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COMPANY PROFILE

With effect from June 21st, 2012, De Dietrich Process Systems India Pvt. Ltd. (“DDPS”) has acquired the whole Glass-Lined Equipment and Pressure Vessels Division of Nile Limited. DDPS India is part of the De Dietrich group, a French-based manufacturer of equipment and systems for the chemical and pharmaceutical industries. De Dietrich has been established in 1684 and the main shareholders are the founders’ descendants. The group has units in 15 countries and is present in Mumbai since 2004. De Dietrich Process Systems is composed of De Dietrich Glass Lining, Rosenmund® filter-dryers and QVF® borosilicate glass components and QVF® Process Systems. Through the integration and synergies of these three product lines, De Dietrich Process Systems has become one of the most comprehensive global suppliers of engineered systems, equipment and services for the fine chemical and pharmaceutical industries. In the attached document, you will find a short presentation of our capabilities and unique solutions. With the acquisition of the Glass-lining business of Nile Limited at Hyderabad, DDPS India will be offering you glass lined equipment produced in Hyderabad, as well as advanced mixing technology and all other products described in this document. De Dietrich Process Systems (DDPS) incorporated in INDIA under the name DE DIETRICH PROCESS SYSTEM INDIA PVT. LTD.

1. SYSTEMS Our specialized and experienced engineering teams have the capability to design systems of equipment to meet specific application requirements based around one or more of our core technologies. In addition, we can include externally-sourced equipment that we design, specify and purchase on your behalf. This ensures that all the equipment is seamlessly integrated to achieve project milestones and processing goals. Engineered Systems provide many benefits over separately purchased components, including :

Combination of the various competences inside DDPS leading to unique solutions and specific designs to fulfil specific processes

Multi-purpose design with full consideration of cGMP constraints Skid-design to allow off-site, pre-shipment testing and reduced installation time

De Dietrich Process Systems multipurpose reaction units The synergies between different activities of De Dietrich Process Systems have allowed us to develop a new range of reaction units. Each skid includes a De Dietrich glass-lined reactor bottom with its agitation system and glass cover, column, phase separator, condensers, receivers, valves and piping made from QVF Borosilicate 3.3 glass. The design has been made according the cGMP. New types of glass connections and gaskets are provided and horizontal dead area deleted. A new specific design of the reactor flange optimises heat transfer surface and sealed insulation installation. This range includes standardized units of 25, 50, 100 and 160 litres, all complying to European Directives (PED among others). Other sizes on request.

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Furthermore, by combining our unique and thorough knowledge of our own equipment with a variety of engineering expertise, we can tackle projects of any size, from small reaction systems to compete industrial plant.

QVF® SUPRA-Line combines the possibilities and benefits of the preceding systems. Hence, the QVF® SUPRA-Flange ensures the benefits of the WPR2002 plane flange:

High mechanical strength by preventing/minimising tensile stress due to its geometry.

In addition to the increased safety of the flat flange the cleaning aspect - especially in relation to the GMP design is of particular importance. Minimum dead space connections are provided by means of a specially developed universal gasket which is positioned by a groove in the flange and thus providing a minimal dead space connection of the glass flanges.

In the case of all other applications where such “GMP aspects“ are of less importance the special features of a flexible ball/socket combination can also be used with the QVF® SUPRA-Flange. The integrated shoulder is fixing the PTFE seal and provides a leakage free connection.

Both the QVF® SUPRA-Flange (flat) and the QVF® SUPRA-Flange (ball/socket) have a fire-polished surface. From the GMP perspective this is without doubt beneficial since it can easily be cleaned. Long-term studies with strongly alkaline media have also shown that a smooth fire polished surface is more resistant to alkaline corrosion and has a longer lifetime than a ground surface

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Process Systems by DDPS Using our customer focused engineering capabilities DDPS has also developed its own process technologies and is offering performance guarantees on Process Systems. DDPS is aware of that a solution for a specific problem can generally not be regarded as an isolated system, but needs to be integrated into the entire process. Hence Process Systems by DDPS are designed not only based on our extended knowledge of our components but also taking the specific demands of our customers into consideration. DDPS uses modern simulation tools, trials in our test facilities and of course our long term experience to design Process Systems meeting our customer's requirements. Furthermore DDPS has developed own process technologies such as but not limited to:

Product Recovery and Product Purification Waste Water Treatment Exhaust Gas/ Exhaust Air Purification Recovery, Concentration and Purification of Mineral Acids Reaction with Halogens Absorption , Adsorption , Distillation ,Extraction, Crystallisation

The service DDPS offers with Process Systems can cover the complete project comprising of conceptual design studies, feasibility studies, trials, basic and detailed engineering, HAZOP-studies, validation, procurement, plant erection, commissioning.

