SPECIAL FEATURES

Highlights of This Issue 5727

CCR Translations

5729 DNA Methylation as a Robust Classifier ofEpithelial Ovarian CancerCharles A. Ishak, Stephanie Lheureux, andDaniel D. De CarvalhoSee related article, p. 5937

5732 A Tumor-Localized Approach to Bypass Anti-4-1BBImmuno-ToxicityTina Tianjiao Su, Xiaobin Gao, and Jun WangSee related article, p. 5878

Reviews

5735 Developments in the Space of NewMAPK PathwayInhibitors for BRAF-Mutant MelanomaJustine V. Cohen and Ryan J. Sullivan

5743 The Promise of Neoadjuvant Immunotherapy andSurgery for Cancer TreatmentJake S. O'Donnell, Esm�ee P. Hoefsmit, Mark J. Smyth,Christian U. Blank, and Michele W.L. Teng

CLINICAL TRIALS: TARGETED THERAPY

5752 Molecular and Clinical Activity of CDX-3379, anAnti-ErbB3 Monoclonal Antibody, in Head andNeck Squamous Cell Carcinoma PatientsUmamaheswar Duvvuri, Jonathan George, Seungwon Kim,Diego Alvarado, Veronique M. Neumeister,Ahmed Chenna, Richard Gedrich, Thomas Hawthorne,Theresa LaVallee, Jennifer R. Grandis, and Julie E. Bauman

5759 Health-RelatedQuality of Life Impact fromAddingBevacizumab to Cisplatin-Pemetrexed inMalignant Pleural Mesothelioma in the MAPSIFCT-GFPC-0701 Phase III TrialGuillaume Eberst, Am�elie Anota, Arnaud Scherpereel,Julien Mazieres, Jacques Margery, Laurent Greillier,Clarisse Audigier-Valette, Denis Moro-Sibilot,Olivier Molinier, Herv�e L�ena, Fr�ed�eric Rivi�ere,IsabelleMonnet,Val�erieGounant,Henri Janicot, RadjGervais,Chrystelle Locher, Emilie Charton, Franck Morin,G�erardZalcman, andVirginieWesteel, onbehalf of theFrenchCooperative Thoracic Intergroup (IFCT)

5766 Photodynamic Therapy for the Treatment ofVertebral Metastases: A Phase I Clinical TrialCarl Fisher, Zakariya Ali, Jay Detsky, Arjun Sahgal,Elizabeth David, Monica Kunz, Margarete Akens,Edward Chow, Cari Whyne, Shane Burch, Brian C. Wilson,and Albert Yee

5777 A Phase 0 Trial of Ribociclib in RecurrentGlioblastoma Patients Incorporating a TumorPharmacodynamic- and Pharmacokinetic-GuidedExpansion CohortAn-Chi Tien, Jing Li, Xun Bao, Alanna Derogatis,Seongho Kim, Shwetal Mehta, and Nader Sanai

CLINICAL TRIALS: IMMUNOTHERAPY

5787 Clinical Response of Live-Attenuated, Listeriamonocytogenes Expressing Mesothelin (CRS-207)with Chemotherapy in Patients with MalignantPleural MesotheliomaRaffit Hassan, Evan Alley, Hedy Kindler, Scott Antonia,Thierry Jahan, Somayeh Honarmand, Nitya Nair,Chan C. Whiting, Amanda Enstrom, Ed Lemmens,Takahiro Tsujikawa, Sushil Kumar, Gina Choe,Anish Thomas, Katherine McDougall, Aimee L. Murphy,Elizabeth Jaffee, Lisa M. Coussens, and Dirk G. Brockstedt

