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July 31, 2014

Focused Ultrasound A Global Perspective

Collaborative Network

7 . 3 1 . 2 0 1 4

F o c u s e d U l t r a s o u n d F o u n d a t i o n

About the Focused Ultrasound Foundation

The Focused Ultrasound Foundation is a medical technologyresearch, education and advocacy organization dedicated to improving the lives of millions of people with serious medicaldisorders by accelerating the development and adoption of focused ultrasound. The Foundation is unique in that it supports a platform technology that utilizes multiple mechanisms of action to treat a wide variety of diseases.

Positioned at the nexus of the large, diverse group of stakeholders comprising the ultrasound community, the Foundation functions as an independent, trusted and unbiased third party,aligning organizations into a cohesive ecosystem with a singlegoal: to make focused ultrasound technology available to patients in the shortest time possible. The Foundation works toestablish a patient centric culture, instill a sense of urgency in allstakeholders, and alleviate barriers to progress.

The Foundation catalyzes collaboration and partnerships, organizes and funds research, spearheads advocacy and patientsupport initiatives, and organizes meetings, symposia and workshops to create and disseminate knowledge and increaseawareness of focused ultrasound. Early-stage research funded by the Foundation “de-risks” subsequent investment, thus encouraging other funding sources such as disease-specific foundations, the NIH, and the biomedical industry to becomemore involved.

The Foundation is on the leading edge of the venture philanthropy and social entrepreneurship movements and is a model of how private philanthropy can work in concert with academia, industry and government to bridge the gap between research and commercialization of a high-impact medical technology.

Established in 2006 as a tax exempt organization, the Foundation is based in Charlottesville Virginia and has global activities.

About Focused UltrasoundFocused ultrasound is a revolutionary, noninvasive therapeutictechnology with the potential to transform the treatment ofmany serious medical disorders including tumors of the brain,breast, prostate, liver and other organs, Parkinson’s disease,epilepsy, and stroke. With ongoing research, focused

ultrasound could address unmet clinical needs and providetreatments which are superior to best current therapy, therebyimproving the quality of life and longevity for millions of patients around the world.

This breakthrough technology uses ultrasonic energy guidedby magnetic resonance or ultrasound imaging to treat tissuedeep in the body without incisions or radiation. Multiple intersecting beams of ultrasound are directed and concentratedwith on a target as small as a grain of rice, much like a magnifying glass can focus multiple beams of light on a single point.

A variety of profound biological effects result at the focal point where the beams converge; where individual beams pass unfocused through adjacent tissue on the way to their target, they exertno effect or damage. Integrated magnetic resonance and ultrasound imaging identifies and targets the tissue to be treated, guides and controls the treatment interactively, in real time, and provides immediate confirmation of the effectiveness of thetherapy. Because focused ultrasound offers many mechanisms of action, treatment of a wide variety of conditions is possible.

Focused ultrasound has the potential to be the ultimate in noninvasive surgery, an alternative or complement for radiation therapy, the means to dissolve blood clots and restore circulation through blocked vessels, and a way to deliver drugsin extremely high concentration to a precise point in the body, thus avoiding systemic toxicity.

Focused ultrasound is performed in an outpatient setting without general anesthesia. There are no incisions or scars, minimal pain and discomfort, and more rapid recovery. The technology has the potential to result in fewer complications such as infection or blood clots, avoid the toxic side effects of drugs and radiation therapy, and deliver treatment that issafer and more effective, costs less, and produces an immediateand verifiable effect.

Focused ultrasound is approved in the US and EU and a number of other countries for treatment of uterine fibroids and approved in the EU and other countries for treatment of bone metastasesand prostate cancer. In addition, extensive research is being conducted around the world on a number of clinical applications.


Charts by subjects

4 Manufacturers by Region

5 Research Sites 5 By Region

6 By Region: North America, South America

7 By Region: Europe

8 By Region: Asia, Oceania

9 Technical Research Sites9 By Region

10 By Region: North America

11 By Region: Europe

12 By Region: Asia

13 Biological Effects Research Sites13 By Region



16 By Region: Asia

17 Pre-clinical Research Sites17 By Region



20 By Region: Asia

21 By Region: Oceania

The information in this report was provided by manufacturers and the focused ultrasound research community to the Focused Ultrasound Foundation. The FUS Foundation aims to provide themost accurate information; if you have more current or updatedinformation please send it to: [email protected].

22 Clinical Research Sites22 By Region


24 By Region: South America25 By Region: Europe26 By Region: Asia27 By Region: Oceania

28 Commercial Treatment28 FUS Approvals by Region

29 By Region and Indications

30 By Country

31 By Region

32 By Region: North America, South America


34 By Region: Africa, Oceania

35 By Region: Asia


July 31, 2014

Manufacturers by Regionn MR guidance n US guidance n MR & US guidance n Camera Guidance

8North America

10Europe

8Asia

n FUS Instruments Inc.

n Histosonics, Inc.

n International Cardio Corporation, LLC

n Kona Medical

n Mirabilis Medica

n Profound Medical Inc.

n SonaCare Medical, LLC

n Verasonics

n Acublate

n EDAP TMS S.A.

n EyeTechCare

n Image Guided Therapy (IGT)

n InSightec LTD

n Medsonic LTD

n Philips Healthcare

n Slender Medical LTD

n Supersonic Imagine

n Theraclion

n Alpinion Medical Systems

n Changjiangyuan TechnologyDevelopment Co., LTD

n Chongqing Haifu (HIFU) Medical Technology Co., LTD

n Mianyang Sonic (SUONIKE) Electronic

n Shanghai A&S Co., LTD

n Shenzhen pro-HIFU MedicalTech. Co., LTD

n Shenzhen Wikkon

n SITU SUNTEC


All Research Sites by Region

67North America

65Europe

1South America

40Asia

2Oceania

175Worldwide Total

Any FUS research site conducting technical, pre-clinical, or clinical FUS research.