Sulphuric and Nitric Acid Recovery Bromine Recovery

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DDPS process plant and pipeline components manufactured from borosilicate glass 3.3 are widely used as the basis for the construction of complete process systems throughout the chemical and pharmaceutical industries, as well as many related areas such as food and drink production, dye works and the electroplating industry. One reason for this widespread use is the special properties of borosilicate glass 3.3, complemented by the use of other highly corrosion resistant materials such as PTFE and ceramics. Secondly, borosilicate glass is an approved and proven material in the construction of pressure equipment.

Extraction Systems De Alcoholisation of Wine

2. EQUIPMENT

DDPS reactors have excellent resistance to corrosion, smooth non-stick properties and non-catalytic inertness. They can be designed for a high range of versatility in multi-product applications, or specialized to optimize a specific processing requirement. Many standard sizes and designs are kept in stock for quick delivery

WELDED AGITATORS The GlasLock® system, which allows for the adjustment and removal of individual blades as well as many impeller choices for improved process mixing.

Multipurpose Hub GlasLock® system

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OptiMix® reactors : from pilot up to production The OptiMix® reactor series has 3 wall baffles built into the glass-lined vessel. This provides superior mixing performance and frees up top head nozzles for improved process control After a first “observation round” during which the demand of glass-lined De Dietrich OptiMix® reactors has been mainly concentrated on pilot size units (100, 250, 400 and 630 litres), we have seen a trend to apply the verified results on half-coiled production reactors of greater sizes : 6300, 12500 and even 16000 litres. The OptiMix® concept (3 integrated baffles) convinces not only by the improvement of mixing properties and the reduction of reaction time, but also by the freeing of all the upper nozzles, and the deletion of product splashes on the wall (no vortex) and of dead zones always difficult to clean. The standardized OptiMix® range has been extended and allows you from now on a complete scale-up from 10 litres laboratory reactors, made of QVF glass, up to 40,000 litres production-sized glass-lined reactors. Existing reactors can be up-graded into OptiMix® ones during a reglass process. More than 200 OptiMix® reactors have been sold in less than three years.

PharmaReactor by De Dietrich : a new design of reactors

A new series of reactors, called PharmaReactor, have been conceived to remain clean. These reactors, totally sheathed, have more openings than a standard DIN reactor of same size. This allows you to install for example retractable spray devices. Internal design is obviously an OptiMix® one ; the integral jacket volume has been reduced to improve heat transfer by increasing fluid circulation speed. A quick release opening device is installed on the hand hole, which makes very fast and easy the installation of a removable spray nozzle device.

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OptiFoil® : a new De Dietrich agitation profile The range of De Dietrich GlasLock® system agitation blade has been extended. The new OptiFoil® design combines the advantages of HydroFoil® blades (high flow) and trapezoidal (low agitated volumes, improved emptying). It gives an optimised solution to guarantee an important axial flow specifically adapted to crystallisations and suspensions and to facilitate operating at very low volumes of products. Its blade profile generates a smooth contact avoiding damage to the most fragile crystals. Low agitated volumes as small as 9 litres for a BE 1000 l, 12 litres for a BE 2500 l and 84 litres for a BE 20000 l. ConductiGlass® : new antistatic glass-lining The ConductiGlass® lining suppress any risk of glass damage due to electrostatic discharges in glass-lined equipment. The homogeneous dispersion in De Dietrich 3009 standard glass of a small amount of Platinum micro-fibres creates a tri dimensional network of micro-condensers into the whole lining thickness. This gives to any ConductiGlass® equipment a new intrinsic property for all its life time : the electrostatic charges flow to earth as soon as they are created, avoiding their accumulation on the glass surface up to high voltages dangerous for the glass. Spark test control and Email Test monitoring remains available. ConductiGlass® is manufactured under license of NGK Insulators Ltd. More than 100 references are available at present. CleanValve : the new De Dietrich glass-lined flush valve The new De Dietrich Clean Valve flush valve series has been developed to guarantee a perfect clean ability. The dead zone has been minimized and its sealing improved. An additional cleaning port, tangential to the outlet nozzle, has been designed with an angle of 5°. A groove machined in this outlet nozzle allows us to drain the last product droplets and prevents liquid retention. The glass-lined stem is machined to guarantee a regular shape. A PTFE chevron packing is used instead of the classical graphite ribbon with an O-ring integrated in the upper PTFE ring. The absence of bellows provides for an excellent cleaning of solid particles when the final product is a slurry.