5799 A Randomized Double-Blind Placebo-ControlledPhase II Trial of Dendritic Cell Vaccine ICT-107 inNewly Diagnosed Patients with GlioblastomaPatrick Y. Wen, David A. Reardon, Terri S. Armstrong,Surasak Phuphanich, Robert D. Aiken, Joseph C. Landolfi,William T. Curry, Jay-Jiguang Zhu, Michael Glantz,David M. Peereboom, James M. Markert, Renato LaRocca,Donald M. O'Rourke, Karen Fink, Lyndon Kim,Michael Gruber, Glenn J. Lesser, Edward Pan,Santosh Kesari, Alona Muzikansky, Clemencia Pinilla,Radleigh G. Santos, and John S. Yu

5808 First-in-Class, First-in-Human Study EvaluatingLV305, a Dendritic-Cell Tropic Lentiviral Vector,in Sarcoma and Other Solid Tumors ExpressingNY-ESO-1Neeta Somaiah, Matthew S. Block, Joseph W. Kim,Geoffrey I. Shapiro, Khanh T. Do, Patrick Hwu,Joseph P. Eder, Robin L. Jones, Hailing Lu,JanH. ter Meulen, Chet Bohac, Michael Chen, Frank J. Hsu,Sacha Gnjatic, and Seth M. Pollack

October 1, 2019 � Volume 25 � Number 19

Clinical Cancer Research

Table ofContents

iv

on January 8, 2021. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

5818 Phase I Trial of an ICAM-1-TargetedImmunotherapeutic-Coxsackievirus A21 (CVA21)as an Oncolytic Agent Against Non Muscle-Invasive Bladder CancerNicola E. Annels, David Mansfield, Mehreen Arif,Carmen Ballesteros-Merino, Guy R. Simpson,Mick Denyer, Sarbjinder S. Sandhu, Alan A. Melcher,Kevin J. Harrington, Bronwyn Davies, Gough Au,Mark Grose, Izhar Bagwan, Bernard Fox, Richard Vile,Hugh Mostafid, Darren Shafren, and Hardev S. Pandha

PRECISION MEDICINE AND IMAGING

5832 Analysis of Cell-Free DNA from 32,989 AdvancedCancers Reveals Novel Co-occurring ActivatingRET Alterations and Oncogenic SignalingPathway AberrationsThereasa A. Rich, Karen L. Reckamp, Young Kwang Chae,Robert C. Doebele, Wade T. Iams, Michael Oh,Victoria M. Raymond, Richard B. Lanman,Jonathan W. Riess, Thomas E. Stinchcombe,Vivek Subbiah, David R. Trevarthen, Stephen Fairclough,Jennifer Yen, and Oliver Gautschi

5843 Mutation Status of RAS, TP53, and SMAD4 isSuperior to Mutation Status of RAS Alone forPredicting Prognosis after Resection ofColorectal Liver MetastasesYoshikuni Kawaguchi, Scott Kopetz,Timothy E. Newhook, Mario De Bellis, Yun Shin Chun,Ching-Wei D. Tzeng, Thomas A. Aloia, andJean-Nicolas Vauthey

5852 Comprehensive Genomic Landscapes in Earlyand Later Onset Colorectal CancerChristopher H. Lieu, Erica A. Golemis, Ilya G. Serebriiskii,Justin Newberg, Amanda Hemmerich, Caitlin Connelly,Wells A. Messersmith, Cathy Eng, S. Gail Eckhardt,Garrett Frampton, Matthew Cooke, and Joshua E. Meyer

5859 ESM1 as a Marker of Macrotrabecular-MassiveHepatocellular CarcinomaJulien Calderaro, L�ea Meunier, Cong Trung Nguyen,Marouane Boubaya, Stefano Caruso, Alain Luciani,Giuliana Amaddeo, H�el�ene Regnault, Jean-Charles Nault,Justine Cohen, Fr�ed�eric Oberti, Sophie Michalak,Mohamed Bouattour, Val�erie Vilgrain,Georges Philippe Pageaux, Jeanne Ramos,Nathalie Barget, Boris Guiu, Val�erie Paradis,Christophe Aub�e, Alexis Laurent, Jean-Michel Pawlotsky,Nathalie Ganne-Carri�e, Jessica Zucman-Rossi,Olivier Seror, and Marianne Ziol

