cochrane library training
TRANSCRIPT
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The Cochrane Library: Train the Trainer for Health Librarians
Canadian Cochrane Network & Centre
Tamara Rader, MLISCochrane Musculoskeletal Group
Institute of Population Health, University of Ottawa
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Canadian Cochrane Network and Centre (CCNC) Funding Organizations
Canadian Institutes of Health Researchincluding 6 CIHR Institutes
CADTH
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Outline of the workshop
Session 1: Introductions and Background Session 2: Cochrane and Systematic Reviews
Break Session 3: The Cochrane Library Session 4: On-line Demonstration
Break Session 5: Small group work Session 6: Wrap up and evaluation
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Session 1: Introductions and Background
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Introductions
Name Background/previous experience Have you ever used the Cochrane Library
before? Are you likely to be searching the Cochrane
Library for your clients or teaching them to search?
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Session 2:
Cochrane and Systematic Reviews
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The problem: information overload…
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The solution: systematic reviews
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Evidence-based PracticeEvidence-based Decision Making
Evidence/Information Expertise or experience
Values, preferences, needs
- from research- highest quality
- past experience- own judgement
- usually patient perspective- based on priorities in life, health beliefs
Decision-making in health care
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What is “evidence”?
Cohort studies Case control studies Cross sectional surveys Case reports Clinical trials Randomized controlled trials Reviews Systematic reviews
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Why don’t doctors use evidence in practice?
Lack of information managementNeed to put results into context Individual studies may be misleading
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Problem of information management
Over 20,000 medical journals published per year
Published research of variable quality and relevance
Health care professionals often poorly trained in critical appraisal skills
Average time professionals have available to read = <1 hour/week
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Need to put results into context
The results of individual studies need to be interpreted alongside the totality of evidence (systematic reviews)
Emphasis on individual studies may distract us
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Individual studies may be misleading
Analyzed 115 articles published in 1990-2003 in the 3 major general medical journals (NEJM, JAMA, Lancet) and specialty journals that had received over 1000 citations each by August 2004
49 reported evaluations of health care interventions; 45 claimed that the interventions were effective.
By 2004 5/6 non randomised studies and 9/39 randomised trials were already contradicted or found to be exaggerated
Ioannidis JP. JAMA 2005
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What do we need to manage the flow of information, keep it in context, and not be mislead by individual
studies?
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Systematic reviews!
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“It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomized controlled trials”.
Archie Cochrane, 1979
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Collaboration’s Mission Statement
The Cochrane Collaboration is a unique worldwide organization that aims to help
people make well informed decisions about health care by preparing, maintaining and promoting the accessibility of systematic
reviews of the effects of health care interventions.
www.cochrane.org
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Why not other types of reviews?
Are a collection of material on a given subjectLooks at all studies on a specific topic (treatment,
correct way to diagnose, prevention)Two ways to review literature: Narrative or Systematic
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What are the different review types?
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Type:
Feature:
Scoping Literature Review
Narrative
Question What is known about a topic
What is known about a topic
Broad
Search strategy
Unknown Unknown Not known
Selection of studies
Known, but post hoc
Unknown Not known
Inferences Thematic, makes comparisons
Descriptive May be based on evidence
Advantages Rapid appraisal, identifies research gaps
Maps what is known
Breadth, historical, phenomena
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NARRATIVE VS SYSTEMATIC
equal weight of studies High quality studies and weighted
General overview Focused question
?Search strategy Methodical and reproducible search
?assessment of studies Quality & relevance assessed
?bias Impartial and relevant results
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What is a systematic review?
A review of a clearly formulated question that uses systematic and explicit methods to identify, select, and critically appraise relevant research, and to collect and analyse data from the studies that are included in the review.
Cochrane Collaboration (2005) Glossary of Terms in The Cochrane Collaboration
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Systematic Reviews
Why a review could be undertaken:● Resolve conflicting evidence
● Uncertainty in practice
● Variations in practice
● Confirm appropriateness of current practice
● Highlight need for future research
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Advantages of Systematic reviews
Reduce bias Reduce random error Explore variability Provide reliable basis for making
decisions Inform and influence future research
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Why Cochrane Reviews?
