clinical evidence in up-regulating mitochondrial energy ......adverse effects of cancer therapy and...
TRANSCRIPT
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Clinical Evidence in Up-regulating Mitochondrial Energy Production,
Improving Cellular Detoxification and Reducing of Fatigue
Rita Ellithorpe, MD
Tustin Longevity Center
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Topics of this presentation
• Cell and mitochondrial membrane damage
• Impact and prevalence of fatigue and energy reduction
• Unique proven solution for fatigue reduction and increased energy – Lipid Replacement Therapy (LRT)
• Clinical study verification of safety and efficacy
• Exciting new patented cardiolipin precursors to LRT
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The Basic Unit of Life … The Cell
Cell Membrane
Mitochondria
Nucleus
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• Cells make up tissues• Tissues make up organs• Organs make up systems• Systems make up the body
• Healthy cells give rise to a healthy body
Cells
Treat the Cell naturally and you treat the body
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Human Cell Schematic
The cell contains all of Life’s processes. Of particular importanceIs the mitochondria, which are the sites of energy production
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Human Cell Schematic
Mitochondrial and Cell membranes
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LipidLayers
Phospholipids
Phospholipids make upBoth the cell and mitochondrial
membranes
Cell Membrane – the outer covering of the cell
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Cell and Mitochondrial (MT) Membranes
Healthy cell membrane Damaged cell membrane
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Your Body’s Cells are in Constant Danger
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Cell and Mt membrane damage
• Membrane damage occurs– Through Oxidation – burning or corroding – Causing disruption, breakage of structure– Results in defective or depleted phospholipids
• Causes of membrane damage– Environmental toxins, medications, poor
nutrition, diseases, stress, aging, burns, trauma, surgery, drugs, over exercise and more
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Cell membrane damage• Mitochondrial damage
– Loss of energy production– Genetic (DNA) mutations– Shutdown of major cell functions– Cell death– Loss of energy to the entire body– Fatigue occurs
• Results– Loss of vital functioning of the cell – Interrupts healthy cell growth– Eventually tissues and organs are damaged– Moderate to severe fatigue– Leads to diseases of aging
• Cancer, heart disease, diabetes, loss of brain function,organ failure, arthritis, chronic fatigue, immune disorders, susceptibility to infections, digestive disorders and many more
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What is Causes Damage to Cells? • Aging• Stress• Medications• Toxins• Certain foods• Diet – Excess sugars and carbs• Others
• All the above cause diseases of aging, chronic, illnesses , damage to every organ in the body and reduced quality of life
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Loss of Mitochondrial Function
Starts with Fatigue
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Fatigue is one of the most common complaints in ambulatory care
• 1159 consecutive patients surveyed in adult primary-care clinics
– Major problem in 24%
– More prevalent in women than in men (28% vs 19%)
– Depression and anxiety were associated with fatigue
– Systemic dysfunction observed
– High prevalence, persistence, and functional consequences of fatigue mandate a search for effective therapy
JAMA 1988 Aug 19;260(7):929-34
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Economic Impact of Fatigue and Energy Reduction
• Fatigue is a major problem in US workforce
– Of 29,000 employees • 38% experienced “low levels of energy, poor sleep, or a
feeling of fatigue
– Fatigue was more common in women than men, in workers less than 50 years old
– $136 billion/year in health-related lost productivity
– 84% of costs were related to reduced performance while at work, rather than absences.
J. of Occupational & Environmental Med. Jan. 2006
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Loss of Mitochondrial Function
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Mitochondrial Associated Conditions
• Mitochondrial disease. University Department of Clinical Neurosciences, Lancet. 2006 Jul 1;368(9529):70-82.
• The Role of Impaired Mitochondrial Lipid Oxidation in Obesity. Biol Res Nurs. 2009 Feb 3.
• New insights into structure and function of mitochondria and their role in aging and disease. Dipartimento di Biochimica, Universit� di Bologna, Bologna, Italy. [email protected]
• The role of mitochondria in inherited neurodegenerativediseases. J Neurochem. 2006 Jun;97(6):1659-75.
• Review of the literature on major mental disorders in adult patients with mitochondrial diseases. 107: Psychosomatics. 2006 Jan-Feb;47(1):1-7.