July 31, 2014


July 31, 2014

Research Sites by Region

67North America

Artann LaboratoriesBoston UniversityBrigham and Women’s Hospital (BWH)Can-AmHIFUChildren’s National HospitalCHI St. Luke’s HealthCity of HopeCleveland ClinicColumbia UniversityDrexel UniversityDuke UniversityFox Chase Cancer CenterGrand Strand UrologyIndiana University Health, University HospitalJewish General HospitalJohns Hopkins University School of MedicineLawson Health Research InstituteLondon Health Sciences Centre (LHSC)Mayo Clinic - MinnesotaMedical University of South Carolina (MUSC)Memorial Sloan-Kettering Cancer CenterMetropolitan UrologyMontefiore Medical CenterNational Institutes of Health (NIH)New York University (NYU) Langone Medical Center

and School of MedicineNorth Carolina State UniversityNYP - Weill Cornell Medical CenterOregon Health and Science UniversityProMedica Toledo HospitalSoutheast Urology NetworkStanford University School of MedicineSunnybrook Health Sciences CentreSwedish Neurosciences InstituteThe Hospital for Sick Children (SickKids)The Methodist Hospital

Thunder Bay Regional Research InstituteTulane UniversityUCLAUCLA Ronald Reagan Medical CenterUniversity Hospitals of Cleveland Case Medical CenterUniversity MRI & Diagnostic Imaging Centers - SouthUniversity of California, DavisUniversity of California at San DiegoUniversity of California San Diego (UCSD) Thornton HospitalUniversity of California San Francisco (UCSF)University of ChicagoUniversity of CincinnatiUniversity of Illinois at Urbana-Champaign (USUC)University of Kansas - KU Bioengineering Research Center

Mechanical EngineeringUniversity of Maryland School of MedicineUniversity of Michigan (UMich)University of MinnesotaUniversity of Texas MD Anderson Cancer CenterUniversity of UtahUniversity of Virginia (UVA) Health SystemUniversity of WashingtonUniversity of Wisconsin Carbone Cancer CenterUrologic Consultants of Southeastern PennsylvaniaUrology AssociatesUrology Centers of AlabamaUrology of San AntonioUT SouthwesternVanderbilt UniversityWake Forest University Baptist Medical CenterWalter Reed National Military Medical CenterWilliam Beaumont Health SystemsWinthrop University Hospital

1South America

Instituto do Cancer do Estado de Sao Paulo (ICESP)




65Europe

Amper KlinikAzienda Ospedaliera San PaoloBasingstoke and North Hampshire HospitalBrustzentrum Marienhospital BottropCareggi General HospitalCenter for Ultrasound Functional NeurosurgeryCentre Léon BérardCharité Universitätsmedizin BerlinCHU de Bordeaux - Hôpital du TonduCHU de Bordeaux - Hôpital Saint-AndréCHU de Lille - Hôpital HuriezCHU de Toulouse - Hôpital RangueilCHU de Tours - Hôpital BretonneauChurchill HospitalCisanello Hospital of University of PisaClinica oculistica Università - Ospedale oftalmicoCyprus University of TechnologyEindhoven University of TechnologyEuropean Institute of OncologyFondazione IRCCS Ca’ Granda Ospedale MaggiorePoliclinicoFraunhofer Institut IBMT

German Cancer Research Center (DKFZ)Hôpital CochinHôpital Pitié-SalpêtrièreHôpitaux Universitaires de Genève (HUG)Hospices Civils de LyonHospital Clínico San CarlosHospital Universitario Marqués de Valdecilla (HUMV)Inserm LyonInstitute for Medical Science and Technology (IMSAT)Institut Gustave RoussyInstitut Langevin (EPSCI)Institut Mutualiste MontsourisInstituto Cartuja de Técnicas Avanzadas en MedicinaKantonspital Winterthur

Klinikum FurthLaboratorio di Tecnologie Oncologiche (LATO) HSR Giglio –

Fondazione Istituto San Raffaele G. Giglio di CefalùMedical Center of Central Bank of Russian FederationN. N. Petrov Research Institute of OncologyNational Medical Surgery CenterNiguarda HospitalOspedale Generale Regionale “Francis Miulli”Research Center for Obstetrics, Gynecology and

Perinatology of Russian Ministry of Health andSocial Development

Rostov Scientific Research Institute of OncologyScuola Superiore Sant’AnnaSt. Guy’s and St Thomas HospitalSt. Mary’s HospitalThe Institute of Cancer Research (ICR)The Intervention Centre, Oslo University Hospital

RikshopitaletThomayer University HospitalUniversità degli Studi di ParmaUniversitätsklinikum TubingenUniversity Children’s Hospital ZurichUniversity Hospital of EndocrinologyUniversity Hospital of GrenobleUniversity Hospital Schleswig-HolsteinUniversity Medical Center (UMC) UtrechtUniversity of GenevaUniversity of HeidelbergUniversity of HullUniversity of L’AquilaUniversity of MunichUniversity of Rome - La SapienzaUrologische Universitätsklinik MagdeburgVTT Technical Research Centre of Finland


July 31, 2014


July 31, 2014


40Asia

307 Hospital of PLA

Apollo Specialty Hospital, ChennaiBreastopia Namba HospitalCentral Hospital of Shanghai Xuhui DistrictCHA Bundang Medical CenterChaim Sheba Medical CenterChaum HospitalChildren’s Hospital of Chongqing Medical UniversityChongqing Medical UniversityFirst Affiliated Hospital of Medical College of

Xi’an Jiaotong UniversityFirst Affiliated Hospital of Zunyi Medical CollegeFirst Maternal and Child Health Hospital of ShanghaiFundan University Huashan HospitalFundan University Shanghai Cancer CenterGsl medical collegeHAIFU HospitalIndraprastha Apollo HospitalInstitute of Ultrasonic Engineering in Medicine

and Clinical Centre for Tumour TherapyJaslok Hospital and Research CentreKochi University HospitalNanyang Technological University

National Medical Research CenterPeking Union Hospital, Chinese Academy of

Medical SciencesPeking University First HospitalPLA 301 Hospital (General Hospital of the

People’s Liberation Army)Queen Mary Hospital of the University of Hong KongRambam Medical CenterSamsung Medical CenterSeoul National University HospitalShinsuma General HospitalSRL Diagnostics - Jankharia ImagingSuining Central HospitalTaipei Medical University HospitalThe First Affiliated Hospital of Chongqing

