citogenÉtica convencional y fish

7/23/2019 CITOGENTICA CONVENCIONAL Y FISH

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CLVBNOEVLCMCBEQOECLBEMH \

ALS@_elfmf fo Noevlcm LEOEOptbslvbz7 Lev% VK% Gmsbe ZbsmfbSmefbqmh


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]u os ue cmzlbvltb2Os oh bzfoemkloevb fo hbs czbkbsbkms fo uem chuhm kovmaslcmfo mcuozfb m su kbzabhbnm vmhos cbkb oh vmkmb hm zohmcle fohbs jzmwbs fotoefloefb fo hm cbesvzlccle tzlkmzlm tzosoeclm fo

cbesvzlcclbeos socuefmzlms ovc% Os cmzmcvozsvlcb fo cmfm

ostoclo mh lnumh }uo oh ekozb fo czbkbsbkms9 oh soz `ukmebvloeo 61 czbkbsbkms oe oh echob fo cmfm chuhm bznmelwmfbs oe:: tmzos muvbsklcbs | = tmz sopumh (`bkjzo P\ | kugoz PP,%


3/46

Hm ClvbnoevlcmOs oh osvuflb foevzb foh cmktb fo hm noevlcmfo hbs czbkbsbkms su osvzucvuzm su `ozoeclm

| foh hunmz fbefo so oecuoevzme

Clvbnoevlcm Cbeqoeclbemh Clvbnoevlcm Kbhocuhmz

ALS@ chslcb

K+ALS@

SI\

CN@

Jmefms ]Jmefms ZJmefms NJmefms C

Jmefms EBZ

Jmefob fo MhvmZosbhucle


4/46

OQBH_CLE FO HM CLVBNOEVLCM

m Gzko Hogoueo cbesvzu|oefb uecmzlbvltb `ukmeb oe su hmjbzmvbzlbfo Tmzs (mjzlh fo =


5/46

Cuhvlqb | cbsoc`m fo Smenzo tozlazlcm


6/46

Cmzlbvltb Cbeqoeclbemh


7/46

VLTBS FO JMEFOB

CZBKBSKLCB


8/46

Jmefms ]

Jmefms ]

Oh tzlkoz kvbfb fo vleclefosmzzbhhmfb

Zo}ulozo ue klczbscbtlbfo ahubzoscoeclm

Jmefms ] jzlhhmevos ; jmefms N bscuzms

Fokbsvzmz hm tbzclbeflsvmh \}

Zonlbeostozlcoevzbkozlcms fo 3| 6 | hms zonlbeossmvohlvmhos | tozlcoe+vzbkzlcms fo mczbcevzlcbs kuosvzmetbhlkbzalskb


9/46

Jmefms Z

Jmefob leqozsb b Z

(*zoqozsb*,Btuosvb mh jmefob Nvlh tmzm volz hbsopvzokbs flsvmhos fo hbsczbkbsbkms (fohoclbeos bzobznmelwmclbeos flsvmhos,


10/46

Jmefms N

Jmefms N+thlfms

FEM zlcb oeNC

Zothlcmclevoktzmem

Kuc`bsnoeos

Jmefms N+bscuzmsFEM zlcb oeMVZothlcmclevmzfmTbcbs noeos


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Lfobnzmkm


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Jmefms C

Jmefms CVmkmb fo hm zonle fo

`ovozbczbkmvlem cbesvlvuvlqmtozlcoevzbkzlcmsTmzm =


13/46

Jmefm Kvbfb Cmzmcvozsvlcms

] Vlecle cbe }ulemczlem Jmefms ahubzoscoevosjzlhhmevos%

N Vlecle cbe Nloksm huonb fotzo+vzmvmkloevb foh czbkbsbkm

Hms jmefms N bscuzmscbzzostbefoe m hms ]

jzlhhmevos

Z Qmzlms vcelcmsTmvze leqozsb mh fo hms ]| N vlhos tmzm foalelz

hbs opvzokbs fo hbsczbkbsbkms%

V Qmzlms vcelcms Zosmhvme hms zonlbeosvohbkzlcms%

C Opvzmccle fo FEM"tzbvoemsvlecle cbe Nloksm

Zosmhvme hms zonlbeoscoevzbkzlcms%

EBZ Vlecle cbe thmvmVloe hms zonlbeos

bznmelwmfbzms foh euchbhb(mczbcevzlcbs oe oh

`bkjzo,


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Vzlsbkm tmzclmh fo :=}MTHLCMCLBEOS


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Fp tzoemvmh Vzlsbkm =3MTHLCMCLBEOS


