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Clotting Factor Common name Function1 antithrombin antithrombin III, antithrombin

III,COAGULATION inhibitor, AT-III

regulates thrombin, factor IX, factorX, factor XI, and factor XII to inhibitthe coagulation cascade.

2 factor I fibrinogen forms fibrin clot after activation bythrombin in the final common

pathway.3 factor II prothrombin together with factor Xa

prothrombinase convertsprothrombin into active thrombin,which in turn helps PLATELETAGGREGATION.

4 factor III tissue factor initiates extrinsic coagulationcascade following vascular injurycofactor with factors VII, VIII, and IXin activating factor X.cofactor in activation of factor VII.

5 factor IV calcium required at several points in the

coagulation cascade.6 factor V proaccelerin or accelerator

globulin,labile factor.necessary to stop coagulationcascade at the end.

7 factor VI accelerin, factor Va activated form of factor Vtogether with factor X convertsprothrombin to thrombin in thefinal common pathway.

8 factor VII serum prothrombin conversionaccelerator (SPCA) orcothromboplastin, stable factor,proconvertin.

activates factor X when calcium andfactor III (tissue factor) are present.

9 factor VIII antihemophilic factor A activates platelet aggregation and

adhesion cofactor with factor IX inactivating factor X.

10 factor IX Christmas factor,antihemophilic factor B, orplasma thromboplastincomponent (PTC)

cofactor with factor VIII in activatingfactor X (vitamin K-dependent).

11 factor X Stuart factor or Stuart-Prowerfactor

activated by complex of tenase(factors VII and IX), factor VII, andcalcium to enable plateletaggregation.Initiates conversion of factor II(prothrombin) to thrombin.

12 factor XI plasma thromboplastinantecedent (PTA)

in the intrinsic pathway, activatesfactor IX when calcium is present.

13 factor XII Hageman factor activates factor XI, thereby startingthe intrinsic pathway.binds to exposed collagen at site of intravascular injury.

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14 factor XIII fibrin stabilizing factor (FSF),fibrinoligase, fibrinase, plasmatransglutaminase, Laki-Lorandfactor, LL factor, LLF, orprotransglutaminase

cross-links and stabilizes fibrin clotafter activation by thrombinneeds calcium as cofactor.

15 high molecularweight kininogen(HMWK)

contact activation factor,Fitzgerald factor, Flaujeacfactor, Williams-Fitzgerald-Flaujeac factor, or Williamsfactor

activates factor XII early in theintrinsic pathway.

16 prekallikrein Fletcher factor or prokallikrein activates factor XII at very beginningof the intrinsic pathway.

17 protein C anticoagulant protein C limits functions of factor V and

factor VIII.with cofactor protein S, inhibitsthrombin to block fibrin clotformation.

18 protein S anticoagulant cofactor protein S limits functions of factor V andfactor VIII.as cofactor for protein C, inhibitsthrombin to block fibrin clotformation.

19 thrombomodulin Fetomodulin cell surface receptor that bindsexcess thrombin, thus inhibitingdangerous clot formation.