, chronic stress or depression has increased infl ammation (Ranjit et al, 2007 Psychosocial

factors & infl ammation, Archives of Internal Medicine, 167, 174-181). Infl ammation included > CRP ,

fi brinogen & IL-6. Suarez et al, 2004, found hostility associated with > IL-1 alpha & beta,

IL-8 in 44 healthy, non-smoking, premenopausal women. More severe depression & hostility

= .cytokine production. There was a link established between > IL-6 & hostility. Suarez et al

Enhanced expression of cytokines Pyschoneuroendocrinology, 29, 1119-1128

Hostility & Infl ammation - IL-6

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• Asthma - Th2 dominance

• Chronic Fatigue Syndrome

• Chronic fungal infection

• Ulcerative colitis

• Depression

• Fibromyalgia

• Chronic sinusitis/rhinitis

• Some forms of tumours

• Chronic allergies, hay fever

• Systemic Lupus (SLE)

• Scleroderma

• Infl ammatory Bowel disease

• Multiple chemical sensitivity

• Antiphospholipid syndrome

• Grave’s disease (hyperthyroid)

• Parasite infection

Th2 Conditions

• Psoriasis

• Pain syndromes

(including chronic tendonitis)

• Crohn’s disease

• Multiple sclerosis

• Type Autoimmune Diabetes

• Lichen planus

• Sjogren’s syndrome

• Hashimoto’s disease (AI

hypothyroid)

• Chronic viral infection

• Primary Biliary Cirrhosis (PBC)

• Ankylosing spondylitis

• Sarcoidosis

• Granuloma annulare

• Fever

• Some researchers suggest

Parkinson’s & Alzheimer’s are Th1

dominant

• Recurrent spontaneous

miscarriage

Th1 Conditions

Th1:

• Interferon-gamma (IFN)

suppresses IL-4

• IL-1 & IL-2

• TNF-beta

• Main partner cell: Macrophage,

CD8+ T cell

Th2:

• IL-4

• IL-5

• IL-6

• IL-9, IL-10 & IL-13

• Main partner cell: B cell, eosinophil (due

to IL-4), mast cells

• Peak production of the pro-infl ammatory

cytokines IL-1, IL-2, IFN-gamma, TNF-

beta all occurs during the night and early

hours when cortisol production is at

lowest level

• The time of the Th1 responses explains

why gastric pain, RA fl are-ups, Crohn’s

disease, colds, dental pain are all worse

in the early morning

Ref: Int Rev Immunol. 1998;16(5-6):635-49.The

chronobiology of human cytokine production.

Petrovsky, Harrison

Cytokines in Th cell Responses- Therapeutically be aware of Th pathway dominance chronobiology

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• Alcohol & recreational drugs can

cause TH2 rigidity

• Immune T cell receptors can alter

their messaging and status in the

immune system depending on

experience

• The normal oscillation between

Th1, Th2 & Th3 balance happens

every few hours as an integral

part of a healthy immune system.

Like the endocrine system there

is an innate chronobiology of the

immune system. which we can

harness & hone our therapeutic

approach with optimal windows of

immune opportunity, depending

on the condition involved

• The chronobiology of the immune

system is regulated via the

suprachiasmatic nuclei in the

hypothalamus

• Healthy (or unbalanced) sleep pattern

have a direct impact on the success of

this immuno-chronobiology, for example

research has found this with natural killer

cells, cancer cell production and the Th1

& Th2 harmony

Porozov S, Cahalon L Weiser M, Branski D, Lider O, Oberbaum M., Inhibition of IL-1 and TNF alpha Secretion from

Resting and Activated Human Immunocytes by Homeopathic Medication Traumeel S. Clinical & Developmental

Immunology. 2004 ;11(2): 143-149.

- 49 -

• Pregnenolone and subsequently DHEA are called the mother of hormones by researchers

because it is used by the body to manufacture many other hormones, including our sex

hormones that are necessary for many body functions (e.g. estrogen, testosterone,

progesterone, cortisol,...) They are responsible for the maintenance of many body functions

such as fat and mineral metabolism, controlling stress, maintaining male and female

characteristics and others. The body produces DHEA and then converts it on demand to

these other hormone

• DHEA stimulates cellular immunity or skewing of TH-1 mediated reaction in the balance where

as cortisol inhibits TH-1 reactions but will stimulate on long term TH-2 mediated reactions.

