R O Y A L C O M M I S S I O N C O L L E G E A N D I N S T I T U E S A T Y A N B U

SYLLABUS (COURSE SPECIFICATION)INSTITUTION YANBU INDUSTRIAL COLLEGE Dat

e5-1-2015

DEPARTMENT CHEMICAL ENGINEERING TECHNOLOGY (CHET)A. Course Identification & General Information

Course Title Advanced Instrumental Analysis

Course Code CHET XXX Credit hrs :03

Program (s) in which the course is offered

CHEMICAL ENGINEERING TECHNOLOGY PROGRAM (CHETP)

Faculty member responsible for the course

Name RoleDr. Jagadeesh Ellil X TeacherEr. Krishna Prasad Rajan

X Program Coordinator

Dr. Jagadeesh Ellil X Course CoordinatorDr.Jagadeesh Ellil X Subject Matter ExpertDr. Fahd Aloufi X Head of Dept.

Level/year at which this course is offered

□ Certificate

□ Vocational □ Associate

Bachelor □ Masters

□ Professional

□ Special Prog.

Year at which this course is offered

□ Prep Year □ Second Year □ Third Year

Fourth Year

□ Fifth Year

Pre-requisites for this course (if any)

None

Co-requisites for this course (if any)

None

Location if not on main campus

Course Description

Micro and Ultra-micro analysis of chemical entities in a variety of matrices is gaining importance in industrial, medical, food and Agriculture sectors. In addition chemical analysis is essential to prevent the proliferation of toxics in our environment. Knowledge on sophisticated instruments, their operational methods and high skills to handle them are essential for this purpose. The Advanced Instrumental Analysis course is designed to provide the students the required knowledge and skill in spectroscopic, electrochemical, chromatographic and thermal analytical methods. The spectroscopic methods would cover Inductively Coupled Plasma-Atomic Emission (ICP-AES), Atomic Absorption, Infra-Red (IR), Ultra Violet-Visible (UV-VIS), Molecular fluorescence, X-Ray Fluorescence (XRF) and Mass Spectrophotometric techniques. Electroanalytical methods included are Conductometry, Potentiometry, Voltammetry and Coulometry. Chromatographic methods include Gas Chromatography and Liquid Chromatography coupled with Mass Spectrometry. Thermal analytical methods cover Thermo Gravimetric Analysis (TGA), Differential Thermo Gravimetry (DTG), Differential Thermal Analysis (DTA) and Differential Scanning Calorimetry (DSC). Course will focus on hand on experience of all the related instruments; sample processing, instrument calibration, sample analysis, data analysis and interpretations.

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B. Course Objectives and Learning Outcomes

Course’s Contribution to Program and College/Institute Goals

The contribution of the course is analytical looked into by mapping course learning outcomes (CLOs) with course objectives. The course objectives are consistent with programs, and college goals to prepare its graduates for a profession ready employment??.

Mapping Matrix (Curriculum Matrix)

Mapping of course learning outcomes (CLOs) to Program(s) goals

ABET/ETAC Student Outcomes / Program Specific Criterions

Mapping of CLOs

to College goals

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Eng

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Eng

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Fun

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Exp

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Des

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Impa

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CLO 1.01

CLO 1.02

CLO 1.03

CLO 1.04

CLO 2.01

CLO 2.02

CLO 2.03

CLO 3.01

CLO 3.02

CLO 3.03

CLO 4.01

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CLO 4.02

CLO 4.03

Course Objectives

1.To gain a fundamental understanding of the theoretical basis of measurements spectroscopy and its dependence on molecular structure, the physical chemistry of underlying interaction of light and matter, and the chemical interactions among molecules that are the driving forces for analytical separations.

2. To be able to select and apply appropriate instrumental methods of analysis to problems in any of the sciences. This goal involves understanding of the fundamental nature and practical applicability of measurement methods and how to apply them to real-world problems.

3. To gain practical knowledge of how to carry out meaningful interpretation of data from analytical chemical measurements. The understanding necessary to interpret data correctly is achieved only by acquiring profound knowledge of both the theory and practice underlying a measurement system and any limitations involved.

Intended Learning Outcomes in the Domains of Learning

1. Knowledge and Understanding

Course Learning Outcomes Teaching Strategies and Activities Assessment Methods

1.01 Describe the principles and applications of electro-analytical methods such as potentiometry, conductometry, coulometry and voltammetry.

