Dear Customer

We are delighted to send you the third edition of our „Chemistry News „ Vol.3 including some of the latest updates of our Chemistry product portfolio.Our Marketing and Sales Team will be more than happy to support and assist you for any further information.

Your sincerely

Chemie Brunschwig AG Team

CHEMISTRYNEWS VOL.3 SEPTEMBER 2017

Contents

Environnement solvents from Biosolve page 2-3HYDROQUANT ® reagents from Biosolve page 4CP Solvents from Biosolve, incl.Promotion page 5 Tailor-made molecules to design drugs from Spirochem page 6 Tobacco alkaloids & nicotine compounds from Toronto page 7Conductivity & Osmolality from Reagecon, incl.Promotions page 8-9New ! Epak Cartridges from Silicycle page 10-11Informations on new Website www.chemie-brunschwig.ch page 12

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Environmental analysisby Biosolve

If you would like to receive a sample for testing, please ask us.

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Complete product flyer or specifications are available. Please contact us also if you would like to receive a price offer.

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HYDROQUANT® Reagents for Water Determination from Biosolve

Biosolve now offers a comprehensive range of coulometric and HYDROQUANT® reagents for water analysis by Karl-Fischer method

Complete brochure availabe, please contact us for more informations

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CP Solvents from Biosolve available from our stock in a few days

Contact us if you would like to receive more information, a certificate of analysis or a price offer.SPECIAL OFFER: 40% benefit from very attrac-tive prices on products listed below.

Have a look on our special offer on CP Solvents available in box of 4X5L.

Products are delivered within 2-3 days after receipt of your order, subject unsold.

Product Description Cat-No. Size Special Price*Acetone CP (HDPE Canister) 01030205 4X5L CHF 97.50

Cyclohexan (HDPE Canister) CP 03130205 4X5L CHF 142.10Ethanol absolute (Dehydrated) CP 05250205 4X5L CHF 130.10Diethyl Ether CP 05280205 4X5L CHF 240.00Ethylacetat CP (HDPE Canister) 05400205 4X5L CHF 110.00Methanol absolute CP 13680205 4X5L CHF 81.10Dichlormethan CP (HDPE Canister) 13790205 4X5L CHF 89.50Methyl Tert Buthyl Ether CP 13890205 4X5L CHF 284.60N-Pentane 95% CP 16050205 4X5L CHF 203.002-Propanol CP 16260205 4X5L CHF 121.90Toluene CP 20150205 4X5L CHF 142.10Petrol Ether 40 - 60 CP 17150205 4X5L CHF 162.70

*Prices are net, without any cumulative discount, ex works and excl. V.A.T. Offer valid until 31.12..2017

Biosole proposes a comprehensive line of Chemically Pure - reagents and solvents. These CP chemicals are suitable for chemical synthesis.

For the complete portfolio of Biosolve products, please visit our new website : www.chemie-brunschwig.ch

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Tailor-made molecules to design the drugs of tomorrow from Spirochem

Why Spirochem ?Their unique repertoire of molecular fragments was designed to help medicinal chemists accelerate drug discovery and lead optimization programs in the Life Science sector. In particular, their products and associ-ated services allow scientists and medicinal chemists to improve ADME properties and design better drugs for tomorrow. SpiroChem is now recognized as the world-leading company on the concept of bioisosterism with succesfully established leadership position on the highly sought-after field of conformationally-restric-ted molecules. They offer bioisosteric replacements for a variety of functional groups, such as acids, amides, heterocycles, lipophilic groups and benzenes.

Why Bicyclo[x.y.z]alkanes? Spirochem bicyclo[x.y.z]alkanes series is a useful addition to our portfolio of innovative chemical tools desi-gned in a continuous effort to provide as many solutions as possible to the medicinal chemistry community for accelerated drug discovery. With the growing success of the bicyclo[1.1.1]pentanes series, Spirochem wanted to extend the chemical spa-ce to their homologated versions. For example, the bicyclo[2.2.2]octanes are elongated versions of the [1.1.1] series and offer a linear positioning of exit vectors. Introduction of a bridge of a different length will generate an angle between the two exit vectors as seen in the [2.1.1], [2.2.1], [3.1.1] and [3.2.2] series (Figure), thereby potentially offering a 3-dimensional alternative to arenes with meta substitution patterns. Their bicyclo[x.y.z]alkanes can also be used as conformationally-restricted analogs of more standard car-bocycles (cyclobutanes, cyclopentanes, cyclohexanes), thereby offering a more rigid scaffold, positioning exit vectors in a fixed orientation and reducing the entropy.