Effects of healthcare interventions, now also diagnostics
Summarize evidence and help people to understand
Careful not to impose own values, preferences, local context
Keep audience in mind while writing All have the same structured format Protocol → Review
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The strength of a Cochrane review
● Rigour of methodology
● Broad scope of literature included
● Updated and maintained
● Inclusiveness of perspectives
● Plain language summary
● Independence from commercial interests
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Cochrane Review - uniqueGrey &
published, in all
languages
Systematic manual searches of key journals
Computerized Databases
Review of reference
lists
Consultation with experts
Identify Studies
Review for Relevance
Not RelevantRelevant
Reject
Critical appraisal
Extract Data
Analyze Data
ConclusionsPlain language
summaryUpdates
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Steps of a Cochrane review
STEP 1: formulate the problem, assemble review team,
and register the title with Review Group
STEP 2: write protocol, submit for peer review, and
publish on Cochrane Library
STEP 3: conduct the Review, publish on Cochrane Library
locate and select studies data collection: study characteristics, risk of
bias, outcome data, other informationanalyse and present results
interpret results and write review
STEP 4: update review
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Review SubmissionIf no review, registered title becomes available
to others
6 Months
Title Registration
Approval of title by Editorial
Board
Protocol SubmissionIf no protocol, registered
title becomesavailable to other
interested reviewers
1.5 Years
Guidelines for Protocol and Review Process
Updating ~ 2 years
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Advantages of authoring a Cochrane review
– Credibility - independence from commercial interests
– Learn critical appraisal skills– Participate in developing systematic review
methods– International exposure in Cochrane Library– Clinically relevant reviews incorporated into many
derivative clinical tools based on Cochrane reviews
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Advantages of authoring a Cochrane review
– Protocols developed for increasing transparency and reducing bias
– Peer review process
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Review Team
Two or more people– For methods– Range of Expertise depending on Review Group
◊ Content
◊ Methodology (including statistical)
◊ Searching (Trials Search Coordinator)
◊ Translation
◊ International (encouraged)
◊ Others – varied regions, settings, consumers
Commitment to the life of the Review!
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Impact of Cochrane Evidence
Cochrane reviews have become known internationally as sources of high quality, reliable health information
The dissemination of Cochrane evidence: an inventory of resources that use Cochrane reviewshttp://209.211.250.105/reviews/impact/dissemination.htm
Press releases by the publisher of The Cochrane Libraryhttp://www.cochrane.org/press/releases.htm
Impact Factor: Impact Factor: The 2008 impact factors have now been published by Thomson ISI. The Cochrane Database of Systematic Reviews has an Impact Factor of 5.182 and is ranked 12th out of 107 in the ISI category Medicine, General & Internal.
Source: http://www.cochrane.org/reviews/impact/
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Recent Cochrane Reviews in the Press
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20 minute Break!
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Session 3:
The Cochrane Library
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www.thecochranelibrary.com
New Editor-in-Chief: Dr. David Tovey
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What is The Cochrane Library?
Main output of Cochrane Collaboration
A collection of databases– Contains Cochrane
reviews & other databases
www.thecochranelibrary.comMargaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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What is the Cochrane Library?
“The Cochrane Library brings together in one place research which looks at the effectiveness of different health care treatments and interventions. It is recognised as the best single source of information on the effects of health care.”
– NICs Guide to the Cochrane Library, Australian Cochrane Centre
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Who publishes it?
Wiley-Blackwell – on behalf of The Cochrane Collaboration– under contract– Available on CD Rom and the Internet
www.thecochranelibrary.com
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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How often is the Cochrane Library updated?
updated and expanded every 3 months or quarterly
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Why do we need the Cochrane Library?
To assist clinicians in keeping up with major developments
To help consumers weigh the potential benefits and harms of treatment
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The Cochrane Library: the databases
Cochrane Database of Systematic Reviews – (CDSR; Cochrane Reviews) 5,785
Database of Abstracts of Reviews of Effects – (DARE; Other Reviews) 9,964
Cochrane Central Register of Controlled Trials – (CENTRAL; Clinical Trials) 575,975
Health Technology Assessment Database – (HTA; Technology Assessments) 7,717
NHS Economic Evaluation Database – (NHSEED; Economic Evaluations) 25,255
Cochrane Methodology Register – (CMR; Methods Studies) 11,572
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Who Provides the Content?