We can state that a long term secretion of cortisol (e.g. stress) will induce a skewing at the

TH-2 side of the balance inducing allergies, some auto-immune diseases and even cancer.

Some auto-immune diseases are TH-1 driven (e.g. Crohn’s disease)

• As TH-3 regulator cells, over the release of TGF-β, inhibit both sides of the balance (down

regulation) it does not directly intervene in the dysbalance but in the intensity of both the

TH-1 or TH-2 expression

• We know from research1 that Traumeel S inhibits the sectretion of IL-1β and TNF-α. These

two mediators inhibit cortisol production. That is why Traumeel S has such an infammation

down regulating effect, amongst others

1. Porozov S, Cahalon L Weiser M, Branski D, Lider O, Oberbaum M., Inhibition of IL-1β and TNF alpha

Secretion from Resting and Activated Human Immunocytes by Homeopathic Medication Traumeel S. Clinical &

Developmental Immunology. 2004 ;11(2): 143-149.

Hormones & Immunomodulation

Vitamin B6 - Washed out/thin collarette potential infl ammatory sign. Also, see l ighter spots -

achromia - Dysglycemia tendency

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• Infl ammatory Bowel Disease (IBD) = < B6 - Podophyllum Compositum, Nux vomica

Homaccord, Traumeel S, Mucosa Compositum, Dopamina D4 granules

• < B6 = > CRP levels (Zeel, Traumeel S, Galium-Heel)

• < B6 could be due to < EFAs

• < B6 can reduce GABA & dopamine

• Elevated urinary GABA could refl ect poor conversion from B6 to succinic acid (Coenzyme

Compositum)

Vitamin B6 undervalued infl ammatory & immune element - Coenzyme Compositum & Ubichinon

Compositum can assist with absorption and CAC utilizilation & effi ciency

• B6 requirements increase during pregnancy

• Urinary B6 loss caused by diarrhea (Diarrheel, Mucosa Compositum or Veratrum Homaccord)

• B6 can be reduced by oral contraceptives, alcohol or yellow dyes such as tartrazine

• Vitamin B6 requires zinc for correct absorption

• Zinc tends to be lower in plasma for up to 2 hours after eating - the heavier the meal the lower

Zn

• Anger or resentment (Staphisagria?)

• Chronobiology (Timing of the therapies)

• Th 1/Th 2 (Which pathway is “rigid”?)

• Metabolic elements (Pancreas & Hepatic)

• Endocrine (Optimal HPA Axis function)

Plasma vitamin B6 level - marker for infl ammation

Infl ammation Regulation

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Hypertrophy IPB (protective/reactive immune system when in balance.

Over/hyperactive when Px imbalanced

Estudos de Caso

Estudos de Caso IPB - Partial atrophy Endocrine

> Flexibility/Adaptability

• Hormones infl uence cytokine levels (prolactin, melatonin, progeterone, cortisol, etc)

• Endocrine & immune systems - brains in a fl uid state

• Female sex hormones, such as estrogen inhibit Th2 reaction & up-regulate Th1 cytokines

• Cortisol inhibits the Th1 reaction & in particular IL-2

• > Stress > Cortisol = < Th1 x IGF < = Herpes simplex virus

Relationship between hormones & cytokines

- 52 -

Estudos de Caso

Estudos de Caso

Estudos de Caso

Smooth Isolated orange pigment > severity of extreme dysglycemia symptoms.

Chomium. & modern iridology

Resentment (usually towards a parent)-

lacuna, crypt or pigment in classical knee

topography. Could be a genetic sign. Pigment

harder to resolve in this topographyWillow Bach

fl ower remedy (massage into knee).

Estudos de Caso

- 53 -

Renal rarefactionKidney dysfunction. Inherent creativity. With small

pigments creative thought

Musical/Artistic AbilityDeep transformation potenital. Flexibility in life as

long as connected with the creativity

Estudos de Caso

Dyscratic Iris

Therapy Resistance

Estudos de Caso

Estudos de Caso

Estudos de Caso

- 54 -

Hyperadrenal

(remember pupillary hippus)

Multiple pigments in inferior

section of the iris = hormonal imbalance.

Males & Females.