SpiroChem AG is the Swiss fine chemicals company, specialised in creating novel building blocks for use in drug discovery by its pharma and biotech partners.

With a growing reputation as a trusted partner of choice in the life sciences industry and increasing demand for SpiroChem’s innovative products, the Company has relocated to new, enlarged facilities in the Rosental Area of Basel. Previously the Company was based at world-renowned ETH Zürich. This relocation is an exci-ting step for the Company as it provides an ideal location for SpiroChem to significantly expand its operations and foster collaborations with existing and new customers and partners.

For more informations, please contact us

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Contact us if you would like to receive more informations or a price offer.

News from Toronto Research Chemical

Discover a complete range of tobacco alkaloids and nicotine related compounds.

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• Extensive range of values: over 45 different values of Conducti-vity standards from 1.3μS/cm to 500,000μS/cm

• This low range of standards includes 1.3μS ±0.5μS the lowest aqueous conductivity standard available worlwide

• Guaranted stability• High level of Accurancy :Accurate to +/-1% *Accurancy for 1.3us/cm is +/-4%• Accreditation to ISO 17025• All values are Certified & Traceable to N.I.S.T:

Reagecon Conductivity Standards with special discount

Contact us if you would like to receive the Reagecon Brochure, a price offer or a free sample for testing.

Product Description Cat-No. Size Special Price*Conductivity Standard 84 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC84 500ml CHF 32.20Conductivity Standard 147 µS/cm @25°C, ISO17025 certified, NIST traceable CSKCS 500ml CHF 32.20Conductivity Standard 1278 µS/cm @20°C CS127805 500ml CHF 32.20Conductivity Standard 1,413 µS/cm @25°C, ISO17025 certified, NIST traceable CSKCL 500ml CHF 32.20Conductivity Standard 12,880 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC12880 500ml CHF 32.20Conductivity Standard 111,800 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC111800 500ml CHF 32.20Conductivity Standard 5 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC5 500ml CHF 123.10Conductivity Standard 10 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC10 500ml CHF 123.10Conductivity Standard 100,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC100M 500ml CHF 123.10Conductivity Standard 1.30 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC13 500ml CHF 123.10Conductivity Standard 100 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC100 500ml CHF 123.10Conductivity Standard 500 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC500 500ml CHF 123.10Conductivity Standard 1,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC1000 500ml CHF 123.10Conductivity Standard 20 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC20 500ml CHF 123.10Conductivity Standard 10,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC10M 500ml CHF 123.10Conductivity Standard 20,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC20M 500ml CHF 123.10Conductivity Standard 50,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC50M 500ml CHF 123.10Conductivity Standard 5,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC5M 500ml CHF 123.10Conductivity Standard 50 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC50 500ml CHF 123.10Conductivity Standard 150,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC150M 500ml CHF 123.10Conductivity Standard 200,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC200M 500ml CHF 123.10Conductivity Standard 200 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC200 500ml CHF 123.10Conductivity Standard 300,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC300M 500ml CHF 123.10Conductivity Standard 2,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC2M 500ml CHF 123.10Conductivity Standard 80,000 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC80M 500ml CHF 123.10Conductivity Standard 23.8 µS/cm @25°C, ISO17025 certified, NIST traceable CSKC238 500ml CHF 123.10

SPECIAL OFFER: 30% discount on all Conductivity standard products listed above

*Prices are net, without any cumulative discount, ex works and excl. V.A.T. Offer valid until 31.12..2017

Reagecon is the world largest producer of conductivity standards and is credited with the invention of low level aqueous standards.

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Complete product flyer or specifications are available. Contact us for your customized formulations.

Special offer on Osmolality Standards from Reagecon

*Prices are net, without any cumulative discount, ex works and excl. V.A.T. Offer valid until 31.12.2017

