classification of antimicrobial agents
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CLASSIFICATION OF
ANTIMICROBIAL AGENTS
DR ARPITA SHRIVASTAV,ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY
COLLEGE OF VETERINARY SCIENCE & A.H. REWA
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Classification of
antimicrobial agents1.Based on mechanism of action
2.Based on therapeutic use/ organisms affected
3.Based on spectrum of activity
4.Based on type of action
5.Antimycobacterial agents
6.Based on source
7.Based on Chemical structure
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1.Based on mechanism of
action
A. Cell wall synthesis inhibitor a. Penicillin
b. Cephalosporins
c. Cycloserine
d. Bacitracin
e. Vancomycin
f. Clotrimazole
g. Monobactum
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Cell membrane synthesis
inhibitor
a. Amphoterecin B
b. Polymyxin
c. Nystatin
d. Meconazole
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Protein synthesis inhibitor
a. Binding with 50s RNA unit-
eg.Chloramphenicol,Tetracyclines, Clindamycin,
Macrolides
b. Binding with 30s RNA unit-eg. Tetracyclines,
Aminoglycosides, Spectinomycin
c. Inhibiting elongation factor-eg. Fusidic acid
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Nucleic acid synthesis
inhibitora. RNA synthesis inhibitor-eg.Rifamycin ,Rifampicin
b. DNA synthesis inhibitor-eg.Quinolones
Interfere with intermediary
metabolisma. sulfonamide
b. Trimethoprim
c. Pyrimethamine
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2.Based on therapeutic use/ organisms affected
Antibacterial
a. Penicillin,,
b. Chloramphenicol
c. tetracyclines
d. Aminoglycosides
Antifungal
a. AmphotericinB,
b. Griseofulvin
c. kotoconazole
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Antiviral
a. Acyclovir
b. Idoxuridine
c. Vidarabine
d. Zidovudine
e. Ribavirin
Antiprotozoal
a. Metronidazole
b. Quinapyramine
c. Diminazine
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Anthelmintics
a. Albendazole
b. Levamisole
c. Niclosamide
d. praziquantel
Ectoparasiticides
a. Cypermethrin
b. Lindane
c. Amitraz
d. Ethion
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3.Based on spectrum of
activity
Broad spectrum
a. Tetracyclines
b. Chloramphenicol
c. Gentamycin
d. Ampicillin
Narrow spectrum-
a. penicillin G
b. Streptomycin
c. Erythromycin
d. Vencomycin
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4.Based on type of action
Bacteriostatics
a. Erythromycin
b. Sulfonamide
c. Trimethoprim
d. Clindamycin
e. Chloramphenicol
Bactericidal
a. Penicillin G
b. Streptomycin
c. Vencomycin
d. Bacitracin
e. Potentiated
sulfonamides
f. Cephalexin
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5.Antimycobacterial agents
a. Isoneazide
b. Paraamino salisyclic acid.
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6.Based on source
Funji
a. Penicillin G
b. Cephalexin
c. Griseofulvin
Actinomycetes-
a. Erythromycin
b. Chloramphenicol
c. Streptomycin
d. Tetracyclines
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Bacteria
a. PolymyxinB
b. Colistin,
c. Bacitracin
Synthetic
a. Sulfonamide
b. Trimethoprim
c. Quinolones
d. Nitrofurans
e. Nitroimidazole
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7.Based on Chemical
structure
a. Sulfonamide group-trimethoprim,ormethoprimbaquiloprim
b. Diaminopyramidine group-Sulphadimidine,sulphadiazine,sulphanilamide
c . Quinolones-nalidixic acid, enrofloxin, ciprofloxin
d. Beta lactam antibiotics-Penicillin G,Ampicillincephalexin Cloxacillin
e. Aminoglycosides –Streptomycin gentamycin
f. Tetracycline-Tetracycline,Doxycyclines,oxytetracyclines
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g. Macrolides-Eryomycin, azithromycin
h. Polypeptide antibiotics --Polymyxin B, Colistin,Bacitracin
i. Nitrofuran derivatives-Nitrofurantoin,furazolidone
j. Nitroimidazoles-Metronidazole, tinidazole
k. Polyene antibiotics- AmphotericinB,Nystatin
l. Imidazole derivatives-Ketoconazole fluconazole, clotrimazole.
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