circulation

KIDNEYS

ureters

bladder

Glomerulus (plasma filtration)

Tubule (reabsorption)

urethra

URINARY-PROTEOMEto the ureter30% circulation

70% urogenital tract

Figure 1

primitive urine

= reabsorption

NEPHRON

final urine

Figure 2

Ureteropelvic junction (UPJ) obstruction

Spontaneousresolution

Relief surgery (pyeloplasty)

?Intermediateobstruction

Spontaneous resolution

pyeloplasty

birth 1 to 2 years

scintigraphies

A

B

–1

–0.5

0

0.5

1

Mem

bers

hip

9 months

spontaneous resolution

surgery

Clin

ical

ev

olu

tio

n

15 months

Pre

dic

tio

n b

ased

on

u

rin

ary

pro

teo

mic

s

Figure 3

LARGE DYNAMIC

RANGELigand peptide library

(millions of different ligands)

Flow-Through:Highly abundant proteins

REDUCEDDYNAMICRANGE

+