ACCEPTED MANUSCRIPT

Characteristics of a Thyroid Carcinoma Cell Line Derived from Spinal Metastasis 

Zhenhua Zhou, Yan Li, Xu Yan, Xudong Wang, Su chen, Jianru Xiao 

Copyright 2016 The Author(s). This is an Accepted Manuscript; not the final Version of Record. You are encouraged to use the final Version of Record that, when published, will replace this manuscript and be freely available under a Creative Commons licence. All other rights reserved.

Cite as Bioscience Reports (2016) DOI: 10.1042/BSR20160403

BIOSCIENCE REPORTS

A thyroid carcinoma cell line named THY28 was established through primary culture of 

the surgical specimens, which were derived from a Chinese patient with spinal 

metastasis. The cell morphology, growth kinetics, cell cycle, chromosome number, cell 

capability of migration, tumorigenicity, cytogenetic features of the cell line were 

investigated. THY28 cells were subcultured in vitro for more than 50 passages with a 

human karyotype. The modal number of its chromosomes was mainly from 67 to 85. The 

doubling time of THY28 cells was 56 hours. The histopathological features of xenograft 

induced by THY28 cells were consistent with the characteristics of thyroid cancer. The 

biological and molecular properties of THY28 cells were not entirely consistent with 

those of other thyroid carcinoma cells such as SW579 and TT cells, indicating biological 

differences between primary and metastatic thyroid carcinoma cell lines. We have 

established a novel thyroid carcinoma cell line derived from spinal metastasis, which will 

provide a useful model for biological or therapeutic studies of thyroid carcinoma 

metastasis. 

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10.1042/BSR20160403. Please cite using the DOI 10.1042/BSR20160403http://dx.doi.org/up-to-date version is available at

encouraged to use the Version of Record that, when published, will replace this version. The most this is an Accepted Manuscript, not the final Version of Record. You are:Bioscience Reports

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