Medical UniversityThe Second Artillery General Hospital of Chinese PLA

The Third Xiangya Hospital of Central South UniversityTokyo Women's Medical HospitalUniversity of Malaya (UMMC)YUCM Severance HospitalYUMC Gangnam Severance Hospital

2Oceania

Future Medical Imaging Group (FMIG)Royal Women’s Hospital Melbourne



Technical Research Sites by Region

40North America

20Europe

3Asia

63 Worldwide Total

July 31, 2014


July 31, 2014

Technical Research Sites by Region and Areas

n Artann Laboratories

Boston University

n n Brigham and Women’s Hospital (BWH)

n Children’s National Hospital

n CHI St. Luke’s Health

n City of Hope

n Columbia University

n Drexel University

n Duke University

n Johns Hopkins University School of Medicine

n Mayo Clinic – Minnesota

Medical University of South Carolina (MUSC)

n North Carolina State University

n ProMedica Toledo Hospital

n Stanford University Medical Center

n n n Sunnybrook Health Sciences Centre

n Swedish Neurosciences Institute

n The Hospital for Sick Children (SickKids)

n The Methodist Hospital

n n Thunder Bay Regional Research Institute

n Tulane University

n UCLA

n n UCLA Ronald Reagan Medical Center

n University MRI & Diagnostic ImagingCenters - Sout

n n n University of California, Davis

University of California at San Diego

n University of California San Francisco (UCSF)

n University of Chicago

University of Cincinnati

n University of Illinois at Urbana-Champaign (UIUC)

n University of Maryland School of Medicine

n n University of Michigan (UMich)

n n University of Minnesota

n University of Texas MD Anderson Cancer Center

n n University of Utah

n University of Virginia (UVA) Health System

n n n University of Washington

n UT Southwestern

n n Vanderbilt University

n Verasonics

n Wake Forest University Baptist Medical Center

40North America

Focused Ultrasound MonitoringFocused Ultrasound Physics

n Focused Ultrasound Transducer technology

n MR imaging for FUS guidance

n Ultrasound imaging for FUS guidance


July 31, 2014


n CHU de Bordeaux – Hôpital Saint-André

CHU de Tours - Hôpital Bretonneau

n Cyprus University of Technology

n Eindhoven University of Technology

n n European Institute of Oncology

n n Fraunhofer Institut IBMT

n n n Inserm Lyon

n n n Institut Langevin (ESPCI)

n N. N. Petrov Research Institute of Oncology

n Niguarda Hospital

n Scuola Superiore Sant’Anna

n St. Mary’s Hospital

n n n The Institute of Cancer Research (ICR)

n University Children’s Hospital Zurich

n University Hospital Schleswig-Holstein

n n University Medical Center (UMC) Utrecht

n University of Heidelberg

n University of Hull

n University of Munich

n VTT Technical Research Centre of Finland

20Europe






July 31, 2014


n Breastopia Namba Hospital

n Kochi University Hospital

n n Seoul National University Hospital3Asia






July 31, 2014

Biological Effects Research Sites by Region

41North America

19Europe

6Asia

67 Worldwide Total


July 31, 2014


n Artann Laboratories

n n Boston University

n n n n Brigham and Women’s Hospital (BWH)n n n n

n

n n n n Children’s National Hospitaln


n n n City of Hope

n n n Columbia University

n n n Drexel University

n n Duke University

n Fox Chase Cancer Center

n n n n Indiana University School of Medicine

n Iowa State University

n n n n Johns Hopkins University School of Medicine

n n Medical University of South Carolina (MUSC)

n National Institutes of Health (NIH)

n North Carolina State University


n n Stanford University School of Medicine

n n n n Sunnybrook Health Sciences Centren n n n n n n n

n Swedish Neurosciences Institute

n The Hospital for Sick Children (SickKids)

n n Thunder Bay Regional Research Institute

n n Tulane University

n n UCLA

n UCLA Ronald Reagan Medical Center

n n n n University of California, Davisn n n n

n n

n n University of California at San Diego

n University of California San Diego (UCSD) Thornton Hospital

n n University of California San Francisco (UCSF)


n n n University of Cincinnati

n n n University of Kansas - KU Bioengineering Research Center Mechanical Engineering

n n n n University of Maryland School of n n n n Medicine

n n n

n n University of Michigan (UMich)

n n n n University of Minnesota

n n n n University of Texas MD Anderson n n n n Cancer Center

n n n University of Utah

n n n n University of Virginia (UVA) Health Systemn

n n n n University of Washingtonn n n n

n n

n n n UT Southwestern

n n n n Vanderbilt Universityn

n n n n Wake Forest University Baptist n n n Medical Center

41North America

n Amplification of cancer biomarkers

n Blood brain barrier opening

n Blood vessel occlusionn Cavitationn Clot lysis n Drug activity

enhancementn Drug deliveryn Hemostasisn Hyperthermian Immunomodulationn Increased vascular

permeabilityn Neuromodulationn Radiation sensitizationn Sonodynamic therapyn Stem cell deliveryn Tissue destruction

(Histotripsy)n Tissue destruction

(Thermal Ablation)n Vasodilatation


July 31, 2014


n n n CHU de Tours - Hôpital Bretonneau

n Churchill Hospital

n n n Cyprus University of Technology

n Eindhoven University of Technology

n European Institute of Oncology

n Imperial College London

n n n n Inserm Lyonn n n

n n n n Institut Langevin (ESPCI)

n N. N. Petrov Research Institute of Oncology

n Rostov Scientific Research Institute of Oncology

n n n n Scuola Superiore Sant’Annan n

n n n n St. Mary’s Hospital

n n The Institute of Cancer Research (ICR)

n n n n University Children’s Hospital Zurichn n n n


n n n n University Medical Center (UMC) Utrecht

n n n n University of Heidelbergn n

n University of Hull

n n University of Munich

19Europe









July 31, 2014

Biological Effects Research Sits by Region and Areas

n Chaim Sheba Medical Center

n n Kochi University Hospital

n n n n Nanyang Technological Universityn n

n n n Samsung Medical Center

n n University of Malaya (UMMC)

n Washokai Sadamoto Hospital

6Asia









July 31, 2014

Pre-Clinical Research Sites

46North America

26Europe

15Asia

87 Worldwide Total

Any FUS research site conducting animal research.