Cochrane Database of Systematic Reviews
Database of Abstracts of Reviews of Effects
Cochrane Central Register of Controlled Trials
Cochrane Methodology Register
Health Technology Assessment Database
NHS Economic Evaluation Database
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Cochrane Database of Systematic Reviews
Database of Abstracts of Reviews of Effects
Cochrane Central Register of Controlled Trials*
Cochrane Methodology Register
Health Technology Assessment Database
NHS Economic Evaluation Database
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Structure of the Cochrane Collaboration
*Specialized registers are added into Cochrane Central Register of Controlled Trials (Central)
The Cochrane Library
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Structure of the Cochrane Collaboration
Cochrane Database of Systematic Reviews
Database of Abstracts of Reviews of Effects
Cochrane Central Register of Controlled Trials*
Cochrane Methodology Register
Health Technology Assessment Database
NHS Economic Evaluation Database
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Structure of the Cochrane Collaboration
*Specialized registers are added into Cochrane Central Register of Controlled Trials (Central)
The Cochrane Library
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The Cochrane Database of Systematic Reviews (CDSR)
The database that contains all the Cochrane Reviews
Issue 2 2009– 3826 complete Cochrane reviews and – 1959 protocols (reviews in progress)
– in html & PDF format
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What is special about CDSR?
up-to-date overviews of existing evidence higher quality than other systematic reviews
(but …) reviews updated with new studies / improved
methods amended / updated from comments and
criticisms– pre- and post-publication
Adapted from Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Why Use the Wiley Version of the CDSR?
Can search the full text of a review– Except for the references
Access to the full text– PDF or HTML
Can browse by – New Reviews– Updated Reviews– All Review – Protocols and Full Reviews
Protocols not available in PubMed Can easily export a citation
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Cochrane Central Register of Controlled Trials (CENTRAL)
c. 580,000 reports of RCTs and other controlled trials
– 330,000 from MEDLINE (all records indexed as RCT or CCT in PT in humans)
– 90,000 additional reports of trials from searching EMBASE
– 160,000 reports of trials from handsearching journals / conference abstracts
Adapted from Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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What is special about CENTRAL?
unique!
best single source of reports of randomized controlled trials
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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What’s new in Cochrane
Summary of Findings Tables – see Reviewers’ Handbook Chapter 11.5
Risk of Bias Tables – see Reviewers’ Handbook Chapter 8.6– http://www.cochrane-handbook.org/
Diagnostic test accuracy reviews – http://srdta.cochrane.org/en/index.html
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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What’s new in Cochrane
Editor-in-Chief appointed late 2008– David Tovey former Editorial Director of the BMJ Group’s
“Knowledge” division, responsible for BMJ Clinical Evidence and its sister product BestTreatments
Podcasts and other multimedia– Podcasts from the most-accessed Cochrane reviews
http://www.cochrane.org/podcasts/index.html
Colloquium presentations as videos, slidecasts RSS newsfeeds from The Cochrane Collaboration Facebook Twitter - http://twitter.com/cochranecollab
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Cochrane Reviews - Improved Status Flags
A full review, complete with results and discussion, possibly including meta-analyses to combine results across studies.
The outline of a review in preparation, including the background, rationale and methods.
A full-text systematic review of methodological studies.
A new protocol or review that has been published in the most recent issue (quarter).
A new search for studies has been conducted for an existing review as published in the most recent issue (quarter).
There has been an important change to the conclusions of the review as published in the most recent issue (quarter).
The protocol has been amended to reflect a change in scope as published in the most recent issue (quarter).
The review or protocol has been withdrawn, which may be because it was considered to be out of date. Reasons for withdrawal are specified in the document.
The review includes comments. Readers can submit comments, which are incorporated into the review together with answers and feedback from the review authors.
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Advanced search
For greater flexibility choose the Cochrane Advanced Search
The Advanced Search screen allows you to build searches by combining several different concepts using Boolean operators (AND, OR or NOT) and lets you limit your search according to particular databases, types of record or year(s).
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Boolean Logic
AND retrieves results that include all the search terms; use AND to narrow results by combining concepts
OR retrieves results that include at least one of the search terms; expanding possibilities of retrieval; use OR to group synonymous terms together
NOT excludes the retrieval of terms from your search.
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Boolean Operators
Aquatic excercises
osteoarthritis Aquatic exercises
osteoarthritis Aquatic
exercises
osteoarthritis Aquatic exercises
osteoarthritis Aquatic exercises
osteoarthritis Aquatic exercises
AND
OR
NOT
osteoarthritis
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Advanced search tips
Use wildcard truncation * to truncate a word (multiple characters), i.e. to search for multiple characters before, within, or after a search string.
E.g. aquatic NEXT exercis*, e.g. exercise, exercises, or exercising
Janet Joyce, The Cochrane Library, Presentation for CAOT, CPA, CASLPA, April 22, 2008, Halifax
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Advanced search tips
Use NEXT to find keywords adjacent to each other (proximity searching)
E.g. aquatic NEXT exercise [Review]
Aquatic exercise for the treatment of knee and hip osteoarthritis
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Advanced search tips
Use NEAR with a number to indicate proximity of terms either before or after each other. The default proximity value for the operator when no number is used is 6.