Product Description Cat-No. Size Special Price*Osmolality Standard 100mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-100 12x5ml CHF 93.80Osmolality Standard 200mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-200 12x5ml CHF 93.80Osmolality Standard 290mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-290 12x5ml CHF 93.80Osmolality Standard 300mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-300 12x5ml CHF 93.80Osmolality Standard 400mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-400 12x5ml CHF 93.80Osmolality Standard 50mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-50 12x5ml CHF 93.80Osmolality Standard 500mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM500 12x5ml CHF 93.80Osmolality Standard 600mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-600 12x5ml CHF 93.80Osmolality Standard 700mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-700 12x5ml CHF 93.80Osmolality Standard Protein Based 240mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-POSM-240 12x5ml CHF 93.80Osmolality Standard Protein Based 280mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-POSM-280 12x5ml CHF 93.80Osmolality Standard Protein Based 320mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-POSM-320 12x5ml CHF 93.80Osmolality Standard Urine Based 300mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-ROSM-300 12x5ml CHF 93.80Osmolality Standard Urine Based 800mOsm/Kg H2O (ISO/IEC 17025 accredited) REROSM-800 12x5ml CHF 93.80Osmolality Standard 1000mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-1000 12x5ml CHF 93.80Osmolality Standard 1500mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-1500 12x5ml CHF 93.80Osmolality Standard 2000mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-2000 12x5ml CHF 93.80Osmolality Standard 2500mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-2500 12x5ml CHF 93.80Osmolality Standard 3000mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-3000 12x5ml CHF 93.80Osmolality Standard 850mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-850 12x5ml CHF 93.80Osmolality Standard 900mOsm/Kg H2O (ISO/IEC 17025 accredited) RE-OSM-900 12x5ml CHF 93.80

SPECIAL OFFER: 30% discount on all Osmolality standard products listed above

• Test results of all standards accredited to ISO17025 • Range 50 to 700mOsm/Kg H2O• United States Pharmacopeia Compliant• European Pharmaacopoeia Compliant• Standards for Clinical Applications• For use with all Osmometers

Reagecon manufactures a wide range of Osmolality Standards for ease of use when calibrating all types of Osmometers, irrespective of brand. All Osmolality stan-dards are manufactured using high purity raw materials in accordance with European and United States Pharma-copoeia guidelines.

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Silicycle SiliaMets E-PAK cartridgesfor large Scale Metal Purification

Processes

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Complete product brochure, specifications or samples for testing are available, please ask us.

New by SilicycleThink Epack

Chemie Brunschwig AGAuf dem Wolf 10CH-4052 Basel

T +41 61 308 91 11F +41 61 308 91 19

info@brunschwig-ch.comwww.chemie-brunschwig.ch 12

Acros OrganicsBroad range of fine chemicals for research, development and production

Alfa AesarFine organics and research chemicals, including boronic acids and esters, aryl homopiperazines, zeolites and fluoroaromatic compounds

Angenequalitative specialty chemicals for use in research and development and commercial manufacturing

Apollo ScientificHigh quality fluorochemical products, organic intermediates and biochemi-cal reagents

Ark PharmBuilding blocks, scaffolds and other advanced intermediates.

BiosolvePeptide, DNA & RNA reagents and sol-vents for synthesis up to production.High purity reagents, formulations and solvents from preparative up to UPLC/MS quality

ChempurInorganics, high purity metals, pure elements, alloys compounds, precious metal catalysts and chemical referen-ce substances

Combi-BlocksCombinatorial building-blocks,organics and fine chemicals

Fisher ChemicalsHigh qualty reagents, solutions and solvents for the most analytical pur-poses: pH, volumetric analysis, ICP/AAS

FluorochemFluorinated products, heterocycles, boronic acids, sulphur compounds, novel organics, organometallics, sila-nes and siloxanes

HepatochemEvoluChem chemistry screening kits ideal tools for the investigation of chemical reaction conditionsEvoluChem PhotoChemistry device + kit designed for facilitate photochemi-cal experiments

LarodanSynthetic and natural lipids, biolipids

LinkHigh quality reagents for oligonucleo-tide synthesis and modification

MaybridgeInnovative chemical building-blocks and screening compounds for the drug discovery industry

Pfaltz & BauerRare and fine chemicals for laborato-ry, scale-up and manufacturing

PolysciencesMonomers and polymers for Micros-copy, Histology, Immunohistochemis-try, Cell Separation, Flow Cytometry, Molecular Diagnostic

ReageconLargest product range of chemical standards and reagents in the world for analytical chemistry

SilicycleFunctionalized silica gels, for he-terogeneous catalysis and for metal scavenging, SPE cartridges and well plates, flash cartridges, silica gels, TLC plates and SPE cartridges

StremMetals, inorganics, organometallics and catalysts

Spirochemspecialized in the design, synthesis and production of novel building blocks for use in drug discovery

TorontoAPIs, impurities & metabolites, stable isotope labeled analogues, buil-ding-blocks, nucleic acid derivatives and forensics

OUR NEW WEBSITE

WWW.CHEMIE-BRUNSCHWIG.CH

INFO ABOUT OUR CHEMISTRY PRODUCT SUPPL IERS

More information available on the new website, please have a look!We would be glad to support you.