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ROSENMUND in Liestal (CH) has now a pilot plant allowing drying trials of approximately 100 litres of product with following technologies : pan dryer RGPD , spherical dryer RGSD and universal horizontal dryer RGUD. Trials are carried out by our process engineers with or without the customer being present. A scale-up is then produced and the customer is able to choose the right technology for his product, comparing investment, efficiency and ergonomics. A pay-back can then be estimated for the different technologies.

EASY-CLEAN : a safety and efficient cleaning During the discharge of a filter-dryer, some product may stick onto the seats of the side discharge valve. By opening and closing the valve, this might become compacted and so reduce the tightness of the valve. To avoid this problem, ROSENMUND developed a new concept called Easy-Clean. This side discharge valve is fitted with light glasses, side sight glasses and glove ports. The operator can open the side discharge valve and is then able to clean the metal seats without losing the integrity, without any exposure to the product or any need for special equipment : a real increase of safety, batch time and product quality.

GasKnife ®: an efficient heel removal for Filter/Dryers The GasKnife® system developed by ROSENMUND enables a total removal of the product heel staying on the filter plate of a filter-dryer by blowing it up to the side discharge valve. This is achieved by means of nozzles fixed under one blade of the agitator. The main advantages are:

Removal of up to 99% of the remaining product Nozzles very close to the product heel Possibility to help the wash (Reslurry and Displacement) of the cake by means of the nozzles of

GasKnife Possibility to use the Gas-Knife nozzle while drying to improve drying efficiency considerably No additional seal required

A rental unit of 0.4 m2 is equipped with GasKnife to conduct trials with customer’s product.

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A very efficient sphere

To the ROSENMUND product range belong some high efficiency dryers : one of the most efficient is the spherical dryer (volume from 25 up to 6000 litres). With an Active Pharmaceutical Ingredient, the FDA and cGMP requirements concerning cleanliness, inspectability, cross contamination are very high, and ROSENMUND recommend then the use of the top driven spherical dryer. The main criteria’s are :

Product discharge at the lowest point of the machine, allowing up to 100% of product to discharge

Opening the lower part of the machine for an easy inspection and access for maintenance

Integrated chopper and possibility to granulate Very low drying time Takes care of dust explosion

Many references over the world.

3. SERVICES

We strongly believe that the relationship between customer and supplier does not stop with the delivery of the equipment. DDPS has developed a global network of local Tech Centers to provide maintenance and support through the entire life cycle of our equipments. These centers offer a broad range of services, including :

Rental equipment : on-site pilot plant testing for filtration, drying, sampling and powder transfer applications

Refurbishing services : older equipment can be brought up to nearly new condition. Equipment such as drives, pumps and seals can be rebuilt in our shops

Training seminars : offered for both maintenance and engineers personnel to ensure optimal operation of the equipment. Training sessions can also bring plant personnel up to speed on the latest developments and innovations.

DE DIETRICH, India offers following services:

Erection, commissioning and help to validation of equipment and systems Preventative maintenance : scheduled maintenance reduces the down time of the equipment,

resulting in higher productivity and fewer costly emergency shut downs Spare parts in stock for quick delivery

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FOR QUERIES Related to Glass Lining & Services Mr. Sridharan Email: sridharan@dedietrich.co.in Mobile: +91 944 0792746 Related to Systems & Services Mr. R.M. Kulkarni Email: rmkulkarni@dedietrich.co.in Mobile: +91 993 090 8909 / 982 153 1306 Please visit our website www.dedietrich.com for more details. DDPS India has a network of sales and service representatives located throughout India. Whether it is the design, construction and installation of equipment or complete systems, as well as the replacement parts and maintenance service, our goal is to be your one stop shop for your processing needs.

Regd. Office :B-803, Sagar Teck Plaza, Sakinaka Jn., Andheri-Kurla Road, Andheri(E), Mumbai, India-400 072 Tel. No. 022 - 67424270 - 76; Fax:022-28505731/94

GL Division : Road No.7, Industrial Estate, Nacharam, Hyderbad, India-500 076. Tel. No. 040 - 27174341; Fax: 040 - 27173203