common diseases of sheep and goats - cdn.ymaws.com · • urolithiasis • pregnancy toxemia ......
TRANSCRIPT
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Overview
• GI Parasites
• Urolithiasis• Pregnancy Toxemia• Listeria• Polioencephalomalacia
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GI Parasites
• Haemonchus contortus barber pole worm• FAMACHA• Multiproduct treatment for individuals
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Urolithiasis
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Urolithiasis
• Very common • Life-threatening recognize & treat early• Males, especially castrated males• High protein diet, diet high in phosphorus, dehydration…• Urethral process &/or sigmoid flexure• Struvite, calcium carbonate?
Minnesota Urolith Center
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Urolithiasis
Clinical Signs• Restless, tail switching, painful, dribbling urine or anuria• Urethral pulsations without urination
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Urolithiasis
Clinical Signs• Restless, tail switching, painful, dribbling urine or anuria• Urethral pulsations without urination• Ventral & preputial edema ruptured urethra• Pain may subside, gradual abdominal distension & depression ruptured
bladder
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Urolithiasis
Diagnostics• +/- Blood chemistry• Radiographs• Ultrasound examination (prognosis)
• With urethral pulsation without urination• Examine kidneys for nephroliths
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Urolithiasis
Treatment• EMERGENCY!• Amputation of urethral process
• High recurrence rate• Urethral catheterization
• Be cautious urethra friable• Walpol’s Solution
• pH 4.5• U/S-guided cystocentesis, 30-50 mL Walpol’s lavage & leave• Urine flow in 24-36 hours, normal voiding 3-5 days
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Urolithiasis
Treatment• Salvage
• Urethrostomy or penile amputation temporary• Breeding animals or pets
• Tube cystotomy• Bladder marsupialization
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Urolithiasis
Tube Cystotomy• Foley (16-24 Fr.) into bladder & exit catheter through ventral abdomen• Clamp catheter ~day 4• Normal urination for 1-2 days before remove• Must be in at least 7 days• Antibiotics, anti-inflammatories, urinary acidifiers• $$$$
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Urolithiasis
Bladder Marsupialization• Primary or after failure of another procedure• $$
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1. Paramedian abdominal incision parallel to prepuce
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2. Apex of bladder exteriorized and decompressed
3. Place stay sutures & incise between stay sutures
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4. Second abdominal incision on opposite side of prepuce
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6. Suture bladder to abdominal wall
5. Pull apex into the second incision by stay sutures
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Urolithiasis
Prevention• Females as pets• Delay castration as long as possible• Increase water intake• Avoid excess protein (grain supplements, legume hay) in pets• Ca:P ration of 1.5-2:1• Urinary acidifiers – monitor pH
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Pregnancy Toxemia
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Pregnancy Toxemia
Metabolic disease of pregnant ruminantsCause:
• Abnormal metabolism of CHOs and fats in late pregnancy (last 2-6 weeks)
Predisposition:• Does carrying 2 or more fetuses• Lean (BCS < 2) or obese (BCS ≥ 4)
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Pregnancy Toxemia
Pathophysiology of disease• Rapid fetal development in late gestation causes rapid mobilization of fat
stores to assure adequate energy• Liver also increases gluconeogenesis to facilitate glucose availability to the
fetus(es).• Negative energy balance increased mobilization may overwhelm capacity
of liver hepatic lipidosis• At same time, ketone bodies produced and accumulated leads to excessive
ketone bodies in blood which increases susceptibility to pregnancy toxemia
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Pregnancy Toxemia: PathophysiologyVicious Cycle
• Hypoglycemia• Lipolysis• Increased NEFAs• Ketone formation
• Ketones further supress gluconeogenesis• Ketone bodies suppress appetite
• Resulting FFA mobilization suppresses liver function
NEFA
Ketone Bodies
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Pregnancy Toxemia: Clinical Signs
May be vague initially• Weakness, lethargy• May separate from herd• Mild ataxia
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Pregnancy ToxemiaClinical Signs
• Anoerxia• Depression/lethargy• Neurologic signs
• Opisthotonos• Dropped head• Periodic convulsion• Apparent blindness
• Bloat • Bruxism• Frothy salivation• Sweet, fruity odor to breath
• Recumbency• Coma
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Pregnancy Toxemia: Clinical Signs
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Pregnancy Toxemia: Clinical Pathology Decreased
• Glucose • 20-40 mg/dL
• Calcium
Increased• SGPT• SGOT• BUN• Creatnine• BHBA
• >3 mmol/L (x10.3=30.9 mg/dL)
• NEFA
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Pregnancy Toxemia: Clinical Pathology
• Dehydration• Stress leukogram• Metabolic acidosis• Increased ketone bodies in urine• Blood ketones
www.abbottdiabetescare.com
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Pregnancy Toxemia: Treatment
Efficacy of treatment depends on…• Timely and correct diagnosis• Early treatment
Fair prognosis early, poor once recumbent
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Pregnancy Toxemia: Treatment
Treatment based on…1. Eliminate negative energy source
• Good quality hay & grain• Starch ferments to proprionate in rumen• Proprionate “Glucogenic” VFA
• Oral propylene glycol: 2-3 oz PO BID• 3-carbon energy source• Glucose precursor
• Parasite issues, etc.?