2Oceania


July 31, 2014

Pre-clinical Research Sites by Region

46North America

n n n n Artann Laboratoriesn

n n n n Boston Universityn

n n n n Brigham and Women’s Hospital (BWH)


n n City of Hope

n n n Columbia Universityn

n n n Drexel University

n Duke University

n n n Fox Chase Cancer Center

n Indiana University Health, University Hospital

n n Johns Hopkins University School of Medicine

n n n Lawson Health Research Institute

n n Mayo Clinic - Minnesota

n n Medical University of South Carolina (MUSC)

n Memorial Sloan-Kettering Cancer Center

n n n n National Institutes of Health (NIH)

n n NYP - Weill Cornell Medical Center

n n n Stanford University School of Medicine

n n n n Sunnybrook Health Sciences Centren n nn n n n n n n n

n

n n Swedish Neurosciences Institute

n n n n The Hospital for Sick Children (SickKids)

n n n n The Methodist Hospital

n n n Thunder Bay Regional Research Institute

n n n n Tulane Universityn n

n n n n UCLAn

n n n n UCLA Ronald Reagan Medical Centern n n

n n University MRI & Diagnostic Imaging Centers - South

n n n University of California, Davis

n n n University of California at San Diego

n University of California San Diego (UCSD) Thornton Hospital

n n n n University of California San Francisco n n n (UCSF)

n n n n University of Chicagon

n University of Cincinnati

n n n University of Illinois at Urbana-Champaign (UIUC)

n n n University of Kansas - KU Bioengineering Research Center Mechanical Engineering

n n n University of Maryland School of Medicine

n n n n University of Michigan (UMich)n n n

n n n n University of Minnesotan n

n n n n University of Texas MD Anderson n Cancer Center

n n University of Utah

n n n n University of Virginia (UVA) Health Systemn

n n n University of Washington

n Urology Centers of Alabama

n UT Southwestern

n n Vanderbilt University

n n Wake Forest University Baptist Medical Center

n Alzheimer’s diseasen Atherosclerosisn Atrial fibrillationn Back and neck painn Benign prostatic hypertrophyn Bladder tumorsn Bone metastases n Brain tumorsn Breast cancer n Breast fibroadenoma n Cancer painn Colon cancer

DepressionDiabetes

n Epilepsyn Essential tremorn Glaucoman Hydrocephalus

Hypertensionn Kidney tumorsn Liver tumorn Ne uropathic painn Obsessive-compulsive

disordern Osteoarthritisn Osteoid osteoman Pancreatic cancern Parkinson’s diseasen Pediatric oncologyn Prostate cancern Prostate tumorsn Septal perforationn Soft tissue tumors

Spinal tumorsn Stroken Thyroid & Parathyroid tumorsn Trigeminal neuralgian Uterine adenomyosisn Uterine fibroids



July 31, 2014


n n Centre Léon Bérard

n n CHU de Bordeaux – Hôpital Saint-André

n n n n Churchill Hospitaln n

n n n n Cyprus University of Technologyn n n

n n n Eindhoven University of Technology

n European Institute of Oncology

n n n German Cancer Research Center (DKFZ)

n Hôpital Cochin

n Hôpitaux Universitaires de Genève (HUG)

n n Hospices Civils de Lyon

n Hospital Clínico San Carlos

n n n n Inserm Lyonn n n n

n n n n Institute for Medical Science and n n n n Technology (IMSAT)n n n n

n n n n Institut Langevin (ESPCI)

n n Instituto Cartuja de Técnicas Avanzadas en Medicina

n Klinikum Fürth

n Scuola Superiore Sant’Anna

n St. Mary’s Hospital

n The Institute of Cancer Research (ICR)

n n n The Intervention Centre, Oslo University Hospital Rikshopitalet

n University Hospital of Grenoble

n n n University Medical Center (UMC) Utrecht

n University of Geneva

n n n n University of Heidelberg


DepressionDiabetes





24Europe



July 31, 2014


15Asia


n n n n Chaim Sheba Medical Center

n n n Chaum Hospital

n n n n Fudan University Cancer Hospitaln n

n Gsl Medical College

n n n n HAIFU Hospitaln n

n Indraprastha Apollo Hospital

n n n Jaslok Hospital and Research Centre


n n n Nanyang Technological Universityn n n n n n n

n Peking Union Hospital, Chinese Academy of Medical Sciences

n n n n PLA 301 Hospital (General Hospital of n n the People’s Liberation Army)

n n n Samsung Medical Center

n Taipei Medical University Hospital

n n University of Malaya (UMMC)


DepressionDiabetes







July 31, 2014


2Oceania

n n n n Future Medical Imaging Group (FMIG)

n Royal Women's Hospital Melbourne


DepressionDiabetes







July 31, 2014

Clinical Research Sites by Region

51North America

52Europe

1South America

39Asia

2Oceania

144Worldwide Total

Any FUS research site treating patients as part of a clinical study.


July 31, 2014


n n n n Artann Laboratoriesn

n n n n Brigham and Women’s Hospital (BWH)n

n Can-AmHIFU

n n n n Children’s National Hospitaln n n n


n n City of Hope

n Cleveland Clinic

n Duke University

n Grand Strand Urology

n Indiana University Health, University Hospital

n Jewish General Hospital

n n Johns Hopkins University School of Medicine

n London Health Sciences Centre (LHSC)

n n Mayo Clinic - Minnesota

n Memorial Sloan-Kettering Cancer Center

n Metropolitan Urology

n n n Montefiore Medical Center

n n n National Institutes of Health (NIH)

n New York University (NYU) Langone Medical Center and School of Medicine

n n NYP - Weill Cornell Medical Center

n Oregon Health and Science University


n Southeast Urology Network

n n n n Stanford University School of Medicine

n n n n Sunnybrook Health Sciences Centren

n n n Swedish Neurosciences Institute

n The Methodist Hospital

n Thunder Bay Regional Research Institute

n n n n Tulane Universityn n

n n n n UCLA

n n n n UCLA Ronald Reagan Medical Centern n n n

n University Hospitals of Cleveland Case Medical Center

n n University MRI & Diagnostic ImagingCenters - South

n n University of California San Diego (UCSD) Thornton Hospital

n n n University of California San Francisco (UCSF)


