chapter 6 (questions 2008-2009 compiled)

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General pathology 2008-2009 Compiled by Bhupinder Bawa Q1. The binding of bacterial lipopolysacchride to cell membrane require all of the following proteins except? A. B. C. D. E. MD2 CD14 TLR4 MyD88 LPS binding protein

Q2. Which of the following can act as ligand for CD21? (Robbins pp 199, PBVD 200) 1. C3b 2. C3d 3. Epstein-Barr virus 4. CD80 5. CD86 A. B. C. D. E. 1,2 4,5 1,2,3 3,4,5 1,3

Q3. Which of the following lymphocytes can directly recognize antigen? 1. 2. 3. 4. 5. A. B. C. D. E. -TCR expressing T-lymphocyte -TCR expressing T-lymphocyte NK-T lymphocytes IgM expressing B-lymphocyte IgD expressing B-lymphocyte 1,2 4,5 1,4,5 2,4,5 1,2,3,4,5

Q4. All the following contribute to innate immunity EXCEPT A. B. C. D. E. Macrophages, neutrophils Complement, NK cells T-cells, B-cells Mucous, saliva Skin

General pathology 2008-2009 Compiled by Bhupinder Bawa Q5. The CD factor that plays an important role in LPS binding to TLR4 A. B. C. D. E. CD14 CD28 CD40 CD86 All the above

Q6. An activated T-cell after exposure to an antigen by MHC II undergo proliferation under the influence of which cytokine A. B. C. D. E. IL-2 IL-6 IL-1 IFN TNF

Q7. Which of the following membrane bound immunoglobin molecules plays the role of B-cell receptor and helps mature B-cell A. B. C. D. E. IgG, IgM IgE, IgM IgM, IgD IgA, IgE IgD, IgE

Q8. The co-stimulatory molecule on CD4 positive cell that is important in T-cell activation by AP (antigen presenting) cells A. B. C. D. E. CD14 CD18 CD28 CD86 CD105

Q9. Which of the CD factor helps B-cell to differentiate into plasma cell? A. B. C. D. E. CD14 CD28 CD40 CD86 CD105

Q10. Which of the following is/are part of the innate immune system? 1) Neutrophils

General pathology 2008-2009 Compiled by Bhupinder Bawa 2) Macrophages 3) Natural killer cells 4) Complement proteins 5) Mucociliary apparatus A. B. C. D. E. 1, 4, 5 1, 3, 4, 5 1, 2, 3, 4, 5 2, 4, 5 5 Q11. Which of the following TLRs has double stranded RNA as a ligand? A. B. C. D. E. TLR1 TLR2 TLR3 TLR4 TLR6 Q12. Which of the following statements is incorrect? A. B. C. D. E. CD3 is the T-cell receptor CD8+ cells recognize antigen in association with MHC I CD4+ cells recognize antigen in association with MHC II CD4 and CD8 molecules are required to initiate signals that activate T cells T cells recognize antigen without requirement for display by MHC molecules Q13. TH2 cells secrete which of the following cytokines? 1) Il-2 2) Il-4 3) Il-5 4) Il-13 5) IFN- A. B. C. D. E. 1, 2, 3 1, 5 2, 3 2, 3, 4 3, 4, 5 Q14. Which TLR is responsible for binding LPS? A. TLR-2 B. TLR-4 C. TLR-6 D. TLR-7

General pathology 2008-2009 Compiled by Bhupinder Bawa E. TLR-8 Q15. Where would you not normally expect to see a majority of T-lymphocytes? A. B. C. D. E. Circulating in blood Ileal Peyers patches Paracortical areas of the lymph node Peri-arteriolar sheaths of the spleen All are correct

Q16. Which of the following is not a component of the T-cell receptor complex on the surface of a helper T-cell? A. B. C. D. E. CD3 CD4 CD28 CD80 TCR-

Q17. A failure of T-cells to express CD40 ligand (now called CD154) has been associated with which immunoglobulin syndrome? (Robbins p.199) A. B. C. D. E. Hypo IgG Hypo IgA Hyper IgG Hyper IgM Hyper IgE

Q18. Which following TLR is involved with viral detection A. B. C. D. E. TLR 2 TLR 3 TLR 4 TLR 5 TLR 6

Q19. Which molecule is not involved in the activation of transcription with TLRs A. B. C. D. E. TIR IRAK CD28 NF- MyD88

Q20. TH2 lymphocytes do not produce

General pathology 2008-2009 Compiled by Bhupinder Bawa A. B. C. D. E. IL-2 IL-3 IL-4 IL-5 IL-13

Q21.Which is not part of Signal 1 of the T-cell receptor complex A. CD4 B. CD28 C. chains D. CD3 complex E. heterodimer Q22.. All of the following dendritic cells function as antigen presenting cells except? A. B. C. D. E. Langerhans cells Follicular dendritic cells Interstitial dendritic cells Circulating dendritic cells Interdigitating dendritic cells