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Mitochondrial Associated Conditions
• Mitochondrial Dysfunction and Psychiatric Disorders. Neurochem Res. 2008 Nov 1.
• Mitoenergetic failure in Alzheimers disease. Am J Physiol Cell Physiol. 2007 Jan;292(1):C8-23. Epub 2006 Jun
• Mitochondrial DNA and ageing. 61: Biochim Biophys Acta. 2006 May-Jun:17557(5-6):611-7.
• Epub 2006 Mar 31.Mitochondrial dysfunction in cardiovasculardisease. 237: Free Radic Biol Med. 2005 May 15;38(10):1278-95.
• Mitochondrial function in cardiomyocytes: target for cardioprotection. 76: Curr Opin Anaesthesiol. 2005 Feb;18(1):77-82.
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Mitochondrial Associated Conditions
• Expanding insights of mitochondrial dysfunction in Parkinson'sdisease. 83: Nat Rev Neurosci. 2006 Mar;7(3):207-19.
• Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer. 267: Curr Med Chem. 2005;12(4):429-41.
• Cell biology of cardiac mitochondrial phospholipids. 400: Biochem Cell Biol. 2004 Feb;82(1):99-112.
• Mitochondria-targeting therapeutic strategies for overcoming chemoresistance and progression of cancer. 490: Curr Med Chem. 2003 Dec;10(23):2517-21.
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What can be done?Repair with LRT
• Repairs cell membranes– Replaces oxidized (damaged) phospholipids– Improves integrity and function– Normalizes electrical potential (activity)
• Enhances mitochondrial (energy sites of the cell)– Improves function – (recharges the powerhouses)– Repairs DNA breakage – necessary for normal balance
• Improves overall function and health of every cell in the body
• Results in improved health and enhanced quality of life
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What is LRT? • A complex proprietary blend of specific
Phospholipids– Good fats that make up cell membranes – Extracted from soy – pure – allergy free
• Probiotics– Friendly bacteria – displace bad bacteria– Aid in normal digestion of food
• Growth media for probiotics– Maintains adequate numbers of probiotics
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REPAIR
LRT repairs and rebuilds cell membranes
Result: LRT: Healthy cell structure and function leading to overall health and energy of the body
Damaged cell membranes can be repaired by adding new healthy phospholipids
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LRT Preclinical Study
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Mitochondrial Function Assay
• A dye (Rhodamine 123) added to blood cells of each subject
• The dye is taken up by the mitochondria– The more dye detected the better the mt function– Direct measure of mitochondrial function and
membrane repair
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Rhodamine 123 Dye Mitochondrial Stain
Healthy cell unstained
Damaged cellunstained
Healthy cell stained
Damaged cell stained
The damaged cell takes up less of the dye because the mitochondria are damaged
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0
500
1000
1500
2000
2500
3000
3500
Control NT Factor
Control
NT Factor
Effects of Mitochondrial FunctionR
h123
upt
ake
Ref: Seidman, MD. Henry Ford Health System, MI; Anti-Aging Medical News 2001
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0
5
10
15
20
25
30
35
40
0 3 6 9 12 15 18
Control
NT Factor
P<.0.002
kHz
dB
Effects of NT Factor on Auditory Threshold Shifts
Ref: Seidman, MD. Henry Ford Health System, MI; Anti-Aging Medical News 2001
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Effects of LRT mtDNA Deletions
0.001
0.002
0.003
0.004
0.005
0.006
0.007
Brain Auditory Nerve StriaVascularis
ControlNT Factor
Del
eted
mtD
NA
/Tot
al m
tDN
A
Ref: Seidman, MD. Henry Ford Health System, MI; Anti-Aging Medical News 2001
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NT Factor – Preclinical Results
• Mitochondrial function was increased
• NT Factor preserved against hearing loss
• Mt DNA deletion test was quantitatively lower –reflecting slowing of the biological aging process by 20%
Ref: Seidman, MD. Henry Ford Health System, MI; Anti-Aging Medical News 2001
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NT Factor Clinical Research Studies
• Purpose
– To determine if NT Factor increases mitochondrial function (integrity)
– To determine if NT Factor decreases fatigue using the Piper Fatigue Survey
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Fatigue Survey Measurements
Piper Fatigue Scoring• Behavioral/severity• Affective meaning• Cognitive/mood• Sensory
* Piper BF, et. al. Oncol. Nurs. Forum. 1998.