16/46

BECBHBNM

HKC

MTHLCMCLBEOS


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Houcoklm Kbebcvlcm Mnufm (K?,

BECBHBNM

MTHLCMCLBEOS


18/46

Qoevmgms=+ Tozklvo qoz mh noebkm oevozb oe uem sbhm qow%:+ Cbeqoeloevo cumefb so sbstoc`m uem mebkmhm

ostocalcm (ogk% T` oe HKC, | cbkb `ozzmkloevm fo

Fp noeozmh tmzm fovocvmz oh c`z mflclbemh%Mebzkmhlfmfos cbkekoevo qlsvbs oe hm tzbnzosle fohm oeaozkofmf fo HKC

Fosqoevmgms

=+ Fovocvm mebzkmhlfmfos osvzucvuzmhos nzmefos( uem jmefm ; 1Kj fo FEM =?4 noeos ,%:+ Eocoslvm kuc`b vzmjmgb | mhvm optozloeclm |

`mjlhlfmfos tbz oh btozmfbz

Qoevmgms | fosoevmgms fo hm Clvbnoevlcmcbeqoeclbemh


19/46

ALS@ ]u os ALS@2

ALS@ os uem vcelcm klpvmfo clvbnoevlcm kbhocuhmz

}uo ebs tozklvo oh flmnesvlcbztlfb fo mebkmhms czbkbsklcms

oe kovmamso b levozamso% _vlhlwm tmzm ohhbuem sbefm fo MFE kmzcmfb


20/46

TZLECLTLBS FO ALS@


21/46

TZLECLTLBS FO ALS@


22/46

Ahubzoscoeco le slvu`|jzlflwmvlbe (ALS@,

Leczokoevm hm soesljlhlfmf ostoclalclfmf | zosbhuclefoh mehlsls czbkbsklcb%

Hms sbefms fo FEM kmzcmfbscbe ahubzbczbkbs sbe usmfbstmzm fovocvmz b cbealzkmznoeos b mebzkmhlfmfosczbkbsklcms }uo qme ksmhh fo hm clvbnoevlcm fozuvlem

Kovmamso ALS@ Levozamso ALS@


23/46

Kovmamso+ ALS@ Levozamso+ALS@


24/46

SBEFMS COEVZBKZLCMS (COT,

SBEFMS FO HBC_S OSTOCALCB (HSL,

SBEFMS TMLEVLEN (^CT,

SBEFM VOHBKZLCM (VOH,

VLTBS FO SBEFMS

V TB FO BEF


25/46

Coevzbkzlcb

Hbcus ostocalcb

Tlevmfb czbkbsklcb

VLTBS FO SBEFMSALS@ CBEQOECLBEMH


26/46

Sbefms Fumh+auslbe

Tmvze ebzkmh Echob oelevozamso

Czbkbsbkms oe kovmamso


27/46

Sbefms Fumh+auslbe

Vzmeshbcmcle zoctzbcmEchob oelevozamso



28/46

Sbefms Jzomi+mttmzv

Tmvze ebzkmh Echob oelevozamso



29/46

Sbefms Jzomi+mttmzv

Vzmeshbcmcle zoctzbcmEchob oelevozamso



30/46

Fovoccle fo Vzlsbkm | Fovozklemcle foh sopb

Sbefms tmzmczbkbsbkms

=3=0:=P\| SZ\%

MTHLCMCLBEOS


31/46

61P\Fovozklemcle fo tzbjmjho cmzlbvltb%

Qozfo ; PZbgb ;\

MTHLCMCLBEOSP+ o \+sbefms coevzbkzlcms


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Kmzcmfbz os uefozlqmvlqb fohczbkbsbkm P 9

Tbsljho Cmzlbvltb7

6>PPfoz(P,

]u so fojozmcbechulz foh `mhhmwnbcbe ALS@2

MTHLCMCLBEOSP+sbefm coevzbkzlcm lfoevlalcmcle fo czbkbsbkm

to}uob sutozeukozmzlb (c`z% Kmzcmfbz,


33/46

Becbhbnm

Sbefms fo hbcus elcbs( fohocle b mkthlalcmcle,T?0 CHI+= Hbcus (=t31,%F>S601 (>}3=,%Zovlebjhmsvbkm (=3}=6,%T?3 (=>t=3%=,%@oz+:" eou (=>}==%:+}=:,%

MTHLCMCLBEOS

Eb Mkthlalcmfb

MkthlalcmfbALS@ " @OZ :

