concepts of aging

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  • Concepts of AgingTomorrows vision...Today!

    http://activeconceptsllc.com

  • Introduction.................................................................................................................................................................3

    Cellular Prejuvenation: Oxidative Damage..........................................................................................................................4

    Cellular Prejuventation: Suspended Animation.................................................................................................................6

    Inflammation as a Precursor to Aging.....................................................................................................................................7

    Plant Stem Cell Technology & Pro-Aging.............................................................................................................................8

    Probiotics & Pro-Aging.................................................................................................................................................................9

    Aging via UV Radiation............................................................................................................................................................10

    Neurocosmetics: Age Defying Beauty..................................................................................................................................11

    Traditional Methods, Novel Approaches.............................................................................................................................12

    References...................................................................................................................................................13

    Click on the logo at any time to return to the Table of Contents

    Version #1/11.18.16

    Table of Contents

  • The science of aging drives the cosmetic market. Despite many years of intense research on the cause of aging, it is still not fully understood and several theories have been proposed to explain the process of aging. By understanding the existing and developing theories of aging, it can be possible to promote successful aging through science focused, technology driven cosmetic claims.

    Outlined in this brochure are major biological pathways of aging that served as inspiration for the development of each active ingredient suggested. Using scientific methods, Active Concepts has developed multifunctional active ingredients supported by proven efficacy data to deliver exceptional benefits.

    Active Concepts built itself upon three pillars; innovative technology platforms, market leading customer support, and products with a purpose. For almost two decades, Active Concepts has diligently embarked on an endeavor to develop complex, active ingredients that provide formulators with unmatched function, in order to meet and exceed the rapidly increasing consumer demand for more effective technologies that promote successful aging.

    The constant demand for new aging products is leading to exciting new

    innovations. The resulting unique dynamic of consumer trends and new scientific

    innovations are truly driving the industry forward.

    Version #1/11.18.16

  • Page 4/14

    Addressing free radical damage at a cellular level and understanding the negative effects of improper cellular metabolism allows for a unique approach to premature skin aging. Free radical damage was one of the first processes associated with aging, going back to the 1950s when Dr. Denham Harman first proposed oxidation as a mechanism for tissue destruction.1 Free radicals are the predominant intracellular pollutant and mitochondria are responsible for approximately 80% of intracellular free radicals. Mitochondria play crucial roles in several age-related diseases, and in the physiology of normal skin aging. The Mitochondrial Free Radical Theory of Aging (MFRTA) states that the accumulation of oxidative damage in the mitochondria, produced as a byproduct of normal cellular respiration, is the main driving force in the aging process.1

    The modern version of the MFRTA proposes that the reactive oxygen species (ROS) superoxide anion, originating from several mitochondrial enzymes, enters into a number of secondary reactions leading to other ROS that ultimately react with and extensively damage cellular macromolecular structures.2 The affected cells accumulate such damage over time and will eventually cease to function normally, contributing to reduced physiological function. Dysfunctional mitochondria send incorrect messages, decrease ATP production, and produce more free radicals. Defective mitochondria replicate their own damaged DNA into new mitochondria, eventually displacing all well-performing mitochondria. Dysfunctional mitochondria are associated with many degenerative diseases. Out of control free radicals cause widespread tissue damage and put our body in a state of oxidative stress. Oxidative stress affects our skin, causing premature signs of aging and disturbing wound healing.

    Mitochondrial Function

    Generation of Reactive Oxygen Species

    Oxidative DamageMitochondrial Mutations

    Mitochondrial Dysfunction

    Aging

    Figure 1. Schematic representation of the mitochondrial free radical theory

    Cellular Prejuvenation: Oxidative Damage

  • Product Code & Name INCI Name Mechanism Multifunctional Benefits

    20757PF AC CytoPure PF Crypthecodinium Cohnii Extract

    Activates the power of glutathione to reduce the accumulation of reactive oxygen species to contribute to cellular longevity and wound healing

    Anti-pollution active Cellular detoxification Wound healing

    20024 ACB Wakame Bioferment Advanced

    Undaria Pinnatifida CellCulture Extract

    Increases oxygen consumption, whilesimultaneously reducing the formation of reactive oxygen species to increase overall mitochondrial efficiency

    Powerful Antioxidant Increases Collagen Synthesis Enhances Cellular Longevity

    16600 ACB Phyto-Biotics Bifidus Lactobacillus Bifidus Lysate ExtractTargets the mitochondria and inhibits apoptosis while also contributing to the longevity of cells to minimize cellular damage

    Increases cellular oxygen consumption Reduces the presence of reactive oxygen species Increases the expression of procollagen

    20355 ACB Ox-Red SOD Superoxide Dismutase

    An intact enzyme complex comprised of superoxide dismutase as well as the associated chaperone proteins, targets the harmful superoxide anion to neutralize free radicals

    Versatile in formulations Anti-irritant capabilities Beneficial for both skin and hair

    Page 5/14

    Cellular Prejuvenation: Oxidative Damage

    Oxidative phosphorylation is the metabolic process that fuels the production of Adenosine Triphosphate (ATP), the major source of energy for our cells. This pathway, also referred to as the electron transport system, transfers electrons from electron donors to electron acceptors. These redox reactions are carried out by a series of mitochondrial protein complexes collectively referred to as the electron transport chain. As the electrons pass through the chain, energy is generated that is used to make ATP. Normally oxygen, the final electron acceptor, is reduced to water. However, leakages occur in the system that generates the formation of damaging hydroxyl and superoxide radicals. Given the intricate structure of mitochondria and their proximity to the toxins that are produced, mitochondria along with mitochondrial DNA are the most vulnerable and susceptible to damage.3 The MFRTA explains that mitochondrial damage increases with age, and is responsible for the physical changes that occur with age.3

    The MFRTA opens the door for the skincare industry to investigate the best ways to harness mitochondrial functions for use in the fight against premature skin aging and promote healthy, youthful skin. Current efforts in the industry focus on the development of active ingredients that will protect the mitochondria and boost their function, with the idea that these ingredients will contribute to increased cell protection, cellular longevity, improved barrier function, and a better functioning extracellular matrix.3

    Upregulating levels of cellular antioxidants through sulfur biology, enhancing oxidative phosphorylation, and increasing oxygen uptake are mechanisms through which the following Active Concepts active ingredients improve mitochondrial activity to ultimately decrease the production of reactive oxygen species and lead to healthy, more youthful looking skin.

    http://activeconceptsllc.com/products/bioferments/acb-wakame-bioferment-advanced/

  • Product Code & Name INCI Name Mechanism Multifunctional Benefits

    20793PF AC CytoSulf PF Plankton ExtractPlankton derived sulfide donors induce cellular stasis for skin that defies aging through practical science

    Slows cellular aging Moisturizing Next generation anti-aging

    Figure 2. Cell Cycle7

    Page 6/14

    Cellular Prejuvenation: Suspended Animation

    Cardiovascular research focused on sulfur dioxide has led to an innovative approach on anti-aging. Sulfur dioxide was previously regarded as a toxic gas in atmospheric pollutants, but it has been f

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