Pigments in this “upper

low section” = thyroid & metabolic

imbalances. Ipotiroidismo. Iodine<,

selenio<

Pigments in the lower iris & of

this sizefemale hormone imbalance. Remember to

support the liver & HPA Axis. Agoniada, Vitex

agnus castus, Paeonia, Siberian ginseng, etc

Flexibility

Estudos de Caso

- 55 -

Claws com Partial Atrophy IPB - endocrine & < progesterone ratio

Clinical CaseAutoimmunity - Female Px, Systemic Lupus

AI- Hashimoto’s

Lens Distortion

- 56 -

• Embryology & Iridology - collarette & IPB formation

• Stress = > maternal neurohormonal production

• Thus > child’s biological susceptibility to emotional distress (Nervoheel, Pulsatilla Compositum)

• Results in physical & psychological consequences of anxiety & stress (Tonico-injeel)

• Prenatal experience hormonally infl uences our positive & negative tendencies during life

(Ginseng Compositum)

• Amygdala-Hippocampus-Hypothalamus (AHH Axis) = Limbic Foundation to PNEI, ECM

terrain & homotoxicology applications

• Embryological development link -observe germinal layers

• Iris tissue correlation with in utero experience and PNEI & HPA Axis pathways during life - in

essence how we respond to stress & trauma and why

• The AHH Axis can have a genetic basis based on our grandparents’ stress & nutritional

experience - epigenetic PNI correlation according to geneticists

Stress & Neurohormonal Production

• Kronfol & Remick, 2000, Cytokines & the brain, American Journal of Clin Psychiatry, 157

683-694

• NKCs reduce during examination, Kiecolt-Glasser, et al 1984, Psychosocial modifi ers of

immunocompetence in medical students. Psychosomatic Medicine, 46, 7-14

• Schneiderman et al, 2005 found that Px with autoimmune disease, in comparison with

healthy individuals, exhibited an overactive proinfl ammatory cytokine production, caused by

constant acute stress response. Stress & Health, Annual Review of Clinical Psychology, 1,

607-628

Immunity & Endocrine Function in PTSD

Amygdala-Hippocampus-Hypothalamus Connection in PNEI & Homotoxicology

Amygdala

- 57 -

• Homotoxicology Adaptogenic - supports the HPA Axis

• PNEI Network Interactions supported

• Supports physiology in times of stress and to function normally

• Counters fatigue

• Involvement of multiple systems - ECM, RES

• Multiple symptom presentations

• Quantum layers of triggers and consequences

• Offers syngergistic solutions

• Disease is a consequence of impaired cellular communication across the PNEI matrix

• Cells use cytokines, hormones & neurotransmitters to interact & communicate across the

PNEI network

• In the blood/lymph/ECM - cytokines are concentrated in picograms & nanograms

Ginseng Compositum

PNEI & Homotoxicology

- 58 -

• New Systems & Topographies

• New Signs and reclassifi cation of existing signs

• Focus on the collarette, pupillary zone & IPB tissues & structures

• PNEI Axis Integration

Modern Iridology

• Immune system

• Endocrine system

• Gastrointestinal system

• Limbic system

• Neurotransmitters

• Chronobiology

• The Cell - Citric acid cycle

Systems

Please refer to the following book >

and the chapter from page 135 on Classical Topographical

Questions in Modern Iridology

www.johnandrewsiridology.net

Modern Iridology approaches do not replace

existing methods, but enhances the iridology

experience for both Px and Pr - due to the abundance

of new and reliable information resources

B Cells & Natural Killer Cells

reduced potential Rx

- 59 -

- 60 -

The Collarette

- 61 -

The Collarette is a prominent

and major landmark in the iris - in eavery sense

In some territories, especially in the USA & Germany

the Collarette is referred to as the Autonomic Nerve Wreath.

In some countries it is know an as the “ruff”.

However, the correct medical & anatomical terminology is the Collarette

- 62 -

• Immunology

• The Endocrine System (Glands for the Hormonal System are placed topographically on the

external border of the collarette)

• Emotional Dynamics of the Collarette

• Embryology with Daniele Lo Rito

• Limbic System

• Psychoneuroendocrinoimmunology

John Andrews is internationally recognised for research and exploration with the Collarette on the following levels:

A combination of new research & technology have provided exciting

new applications in iridology - the analysis of the collarette provides

the ability to ask the right type of questions to decide

on any short or long term treatments

- 63 -

The IPB & the collarette demonstrates the genetic & epigenetics links

Every Iris is Individualjust like the person it belongs to

This is why the collarette is being

utilised in biometric security scanning The Integrity of the Collarette

The iris, and particularly

the Collarette, is individual to us

to an even greater degree than

fi ngerprints

• The emerging science of epigenetics also

helps to validate iridology

• Within this fi eld geneticists have concluded

that the emotional & psychological traumas

an individual has inherited from their parents

or grandparents can have a profound

infl uence on the genetic development of

physical disease for that person - without

altering the DNA structure

• This is exactly what we can identify with the

many layers of transparent maps of the iris

• What we assess with the iris & IPB is an

expression of epigenetic aspects

Epigenetics

Iridology validates Epigenetics

- 64 -

Cronobiologia

• Px = Patient

• CR = Circadian rhythm

• HPA = Hypothalamic-pituitary-adrenal axis

• PNEI = Psycho-neuro-endocrino-immunology

• ECM = Extracellular matrix

• Pr = Practitioner

• IPB = Inner Pupillary Border

• Rx = right eye/iris

• Lx = left eye/iris

• CNS = central nervous system

• CAC = citric acid cycle or Kreb’s cycle

• PRL = Prolactin

• GH = Growth hormone

Abbreviations

24.2 Hour Individual Chronobiology Iris Map

- 65 -

• Utilizes the Collarette with a 24.2 chronobiology timeframe for humans - collarette divided

into 14.8° sections

• Connects with all topographies/systems in modern iridology - pupillary zone, IPB, emotional,

PNEI, cellular - citric acid & modern iridology chart - Grafi co de iridologia moderna

• Correlations with classical iridology as well

• We can identify our personal biological body clock, regulated by the hypothalamic

suprachiasmatic nucleus (SCN), using the collarette and connect with important signs on

the IPB and the other topographies or we can connect with signifi cant topolabile iris signs -

these are markings signifi cant for what they are; not where they are

• In the future we can check our individualised gene maps with our chronobiology map and

the IPB

• So for example we have a M sign on the IPB - se next image - we know this is important, but

the meaning is further enhanced if we have a sign on the collarette for 08.30 AM, 13.30 PM,

15.30 PM & 19.30 PM - we can prescribe for these times for the Px - diet, zinc, chromium,

spirulina, Gymnema, Myrtillo fruc, Bauhinia (Pata de Vaca), etc

Individual Chronobiology Map

M Sign IPB- Signifi cant blood sugar sign

- 66 -

- 67 -

- 68 -

- 69 -

- 70 -

• The term chronobiology come from the Greek

word for time chronos meaning “time” and the

study of life biology, basically time-biology of

plants, animals & humans

• Chronobiology is the science that studies how

living organisms adapt to the cycles of the

sun &moon to establish biological rhythms

• In the 1970s this began looking at the sleep/

wake cycle, but has since extended to

look at all systems/organs in the body and

chronopharmacology

• One of the main landmarks of the iris

• Scientifi c studies throughout the world have demonstrated its signifi cance in disease tendency

• Recent research has examined its embryological origin & developmental completion at 6

months gestation, except in rare cases (complete collarette atrophy)

• vOngoing research has explored the emotional & PNEI interpretation of the collarette’s

structure

• The collarette has several levels of information pertaining to physical and emotional tendencies

including that of the neuroendocrine & immune systems

• The collarette does not change its structure, unless due to trauma or surgery to the iris or

pupillary deformation - in reality transient dynamics of the pupil or even the iris tonus give the

basis for such claims

• Analysis & interpretation of the Collarette is suitable for iris types, indeed it is the most

accessible iris structure available and will provide multiple levels of information, when other

signs may prove to be non-existent or unclear

Chronobiology Defi nition

Collarette Summary

The Iridologist needs to observe for uniformity

in the collarette

- 71 -

Even though the collarette can be

described as a boundary wall, it

transcends all iris boundaries - well in

99.8% of cases - it is easily identifi ed

& assessed in all iris types leading to

multiple levels of information

Elephants - IPB - One of the most

important IPB signs - yet discovered

- as it highlights the importance of

HPA Axis balance. usually in a frontal

location. Emotional epigenetics & the

limbic system

• Genetic history of HPA compromise & susceptibility - especially with infl ammation -

compounds the Stress Axis - Adpatogens & other forms of suitable cellular support

• Thus often seen in Autoimmunity, polyarthritis, poor ECM drainage, dysmetabolic

mesenchymia, chronic fatigue syndrome (CFS), etc

• Good emotional memory, will learn from negative emotional experience & stress - emotional

epigenetics.