TRANSLATIONAL CANCER MECHANISMSAND THERAPY

5866 Identification of Recurrent Activating HER2Mutations in Primary Canine PulmonaryAdenocarcinomaGwendolen Lorch, Karthigayini Sivaprakasam,Victoria Zismann, Nieves Perdigones,Tania Contente-Cuomo, Alexandra Nazareno,Salvatore Facista, Shukmei Wong, Kevin Drenner,Winnie S. Liang, JosephM. Amann, Sara L. Sinicropi-Yao,Michael J. Koenig, Krista La Perle, Timothy G. Whitsett,MuhammedMurtaza, Jeffrey M. Trent, David P. Carbone,and William P.D. Hendricks

5878 Tumor-Localized Costimulatory T-CellEngagement by the 4-1BB/HER2 BispecificAntibody-Anticalin Fusion PRS-343Marlon J. Hinner, Rachida Siham Bel Aiba,Thomas J. Jaquin, Sven Berger, Manuela Carola D€urr,Corinna Schlosser, Andrea Allersdorfer,Alexander Wiedenmann, Gabriele Matschiner,Julia Sch€uler, Ulrich Moebius, Christine Rothe,Louis Matis, and Shane Anthony OlwillSee related commentary, p. 5732

5890 Bispecific Antibodies Enable Synthetic AgonisticReceptor-Transduced T Cells for TumorImmunotherapyClara H. Karches, Mohamed-Reda Benmebarek,Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus,Martina Geiger, Felicitas Rataj, Bruno L. Cadilha,Stefanie Lesch, Constanze Heise, Ramona Murr,Johannes vom Berg, Martin Jastroch, Daniel Lamp,Jian Ding, Peter Duewell, Gerhard Niederfellner,Claudio Sustmann, Stefan Endres, Christian Klein, andSebastian Kobold

5901 Activation of JAK/STAT Signaling inMegakaryocytes Sustains MyeloproliferationIn VivoBrittany Woods, Wei Chen, Sophia Chiu,Christian Marinaccio, Chunling Fu, Lilly Gu,Marinka Bulic, Qiong Yang, Anouar Zouak, Shengxian Jia,Praveen Kumar Suraneni, Kailin Xu, Ross L. Levine,John D. Crispino, and Qiang Jeremy Wen

5913 Clinical and Genome-Wide Analysis of SerumPlatinum Levels after Cisplatin-BasedChemotherapyMatthew R. Trendowski, Omar El-Charif, Mark J. Ratain,Patrick Monahan, Zepeng Mu, Heather E. Wheeler,Paul C. Dinh Jr, Darren R. Feldman,Shirin Ardeshir-Rouhani-Fard, Robert J. Hamilton,David J. Vaughn, Chunkit Fung,Christian Kollmannsberger, Taisei Mushiroda,Michiaki Kubo, Robyn Hannigan, Frederick Strathmann,Lawrence H. Einhorn, Sophie D. Fossa, Lois B. Travis, andM. Eileen Dolan

Table of Contents

v

on January 8, 2021. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

5925 Unbiased Metabolic Profiling Predicts Sensitivityof High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with6-Diazo-5-Oxo-L-NorleucineSabrina Z. Wang, Brad Poore, Jesse Alt, Antoinette Price,Sariah J. Allen, Allison R. Hanaford, Harpreet Kaur,Brent A. Orr, Barbara S. Slusher, Charles G. Eberhart,Eric H. Raabe, and Jeffrey A. Rubens

5937 Molecular Classification of Epithelial OvarianCancer Based on Methylation Profiling: Evidencefor Survival HeterogeneityClara Bodelon, J. Keith Killian, Joshua N. Sampson,William F. Anderson, Rayna Matsuno, Louise A. Brinton,Jolanta Lissowska, Michael S. Anglesio,David D.L. Bowtell, Jennifer A. Doherty, Susan J. Ramus,Aline Talhouk, Mark E. Sherman, andNicolas WentzensenSee related commentary, p. 5729

