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microgenicsThe Value of Innovation

European HeadquartersMicrogenics GmbH

Spitalhofstr. 94, D-94032 Passau, GermanyPhone: (+49) 0851 / 886 89 0

Fax: (+49) 0851 / 886 89 10Service Fax: 00800 / 110 110 10

E-mail: info@microgenics.de

®C E D I A is a registered trademark of Roche Diagnostics

Buprenorphine

Propoxyphene

Methadone

D A TC l o n e d E n z y m eD o n o r I m m u n o a s s a y s

®C E D I A

®C E D I A

C l o n e d E n z y m eD o n o r I m m u n o a s s a y s

D A T

®C E D I A l o n e d n z y m e o n o r m m u n o s s a y sC E D I A

The Microgenics product line offers the most comprehensive range of Drugs of Abuse tests,including several unique assays, for your changing drug screening needs.

assays are valued worldwide for their superior performance and stability characteristics.

®C E D I A

®C E D I A

Recombinant bioengineering technology ensures consistent lot-to-lot performance

Virtually no signal in the absence of drug due to two separate inactive enzyme fragments

Both qualitative and semi-quantitative testing possible

Extended linear assay range ensures excellent semi-quantitative performance

Liquid stable, ready-to-use Multi-Drug Calibrators and Controls

Measurement at 570 nm enables whole blood and serum testing

Barcoded reagents and applications for Hitachi Analysers (902, 911, 912, 917 and Modular)

Reagent bottles fit directly onto most clinical chemistry analysers (e.g. Olympus, Abbott etc.)

KEY FEATURES:

Opiate

Heroin Metabolite

Benzodiazepines

Methadone Metabolite

Sample Check

PCP

Multi-Level THCLSD

CocaineBarbiturate

Amph / Ecstasy

Linearity bysemi-quantitativeDetermination(ng/mL)

ORDERING INFORMATION

R e a g e n t s S i z e / N o 1 S i z e / N o 2 S i z e / N o 3

Amph / Ecstasy TSC / 1 001 04 MCC / 1 001 03 LC / 1 000 40Heroin Metabolite (6-AM) TSC / 1 001 07 MCC / 1 001 08 LC / 1 000 30Babiturates TSC / 1 000 84 MCC / 1 000 93 LC / 1 661 213Benzodiazepines TSC / 1 000 85 MCC / 1 000 94 LC / 1 775 561Buprenorphine TSC / 1 001 90 MCC / 1 002 40Cocaine TSC / 1 000 86 MCC / 1 000 95 LC / 1 661 230LSD SC / 1 732 137 MC / 1 732 145Methadone Metabolite (EDDP) TSC / 1 000 87 MCC / 1 000 96 LC / 1 868 217Methadone TSC / 1 000 88 MCC / 1 000 97 LC / 1 730 916Multi-Level THC TSC / 1 000 91 MCC / 1 001 00 LC / 1 661 256Opiates TSC / 1 000 89 MCC / 1 000 98 LC / 1 661 248PCP TSC / 1 001 72 MCC / 1 001 73 LC / 1 815 784Propoxyphene TSC / 1 001 70 MCC / 1 001 71 LC / 1 661 523Sample Check MC / 1 815 555 LC / 1 815 563

T C

C

EnzymeAcceptor (EA)

Inactive EnzymeFragments

EnzymeDonor (ED)

T e c h n o l o g y®C E D I Abased on genetic engineering

of enzyme fragments

ED-AnalyteConjugate

EA

AntibodyED-AnalyteConjugate EA EA

Antibody-ED-Analyte Complex

Anti-analyte antibody can bind the ED-Analyte conjugateand block formation of active enzyme

+

+ + +

A n a l y t e C u t - o f f ( n g / m L )

Amph / Ecstasy 300500 0 - 5000

1000

Heroin Metabolite (6-AM) 10 0 - 20

Barbiturate 200 0 - 3000300

Benzodiazepines 200 0 - 5000300

Buprenorphine 5 0 - 75

Cocaine 150 0 - 5000300

Methadon Metab. (EDDP) 100 0 - 2000

LSD 0,5 0 - 3

Methadone 300 0 - 1000

Multi-Level THC 2550 0 - 100

100

Opiate 300 0 - 2000

PCP 25 0 - 150

Propoxyphene 300 0 - 5000

ActiveEnzyme

Analyte ED-AnalyteConjugate EAAnti-

body

Antibody-Analyte Complex

+ + + +

ActiveEnzyme

04/2004 Rolf Schönswetter, Passau

ActiveEnzyme

Analyte from the sample competes for binding to the antibody,making ED-Analyte conjugate available for enzyme complementation