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Effects of LRT on Fatigue Reduction
7.4
4.6
1.5
6.2
3.9
2.1
5.4
3.1
2.0
4.4
3.3
1.91
2
3
4
5
6
7
8
9
10
Day 0 Day 30 Day 60 Day 90
SevereModerateMild
Pipe
r Fat
igue
Sca
le
Fatigue Categories
Agadjanyan M, et al, Nutritional Supplement (NT Factor™) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects, Journal of Chronic Fatigue Syndrome 2003 Jan; 11(3):23-36.
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Average Percent Increase* in MitochrondrialFunction with NT Factor
23
43 43
05
101520253035404550
30 Days 60 Days 90 Days
Perc
ent i
ncre
ase
Star
ting
Poin
t
* RhodamineDye 123 uptake values
Post Treatment with NT FactorAgadjanyan M, et al, Nutritional Supplement (NT Factor™) Restores Mitochondrial Function and Reduces Moderately Severe
Fatigue in Aged Subjects, Journal of Chronic Fatigue Syndrome 2003 Jan; 11(3):23-36.
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Reduction of Fatigue Using LRT in an Additional Clinical Study
7.9
6.1
4.7
123456789
10
Day 0 30 Days 60 Days
Fatig
ue S
ever
ityPi
per F
atig
ue S
cale
Post Treatment with NT Factor
N=34P=0.0001
Ellithorpe RR, Settineri RA, Nicolson GL, Pilot Study: Reduction of Fatigue by Use of a Dietary Supplement Containing
Glycophospholipids, Journal of the American Nutraceutical Association 2003 Winter; 6(1):23-28.
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LRT Cuts Biological Age in Half
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LRT Reduces Biological Age
• Reversal of Age-related Energy Loss by NT Factor in 70 year Old Population to Levels of 29 year old Control Group within 8 Weeks
Journal of Chronic Fatigue Syndrome Jan; 11(3):23-36 2003Journal of the American Nutraceutical Assoc. 6 (1): 23-38 2003Journal of Celllular Biochemistry. 100: 1352-1369 2007Clinical Expeperimental Metastasis 25: 161-169 2008 Otolaryngology--Head and Neck Surgery Sep; 127(3):138-44 2002
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LRTClinical Trials Summary
.
Conditionor Illness
Average Age
Piper Fatigue
Significance
Aged 70 35.5% reduction
P<0.001
Fatigue 50.3 40.5% reduction
P<0.0001
CFS/FMS 44.8 43.1% reduction
P<0.0001
GeneralPopulation
57 37% in one week
P<0.001
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LRT Safety
• Over 38 million doses to date
• No major adverse events reported
• Minor complaints – upset stomach and loose stools in <1% - Usually resolved within a few days
• No side effects or adverse effects reported in 5 clinical trials
• No reported drug interactions
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Publications on LRT• Ellithorpe, R.R., Settineri, R. and Nicolson, G.L. Reduction of fatigue by use of a dietary
supplement containing glycophospholipids. J. Am. Nutraceut. Assoc. 6(1): 23-28 (2003).• Nicolson, G.L. Chronic fatigue, aging, mitochondrial function and nutritional supplements.
Townsend Letter Doctors 240(7): 72-76 (2003).• Nicolson, G.L. Lipid replacement as an adjunct therapy in chronic fatigue, anti-aging and
restoration of mitochondrial function. J. Am. Nutraceut. Assoc. 6(3): 22-28 (2003).• Agadjanyan, M., Vasilevko, V., Ghochikyan, A., Berns, P., Kesslak, P., Settineri, R.A. and
Nicolson, G.L. Nutritional supplement (NT Factor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects. J. Chronic Fatigue Syndr. 11(3): 23-36 (2003).
• Nicolson, G.L. Lipid replacement/antioxidant therapy for anti-aging, fatigue and restoration of mitochondrial function. AgroFood High Tech 16(3): 20-23 (2004).