5947 ERK Regulates HIF1a-Mediated PlatinumResistance by Directly Targeting PHD2 inOvarian CancerZhuqing Li, Wei Zhou, Yi Zhang, Wei Sun,Mingo M.H. Yung, Jing Sun, Jing Li, Chi-Wei Chen,Zongzhu Li, Yunxiao Meng, Jie Chai, Yuan Zhou,Stephanie S. Liu, Annie N.Y. Cheung, Hextan Y.S. Ngan,David W. Chan, Wei Zheng, and Wenge Zhu

5961 The Genomic Landscape of Merkel CellCarcinoma and Clinicogenomic Biomarkers ofResponse to Immune Checkpoint InhibitorTherapyTodd C. Knepper, Meagan Montesion, Jeffery S. Russell,Ethan S. Sokol, Garrett M. Frampton, Vincent A. Miller,Lee A. Albacker, Howard L. McLeod, Zeynep Eroglu,Nikhil I. Khushalani, Vernon K. Sondak, Jane L. Messina,Michael J. Schell, James A. DeCaprio, Kenneth Y. Tsai, andAndrew S. Brohl

5972 Liver- and Microbiome-derived Bile AcidsAccumulate in Human Breast Tumors and InhibitGrowth and Improve Patient SurvivalWei Tang, Vasanta Putluri, Chandrashekar R. Ambati,Tiffany H. Dorsey, Nagireddy Putluri, and Stefan Ambs

5984 Dual Farnesyl and Geranylgeranyl TransferaseInhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic TumorsAslamuzzaman Kazi, Shengyan Xiang, Hua Yang,Liwei Chen, Perry Kennedy, Muhammad Ayaz,Steven Fletcher, Christopher Cummings,Harshani R. Lawrence, Francisca Beato, Ya'an Kang,Michael P. Kim, Andrea Delitto, Patrick W. Underwood,Jason B. Fleming, Jose G. Trevino, Andrew D. Hamilton,and Said M. Sebti

5997 Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–MediatedSodium Iodide Symporter (NIS) Gene 131ITherapyChristina Schug, Carolin Kitzberger, Wolfgang Sievert,Rebekka Spellerberg, Mariella Tutter, Kathrin A. Schmohl,Bernadette Eberlein, Tilo Biedermann, Katja Steiger,Christian Zach, Markus Schwaiger, Gabriele Multhoff,Ernst Wagner, Peter J. Nelson, and Christine Spitzweg

LETTERS TO THE EDITOR

6009 Clinical Significance of AR-V567es in ProstateCancer—LetterTakuma Uo and Stephen R. Plymate

6010 Clinical Significance of AR-V567es in ProstateCancer—ResponseScott T. Tagawa, Emmanuel S. Antonarakis, Ada Gjyrezi,Giuseppe Galletti, and Paraskevi Giannakakou

AC icon indicates AuthorChoice

For more information please visit www.aacrjournals.org

Table of Contents

vi

on January 8, 2021. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

ABOUT THE COVER

The cover shows a section of a tumor biopsy from a patient with malignant mesothelioma.Multiplex immunohistochemical staining reveals different immune cell populationsinfiltrating the tumor. For details, see the article by Hassan and colleagues on page 5787 of thisissue.

Table of Contents

vii

on January 8, 2021. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

2019;25:5727-6011. Clin Cancer Res     25 (19)

  Updated version

  http://clincancerres.aacrjournals.org/content/25/19

Access the most recent version of this article at:

   

   

   

  E-mail alerts related to this article or journal.Sign up to receive free email-alerts

  Subscriptions

Reprints and

  .pubs@aacr.org

To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at

  Permissions

  Rightslink site. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC)

.http://clincancerres.aacrjournals.org/content/25/19To request permission to re-use all or part of this article, use this link

on January 8, 2021. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from