n University of Cincinnati

n n University of Maryland School of Medicine

n University of Michigan (UMich)

n n n University of Texas MD Anderson Cancer Center

n n n n University of Virginia (UVA) Health n n System

n University of Wisconsin Carbone Cancer Center

n Urologic Consultants of Southeastern Pennsylvania

n Urology Associates

n Urology Centers of AlabamaUrology of San Antonio

n n UT Southwestern

n Vanderbilt University

n Walter Reed National Military Medical Center

n William Beaumont Health Systems

n Winthrop University Hospital


DepressionDiabetes





50North America



July 31, 2014



DepressionDiabetes





1South America

n n n n Instituto do Cancer do Estado de n Sao Paulo (ICESP)



July 31, 2014


n n n n Amper Klinik

n Azienda Ospedaliera San Paolo

n Basingstoke and North Hampshire Hospital

n n n n Brustzentrum Marienhospital Bottrop

n n n n Careggi General Hospitaln n n

n n n n Center for Ultrasound Functional Neurosurgery

n n n n Centre Léon Bérardn

n n n Charité Universitätsmedizin Berlin

n CHU de Bordeaux - Hôpital du Tondu

n CHU de Bordeaux - Hôpital Saint-André

n CHU de Lille - Hôpital Huriez

n CHU de Toulouse - Hôpital Rangueil

n CHU de Tours - Hôpital Bretonneau

n n n Churchill Hospital

n n n n Cisanello Hospital of University of Pisan n

n Clinica oculistica Università - Ospedale oftalmico

n n n n European Institute of Oncologyn n n n

n EyeTechCare

n Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

n Hôpital Pitié-Salpêtrière

n Hospices Civils de Lyon

n Hospital Clínico San Carlos

n n n n Inserm Lyon

n Institut Gustave Roussy

n Institut Mutualiste Montsouris

n Instituto Cartuja de Técnicas Avanzadas en Medicina

n n Kantonspital Winterthur

n Klinikum Fürth

n n Laboratorio di Tecnologie Oncologiche(LATO) HSR Giglio – Fondazione Istituto San Raffaele G. Giglio di Cefalù

n n n n Medical Center of Central Bank of n n Russian Federation

n n N. N. Petrov Research Institute of Oncology

n n n n National Medical Surgery Centern n

n n n n Niguarda Hospital

n Ospedale Generale Regionale “Francis Miulli’

n Research Center for Obstetrics, Gynecology and Perinatology of Russian Ministry of Health and Social Development

n Rostov Scientific Research Institute of Oncology

n St. Guy’s and St Thomas Hospital

n n n n St. Mary’s Hospitaln

n The Institute of Cancer Research (ICR)

n The Intervention Centre, Oslo University Hospital Rikshopitalet

n Thomayer University Hospital

n Università degli Studi di Parma

n Universitätsklinikum Tübingen

n n n n University Children’s Hospital Zurichn

n n University Hospital of Endocrinology


n n n n University Medical Center (UMC) Utrecht

n University of Heidelberg

n n University of Hull

n n n University of L’Aquila

n n University of Munich

n n n n University of Rome - La Sapienzan n n

n Urologische Universitätsklinik Magdeburg


DepressionDiabetes





50Europe



July 31, 2014


n n n n 307 Hospital of PLA

n n

n Apollo Specialty Hospital, Chennai


n Central Hospital of Shanghai Xuhui District

n n CHA Bundang Medical Center

n n Chaim Sheba Medical Center

n n Chaum Hospital

n n n n Children’s Hospital of Chongqing n n Medical University

n Chongqing Medical University

n n First Affiliated Hospital of Medical College of Xi’an Jiaotong University

n n n n First Affiliated Hospital of Zunyi n n Medical College

n n n n First Maternal and Child Health n n Hospital of Shanghai

n Fundan University Huashan Hospital

n n n n Fundan University Shanghai n n Cancer Center

n Gsl medical college

n n n n HAIFU Hospitaln n

n Indraprastha Apollo Hospital

n n n n Institute of Ultrasonic Engineering n n in Medicine and Clinical Centre

for Tumour Therapy

n n n n Jaslok Hospital and Research Centre


n n n Nanyang Technological Universityn n n

n n n n National Medical Research Centern n

n Peking Union Hospital, Chinese Academy of Medical Sciences

n Peking University First Hospital

n n n n PLA 301 Hospital (General Hospital n n of the People’s Liberation Army)

n n n n Queen Mary Hospital of the n n University of Hong Kong

n n n Rambam Medical Center

n n Samsung Medical Center

n n Shinsuma General Hospital

n SRL Diagnostics - Jankharia Imaging

n n n n Suining Central Hospitaln n

n n Taipei Medical University Hospital

n n n n The First Affiliated Hospital of n n Chongqing Medical University

n n n n The Second Artillery General Hospital n n of Chinese PLA

n n n n The Third Xiangya Hospital of n n Central South University

n Tokyo Women’s Medical Hospital

n n n n University of Malaya (UMMC)n n n n

n n n YUCM Severance Hospital

n n n YUMC Gangnam Severance Hospital


DepressionDiabetes





39Asia



July 31, 2014



DepressionDiabetes





2Oceania

n n n n Future Medical Imaging Group (FMIG)

n n The Royal Women’s Hospital Melbourne



July 31, 2014

FUS Approvals by Region

Medical Condition United States Canada Europe Asia Latin America Middle East

Adenomyosis ✓Bone ✓ ✓ ✓ ✓ ✓ ✓Breast Cancer ✓ ✓Breast Fibroadenoma ✓ ✓Essential Tremor ✓ ✓Facet Rhizotomy ✓Hyperparathyroidisim ✓Kidney Cancer ✓ ✓Liver ✓ ✓Neuropathic Pain ✓ ✓Osteoid Osteoma ✓ ✓Pancreatic Cancer ✓ ✓Parkinson’s Tremor ✓ ✓Prostate Cancer ✓ ✓ ✓ ✓ ✓Thyroid Nodules ✓ ✓Uterine Fibroids ✓ ✓ ✓ ✓ ✓ ✓