E.g. aquatic NEAR exercise* [Protocol]
Aquatic therapy exercise for treating rheumatoid arthritis
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Advanced search tips
Exact phrase search: Insert a term within quotation marks to create an exact match.
E.g. “water gymnastics” The review found that specifically tailored
strengthening exercise, sitting pelvic tilt exercise programs and water gymnastics all reported beneficial effects
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Organizing the search….
PICO - A well-formulated question makes it easier to produce the strategy and find the evidence
Strategy will be based on controlled vocabulary (Medical Subject Headings), and text words (develop list of key terms, synonyms)
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Start with PICO
Patient/Population
Intervention
Comparison
Outcome
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Framing the question
Are aquatic-exercise interventions in the treatment of knee and hip osteoarthritis effective and safe?
In patients with knee or hip osteoarthritis (population)
Are aquatic-exercise interventions (intervention)
No comparator (comparison)
Effective and safe? (outcome)?
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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PICO
Patient groupPatient group
• Knee osteoarthritisKnee osteoarthritis• Hip osteoarthritisHip osteoarthritis
Intervention
• Aquatic exercise interventions
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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PICO
Patient groupPatient group
• osteoarthritis, knee (MeSH)• osteoarthritis, hip (MeSH)• (osteoarthritis OR osteoarthros*)
AND (knee OR hip)
Intervention
• hydrotherapy (MeSH)• balneology (MeSH)• swimming (MeSH)• balneotherap*• aquatic NEXT exercis*• (aquatic OR water) NEXT sport*• pool NEXT therap*• water NEXT aerobic*• water NEXT exercis*• water NEXT run*• water NEXT training• water NEXT gymnastic*• (water* OR aquatic OR pool) AND
physiotherapy
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Resources for Customized Searching
Select Cochrane Central Register of Controlled Trials
Search for the following codes in “All Text” and – Language Codes
http://www.nlm.nih.gov/bsd/language_table.html
– Review Group Register Codes http://www3.interscience.wiley.com/cgi-bin/mrwhome/10
6568753/CENTRALHelpFile.html#app
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Managing References
Bibliographic software – Reference Manager, EndNote, Procite,
RefWorks, etc.– Direct export is available for many databases– Useful for importing references from multiple
databases and removing duplicates– Compatible with RevMan
Janet Joyce, The Cochrane Library, Presentation for CAOT, CPA, CASLPA, April 22, 2008, Halifax.
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Staying Current
http://www.cochrane.org/news/index.shtml– New Cochrane Reviews– Podcasts of new reviews– Cochrane in the News – Cochrane Workshops– Cochrane Press Releases– Cochrane on Facebook– Cochrane on Twitter
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Different types of research questions
What are the benefits and harms of treatment ‘X’ in animal models?
What are the benefits and harms of treatment ‘X’ in humans?
What are the benefits and harms of a new service delivery configuration?
What are the benefits and harms of a quality improvement initiative?
What is the accuracy of a diagnostic text ‘X’?
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Different types of research questions
(continued) What is the accuracy of routine coding
following hospital discharge? What are the experiences of patients
undergoing treatment ‘X’? What is the prevalence of condition ‘X’? How strong is the association between gene
‘A’ and disease ‘X’? …and more!
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When would you search theCochrane Library?
What is the effective treatment of y? What is the effective treatment of y in
condition x? Is treatment y better than treatment z? What is the accuracy of a diagnostic text ‘x’?
Boagey, Paul. Using the Cochrane Library. University of Southampton Library, November 2007. http://www.soton.ac.uk/library/subjects/sonm/pptcochranenov2007.ppt
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When NOT to use the Cochrane Library
General health care information: prognosis, causal, epidemiology...
Statistics: incidence and prevalence
Needs assessment studies
Boagey, Paul. Using the Cochrane Library. University of Southampton Library, November 2007. http://www.soton.ac.uk/library/subjects/sonm/pptcochranenov2007.ppt
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Session 4:
On-Line Demonstration
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The Cochrane Library has many features that make finding the information you are after fast and accurate…
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“searching for all text schizo, drugs, atypical
and antipsychotic. in All Fields in The Cochrane
Database of Systematic Reviews"
“searching for all text schizo, drugs, atypical
and antipsychotic. in All Fields in The Cochrane
Database of Systematic Reviews"
An Advanced Search of The Cochrane Library…
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… Returns the following results:
You can toggle between results listed for the different databases in The Cochrane Library here
You can toggle between results listed for the different databases in The Cochrane Library here
Use these links to restrict your search results to Reviews only,
or Protocols (reviews in progress) only.
