communication between cells and tissue in the body

8/11/2019 Communication Between Cells and Tissue in the Body

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BY : Dr.Sumihar M.R.Pasaribu

Departement of Biochemistry and Clinical Chemistry

Medicine Faculty University of Methodist

Indonesia

COMMUNICATION

BETWEEN CELLS AND

TISSUE IN THE BODY


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KOMMUNICATION

BETWEEN CELLS AND TISSUE

IN THE BODY

To undestand:

The nature of cellular communication Tissue receptor and mechanisms of

signal tranduction

Disorder of signal transduction system


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The survival of multicellular organisms

depends on their ability to integrate and

coordinate differentiated cell function tomaintain homeostasis.


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PRINCIPAL TYPES OF SIGNAL MOLECULES

UTILIZED FOR COMMUNICATION BETWEEN

CELLS AND TISSUE

1. HORMONES

2. NEURTRANSMITER

3. LOCAL MEDIATOR


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SUBDIVISION OF SIGNAL MOLECULES

ACCORDING TO RELATION BETWEEN THE

PRODUCTION SITE AND THE TARGET SITES

SIGNAL MOLECULES CAN BE SUB DIVIDED INTO THREE GROUPS,

AUTOCRINE : Molecules released from certain cells influence the

behaviour of the same cells.

( SOME GROWTH FACTOR ,EICOSANOIDS)

PARACRINE : The signalling molecules released from certain cells

influence the activity of target cells that lie very close to them

(NEUROTRANSMITTERS AND NEUROHORMONES)

ENDOCRINE: molecules released from the endocrine glands are

transported to distant target tissue for activity.


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SUB DIVISION OF SIGNAL MOLECULES

ACCORDING TO THEIR CHEMICAL NATURE

CHEMICALLY ,SIGNAL MOLECULES CAN BE GROUPED

INTO FOUR MAJOR CALSSES:

1. AMINO ACIDS OR THEIR DERIVATES

1. CATECOLAMINE2. TIROID HORMONE

3. BEBERAPA NEUROTRANSMITER

2. PEPTIDES

1. FROM PANCREAS AND GUT

3. STEROIDAL COMPOUND

1. SEX HORMONES

4. FATTY ACID DERIVATES

1. EICOSANOID


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SIGNAL MOLECULE AND

RECEPTOR INTERACTION

ALL RECEPTOR TO WHICH SIGNAL

MOLECULES BIND ARE PROTEIN

HAVE AT LEAST TWO FUNCTIONALDOMAIN-ONE TO RECOGNISES AND BINDS

TO THE SIGNAL MOLECULE,ANOTHER

THAT INITIATES A RESPONSE(SIGNAL

TRANSDUCTION) SOME CELLS HAVE MORE THAN ONE

RECEPTOR TYPE FOR THE SAME LIGAND


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SPEED AND DURATION OF

RESPONSE TO RECEPTOR

MEDIATES SIGNALS

FEW MILLISECONDS OR BE SUSTAINED

FOR SEVERAL HOURS OR DAY

RAPID RESPONSES ARE REQURIED FORCHANGES IN THE RATE OF REACTIONS

INVOLVED IN METABOLIC REGULATION( eq.BY

HORMONES)

SLOW RESPONSES OCCUR WHEN A SIGNAL

MOLECUL ACTS TA THE GENE LEVEL.


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HORMONES CAN BE CLASSIFIED IN

SEVERAL WAYS

1. CHEMICAL

2. SOLUBILITY PROPERTIES

3. LOCATION OF RECEPTORS

4. THE NATURE OF SIGNAL USED TO

MEDIATE HORMONAL ACTION

WITHIN THE CELL.


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Calassification of Hormones

by mechasnism of action

1. Hormones that bind to intracellular receptor

2. Hormones that bind to cell surface receptors.

1. The second messenger is cAMP2. The second messenger is cGMP

3. The second messenger is Calcium or

Phospatdylinositol(or Both)

4. The second messenger is a kinase or phospatasecascade


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Calassification of Hormones

by mechasnism of action


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Hormones that bind to intracellular

receptor

1. ANDROGEN

2. CALCITRIOL(1,25(OH)2

3. ESTROGEN4. GLUCOCORTICOID

5. MINERALOCORTICOIDS

6. PROGESTIN7. RETINOIC ACID

8. TYHROID HORMONES(T3& T4)


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Hormones that bind to cell surface

receptors

1. The second messenger is cAMP1. Adregergic Catecolamine

2. -Adregergic Catecholamines

3. ACTH

4. ADH

5. Calcitonin6. HcG

7. CTRH

8. FSH

9. Glucagon

10. Lipotropin

11. LH12. Melanocyt Stimulating Hormone

13. Paratyhroid Hormone

14. Somatosttain

15. TSH


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G-Protein Receptor


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RECEPTOR TYROSINE

KINASE


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RECEPTOR TYROSINE

KINASE


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Second messenger cAMP


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2.The second messenger is

cGMP

1. Atrial Natriuretic Factor

2. Nitric oxide


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3.The second messenger is Calcium or

Phospatdylinositol or Both)

1. Acetylcholine (Muscarinic)

2. - adrenergic catecholamines

3. Angiotensin II

4. ADH(vaopressin)5. Cholecystokinin

6. Gastrin

7. Gonadotropin Releasing hormone(GnRH)

8. Oxitocyn

9. Platelet-derived growth factor

10. Substance P

11. Thyrotropin-releasing hormone


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4.The second messenger is a kinase or

phospatase cascade

1. Adiponectin

2. Chorionic somatomammotropin

3. Epidermal growth factor

4. Eryhtropoetin

5. Fibroblast growth factor6. Growth hormones

7. Insulin

8. Insulin-like growth factor I and II

9. Leptin

10. Nerve growth factor11. Platelet derived growth factor

12. Prolactin


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Ringkasaan tipe2 hormon

reseptor pada membran plasma


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communication between cells and tissue in the body

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