July 31, 2014

Commercial Treatment Sites by Indications and Regions

North American 7 Bone Metastases n 1 Breast Cancer n 1 Kidney Tumorsn 1 Liver Tumors n 1 Osteoid Osteoman 11 Prostate Cancern 1 Soft Tissue Tumorsn 15 Uterine Fibroids

South American 4 Prostate Cancern 1 Uterine Fibroids

Europen 9 Bone Metastases n 14 Breast Cancer n 8 Breast Fibroadenoma n 1 Essential Tremor n 14 Kidney Tumorsn 14 Liver Tumorsn 1 Neuropathic Painn 14 Osteoid Osteoman 1 Parkinson’s Tremorn 162 Prostate Cancern 14 Soft Tissue Tumorsn 37 Uterine Fibroids

Asian 2 Bone Metastasesn 89 Breast Cancer n 1 Essential Tremor n 88 Kidney Tumorsn 88 Liver Tumors

1 Multiple Myeloma n 88 Osteoid Osteoman 1 Parkinson’s Tremorn 22 Prostate Cancern 91 Soft Tissue Tumorsn 112 Uterine Fibroids

African 1 Prostate Cancer

Oceanian 2 Uterine Fibroids

Any site with a focused ultrasound system and regulatory approval from the respective country and charging for procedures.


July 31, 2014

Commercial Treatment Sites by Country

North AmericaBahamasBermudaCanadaCosta RicaCubaDominican RepublicMexicoUnited States

South AmericaBoliviaBrazilEcuador

PolandRomaniaRussiaSpainSwitzerlandUkraineUnited Kingdom

AsiaChinaIndiaIsraelJapanKazakhstanKingdom of Saudi ArabiaLebanonMalaysiaPakistanPhillipinesRepublic of KoreaSingaporeSyriaTaiwanUnited Arab EmiratesVietnam

AfricaSouth Africa

OceaniaAustralia

EuropeAustriaBelgiumBulgariaDenmarkFranceGermanyItalyMonacoThe NetherlandsNorway



July 31, 2014

Commercial Treatment Sites by Region

30North America

211Europe

5South America

146Asia

2Oceania

395Worldwide Total

1Africa



July 31, 2014


Brigham and Women’s Hospital (BWH)Can-Am HIFU

Center for Advanced MedicineCity of HopeCleveland Clinic CanadaClinica Union MedicaDoctors HospitalDon Mills Surgical UnitDuke Health Center at SouthpointFocused Ultrasound NorthwestFox Chase Cancer CenterGalenia HospitalHospital CIMA San JoseHospital Medical Surgical Research Center (CIMEQ)Imagen Por ResonanciaKing Edward VII Memorial HospitalLes Cours Medical CentreMayo Clinic – MinnesotaMedica Sur TlalpanMemorial Sloan-Kettering Cancer Center

Riverside Methodist HospitalSan Javier Hospital MarinaStanford University Medical CenterSunnybrook Health Sciences CentreThunder Bay Regional Research InstituteUCLA Ronald Reagan Medical CenterUniversity MRI & Diagnostic Imaging Centers – SouthUniversity of California San Diego (UCSD)

Thornton HospitalUniversity of California San Francisco (UCSF)University of Virginia (UVA) Health System

30North America

Centro de urología avanzada de la Clínica IncorHospital AC Camargo de São PauloHospital Carlos Andrade MarínHospital Policia Nacional GuayaquiInstituto do Cancer do Estado de Sao Paulo (ICESP) 5

South America



July 31, 2014


211Europe

CHU de BâleCHU de Bordeaux – Hôpital du TonduCHU de Bordeaux – Hôpital Saint-AndréCHU de GenêveCHU de Limoges – Hôpital DupuytrenCHU de Nancy – Hôpital de BraboisCHU de Nice – Hôpital PasteurCHU de Reims – Hôpital Robert DebréCHU de RennesCHU de Rouen – Hôpital Charles NicolleCHU de Toulouse – Hôpital RangueilCHU de Tours – Hôpital BretonneauCHU Nord Saint EtienneCHU v de LausanneCisanello Hospital of University of PisaClínica Virgen Blanca S.A.Clinical Diagnostis Center ZdorovieClinique d’AlembertClinique Beau SoleilClinique De MontchoisiClinique des GrangettesClinique du PalaisClinique Generale BeaulieuClinique Mutualiste Eugène AndréClinique Saint GeorgesClinique Saint-MichelClinique Universitaire Saint-Luc (UCL)Clinique urologique Nantes AtlantisCROB IRCCS RioneroDiakonie-Klinikum StuttgartDiakonie Krankenhaus Kreuznacher DiakonieDRK-Seepark Klinik Debstredt GmbHDTL MedicaEuropean Institute of OncologyEv. Jung-Stilling-KrankenhausEv. Krankenhaus Göttingen-Weende e.V.Foligno HospitalFranciscus ZiekenhuisFranziskus-KrankenhausGemeinschaftspraxis fur urologieGPR Gesundheits-und PfegezentrumRusselsheim gGmbH-KlinikumGroupe Hospitalier Diaconesses Croix Saint-SimonHIFU Clinic – AMEDS CentrumHIFU Terramed Conformal CentreHôpital Edouard HerriotHôpital FochHôpital Jeanne de FlandreHôpital Pitié-SalpêtrièreHôpital TenonHospital Gral. Universitario Gregorio MaranonHospital of Mutua De Terrassa UniversityIMEXINI Divisione CanistroINI Divisione GrottaferrataInstitut Jules BordetInstitut Mutualiste MontsourisInstituto Cartuja

John Radcliffe HospitalKantonspital WinterthurKantonsspital FrauenfeldKatholisches Klinikum Essen GmbHKiev City Oncology HospitalKlink fur Prostata-Therapie GmbHKlinikum FurthKlinikum ItzehoeKlinikum KonstanzKlinikum NurnbergKlinik und Poliklinik fur Urologie der Universität