Use these links to restrict your search results to Reviews only,
or Protocols (reviews in progress) only.
Save or edit your search using
these links.
Save or edit your search using
these links.
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MeSH (Medical Subjects Heading Search)
Let us look at an example MeSH search
Let us look at an example MeSH search
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Use the Thesaurus to search for MeSH descriptors
Use the Thesaurus to search for MeSH descriptors
MeSH (Medical Subjects Heading Search)
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Or use qualifiers.Or use qualifiers.
MeSH (Medical Subjects Heading Search)
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Search History
Select Search History to combine searches, enter their number together
with Boolean operator of choice (AND, OR, NOT).
Select Search History to combine searches, enter their number together
with Boolean operator of choice (AND, OR, NOT).
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Combine searches by entering their number together with Boolean operator of
choice (AND, OR, NOT).
Combine searches by entering their number together with Boolean operator of
choice (AND, OR, NOT).
Search History
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Search History
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Your combined search will then appear in your Search History. Your combined search will then appear in your Search History.
Search History
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15 minute Break!
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Session 5: Small Group Work
www.thecochranelibrary.com
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Case Studies
Read the case study provided Formulate the question Experiment with the search features of the
Cochrane Library & try and find a suitable review or other paper to address the question
Repeat with the case on the reverse!
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Session 6:
Wrap up and Evaluation
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Workshop planning
Practical issues Programme issues Evaluation issues Equipment Training materials On the day...
Irene Wiik & Lena Nordheim. How to plan a finding the evidence workshop. Nordic Baltic EAHIL Workshop. Powerpoint. June 26, 2003 Oslo, Norway. http://www.eahil.net/conferences/oslo/programme.htm
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Teaching methods
Classroom approach Interactive:
– Small groups– Intermediary tasks– Hands-on
A mix of both approaches
Irene Wiik & Lena Nordheim. How to plan a finding the evidence workshop. Nordic Baltic EAHIL Workshop. Powerpoint. June 26, 2003 Oslo, Norway. http://www.eahil.net/conferences/oslo/programme.htm
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Cochrane Library User Training Resources
http://www.cochrane.org/resources/clibtrain.htm
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Cochrane Library Training Materials
www.thecochranelibrary.com– see under Help! (New Users Start Here)
Brochures E-learning modules Online help manual Quick reference guides User guides Dates and Statuses explained Help file for CENTRAL (Creation Details) WebEx
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Cochrane Library Online Modules
The Cochrane Library – Module 1– (8 minutes)– www.brainshark.com/wiley/cochrane1
Tips on Advanced and MESH searching – Module 2– (7 minutes)– www.brainshark.com/wiley/cochrane2
Setting up Saved Searches and e-mail Alerts – Module 3– (7 minutes) – www.brainshark.com/wiley/cochrane3
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Cochrane Library Tutorial
The Cochrane Library on Wiley InterScience User Guide Version 2.2
– http://www3.interscience.wiley.com/homepages/106568753/userguide.pdf
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Training Ideas
Fill out the back of your evaluation form
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The Cochrane Library Users’ Group
Offers:Answers from the expertsA forum for information-sharingAn opportunity for feedback
To get involved:www.CLUG.iwh.on.ca
Or contact Emma Irvin [email protected]
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Cochrane for Librarians
The Cochrane Information Retrieval Methods Group– http://www.irmg.cochrane.org/en/index.html
Have your say!
Carol Lefebvre. The Cochrane Library – an update, Wiley Sunrise Seminar. MLA, Honolulu, Hawaii, 18 May 2009.
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Contributions to slides
Cochrane Centre staff Emma Irvin (IWH) Victoria Pennick, Managing Editor, Cochrane Back Review Group Doug Salzwedel, Cochrane Hypertension Group Margaret Sampson, Children's Hospital of Eastern Ontario (CHEO) Dr. Jill Hayden, Cochrane Network Site rep at Dalhousie University
(stakeholder slide) Carol Lefebvre, UK Cochrane Centre, Oxford University Kate Light, NHS Centre for Reviews and Dissemination, York
University Donna Dryden, Lisa Hartling and Carol Spooner, Alberta Research
Centre for Health Evidence (ARCHE) Paul Boagey, Unversity of Southamptom Library, UK Irene Wiik & Lena Nordheim, Norwegian Directorate for Health and
Social Affairs
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Questions?