• Nicolson, G.L. Lipid Replacement/Antioxidant Therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathol. Oncol. Res. 11: 139-144 (2005).
• Nicolson, G.L. and Ellithrope, R. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. J. Chronic Fatigue Syndr. 13(1): 57-68 (2006).
• Nicolson, G.L. and Conklin, K.A. Molecular replacement for cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of cancer therapy. Cancer Genomics Proteomics 3: 159-168 (2006).
• Nicolson, G.L. Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function. J. Cell. Biochem. 100: 1352-1369 (2007).
• Nicolson, G.L. Lipid replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function in metabolic syndrome and fatiguing illnesses. Townsend Lett. 286: 112-120 (2007).
• Conklin, K.A. and Nicolson, G.L. Molecular replacement in cancer therapy: reversing cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of therapy. Curr. Cancer Therapy Rev. 4: 66-76 (2008).
• Ellithorpe, R., Settineri, R. and Barwick, D.L. Detox outside the box. Living healthier, better and longer with the newest chelation therapy. Sierra Productions, 103 pp. (2008).
• Nicolson, G.L. and Conklin, K.A. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by Molecular Replacement Therapy. Clin. Exp. Metastasis 25: 161-169 (2008).
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Toxic Heavy Metals
• Heavy metals and other toxins– Cause cell membrane damage– Produce production of free
radicals– Cause oxidative stress
Vanlangenakker, N, Curr Mol Med. 2008 May;8(3):207-20 Vanlangenakker, N, Curr Mol Med. 2008 May;8(3):207-20
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Oxidative Damage to Cell Membranes
Healthy Membrane Oxidative Stress Damage
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Time-Lapse Microphotography of Toxic Effects on Human Cells
Time-Lapse Microphotography of Toxic Effects on Human Cells
Free Radical Oxidative DamageFree Radical Oxidative Damage
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Major Toxic Heavy Metals
• Most Severe – Lead - Pb– Cadmium - Cd– Mercury - Hg– Aluminum - Al– Nickel – Ni– Arsenic
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There are NO Safe Levels of Heavy Metals
• Low levels are becoming dangerous
• Low levels accumulate
• Low levels become stored
• Low levels become higher
• Multiple toxins compound the danger
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Global Chronic Low Level Metal Toxicity
• Recognized by:– US Environmental Protection Agency (EPA)– Food & Drug Administration (FDA)– Centers for Disease Control (CDC)– State Health Departments
• Treatment standards are needed– Preventative measures– Comprehensive medicine with proven results– Reduction of crisis management
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Death Rates of Participants with Low Pb Levels in NHANES III
Survey
39
17
4646
68
0
10
20
30
40
50
60
70
80
10 20 30
All CausesCardiovascular Diseases Cancer
Per
cent
Incr
ease
in M
orta
lity
Per
cent
Incr
ease
in M
orta
lity
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern Med, 2002, 162: 2443-2449Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern Med, 2002, 162: 2443-2449
Blood Lead Levels (µg/dL)Blood Lead Levels (µg/dL)
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Random Blood Sampling of Dr. Ellithorpe’s Patients: Presence Excessively High Heavy Metals
Per
cent
of P
atie
nts
Per
cent
of P
atie
nts
N=251N=251100
2217
0
25
50
75
100Presence of Heavy MetalsElevated Heavy MetalsPotentially Toxic Heavy Metals
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48
Sources of Toxic Metals Aluminum
Source: Agency for Toxic Substances & Disease Registry
• Aluminum cookware • Aluminum foil• Antacids• Antiperspirant• Baking powder
(aluminum containing• Buffered aspirin• Canned acidic foods• Food additive• Lipstick• Medications and drugs
(anti-diarrheal agents, hemorrhoid medications, vaginal douches)
• Aluminum cookware • Aluminum foil• Antacids• Antiperspirant• Baking powder
(aluminum containing• Buffered aspirin• Canned acidic foods• Food additive• Lipstick• Medications and drugs
(anti-diarrheal agents, hemorrhoid medications, vaginal douches)
• Medications and drugs (anti-diarrheal agents, hemorrhoid medications, vaginal douches)
• Processed cheese• “Softened" water• Tap water
• Medications and drugs (anti-diarrheal agents, hemorrhoid medications, vaginal douches)
• Processed cheese• “Softened" water• Tap water
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Health Conditions Associated with Aluminum
• Respiratory problems– Coughing– Asthma
• Alzheimer’s disease• Bone disease• Skeletal problems• Skin rashes• Neurological development in children
Source: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metal-Arsenic
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
• Air pollution
• Antibiotics given to commercial livestock
• Certain marine plants
• Chemical processing
• Coal-fired power plants
• Defoliants
• Drinking water
• Drying agents for cotton
• Fish
• Air pollution
• Antibiotics given to commercial livestock
• Certain marine plants
• Chemical processing
• Coal-fired power plants
• Defoliants
• Drinking water
• Drying agents for cotton
• Fish
• Herbicides
• Insecticides
• Meats (from commercially raised poultry and cattle)
• Metal ore smelting
• Pesticides
• Seafood (fish, mussels, oysters)
• Specialty glass
• Wood preservatives.