Lectures

Laboratory Exercises

Problem Solving Through Interactive Brainstorming Sessions

Projects and presentation

Reflective Activities

Assignments

Quizzes

Theory Examination

Laboratory Examination1.02 Describe the principles, general procedures for qualitative and quantitative applications of absorption , emission and fluorescence spectroscopy

1.03 Describe atomic and molecular spectroscopic instrumentations and their applications in analytical laboratory.

1.04 Describe principles and applications of selected analytical methods of separation.

1.05 Describe the main components of a gas and liquid chromatographs and their applications

1.06 Describe the principles, general procedures, and applications of thermal analytical techniques

1.07 Perform data analysis to interpret results, sample processing for various types of analyses and calibration of analytical instruments

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2.00 Cognitive Skills

Course Learning Outcomes Teaching Strategies and Activities Assessment Methods

2.01 Problem solving - Choose a proper analytical method and design a suitable procedure for estimating an analyte in a sample

Lectures

Small group interactive sessions

Laboratory Exercises

Lab reports

Assignments

Time-constrained exam and assignments2.02 Logical thinking and analysis – Perform

troubleshooting when precision and accuracy are not met with as desired in an analysis

2.03 Intellectual flexibility – Produce reliable results by adopting proper calibration procedures

3.00 Interpersonal Skills and Responsibility

Course Learning Outcomes Teaching Strategies and Activities Assessment Methods

3.01 Clarify personal values and objectives Assignments

Small group interactive sessions

Lab reports

Time-constrained exam and assignments

3.02 Work with a variety of people

3.03 Manage tasks and solve problems

4.00 Communication, Information Technology and Numerical Skills

Course Learning Outcomes Teaching Strategies and Activities Assessment Methods

4.01 Search appropriate literature and other scientific resources for problem formulation, analysis and design.

Expose and guide to self-directed learning so as to conduct independent internet and library based research to solve problems in the challenging areas of analytical chemistry

Train to lead a team to carry out a specific set of analysis on a variety of samples or different

Mid lab exam

Final lab exam

Completion of tasks in weekly laboratory exercises

Mini projects

4.02 Appraise appropriate mathematical tools (software, hardware and mathematical algorithms) for the solution of related problems in electronic systems engineering.

4.03 Communicate effectively, both orally and in written form using appropriate media, on complex engineering activities with the

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engineering community and with society at large.

analyses on the same set of samples through group projects

5.00 Psychomotor Skills (if applicable)

Course Learning Outcomes Teaching Strategies and Activities Assessment Methods

N/A N/A N/A

C. Course Components

Total Contact Hours and Credit Hours per Semester

Lecture Laboratory Tutorial Practical Other Total

Contact Hours 30 45

Credit Hours 2 1

Forms and Schedule of Assessment Tasks During the Semester

Assessment taskForm of assessment

Week due Proportion of final assessmentSummative Formative

☐ ☐ %

Assignments X ☐ 3,5, 7,11,13 5%

Quizzes X ☐ 3,5, 7, 11, 13

10%

Mid-Term Tests (Lab) X ☐ 8 10%

Mid-Term Tests (Theory) X ☐ 9 15%

Performances (Lab) X ☐ 15 10%

Final Examination (Lab) X ☐ 15 15%

Final Examination (Theory) X ☐ 16 35%

Student Support

)Availability of teaching staff for individual student consultations and academic advice per week)

10 hours per week

Topics to be Covered

List of topics Weeks Contact Hours

Electro-analytical Methods

State and explain the method of Representation of Electrochemical cells.

1,2 4

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Perform Calculation of Electrode Potentials and Applications of them.

Explain Reference electrodes, Indicator electrodes and their applications

Explain the principle of potentiometric Titrations and its employment in certain specific cases.

Describe the principle and method of Conductometric titrations.

Describe the principle and application of Coulometric and voltametric Methods of analysis.

Molecular Spectroscopy and Analytical Applications

Describe the basic principles absorption, emission and fluorescence spectroscopy

Explain the basic architecture of Spectrophotometers and describe the function of each component of the instrument viz. optical materials, source of radiation, wavelength selector, and detector

Differentiate and elaborate on the advantages various types of UV/Visible &IR spectrophotometers.

Describe qualitative and quantitative applications of molecular spectrophotometry

Explain the principle ,instrumentation and application of spectrofluorimeters

5,6 4

Atomic Absorption and Emission Spectroscopy and Their Analytical Applications

Identify the requirements for atomic spectrophotometry. Explain the process of atomization Describe the various types of atomizers and their advantages. Explain the working principles of Atomic Absorption Spectrophotometer and

its application for quantitative analysis. Explain the operation of Inductively Coupled Plasma Atomic Emission

Spectrophotometer and its application in simultaneous and multi-elemental analysis

Describe the principle, instrumentation and analytical applications of X-ray spectrometry.