Tamara Rader, MLISKnowledge Translation SpecialistCochrane Musculoskeletal [email protected]
Mary Ellen SchaafsmaCanadian Cochrane CentreInstitute of Population HealthPhone: (613) 562 5800 x5224Fax: (613) 562 5659Email: [email protected]: www.ccnc.cochrane.org
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Thank you!
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The Cochrane Collaboration
Structure - established as an international organisation in 1993, registered as a charity in the U.K.
Aim - to help people make well-informed decisions about health care.
How - by preparing and promoting access to systematic reviews of the effects of healthcare interventions.
Publishing Output – The Cochrane Library
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Double-blind,
placebo-controlled,
randomizedclinical trial
RandomizedControlled Trial
Controlled, Prospective Trial(eg. cohort trial)
Retrospective Trials(eg. case-control trial, case series)
Indirect Evidence, Anecdotes, Case Reports,Expert Opinion Consensus Committees
Levels of evidence, variable quality
Research users (consumers,health care professionals and policy makers) often poorly trained in critical appraisal skills
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What is a Randomized Controlled Trial (RCT)
Randomised controlled trials are the most rigorous way of determining whether a cause-effect relation exists between treatment and outcome and for assessing the cost effectiveness of a treatment.
Bonnie Sibbald and Martin Roland. Understanding controlled trials: Why are randomised controlled trials important? BMJ, Jan 1998; 316: 201.
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Evans, Jennifer. Figure 1 Design of a Randomised Controlled Trial In: Epidemiology in Practice: Randomised Controlled Trials. J Comm Eye Health, 1998;11(26) 27.
http://www.cehjournal.org/download/ceh_11_26_026.pdf
What is a Randomized Controlled Trial (RCT)
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The Cochrane Collaboration
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Centres13
Networks
Methods Groups
13
Fields16
Steering Group
Structure of The Cochrane Collaboration
Review Groups
52
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Structure of the Cochrane Collaboration
Source: http://www.cochrane.org/resources/leaflet2of5structure.htm
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Steering Group
Made up of representatives from all sectors of the Collaboration
Meets twice a year Develops policies and strategies for the
Collaboration Is supported by the Collaboration Secretariat
Steering Group
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Cochrane Centres
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Cochrane Centres
Promote awareness of The Cochrane Collaboration
Support The Cochrane Collaboration on a
geographical basis Help coordinate and support members
e.g. education & training Establish partnerships
Centres
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Canadian Cochrane Centre
Director – Jeremy Grimshaw Executive Director – Mary Ellen Schaafsma Knowledge Broker – Cheryl Arratoon Education Coordinator – Adrienne Stevens Communications Specialist – Jeanette Doucet Administrative Assistant – Lisa McGovern Policy Liaison Initiative – John Lavis, Lori Greco (McMaster site)
Email: [email protected]
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Cochrane Review Groups
International group of experts with an interest in a health problem area
Prepare and maintain systematic reviews on
– Treatment of Disease of Health Problems– Assessment of Diagnostic Tests– Methodology of Systematic Reviews
Willing and able to review all relevant research on specified health care problems
CRGs
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• Back Review Group
• Effective Practice and Organization of Care RG
• Hypertension Review Group
• Inflammatory Bowel Disease and Functional Bowel Disorders Review Group
• Musculoskeletal Review Group
Cochrane Review Groups
Worldwide there are 52 registered review groups,5 of which have their editorial base in Canada
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Cochrane Review Group Products
Systematic Reviews– these are published in The
Cochrane Library in the Cochrane Database of Systematic Reviews
Specialised Registers– These get incorporated into the
Cochrane Central Register of Controlled Trials in The Cochrane Library
CRGs
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Represent a population, group, or type of care that overlaps multiple review group areas
E.g., primary care, health care of older people
Ensures their priorities are reflected in the work of Review Groups
Child Health FieldHealth Equity Field
Cochrane Fields
Fields
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Cochrane Methods Groups
• Develop methodology and advise the Collaboration on how the validity and precision of systematic reviews can be improved
e.g.. Statistical methods, non-randomized studies, information retrieval
Bias Methods Group
Methods
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The Cochrane Consumer Network
Supports the role of consumers within Cochrane
Provides information and a forum for networking among consumers involved in the Collaboration
Facilitates the dissemination of information to patients & families
Consumer Network
http://www.cochrane.org/consumers/homepage.htm
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120120
Canadian Cochrane Network
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Canadian Cochrane Centre Affiliates
22 healthcare professional, research, and patient organizations
Advise CCNC on future directions and activities
Promote the awareness, appreciation, distribution, and use of Cochrane reviews among their members
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Affiliate Organizations - sample
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Key Characteristics of a Systematic Review
Clearly stated title and objectives for the review
Comprehensive strategy to search for studies that address the objectives of the review (relevant studies) to include unpublished as well as published studies
Explicit and justified criteria for the inclusion or exclusion of any study
Comprehensive list of all studies identified
Clear presentation of the characteristics of each study included and an analysis of methodological quality
Comprehensive list of all studies excluded and justification for exclusion
Clear analysis of the results of the eligible studies using statistical synthesis of data (meta-analysis) if appropriate and possible
Sensitivity analyses of the synthesised data if appropriate and possible
Structured report of the review clearly stating the aims, describing the methods and materials and reporting the results
Kate Light, The Cochrane Library: Self Training Guide and Notes, 2003 Issue 4, Centre for Reviews and Dissemination, University of York, November 2003.
