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condyloma acuminatum

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1 Definition Condyloma acuminatum(also known as condyloma acuminata,genital wart or venereal warts ) is a proliferative disease caused by human papillomavirus of some types.

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2 etiology The primary human papillomaviruses(HPV) that cause condyloma acuminatum are: HPV 6 HPV 11 HPV 16 HPV 18 all are mucotropic viruses

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3 transmission and epidemic main way of infection the contact infection is the main path of the condyloma acuminatum the infectivity is the most strong in the stage of about 3 months. Infrequently it could be spread by contaminated pants,bathtub or towels and so on. It is contracted by close contact without sexual behaviour in family. And fetuses are contracted by the infected birth canal or the close contact with infected mothers.

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4 clinical manifestation The incubation period is 1 to 8 months(usually 3 months) and the leisons appear primarily in and around the skin or mucous membranes of the genital area.

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Lesions The lesions start with soft erythrous tiny papules which are sarcoid mammilliform ecptomas, range in size from pinpoint to mung bean,with the rough surface.then the papules growth into size of peanut kernel cauliflower-like or comb shape-like huge pedunculated masses develop from mutual confluence,which are easy to bleed during sexual life. Erosion and ulcer may develop when blood supply is not sufficient in the warts or secondary infection is existing.

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Relationship with neoplasmata genitalis It has been confirmed that condyloma acuminatum is associated with the cancer of the genital,especially carcinoma cervicis. The development of about 15% carcinoma of penis, 5% cancer of vulva and considerable cancer of anus is on the long-term foundation of condyloma acuminatum.

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5 histopathology acanthosis vacuolus bulliform cells are present in the superficial or superficial middle epidermis, trochanterellus is thicking and prolonging with papillomatous hyperplasia.

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6 diagnosis and differential diagnosis sexual behavior outside of the marriage or mate with a history of infection typical lesions histopathology inspection when it is necessary

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7 treatment topical treatment 0.5% podophyllotoxin tinctura 2 times daily, 3 days is a course of treatment repetition needs an interval of more than 4 days,pay attention to preserve the normal skin or mucous membranes around warts. It can cause abnormal embryos and is forbade to using in the pregnant women. laser and hypercator cauterize or cut the warts

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injecting interferon or transfer factor for condyloma acuminatum of recurrent attacks, taking Chinese traditional and herbal drugs orally,or topical treatment with interferon cream..