O


34/46

Becbhbnm

jcz"mjh vzmeshbcmcle v(


35/46

HKC SBEFM FO A_SLEv


36/46

EONMVLQB TMZM A_SLE NELCM TKH"ZMZM

TKH SBEFM TKH

ZMZM

SBEFMZMZM

TBSLVLQB TMZM A_SLE NELCM TKH"ZMZM

ZMZMTKH

TKH"ZMZMTKH"ZMZM

MTHLCMCLBEOS

MTHLCMCLBEOS


37/46

ALS@ ebzkmh ALS@ v(=69=0,

Ln@ =6

Jch: =0

Ausle

Vzmeshbcmcle =69=0

Fumh Auslbe+ VzmeshbcmclbeosMTHLCMCLBEOS

MTHLCMCLBEOS


38/46

Ebzkmh Vzmeshbcmcle oe Jch:

Jch : Sthlv

Jzomi mttmzv + Vzmeshbcmclbeos

Vzmeshbcmcle oe Jch:

MTHLCMCLBEOS


39/46

ALS@Qoevmgms7 Hm zosbhucle os juoem ( :kj,% Tuofo soz mthlcmfm m chuhms oe chuhms oe flqlsle cbkb oe eb

flqlsle% Hm vcelcm os cbealmjho% Hm `ljzlfmcle cbe khvlthos sbefms tozklvo hm fovoccle fotzbfucvbs fo vzmeshbcmcle% Tuofo lfoevlalcmz ue zmenb fo kuvmclbeos% Kbelvbzob tozlflcb b oeaozkofmf zoslfumh oe KB%Fosqoevmgms7

Eb tuofo fovocvmz to}uoms kuvmclbeos% Bklvo _eltmzoevmh flsbkms% Bklvo Leqozslbeos% Sbefms eb osve cbkozclmhkoevo flstbeljhos tmzm vbfbs hms

zonlbeos czbkbsklcms%


40/46

Cmzlbvltmcle ostocvzmh ( SI\,

SI\


41/46

SI\Qoevmgms7 Kmtob fo tuevbs fo }ulojzo czbkbsklcbs% Fovoccle fo vzmeshbcmclbeos suvlhos% Lfoevlalcmcle fo czbkbsbkms kmzcmfbzos zonlbeos

`bkbneomkoevo tlevmfms| czbkbsbkms fbjho kleuvo

Cmzmcvozlwmcle fo zomzzonhbs cbkthogbs%Fosqoevmgms7 O}ultbs ku| cbsvbsbs% Hm vcelcm os hmjbzlbsm% Eb so tuofoe fovocvmz zomzzonhbs czbkbsklcbs cbe =

shb czbkbsbkm% Jmgm zosbhucle (km|bz m =? Kj ,% Ostocalcb tozb eb cbkb kvbfb fo sczooelen%

@ j f N


42/46

@ljzlfmcle Noeklcmcbktmzmvlqm ( CN@,
http://theoncologist.alphamedpress.org/content/vol8/issue1/images/large/45_fig3.jpeg


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CN@

Qoevmgms7 Zo}ulozo shb FEM noeklcb vukbzmh% Tuofo soz mthlcmfb m voglfbs azoscbs b

cbenohmfbs hleoms cohuhmzos | kuosvzmsmzc`lqmfms algmfms cbe abzkmhlem |tmzmalemfms%

Fosqoevmgms7 Eb tuofo fovocvmz mebzkmhlfmfos

jmhmecomfms% Cbtlms fo cmkjlbs czbkbsklcbs 8 =4 kj% Eb

sbe zosuohvbs


44/46

Cumefb mthlcmz ALS@2

Musoeclm fo voglfb azoscbSl so `m mthlcmfb clvbnoevlcm7

Cmzlbvltbs ebzkmhos (hleabclvb V, Kovmamsos cbe czbkbsbkms fo kmhm

cmhlfmf

Cmzlbvltbs ku| cbkthogbs flaclhos fofoalelz


45/46

CLVBNOEVLCM Zo}ulozo chuhmsoe flqlsle Zo}ulozo voglfb

azoscb Tozklvo fovocvmzmhvozmclbeosfo vbfb oh noebkm Jmgb cbsvoocbeklcb

ALS@ Eb zo}ulozo chuhmsoe flqlsle Tozklvo osvuflmz

kmvozlmh tmzmalemfb bcbenohmfb Sbhb mtbzvmleabzkmcle fo hmsbefm }uo so uvlhlwm Kbfozmfb cbsvo

ocbeklcb

CLVBNOEVLCM CBEQOECLBEMH qs ALS@


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citogenÉtica convencional y fish

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