http://toolkit.lrcnetwork.org/English/Training/Cochrane-Intro-Eng.pdf
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Develop a Title
Turn PICO question into a declarative title Should be specific and unambiguous Should clearly state the focus of the review Cochrane has standard formats
Donna Dryden and Lisa Hartling. Defining the Question and Protocol Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Title Registration
Find Cochrane Review Groups (CRGs) relevant to your topichttp://www.cochrane.org/contact/entities.htm#CRGLIST
Avoid overlap and duplication Registration form
Donna Dryden and Lisa Hartling. Defining the Question and Protocol Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Step 2: The Protocol
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Protocol Development
Framework for conducting review– Reviews are retrospective in nature– Want to minimize BIAS
Invest Time– The more you can identify up front, the more
rigorous your review will be Changes
– Not completely avoidable – Highly susceptible to bias– Need to be documented and reported
Donna Dryden and Lisa Hartling. Defining the Question and Protocol Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Protocol (continued)
Helps to avoid duplication of effort Transparency and clarity are fundamental! You want your review to be reproducible Cochrane protocols published Document changes between protocol and
review!
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Elements of a Protocol
Cover sheet– Title, citation details, contact addresses
Background Objectives Methods
– Criteria for considering studies for the review– Primary and secondary outcome(s)– Search methods for identification of studies– Data collection– Data Analysis
Donna Dryden and Lisa Hartling. Defining the Question and Protocol Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Other Elements of a Protocol
Acknowledgements Contributions of authors Declarations of interest Sources of support Tables and figures relevant to the
background or methods References
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Process
Cochrane Review Group (CRG) is involved for all steps
Review Manager (RevMan) softwarehttp://www.cc-ims.net/RevMan
Appraisal by editorial staff at CRG Protocol published in CDSR, then review
published in CDSR when completed
Donna Dryden and Lisa Hartling. Defining the Question and Protocol Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Step 3: Conducting the Review
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Structure of a Full Cochrane Review
1. Plain-language summary2. Structured Abstract3. Background4. Objectives5. Selection Criteria6. Search strategy for
identification of studies 7. Methods of the review
8. Description of Studies9. Methodological quality of
included studies10. Results11. Discussion12. Author’s Conclusions13. Acknowledgements14. References
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Other Elements of a Cochrane Review
Supplementary information– Data and analyses– Appendices
About this article– Contributions of authors– Declarations of interest– Sources of support– Differences between protocol and review– Notes
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Dissemination
Co-publication agreements have been made with several journals - see Handbook, section 2.4
Cochrane reviews must remain free for dissemination in any and all media, without restriction
Carol Spooner. Completing Your Review. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 5, 2008.
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Dissemination, cont.
Some Journals insist publication of the review in CDSR should not precede publication in print
In this case, authors should submit a review after agreement from CRG editor and before publication in CDSR
Carol Spooner. Completing Your Review. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 5, 2008.
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Step 4: Updating Your Review
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Updating
Current recommendation – Every 2 years or when important new
evidence available
if less - risk being out of date and misleadingif too frequent - may introduce a bias related to
the slower publication of studies with negative and inconclusive results.
– Know your subject area: anything new …See Handbook section 10.5 for guidance
Carol Spooner. Completing Your Review. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 5, 2008.