• Herbicides
• Insecticides
• Meats (from commercially raised poultry and cattle)
• Metal ore smelting
• Pesticides
• Seafood (fish, mussels, oysters)
• Specialty glass
• Wood preservatives.
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Fluoridation and ArsenicThe Hazards Behind the Faucet
• Arsenic now classified as a Class 1 human carcinogen
• EPA has proposed reducing minimum level from 50 ppb to 5 ppb.
Recent epidemiological work from Finland
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Health Conditions Associated with Heavy Metal Toxicity – Arsenic (Cont’d)
• Inorganic arsenic can increase the risk of*:– Lung cancer– Skin cancer– Bladder cancer– Liver cancer– Kidney cancer– Prostate cancer
Source: Agency for Toxic Substances & Disease Registry*Source: WHO, DHHS, EPA
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Health Conditions Associated with Heavy Metal Toxicity - Arsenic
• Sore throats• Lung irritation• Nausea & vomiting• Low red & white blood cell count• Abnormal heart rhythm• Damage to blood vessels• Sensation of pins & needles • Darkening of skin• Appearance of small corns or warts
Source: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metals-Cadmium
Source: Agency for Toxic Substances & Disease Registry
• Air pollution
• Art supplies
• Bone meal
• cigarette smoke
• Food (coffee, fruits, grains, and vegetables grown in cadmium-laden soil)
• Meats [kidneys, liver, poultry] or refined foods)
• Freshwater fish
• Fungicides
• Highway dusts
• Incinerators
• Mining
• Air pollution
• Art supplies
• Bone meal
• cigarette smoke
• Food (coffee, fruits, grains, and vegetables grown in cadmium-laden soil)
• Meats [kidneys, liver, poultry] or refined foods)
• Freshwater fish
• Fungicides
• Highway dusts
• Incinerators
• Mining
• Nickel-cadmium batteries
• Oxide dusts
• Paints
• Phosphate fertilizers
• Power plants
• Seafood (crab, flounder, mussels, oysters, scallops)
• Sewage sludge
• “Softened" water
• Smelting plants
• Tobacco and tobacco smoke
• Welding fumes
• Nickel-cadmium batteries
• Oxide dusts
• Paints
• Phosphate fertilizers
• Power plants
• Seafood (crab, flounder, mussels, oysters, scallops)
• Sewage sludge
• “Softened" water
• Smelting plants
• Tobacco and tobacco smoke
• Welding fumes
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Health Conditions Associated with Heavy Metal Toxicity - Cadmium
• Vomiting• Diarrhea• Kidney disease• Fragile bones• Carcinogenic
Source: Agency for Toxic Substances & Disease Registry*Source: DHHS
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Sources of Toxic Metals-Mercury
Source: Agency for Toxic Substance & Disease Registry
• Air pollution
• Batteries
• Cosmetics
• Dental amalgams
• Diuretics (mercurial)
• Electrical devices and relays
• Explosives
• Foods (grains)
• Fungicides
• Fluorescent lights
• Air pollution
• Batteries
• Cosmetics
• Dental amalgams
• Diuretics (mercurial)
• Electrical devices and relays
• Explosives
• Foods (grains)
• Fungicides
• Fluorescent lights
• Freshwater fish (especially large bass, pike, and trout)
• Insecticides
• Mining
• Paints
• Pesticides
• Petroleum products
• Saltwater fish (especially large halibut, shrimp, snapper, and swordfish), shellfish
• Tap water
• Freshwater fish (especially large bass, pike, and trout)
• Insecticides
• Mining
• Paints
• Pesticides
• Petroleum products
• Saltwater fish (especially large halibut, shrimp, snapper, and swordfish), shellfish
• Tap water
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Facts About Mercury Toxicity
• Mercury Vapor– Most toxic
• 100% absorbed at low dose• 74% absorbed at higher levels
– Accumulates in critical organs*• Brain• Kidney• Transfers across the placental membrane into