EA ED-ANALYTE CONJUGATE and can form Active Enzyme

Enzyme FragmentComplementation

GeneticEngineering

ActiveEnzyme

E. coliß-Galactosidase

The Value of Innovation

microgenics

microgenics

microgenics

microgenics

microgenics

microgenics

microgenics

microgenics

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microg

enics

microg

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microgen

ics

microgen

ics

microgenicsmicrogenicsmicrogenicsmicrogenics

cyan blackmagenta yellow

microgenicsThe Value of Innovation

European HeadquartersMicrogenics GmbH

Spitalhofstr. 94, D-94032 Passau, GermanyPhone: (+49) 0851 / 886 89 0

Fax: (+49) 0851 / 886 89 10Service Fax: 00800 / 110 110 10

E-mail: info@microgenics.de

®C E D I A is a registered trademark of Roche Diagnostics

Buprenorphine

Propoxyphene

Methadone

D A TC l o n e d E n z y m eD o n o r I m m u n o a s s a y s

®C E D I A

®C E D I A

C l o n e d E n z y m eD o n o r I m m u n o a s s a y s

D A T

®C E D I A l o n e d n z y m e o n o r m m u n o s s a y sC E D I A

The Microgenics product line offers the most comprehensive range of Drugs of Abuse tests,including several unique assays, for your changing drug screening needs.

assays are valued worldwide for their superior performance and stability characteristics.

®C E D I A

®C E D I A

Recombinant bioengineering technology ensures consistent lot-to-lot performance

Virtually no signal in the absence of drug due to two separate inactive enzyme fragments

Both qualitative and semi-quantitative testing possible

Extended linear assay range ensures excellent semi-quantitative performance

Liquid stable, ready-to-use Multi-Drug Calibrators and Controls

Measurement at 570 nm enables whole blood and serum testing

Barcoded reagents and applications for Hitachi Analysers (902, 911, 912, 917 and Modular)

Reagent bottles fit directly onto most clinical chemistry analysers (e.g. Olympus, Abbott etc.)

KEY FEATURES:

Opiate

Heroin Metabolite

Benzodiazepines

Methadone Metabolite

Sample Check

PCP

Multi-Level THCLSD

CocaineBarbiturate

Amph / Ecstasy

Linearity bysemi-quantitativeDetermination(ng/mL)

ORDERING INFORMATION

R e a g e n t s S i z e / N o 1 S i z e / N o 2 S i z e / N o 3

Amph / Ecstasy TSC / 1 001 04 MCC / 1 001 03 LC / 1 000 40Heroin Metabolite (6-AM) TSC / 1 001 07 MCC / 1 001 08 LC / 1 000 30Babiturates TSC / 1 000 84 MCC / 1 000 93 LC / 1 661 213Benzodiazepines TSC / 1 000 85 MCC / 1 000 94 LC / 1 775 561Buprenorphine TSC / 1 001 90 MCC / 1 002 40Cocaine TSC / 1 000 86 MCC / 1 000 95 LC / 1 661 230LSD SC / 1 732 137 MC / 1 732 145Methadone Metabolite (EDDP) TSC / 1 000 87 MCC / 1 000 96 LC / 1 868 217Methadone TSC / 1 000 88 MCC / 1 000 97 LC / 1 730 916Multi-Level THC TSC / 1 000 91 MCC / 1 001 00 LC / 1 661 256Opiates TSC / 1 000 89 MCC / 1 000 98 LC / 1 661 248PCP TSC / 1 001 72 MCC / 1 001 73 LC / 1 815 784Propoxyphene TSC / 1 001 70 MCC / 1 001 71 LC / 1 661 523Sample Check MC / 1 815 555 LC / 1 815 563

T C

C

EnzymeAcceptor (EA)

Inactive EnzymeFragments

EnzymeDonor (ED)

T e c h n o l o g y®C E D I Abased on genetic engineering

of enzyme fragments

ED-AnalyteConjugate

EA

AntibodyED-AnalyteConjugate EA EA

Antibody-ED-Analyte Complex

Anti-analyte antibody can bind the ED-Analyte conjugateand block formation of active enzyme

+

+ + +

A n a l y t e C u t - o f f ( n g / m L )

Amph / Ecstasy 300500 0 - 5000

1000

Heroin Metabolite (6-AM) 10 0 - 20

Barbiturate 200 0 - 3000300

Benzodiazepines 200 0 - 5000300

Buprenorphine 5 0 - 75

Cocaine 150 0 - 5000300

Methadon Metab. (EDDP) 100 0 - 2000

LSD 0,5 0 - 3

Methadone 300 0 - 1000

Multi-Level THC 2550 0 - 100

100

Opiate 300 0 - 2000

PCP 25 0 - 150

Propoxyphene 300 0 - 5000

ActiveEnzyme

Analyte ED-AnalyteConjugate EAAnti-

body

Antibody-Analyte Complex

+ + + +

ActiveEnzyme

04/2004 Rolf Schönswetter, Passau

ActiveEnzyme

Analyte from the sample competes for binding to the antibody,making ED-Analyte conjugate available for enzyme complementation

EA ED-ANALYTE CONJUGATE and can form Active Enzyme

Enzyme FragmentComplementation

GeneticEngineering

ActiveEnzyme

E. coliß-Galactosidase

The Value of Innovation

microgenics