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139Updates
Draft Protocol peer review
Draft review peer review
Final Protocol Published on Cochrane
Library
Final review Published on Cochrane
Library
Perform review Identify studies, apply eligibility criteria, extract and
analyse data
Question registeredHenderson I. Craig, Wilcken N, Ghersi D, Davis N, Parker S, Carrick S. How to Read and Do a Cochrane Systematic Review. Leura V International Breast Cancer Conference, Sydney Australia, November 10-14, 2004.http://www.ctc.usyd.edu.au/cochrane/publications/presentations/CBCG%20-%20Leura%20V%20workshop%20November%202004.ppt
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Resources for conducting a Cochrane review
www.cochrane.org
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Additional Cochrane Resources
Review production resources for authors & managing editorshttp://www.cochrane.org/resources/revpro.htm
Cochrane Handbook for Systematic Reviews of Interventionshttp://www.cochrane.org/resources/handbook/index.htm
Cochrane Collaborationopen learning material for reviewershttp://www.cochrane-net.org/openlearning/
Undertaking Systematic Reviews of Research on Effectivenesshttp://www.york.ac.uk/inst/crd/pdf/crdreport4_complete.pdf
RevMan homepage (Review Software)http://www.cc-ims.net/RevMan
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What are systematic reviews of diagnostic test accuracy?
powerful tools for producing reliable and precise measures of the accuracy of a test for specific patient/participant group and setting
building reviews and summarizing study results can be methodologically challenging
information obtained from these reviews is useful for assessing the accuracy of a test or tests
evidence from randomized controlled trials of combined 'test and treatment' strategies, and reviews of such studies, are needed
Source: http://www3.interscience.wiley.com/homepages/106568753/what_diagnostic.pdf
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Specialized registers
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What is a Specialized Register?
Most Review Groups maintain a trials register Can be the primary source of studies for many
systematic reviews Each Review Group has a Trial Search
Coordinator that compiles the register Specialized registers are incorporated into The
Cochrane Library at the discretion of the Trials Search Coordinator
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Hand-searching
Hand-searching refers to the planned searching of a journal page by page including editorials, letters, etc., to identify all reports of randomized controlled trials
All Review Groups are responsible for handsearching journals and conference proceedings
Unique results are incorporated into their specialized register
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Step 1: Defining the Question and Assembling the Review Team
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Defining the Question
First and most important decision– Guides the rest of the review– End users’ determination of relevance
Take adequate time to draft and discuss with co-reviewers
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Broad vs Narrow Questions
Choice dependent on a number of factors: Question’s relevance and potential impact Supporting theoretical, biological, and
epidemiological information Generalizability and validity of answers Available resources
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The Well-defined Clinical Question
Population Intervention Comparator Outcomes Study Design
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Study Designs
Most Cochrane reviews use RCTs as threshold
Some reviews/groups expand to other study designs– sometimes RCTs not appropriate– EPOC reviews include a variety of designs based
on the interventions (e.g., mass media)
Don’t consider less rigorous study designs based on whether you think no RCTs have been done Donna Dryden and Lisa Hartling. Defining the Question and Protocol
Development. PowerPoint presentation. Author Training Workshop, Canadian Cochrane Symposium, Edmonton, Alberta, March 8, 2008.
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Question Format
Among…,
does…,
compared to…,
result in…?
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Review:
Name as many types of materials as you can that are found in The Cochrane Library
1. Protocols of systematic reviews
2. Systematic reviews
3. Health technology assessments
4. Randomized controlled trials
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Review:
How would you approach finding what the Cochrane Library has on asthma?– Answer: Click on Cochrane by topics, airways (4
hits)– Answer: Click on by review group and choose
airways (4 hits)– Simple search - asthma = There are 189 results
out of 5320 records for: "asthma in Title, Abstract or Keywords in Cochrane Database of Systematic Reviews"
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Searching….
Advanced search: “Search all text” =
Show Results in:Cochrane Reviews [473] | Other Reviews [212] | Clinical Trials [16160] | Methods Studies [85] | Technology Assessments [76] | Economic Evaluations [481] | Cochrane Groups [11]
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt
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Searching….
MeSH searching: Enter asthma, and click on “Go to MeSH trees”; term occurs in 4 Tree structures (i.e._) and request all results
Results: Show Results in:Cochrane Reviews [111] | Other Reviews [133] | Clinical Trials [7304] | Technology Assessments [55] | Economic Evaluations [416] Here you are getting records in which a decision has been made that the topic includes Asthma
Margaret Sampson. The Cochrane Library, CHLA, Halifax, May 30, 2008.http://www.library.ns.ca/files/Cochranetraining_0.ppt