7,8 4

Analytical Separation,Chromatography and their Analytical Applications Explain the Importance of separation in chemical analysis. Describe the Principles and calculations involved in Separation by liquid-liquid

and solid phase Extraction. Explain the Applications of Separation by Ion-Exchange. Describe the process of Chromatographic Separations Explain the architecture of Gas chromatograph and describe its Operational

details Elaborate on the applications Gas Chromatography

9,10 4

Mass Spectrometry Explain the principles of mass spectrometry Describe the parts and components of mass spectrometer and their functions

11 2

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R O Y A L C O M M I S S I O N C O L L E G E A N D I N S T I T U E S A T Y A N B U Explain the applications of GC and LC coupled with MS

Thermal Analysis and applications Explain the principle of thermo gravimetric analysis, Differential thermal

analysis and differential scanning calorimetry Describe the instrumentation details of TGA, DTA and DSC Describe the applications of thermal analysis.

12 2

Sample processing , Instrument Calibration , Data analysis and reporting Understanding the various methods of processing solid, liquid and gaseous

samples for various types of instrumental analyses.

Explain Standardization and Calibration procedures.

Describe the various Important Terms in the domain of Instrumental Analysis such as analyte, blank, matrix, sensitivity and detection limit.

Define and calculate the confidence interval, confidence level and confidence limits.

Identify the Types and Sources of Errors.

Perform Statistical Treatment of Random Errors.

Detect Gross Errors by Q Test.

Report analytical data in standard forms

13,14 4

Review 15 2

Final Examination 16 3 hours

Laboratory Outline (if applicable)

Laboratory exercises Weeks Contact Hours

Lab1: Determination of the Endpoint of an oxidation reduction titration by

Potentiometric Titration1 3

Lab2: Determination of Acid Concentration by Conductometric Titration 2 3

Lab3: Determination of metal ion concentration in an aqueous sample by ASV 3 3

Lab4: Determination of the amount of metal deposited on an electrode by Coulometry 4 3

Lab5: Estimation of ferric iron in a sample by complex formation and

spectrophotometry 5 3

Lab 6: Study on interaction of Infra-Red light with molecules and Interpretation of

Selected IR Spectra6 3

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Lab 7: Determination of the concentration of an organic compound by

spectrofluorimetry7 3

Mid Lab 8 3

Lab 8: Study of Matrix effect and elimination of it by standard addition technique for

the analysis of metal ion by Atomic Absorption Spectroscopy9 3

Lab 9: Simultaneous multi-elemental analysis of a water sample by ICP-AES 10 3

Lab 10: Resolving Chromatographic peaks by temperature programming in the analysis

of a mixture of hydrocarbons11 3

Lab 11: Analysis of a mixture of hydrocarbons with GC-MS 12 3

Lab 12: Analysis of some trace organics extracted from air by HPLC 13 1.5

Lab 13: A study on the thermal behavior of a polymer by simultaneous TGA and DSC 13 1.5

REVISION 14 3

FINAL LAB EXAM 15 3

A. Teaching and Learning Resources and Facilities

Required Textbook(s)

Title and ISBN Author(s) Publication year Edition Publisher

Principles of Instrumental Analysis -13:978-0495-01201-6

Skoog, Holler and Crouch

2007 6th Thomson Brooks/Cole

Essential References / Recommended Books

Title and ISBN Author(s) Publication year Edition Publisher

Analytical Chemistry Gary D. Christian 2004 6th John Wiley & Sons

Chemical Analysis Rouessac and Rouessac 2001 4th John Wiley & Sons

Required Software/Computer-Based Programs/Laboratory Equipment

Name Version (if any) Model/Year Company Other

UV-VIS Spectrophotometer Cary 50 Varian

Potentiometer 744 pH meter Metrohm

Conductivity meter Seven easy Mettler-Toledo

Polarograph Metrohm

Infra-Red Spectrophotometer IR Affinity-1 Shimadzu

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Atomic Absorption Spectrophotometer

AA 6200 Shimadzu

EDXRF Spectrophotometer Brucker

Inductively Coupled Plasma-Atomic Emission Spectrophotometer

icap6300 Thermo

scientific

Gas Chromatograph GC-2014 Shimadzu

Gas Chromatograph-Mass Spectrometer

Agilent

High Performance Liquid Chromatograph

Agilent

Simultaneous thermogravimetric analyzer and differential scanning calorimeter

SDT Q600 TA Instruments

Polarimeter Polax-2L Atago

B. Course Evaluation and Improvement Processes

Students’ feedback

Contents review through a technical forum of 3-4 faculty members

Contents review frequency: End of each semester

DeveloperHead of

Department(s)

Curriculum Development Unit

Head(s)

Head - Curriculum Development Dept.

Name Dr. Jagadeesh Ellil Dr. Fahd Aloufi

Signature

Completion Date 5-1-2015 5-1-2015

Received Date

Approved Date

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