1998 amino acids, peptides

amino acids, peptidesU 0400

32 - 251Synthesis of Ring-Halogenated Histidines and Histamines. —Histamines (or the corresponding histidine methyl esters) are halogenatedpredominantly in 5 position leading to monohalo compounds (III), whichmay be used for the preparation of mixed dihalo derivatives, such as (IV).2-Halo derivatives are only obtained via dehalogenation of 2-halo-5-bromo or2-halo-5-iodo compounds. — (JAIN, R.; AVRAMOVITCH, B.; COHEN, L.A.; Tetrahedron 54 (1998) 13, 3235-3242; Dep. Med. Chem., Natl. Inst. Pharm.Educ. Res., Punjab 160 062, India; EN)

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