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Pregnancy Toxemia: TreatmentTreatment based on (continued)…
2. Removal of factors that affect energy requirements (3 Options)1) Prolonged medical support of dam2) Induction of parturition3) Immediate Cesarean section
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Pregnancy Toxemia: TreatmentTreatment based on (continued)…
2. Removal of factors that affect energy requirements (3 Options)1) Prolonged medical support of dam2) Induction of parturition3) Immediate Cesarean section
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Pregnancy Toxemia: TreatmentPossible to save dam and fetusesPoor prognosis for both dam and kidsProvide dextrose, fluids, calcium
• IV dextrose infusions• 5-7 g q 3-4 hours, preferably CRI• 5% dextrose, 10-20 mEq/L of potassium, 25 mL of calcium borogluconate/L
• 20-40 units of insulin (Humulin R)• Blcoks hormone sensitive lipase• Dose to effect, monitor glucose• Approximately 4X/day or CRI
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Pregnancy Toxemia: TreatmentTreatment based on (continued)…
2. Removal of factors that affect energy requirements (3 Options)1) Prolonged medical support of dam2) Induction of parturition3) Immediate Cesarean section
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Pregnancy Toxemia
2) Induction of parturition• 10 mg of Lutalyse® in goats• 15 mg dexamethasone in sheep• Dam may not survive until parturition (36-48 hours)• Fetuses may be premature
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Pregnancy Toxemia: Treatment
Treatment based on (continued)…2. Removal of factors that affect energy requirements (3 Options)
1) Prolonged medical support of dam2) Induction of parturition3) Immediate Cesarean section
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Pregnancy Toxemia: Treatment
3) Immediate Cesarean section• Best prognosis for dam• Most common reported reason for C-section in small ruminants
Recovery of dam is often dramatic (within 24-48 hours)• Warn owners and be prepared to euthanize kids if premature
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Pregnancy Toxemia: Prevention
Increase nutritional plane in last 6 weeks of pregnancyGroups dams according to…
• Number of fetuses (ultrasound)• Age• Body condition
Prevent stress during pregnancy
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Pregnancy Toxemia: Prevention
Breeding Management• High fecundity associated with increased incidence• Breed at appropriate age – often delayed in show does• Show does are over-conditioned• Cull older does
• Increased incidence with age/parity• Most first parity cases are show/pets over-conditioned
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Pregnancy Toxemia: Prevention
Nutritional Management• Begin with good quality forage• BCS and feed accordingly• Ultrasound
• Pregnancy status• Singletons/twins/triplets
• Establish feeding groups• Increase feed as needed for weather conditions
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Listeriosis
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Listeriosis
Listeria monocytogenes• Ubiquitous in environment of farm animals• May be shed by healthy carriers• Shed in feces, tears, nasal secretions, uterine fluid, milk (zoonotic)• Survive for months to years in soil, feces, contaminated feed
• Improperly fermented silage (pH > 5.5)• Spoiled forages
• Rotten vegetation• Bottom of hay bales
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Listeriosis
Clinical signs• Encephalitis• Septicemia• Abortions Usually occur as separate disease entities• Mastitis• Ophthalmitis
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Listeriosis
Clinical Signs• Acute disease that progresses rapidly• Usually unilateral, loss of function of multiple cranial nerves• Recumbency, torticollis, opisthotonos• Case fatality ~100% if untreated
Sheep and Goat Medicine, Pugh & Baird
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Listeriosis
Diagnosis• Typically based on clinical signs• CSF may be helpful
• Elevated protein & nucleated cells, predominately mononuclear cells• Postmortem
• CNS microabscessation• Neuronal necrosis
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Listeriosis
Treatment• Antibiotic therapy
• Oxytetracycline• Penicillin• Florfenicol
• Antiinflammatory therapy• NSAIDs – flunixin
• Supportive therapy• Fluid therapy• Ophthalmic antibiotics if keratitis/conjunctivitis• Management of down animal
• Thiamine?
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Listeriosis
Prevention• Feed off of ground• Feed square bales or clean around round rolls of hay
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Polioencephalomalacia (PEM)
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Polioencephalomalacia (PEM)
Severe disruption of cerebral energy metabolism
Accumulation of sodium and water
Edema, swelling, pressure necrosis on cerebral neurons
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PEM
Many causes • Thiamine deficiency• Sulfur toxicosis• Sodium toxicosis & water deprivation• Lead toxicosis
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PEM
Clinical Signs• Usually bilaterally symmetric• Develop rapidly & often progress
• Wondering aimlessly• Become recumbent• Central blindness • Opisthotonos• Muscle tremors• Extensor rigidity• Convulsions• Nystagmus
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PEM
Diagnosis• Most commonly signalment, history and clinical signs• Rapid response to thiamine therapy• Bloodwork – usually unrewarding• CSF – mild increases in protein and mononuclear cells
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PEM
Treatment• Thiamine hydrochloride
• Immediate thiamine replacement (10 mg/kg) IV slowly • Continue thiamine therapy for several days at 10 mg/kg SQ/IM q 3-6 hours• Improvement often observed within 6-24 hours• Frequency can be slowly reduced
• Mannitol 20%• 1-2 g/kg IV• Followed by dexamethasone (1 mg/kg) 3 hrs later
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PEM
Prevention• Adequate good quality roughage• Slow adaptation to dietary changes• Preventing ruminal acidosis• Avoiding phytothiaminases
• Bracken fern, horsetails, etc
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Questions?
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Caseous Lymphadenitis (CL)
• Corynebacterium pseudotuberculosis• Usually external abscesses in skin or LNs• Lives in soil for > 1 year
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Caseous Lymphadenitis
Diagnosis• Culture• Necropsy• Blood test
Treatment• Complete surgical excision best• Isolate for treatment – do not
open in environment with other goats
• If draining, flush with Nolvasan or iodine
• Cull!
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Caseous Lymphadenitis
Control & Prevention• ID & cull affected animals• Avoid skin injuries• Good hygiene• Purchase from CL-free herds/flocks• Vaccination?
• Do not vaccinate naïve herds