computational mechanics & numerical mathematics university of groningen multi-scale modeling of...
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![Page 1: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/1.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
Multi-scale modeling of the carotid artery
G. Rozema, A.E.P. Veldman, N.M. MauritsUniversity of Groningen, University Medical Center Groningen
The Netherlands
![Page 2: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/2.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
ACC: common carotid artery
ACE: external carotid artery
ACI: internal carotid artery
distal
proximal
Area of interest
Atherosclerosis in the carotid arteries is a major cause of ischemic strokes!
![Page 3: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/3.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
• A model for the local blood flow
in the region of interest:
– A model for the fluid dynamics: ComFlo
– A model for the wall dynamics
• A model for the global cardiovascular
circulation outside the region of interest
(better boundary conditions)
A multi-scale computational model: Several submodels of different length- and timescales:
Carotid bifurcation
Fluid dynamics
Wall dynamics
GlobalCardiovascular
Circulation
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
Computational fluid dynamics: ComFlo
• Finite-volume discretization of Navier-Stokes equations
• Cartesian Cut Cells method– Domain covered with Cartesian grid
– Elastic wall moves freely through grid
– Discretization using apertures in cut cells
• Example:Continuity equation Conservation of mass:
![Page 5: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/5.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
Boundary conditions
• Simple boundary conditions:
• Future work: Deriving boundary conditions from lumped parameter models, i.e. modeling the cardiovascular circulation as an electric network (ODE)
Inflow
Outflow Outflow
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
The wall dynamics (1)
• Simple algebraic law:
• Independent rings model:
wr(z,t) and wz(z,t): displacement of vessel wall in radial and longitudinal direction
Elasticity Pressure
PressureElasticityInertia
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
• Generalized string model:
• Navier equations:
Wall dynamics (2)
Elasticity PressureInertia DampingShear
Elasticity
PressureShear
Inertia
![Page 8: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/8.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
Modeling the wall as a mass-spring system
• The wall is covered with pointmasses (markers)
• The markers are connected with springs
• For each marker a momentum equation is applied
x: the vector of marker positions
![Page 9: Computational Mechanics & Numerical Mathematics University of Groningen Multi-scale modeling of the carotid artery G. Rozema, A.E.P. Veldman, N.M. Maurits](https://reader030.vdocuments.mx/reader030/viewer/2022032806/56649efd5503460f94c117e6/html5/thumbnails/9.jpg)
Computational Mechanics & Numerical MathematicsUniversity of Groningen
The mass-spring system compared to the (simplified) Navier equations
• Navier equations– Material points move in radial and longitudinal direction only
• Generalized string model– Material points move in radial direction only
• Mass-spring system– Material points (markers) are completely free: Conservation of
momentum in all directions:
Inertia Shear Elasticity Damping Pressure
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
Weak coupling betweenfluid equations (PDE)and wall equations (ODE)
Weak coupling betweenlocal and global hemodynamic submodels
Future work: Numerical stability
Coupling the submodels
Carotid bifurcation
Fluid dynamicsPDE
Wall dynamicsODE
GlobalCardiovascular
Circulation
ODE
pressurewall motion
Boundary conditions
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
Results: clinical data and CFD
• Example: Doppler flow wave form. Model variations: Rigid wall / elastic wall, Traction-free outflow / peripheral resistance
A B C D
Elastic wall No No Yes Yes
Peripheral resistance No Yes No Yes
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Computational Mechanics & Numerical MathematicsUniversity of Groningen
Results (2): Conclusion
• Both elasticity and peripheral resistance must be taken into account to obtain a close resemblance between measured and calculated flow wave forms
• Future work:– Clinical follow-up data
– 3D ultrasound
– Patient specific modeling