Regensburg am Caritaskrankenhaus St. JosefKrankenhaus der Barmherzigen Bruder WienKrankenhaus Dresden-FriedrichstadtKrankenhaus HietzingKrankenhaus NordwestLaboratorio di Tecnologie Oncologiche (LATO)

HSR Giglio – Fondazione Istituto San RaffaeleG. Giglio di Cefalù

Loretto-KrankenhausMain Military Clinical Burdenko’s HospitalMarienhospital Arnsberg GmbHMarien-Hospital MarlMedical Center of Central Bank of Russian FederationMilitary Medical Academy St. PetersburgMonikiMoscow City Clinical Hospital BotkinMoscow Regional Rehabilitation Center of RoszdravMount Alvernia HospitalN. N. Petrov Research Institute of OncologyNational Medical Surgery CenterNiguarda HospitalNII of UrologyNottingham University City Hospital NHS TrustNuova Villa ClaudiaOrenbourg Oncology CenterOspedale “Cardinal Massaia” di AstiOspedale “Misericordia e Dolce” di PratoOspedale di GoriziaOspedale di MassaOspedale di Nocera Inferiore Umberto IOspedale San Bartolomeo di SarzanaOspedale San Raffaele Giglio di CefalùOspedale Sant’ Anna di ComoP.O. di CastellanzaP.O di EsteParacelsus Klinik GolzheimParacelsus Klinik Reichenbach GmbHPoliclínica San AntonioPoliclinico GemelliPolyclinique Bordeaux Nord AquitainePolyclinique du Parc RambotPolyclinique Jean VillarPrincess Grace HospitalRadiologische GemeinschaftspraxisRamsay Springfield HospitalResearch Center for Obstetrics, Gynecology and

Perinatology of Russian Ministry of Healthand Social Development

ResoFus – Centre Medic AlomarRome American HospitalRostov Scientific Research Institute of OncologyRotkreuzklinikum MunchenSaint Marina HospitalSamara Oncoly CentreSankt Katharinen KrankenhausSaratov City Medical AcademySegeberger KlinikenSora Cancer CentreSpire Parkway HospitalSt. Antonius-HospitalSt. Barbara HospitalSt. Elisabethen-Krankenhaus der Katharina-Kasper

gGmbHSt. Elisabeth-Krankenhaus Köln-HohenlindSt. Elisabeth-Krankenhaus LeipzigSt.-Josefs-Hospital GmbHSt. Mary’s HospitalStädtisches Klinikum MunchenStepping Hill NHS HospitalSt. Petersburg Oncology DispanserSussex Nuffield HospitalThe Community Foundation Serving Richmond

and Central VirginiaThe Essex NuffieldThe HIFU Clinic Spire Gatwick Park HospitalThe I. M. Sechenov Moscow Medical Academy (MMA)The Intervention Centre, Oslo University Hospital

RikshopitaletThe King George Hospital NHS TrustThe Princess Royal Hospital NHS TrustTheresienkrankenhaus MannheimThe Priory HospitalThe Royal Free NHS Trust HospitalThe Royal Surrey County Hospital NHS TrustThe Wellington HospitalThe Winterbourne HospitalThomayer University HospitalTILAK Unternehmen GesundheitUfa Oncology CenterUniversitätsklinikum Bonn (University Hospital Bonn)Universitätsspital BaselUniversitatsspital NordUniversity Children’s Hospital ZurichUniversity College London HospitalsUniversity Hospital, MR CenterUniversity Hospital of EndocrinologyUniversity Hospital Schleswig-HolsteinUniversity Medical Center (UMC) UtrechtUniversity Medical Center LubeckUniversity of L’AquilaUniversity of OxfordUniversity of Rome – La SapienzaUniversity of ViennaUrologisches ZentrumUrologische Universitätsklinik HeidelbergZaans Medisch Centrum

Aarhus University HospitalAgaplesion Diakonieklinikum HamburgAkademisches Lehrkrankenhaus der Universitat

FreiburgAlgemeen Ziekenhuis MiddelheimAlliance Medical, ItalyAmper KlinikAmphia ZiekenhuisAsklepios Kliniken Weißenfels-Hohenmölsen GmbHAsklepios Klinik UckermarkAsklepios Paulinen KlinikAz. Osp. San Giovanni Battista – Le MolinetteAzienda Ospedaliera ‘Di Venere – Giovanni XXIII’Azienda Ospedaliera A. CardarelliAzienda Ospedaliera Sant’AndreaAzienda Ospedaliera S.Maria degli AngeliAzienda Ospedaliera Universitaria Tor VergataAzienda Sanitaria Locale 21BMI Goring Hall HospitalBMI Highfield HospitalBMI The Kings Oak HospitalBrighton and Sussex University HospitalBrustzentrum Marienhospital BottropCareggi General HospitalCasa di Cura Abano TermeCasa di Cura Candela SpACasa di Cura ColumbusCasa di Cura Villa SerenaCEMEDI Diagnostico por imagenCenter for Ultrasound Functional NeurosurgeryCenter of Family Planning & Reproduction (CFPR)Central Bank Medical CenterCentral Institute of Traumatology and OrthopedicsCentre Hospitalier de ChambéryCentre Hospitalier de La Rochelle – Hôpital Saint LouisCentre Hospitalier de SaintongeCentre Hospitalier Grace de MonacoCentre Hospitalier Nord de Marseille – CHU

Centre Hospitalier Régional Universitaire de LilleCentre Hospitalier Regional Universitaire de ToursCentre Hospitalier Universitaire de CaenCentro Hospitalario QuirónCharité Universitätsmedizin BerlinCHRU de Guadeloupe – Hôpital les AbymesCHRU de Lille – Hôpital HuriezCHRU de Strasbourg – Hôpital Civil