• Tendency to Anxiety

• Elevated cortisol Tendency(the “A” in the HPA axis)

• Dysglycaemic Tendency - Elephants emphasize any blood sugar dysregulation

• Leptin disturbances leading to poor hypothalamic control of fat metabolism

IPB Elephants Review

- 72 -

HPA Axis

- 73 -

- 74 -

- 75 -

- 76 -

• Emotional Anatomy Correlations

• Each organ or gland carries an emotional, psychological & energetic memory & interaction

• Hormones, neurotransmitters, immune cells & cytokines have these correlations - PNEI!

• Psycho-emotional iris topography (applicable to any of the iris maps)

Avaliação profunda dos níveis físicos e emocional

Iris melanocytes

- 77 -

Amygdala - Rx

- 78 -

Hypothalamus

Hypothalamus - Radial Sign

Hypothalamus

& Limbic System

- 79 -

www.johnandrewsiridology.net

All information has been extensively revised &

updated from previous editions and over ten new

chapters have been produced. The book comes

complete with 270 slide iris image gallery

New in 2008 - 270 page comprehensive iridology text book for

the practitioner, tutor, student or researcher

The solitary sign

Either lacuna or pigment - on the collarette is highlighted

in the modern iridology approach

In Modern iridology this type of iris is not a

“Weak” constitution, etc. This is a fl exible & absorbant

person that can endure a lot of stress. with a distended

collarette there is a dominance of the paternal DNA

Geographical Tongue

- 80 -

Also in this case the pupillary mydriasis (page 35) that

could indicate adrenal hypofunction/fatigue - check if not

a child or adolescent

Modern iridology does not overlook the pure brown iris.

80% approx of global population has brown iris

With the brown iris the focus is usually the collarette,

Pupillary zone, Pupil & IPB - all the signs associated in

these areas. The potential importance for new modern

iridology maps becomes apparent

Erratic/misshapen Collarette-

selenium tendency

(check autoimmunity, thyroid, immune status, blood

group 0, etc)

When we are faced a lot of a certain iris sign then it

is usually less signifi cant to them individually. More =

Less. Less = More. Look for what stands out against the

iris background. By the way, many iris pigments in the

lower section show an endocrine tendency

- 81 -

Linear Collarete, orange pigment in the Limbic/cerebral

areas. Also note Magnesium (whitened) & Zinc (restricted

collarette) - all suggest a dysglycemia tendency with

neurological symptoms if the Px is out of balance

In modern iridology there is no need to “overdiagnose/

analyse” when faced with many signs. Focus on

the smaller signs - pigments. Also the iridomelanin

pigments suggest tyrosine conversion compromise in

the liver

• Elevated & multibridged collarette structure - “progesterone collarette” - Andrews

• New Hypothalamus Sign - Pupillary Zone topography

• Claws’ morphologies on the Inner Pupillary Border

• Partial atrophy on the IPB

Main Iris Signs & Progesterone Tendency

- 82 -

The Central Role of the Collarette in Iris Analysis

Collarette Bridge

The Central Role of the Collarette in Iris Analysis

Progesterone Collarette - highlighting previous progesterone ratio imbalance

leading to endocrine, immune, metabolic (blood sugar) & infl ammatory

conditions - full research to be published 2010. The Collarette becomes

elevated, thickened & is genetically multibridged. Claws on the IPB clarify &

enhance the analysis

- 83 -

Pupillary membrane

Claws IPB - Progesterone

- 84 -

- 85 -

- 86 -

The Pigment Triangle (Pigment Triad)

The pigment triangle links three pigments of similar type

& size as means of immune system tendencies from the

pigment type and/or topography - PNEI & ECM dynamics

are involved

Pigment Triangle

Andrews Modern Iris research - to be published 2011

Pigment Triangle

Links 3 pigments of similar type & size as means of

immune system tendencies from the pigment type and/or

topography - PNEI & ECM compromise

Pigment Triangle

Pigment Triangles with one or more of the pigments on

the Collarette have > signifi cance for the Px

- 87 -

Pigment Triangle

They can appear in any iris type & the immune system &

ECM indications are the same

• Improved accuracy & competence

• Flexibility for the practitioner & patient (Px)

• Multifaceted approach with the integration of different and varied methods & systems

• Priority of signs

• Improved confi dence

• Positive Px Empowerment

Modern Iridology Summary

- 88 -

The noblest joy is in the understanding

Leonardo Di Vinci

Merci

Thanks for your attention & participation

johnandrewsiridology@hotmail.com