the fetus*Vimy M. Hahn LJ. Klober R. Takahashi Y. Lorscheider FL. Mercury uptake in sheep fetus from dental fillings, 32nd Annual Meeting of the Canadian Federation of Biological Societies 14-17 June 1989 and 2nd Meeting of the International Society for Trace Element Research in Humans 8/89
*Clarkson TW, Magos L, Greenwood MR: The transport of elemental mercury into fetal tissues. Biol Neonate 21:239-44, 1972
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Aluminum – Links to Alzheimer’s Disease (AD)
• Environmental aluminum is linked to increased rates of AD– Seven studies have related elevated aluminum
concentrations in drinking water to an increased incidence of AD
• Case control study - association of AD and lifetime exposure to aluminum in antiperspirants and antacids. – The more antiperspirant that was used, the more likely the
person would develop AD – The same held true for aluminum antacids. – The risk in high users was as high as 300%.
American Journal of Epidemiology 2000;152:59-66
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Sources of Toxic Metals-Lead
Source: Agency for Toxic Substance & Disease Registry
• Air pollution• Ammunition (shot and bullets)• Bathtubs (cast iron, porcelain,
steel)• Batteries• Canned foods• Ceramics• Chemical fertilizers• Cosmetics• Dolomite• Dust• Foods grown around industrial
areas• Gasoline• Hair dyes and rinses
• Air pollution• Ammunition (shot and bullets)• Bathtubs (cast iron, porcelain,
steel)• Batteries• Canned foods• Ceramics• Chemical fertilizers• Cosmetics• Dolomite• Dust• Foods grown around industrial
areas• Gasoline• Hair dyes and rinses
• Leaded glass• Newsprint and colored
advertisements• Paints• Pesticides• Pewter• Pottery• Rubber toys• Soft coal• Soil• Solder• Tap water• Tobacco smoke• Vinyl 'mini-blinds'
• Leaded glass• Newsprint and colored
advertisements• Paints• Pesticides• Pewter• Pottery• Rubber toys• Soft coal• Soil• Solder• Tap water• Tobacco smoke• Vinyl 'mini-blinds'
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Health Conditions Associated with Heavy Metal Toxicity - Lead
• Central nervous system• Kidneys• Reproductive system• Decrease reaction time• Weakness in fingers, wrists, ankles• Memory• Anemia• Carcinogenic
Source: Agency for Toxic Substances & Disease Registry*Source: DHHS
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Health Conditions Associated with Lead (Cont’d)
• Children are more vulnerable– Blood anemia– Severe stomachache– Muscle weakness– Brain damage– Mental and physical growth
Source: Agency for Toxic Substances & Disease Registry
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Health Conditions Associated with Lead (Cont’d)
• Younger or unborn children– Premature births– Smaller babies– Decreased mental ability in infant– Learning difficulties– Reduced growth
Source: Agency for Toxic Substances & Disease Registry
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Health Conditions Associated with Heavy Metal Toxicity - Nickel
Source: Agency for Toxic Substances & Disease Registry*Source: DHHS
• Appliances• Buttons• Ceramics• Cocoa• Cold-wave hair permanent• Cooking utensils• Cosmetics• Coins• Dental materials• Food (chocolate, hydrogenated oils, nuts,
food grown near industrial areas)• Hair spray• Zippers
• Appliances• Buttons• Ceramics• Cocoa• Cold-wave hair permanent• Cooking utensils• Cosmetics• Coins• Dental materials• Food (chocolate, hydrogenated oils, nuts,
food grown near industrial areas)• Hair spray• Zippers
• Industrial waste• Jewelry• Medical implants• Metal refineries• Metal tools• Nickel-cadmium batteries• Orthodontic appliances• Shampoo• Solid-waste incinerators• Stainless steel kitchen utensils• Tap water• Tobacco and tobacco smoke• Water faucets and pipes