July 31, 2014


Christiaan Barnard Memorial Hospital INTAMED

1Africa


Future Medical Imaging Group (FMIG)The Royal Women’s Hospital Melbourne2

Oceania


July 31, 2014


146Asia

307 Hospital of PLA

Affiliated Hospital of Armed Police’s Medical CollegeAffiliated Hospital Of Chuanbei Medical CollegeAffiliated Hospital of Qinghai Medical CollegeAffiliated Hospital Of Xinxiang Medical CollegeAffiliated Hospital of Yokohama UniversityAizu Chuo HospitalAl Zahra HospitalBaoji Maternal and Child Health HospitalBaoson HospitalBeijing Cancer HospitalBeijing HospitalBharat Scans Private LimitedBreastopia Namba HospitalCardinal TienCHA Bundang Medical CenterChaim Sheba Medical CenterChang Gung Memorial Hospital (Chiayi)Chang Gung Memorial Hospital (Kaohsiung)Chang Gung Memorial Hospital (Keelung)Chang Gung Memorial Hospital (Linkou)Chang Gung Memorial Hospital (Taipei)Changhua Christian HospitalChaum HospitalChengdu Maternal and Child Health Center HospitalChengdu Shuangnan HospitalChildren’s Hospital of Chongqing Medical UniversityChina Medical University Beigang HospitalChongqing Three Gorges Central HospitalCity Hospital of Bincheng District in Binzhou CityClinical E.T.Clumax DiagnosticsConcept Medicare (India) Pvt Ltd.Dalian Friendship HospitalDar al Shifaa HospitalDaxian People’s HospitalDengfeng People’s HospitalEkaterinburg Regional Hospital N1/URAL Medical

Univercity Central Ural RegionFifth People’s Hospital of Nanchong CityFirst Affiliated Hospital, Zhengzhou UniversityFirst Affiliated Hospital of Guangxi Medical University

First Affiliated Hospital of Kunming Medical UniversityFirst Affiliated Hospital of Zunyi Medical CollegeFirst Maternal and Child Health Hospital of ShanghaiFortis HospitalFudan University Cancer HospitalFujian Provincial HospitalFukuoka Tokushukai HospitalFukuoka Tokushukai Medical CenterFuling Center Hospital of ChongqingGazprom medical centre, OMSKWest Siberia RegionGuangzhou First Municipal People’s HospitalGuantao People’s Hospital of HebeiHAIFU HospitalHaifu Hospital of Tangshan Transportation Group Co. Ltd.Haikou Municipal HospitalHokuto HospitalHong-Kong Sanatorium & hospitalHôpital Sacré CoeurHuainan Eastern HospitalHuabei Oil Field general hospital groupHuanggang Center HospitalHubei Maternal and Child Health HospitalIncheon Christian HospitalIncheon St. Mary’s Hospital of the Catholic UniversityInstitute of Ultrasonic Engineering in Medicine

and Clinical Centre for Tumour TherapyIseikai hospitalItabashi Chuo Medical Center, TokyoJapan Affiliated Hospital of Chiba UniversityJaslok Hospital and Research CentreJiangmen Wuyi Traditional Chinese Medicine HospitalJiangsu Armed Police Corps HospitalJiangsu Cancer HospitalJilin Center HospitalJiugang HospitalJiujiang Maternal and Child Health HospitalJixi People’s HospitalKaixian People’s HospitalKaoshiung Veterans General HospitalKhanty-Mansysk Regional hospital North SiberiaKing Fahad Medical CityKing Khalid University HospitalKKWomen and Children’s HospitalKochi University HospitalLianyungang Orient HospitalLiaoning Fushun Cancer HospitalLuoyang Center HospitalMaternal and Child Health Hospital of Yubei DistrictNanshi HospitalNational Kidney and Transplant InstituteNational Medical Research CenterNo. 91 Central Hospital of the Liberation ArmyNong Ken HospitalObstetric Hospital of Changchun


Peking Union Hospital, Chinese Academy of Medical SciencesPeking Union Medical CenterPeople’s Hospital of Hunan ProvincePeople’s Hospital of Nanchuan DistrictPeople’s Hospital of XingtaiPLA 301 Hospital (General Hospital of the

People’s Liberation Army)Primus Super Specialty HospitalQueen Mary Hospital of the University of Hong KongRamayya Pramila Urology HospitalRambam Medical CenterRussian Railways (RZD) Hospital Central SiberiaSamsung Medical CenterSapporo Toho hospitalShaanxi Maternal and Child Health HospitalShandong Cancer HospitalShandong Guangrao Traditional Chinese Medicine HospitalShandong Qianfoshan HospitalShanxi Traditional Chinese Medicine HospitalShenzhen Maternal and Child Health Center HospitalShinsuma General HospitalSichuan UniversitySindh Institue of Urology and TransplantationSingapore General HospitalSRL Diagnostics – Jankharia ImagingSt. Peter’s HospitalSuining Central HospitalSuining Hospital of Traditional Chinese MedicineSun Yat-Sen University Cancer CenterSunrise HospitalTaipei Medical University HospitalThe 452nd PLA HospitalThe Daqing Oil Field General Hospital GroupThe First Affiliated Hospital of Chongqing Medical UniversityThe First Affliated Hospital of Wannan Medical CollegeThe First People’s Hospital of ShijiazhuangThe Fourth People’s Hospital of ShenzhenThe Second Affiliated Hospital of Hebei Medical UniversityThe Second Artillery General Hospital of Chinese PLA

The Sixth People’s Hospital of NeijiangThe Tenth People’s Hospital of ShanghaiThe Third Xiangya Hospital of Central South UniversityTung’s Taichung MetroHarbor HospitalUniversity of Malaya (UMMC)Women’s Center IndiaXiaoshan Birth Control StationXijing Hospital of The Fourth Military Medical UniversityYamanashi University Medical HospitalYanbian Tianquan HospitalYongchuan Maternal and Child Health HospitalYonsei University College of MedicineYUMCGangnam Severance HospitalZibo Municipal Maternal & Children Health Hospital


July 31, 2014

1230 Cedars Court, Suite F

Charlottesville, VA 22903

www.fusfoundation.org

Contact

Heather Huff-Simonin, MBADirector, Global Business Development

434.326.9829 OFFICE

[email protected] EMAIL

The information in this report was

provided by manufacturers and the

focused ultrasound research community

to the Focused Ultrasound Foundation.

The FUS Foundation aims to provide

the most accurate information;

if you have more current or updated

information please send it to:

[email protected].

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