PerkinElmer brings together the technologies you

need for a more complete understanding of cellular signaling and morphology in the context of the biological system. Our instruments, reagents and assay technologies make up the only offering that includes multidirectional biochemical and cellular solutions to help researchers

locate, detect and quantitate complex cellular events. PerkinElmer offers superlative technologies from3H-SAM – recognized as the gold standard for direct methyltransferase measurement – to the world’s leading kinase assay portfolio. We help you navigate the complexities of epigenetics research and find the answers you’re looking for.

Navigating the complexities of epigenetics research.

Capabilities Assay Technologies Instrumentation Target Areas of Study

• Direct quantitation of methyltransferase activity

• Detection of full-length protein:protein interactions for readers of histone code

• Rapid testing of probe libraries for proteins involved in epigenetic regulation

• Kinase activity and pathway signaling

• 3H-SAM methylation assay

• SPA (scintillation proximity assay)

• Alpha Technology toolbox

• LANCE® TR-FRET toolbox

• DELFIA® TRF reagents

• EnVision® Multilabel Plate Reader

• EnSpire™ Multilabel Plate Reader

• MicroBeta2™ Liquid Scintillation Counter

• ViewLux™ ultraHTS Microplate Imager

• JANUS® Automated Workstation

• Cancer

• Stem cells

• Immunology

• Neurodegenerative diseases

• Metabolic diseases

LOCATEDETECTQUANTITATE

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These technologies are part of PerkinElmer’s comprehensive solution for understanding cellular signaling and morphology in the context of the biological system. Only PerkinElmer provides multidirectional biochemical and cellular approaches, which enable researchers to locate, detect and quantitate complex cellular events in the area of cancer and other disease research.

Please contact us for more information: www.perkinelmer.com/ContactUs

For a complete listing of our global offices, visit www.perkinelmer.com/ContactUs

Copyright ©2010, PerkinElmer, Inc. All rights reserved. PerkinElmer® is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners. 009248_01 Printed in USA Jul. 2010

PerkinElmer, Inc. 940 Winter Street Waltham, MA 02451 USA P: (800) 762-4000 or (+1) 203-925-4602www.perkinelmer.com

Toolbox or custom, PerkinElmer assays fit your research

3H-SAM – adenosyl-L-methionine, S-[methyl-3H] – can be used generically regardless of the methyltransferase substrate. Highly sensitive and capable of quantitatively measuring direct methyl transfer, 3H-SAM expands your screening ability. Even low-activity enzymes can be measured with specificity. Format your assays with SPA (scintillation proximity assay) to enable your radiometric assay for speed, sensitivity and versatility with no separation steps.

Alpha Technology assays are unique because they can measure nearly any biological interaction, when Donor and Acceptor beads are brought into proximity over large complex ranges. The Alpha toolbox lets you build custom assays with a range of uncoated beads that can be conjugated or ready-to-use beads coated with a variety of molecules. Building your reader, writer or eraser assays is easy and cost-effective with Alpha Technology.

LANCE toolbox reagents and custom labeling can be used to develop your assay, no matter what you want to study. Consult with us for your assay design and let our scientific experts deliver your superior TR-FRET europium chelate-labeled reagents. LANCE europium chelates have been optimized for assay performance, signal level, energy transfer efficiency, background and sensitivity of the assay to interferences.

DELFIA is the natural choice for dealing with difficult samples. With detection based on time-resolved fluorescence (TRF), it has been proven for detection of epigenetic marks in fixed cell assays. Additionally, it is well suited for adapting ELISA assays where rare biological events need to be detected in complex matrices.

EnVision Multilabel Plate Reader for multiple assay platforms combines the sensitivity of a filter-based system and the flexibility of a monochromator in one system.

High-performance EnSpire Multilabel Plate Reader provides comprehensive data analysis, fast assay setup and a large touch screen for easy operation in any size lab.

Combining liquid scintillation counter reliability with plate reader simplicity, the MicroBeta2 system is designed for robust performance with both radiometric and glow luminescent assays.

ViewLux CCD Imager provides ultra-high throughput for imaging of red light emission from SPA Imaging beads. ViewLux also provides high quantum efficiency for SPA and FlashPlate® technology and other high throughput screening of radiometric assays.

The JANUS Automated Workstation provides the cornerstone for automating sample preparation and assay setup, offering stand-alone liquid handling or a fully integrated solution to automate your epigenetics screening workflows.

Highly sensitive instruments for a complete solution

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