• Industrial waste• Jewelry• Medical implants• Metal refineries• Metal tools• Nickel-cadmium batteries• Orthodontic appliances• Shampoo• Solid-waste incinerators• Stainless steel kitchen utensils• Tap water• Tobacco and tobacco smoke• Water faucets and pipes
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64
Health Conditions Associate with Nickel
• Apathy• Blue-colored lips• Cancer • Contact dermatitis• Diarrhea• Fever, Headaches• Dizziness• Gingivitis
InsomniaNauseaRapid Heart rate Skin rashes Shortness of
breath Stomatitis Vomiting
InsomniaNauseaRapid Heart rate Skin rashes Shortness of
breath Stomatitis Vomiting
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Cancers Associated with Heavy Metals
Toxic Metal Type of CancerArsenic Skin, Lung, Bladder, Kidney, Liver, ProstateMercury Liver, Esophageal, Lung, ProstateAluminum Bladder, Kidney, BrainNickel Lung, nasalCadmium ProstateUranium LungTungsten LungAntimony LungBeryllium Lung
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What can we do about Toxins?
• Remove Toxins• Repair Damaged Cells• Revitalize Your Health
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Detoxification
• EDTA FDA approved for lead removal • Also chelates other metals
– Suppository form - CaNa2 EDTA (Detoxamin)
• Can be used in combination with IV, oral or as stand alone therapy
– EDTA IV chelation• Expensive• Time consuming – 3-5 hours• Invasive• Greater risk
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An Important Major Research Discovery
• “Ninety Percent Reduction in Cancer Mortality after Chelation Therapy with EDTA”
– Blumer, W., Cranton, E. “Textbook on EDTA Chelation Therapy, 2nd ed. Ch, 12, Pp. 185-201
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CaNa2 EDTA Suppository Bioavailability
*Blood - tissue ratio*Blood - tissue ratio
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Effects CaNa2 EDTA Suppositories on Elevated Lead Urine Levels in Children
4.2
61.45
9
22.7
0
20
40
60
80
100
0 1 10 20 30
Pre-Treatment Baseline After 1st Suppository 10 Days of Suppository 10 Days After Suppository 10 Days Additional Suppository
325.6325.6
µg/d
Lµg
/dL
Treatment DayTreatment Day
N=20N=20
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Treatment with CaNa2 Suppositories Chronic Prostate Pain Symptom Scores
0
1
2
3
4
5
6
7
Urinary Symptoms Pain Symptoms QOL Score
Pre Treatment
Post Treatment
*P<0.05
** ** **
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Treatment with CaNa2 Suppositories Chronic Prostate Pain Symptom - Total Scores
0
2
4
6
8
10
12
Total Mean Score
Pre Treatment
Post Treatment
*P<0.05**
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Treatment with CaNa2 Suppositories International Prostate Symptom Score
(IPSS) Results
0
1
2
3
4
IncompleteEmptying
Frequency Intermittency Urgency Weak Stream Straining Nocturia QOL Score
Pre Mean
Post Mean
*P<0.05
**
**
**
**
**
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Treatment with CaNa2 Suppositories International Total Prostate Symptom
Score (IPSS) Results
024
68
101214
Total Mean Score
Pre Treatment
Post Treatment
*P<0.05
**
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Practical Clinical Case StudyUsing CaNa2 EDTA Suppositories
Practical Clinical Case StudyUsing CaNa2 EDTA Suppositories
42 y/o • W • F • 145 lbs. • Photographer • Fibromyalgia • Chronic Fatigue • Hypothyroid
Outcome: 11/04 – Energy good • Exercises daily (45 min.) with mild to moderate pain of fibromyalgia • Increased daily activities
Date Ar Cd Pb Hg Ni
8/02 220 2.5 20 24 49
12/02 4.5 2.1 7.4 15 25
5/03 45 3.2 12 8.9 18
F.K.
