1999 alkaloids

alkaloidsU 0600

33 - 241Quararibea Metabolites. Part 4. Total Synthesis and ConformationalStudies of (±)-Funebrine and (±)-Funebral. — The main secondarymetabolites of Quararibea funebris, funebrine (I) and funebral (II), isolatedfrom the flowers of title species in insufficient quantity, are synthesized for fullbiological evaluation. Their conformational preferences are studied by molecularmechanics calculation, NMR chemical shift, NOE, and barrier to rotationmeasurements. — (DONG, YING; PAI, NIRANJAN N.; ABLAZA, SHERIL.; YU, SHAO-XIA; BOLVIG, SIMON; FORSYTH, DAVID A.; LE QUESNE,PHILIP W.; J. Org. Chem. 64 (1999) 8, 2657-2666; Dep. Chem., Northeast.Univ., Boston, MA 02115, USA; EN)

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