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Practical Clinical Case StudyUsing CaNa2 EDTA Suppositories
Date Cd Hg Pb Ni
5/03 1.7 30 43 9.5
2/04 1.0 2.6 27 17
2/05 1.0 18 27 13
55 y/o • W • F • 131 lbs. • School Teacher • Chronic LBP • Fatigue • Hypothyroid
Outcome: 7/04 – Excellent energy • Exercise 3x/day – water aerobics • Back pain stable • Reduced need for medications.
Patient K.M.
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Practical Clinical Case StudyUsing CaNa2 EDTA Suppositories
Date Cd Hg Pb Ni
10/02 1.2 5.2 27 8.4
2/03 0.9 4.4 18 3.6
10/03 1.4 9.8 20 1.6
5/04 0.7 3.8 16 7.7
12/04 1.0 1.6 12 12
52 y/o • M • 175 lbs. • Electrician • Chronic Anxiety Panic Attacks • Hypertension • LBP
Outcome: 10/04 – Anxiety greatly improved • Reduced need for auxiolytic medication • Improved BP • Reduced anti-hypertensive medication • LBP improved • Exercises daily (30 min.)
Patient M.O.
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Before Treatment
After Treatment with 60 Detoxamin Suppositories
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Comparison of IV Chelation and CaNa2 EDTA Suppositories
IV Chelation
RectalSuppositories
Non-Invasive No Yes
Quick and easy to use No Yes
Inexpensive No Yes
Increased safety No Yes
Broad spectrum metal removal Yes Yes
FDA approved Yes Yes
Clinically proven Yes Yes
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• 9 years +, 4000 patients, over 400,000 doses of Detoxamin
– Results in General• Improved mental clarity• Increased energy• Increased endurance• Reduced blood pressure• Enhanced cardiovascular performance• Improved libido and erectile function and prostate
conditions• Improved overall quality of life
Detoxamin Suppositories and Vital Cellular Nutrition
Dr. Ellithorpe’s Clinical Safety Experience with CaNa2 EDTA Suppositories
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The Three R’s of Health
• Remove Toxins– Detoxamin chelation suppositories
• Repair Cell Membranes– Vital Cellular Nutrition with NT Factor
• Revitalize cellular & systemic health– Enzymes and Antioxidants
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Glycophospholipid Supplements with NT Factor (LRT)
• Complete nutritional formula– Vitamins– Minerals– Antioxidants– Essential fatty acids– LRT– the key to healthy cell function
• Phospholipids (lipids of cell membranes)• Probiotics (good bacteria for intestinal health)
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TLC’s Foundation Recommendations
• Supplement your diet– Vital Cellular Nutrition with NT Factor
• Repairs and rebuilds cell membranes• Increases energy• Provides long term protection
– Enzymes• Support mostly all metabolic processes• Aids in digestion
– Antioxidants• Freeze-dried fruits and vegetables • Reduces oxidative stress and free radical damage
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Begin with Positive Lifestyle Changes
• Manage stress– Don’t take on more than
you can handle
• Get enough sleep– 8 is the magic number
• Eat a balanced diet– Plenty of unsprayed fruits,
vegetables and whole grains
• Reduce carbohydrates
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Positive Lifestyle Changes (Cont’d)
• Drink non-fluoridated, non-chlorinated water– Half your weight in
pounds as ounces
• Exercise on a regular basis– Even if it’s just walking
for 30 minutes a day
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Clinical Evidence in Up-regulating Mitochondrial Energy Production, Improving Cellular Detoxification and Reducing of Fatigue
Speaker: Rita Ellithorpe, MD
The following potential conflict of interest relationships are germane to my presentation:
Company Name: World Health Products, LLCSpeakers Bureau: NoneStock Shareholder: No
Grant/Research Support: World Health Products, LLCConsultant: Rita Ellithorpe, MD
Status of FDA devices used for the material being presentedEnter Device Name: NA
Status of off-label use of devices, drugs or other materials that constitute the subject of this presentation: CaNa2 EDTA