Q23. All of the following are true for NK cells except? A. B. C. D. E. They are not MHC restricted They are bone marrow derived CD16 and CD 56 are used to identify NK cells Their cytoplasm contains perforin and granzymes They express both Fc receptor and antigen specific TCR

Q24. What is the sequence of events during antigen processing and presentation? 1. 2. 3. 4. 5. A. B. C. D. E. binding of peptides to newly synthesized MHC molecules transportation of MHC molecule to cell surface proteolysis of antigen into short peptides presentation of antigen to lymphocytes phagocytosis of foreign antigen 1,2,3,4,5 3,4,5,2,1 5,3,2,1,4 5,3,1,2,4 3,5,4,2,1

Q25. The following are the professional antigen presenting cells (APCs)

General pathology 2008-2009 Compiled by Bhupinder Bawa 1. 2. 3. 4. 5. Dendritic cells Macrophages Neutrophils B-cells T-cells A. B. C. D. E. 1 1,4 1,2,3,4 1,2,4 1,2

Q26.The significance of CD16 on the NK cells 1. 2. 3. 4. 5. Identification marker IgG mediated cytotoxicity Identification of virus infected cells Inhibitory receptor to MHC I No significance A. B. C. D. E. 1 1,2 1,2,3 4,5 5

Q27. Which of the following is not true regards MHC molecules A. B. C. D. E. NK cells are not MHC restricted NK cells recognize self by MHC I Endogenous antigens can express MHC I MHC I is expressed only by infected cells Exogenous antigens are expressed on MHC II

Q28. Which of the following pairs (tissue: monocyte/macrophage cell type) is incorrect? A. B. C. D. E. Liver: Kupfer cells Bone: Osteoclasts Kidney: Histiocytes Brain: Microglial cells Lung: Alveolar macrophages Q29. In a virally infected cell, which change in cell surface molecule expression would result in NK cell-mediated lysis?

General pathology 2008-2009 Compiled by Bhupinder Bawa A. B. C. D. E. Increased MHC class I expression Decreased MHC class I expression Increased MCH class II expression Decreased MHC class II expression Both a and d are correct Q30. Which CD molecule allows NK cells to function in antibody-dependent cellmediated cytotoxicity (ADCC)? A. B. C. D. E. CD16 CD56 CD94 NKG2D MHC class I receptor Q31. Which of the following steps is not involved with processing of intracellular antigens (Ags)? A. B. C. D. E. Ags are degraded by the proteasome complex Ags are internalized within endosomes or lysosomes MHC class I/peptide complex is recognized by CD8+ T-lymphocytes MHC class I/peptide complex is transported to the plasma membrane Ag peptides are complexed with MHC class I in the endoplasmic reticulum Q32.. Which cells express MHC class I molecules 1. 2. 3. 4. 5. B lymphocytes Dendritic cells Macrophages Kupffer cells Hepatocytes A. B. C. D. E. 1 1,2 1,2,3 1,2,3,4 1,2,3,4,5

Q33. NK-cell mediated lysis requires A. B. C. D. E. Decrease/loss of MHC class I molecules Expression of antigen-specific molecules Increase in ligands for activating receptor A&C All of the above

General pathology 2008-2009 Compiled by Bhupinder Bawa Q34. Which cytokine is not a part of innate immunity A. B. C. D. E. IL-1 IL-6 TNF- TGB- Type 1 interferons

Q35. Peptide fragments of MHC class I molecules bind between A. B. C. D. E. 1-2 2-3 1-1 1-2 1-3

Q36. Which of the following statements about NK cells is incorrect? A. B. C. D. E. Do not develop memory cells They are bone marrow derived Express CD3 but not CD4 or CD8 Are also referred to as large granular lymphocytes Contain cytotoxic granules containing perforin and granzyme Q37. Which of the following groups of chemokines are primarily produced by macrophages? A. B. C. D. E. C-C C-C-C C-X-C X-C-X C-X-X-C Q38. Which of the following statements about the MHC-II pathway is incorrect? A. B. C. D. E. MHC-II molecules have an and chain MHC-II presents antigen to CD4+ T-cells MHC-II molecules are associated with an invariant chain in the ER Binding of MHC-II and antigen peptide occurs in an endocytic vesicle Peptides that bind to MHC-II are usually derived from an endogenous source Q39. Atopic individuals are characterized by? A. Genetic predisposition to develop immediate hypersensitivity reactions B. More IL-4 producing Th2 cells C. Higher serum IgE levels

General pathology 2008-2009 Compiled by Bhupinder Bawa D. A and C only E. All of the above Q40. All of the following are required for direct activation and survival of eosinophils except? A. B. C. D. E. IL-3 IL-5 IL-13 Eotaxin GM-CSF

Q41. Which of the following can lead to vascular permeability, smooth muscle spasm and chemotaxis? A. B. C. D. E. PAF Histamine Leukotriene B4 Prostaglandin D2 Leukotrienes C4, D4

Q42 .Mice deficient of TH2 cell differentiation compromises to mount which type of hypersensitivity reaction A. B. C. D. E. Type 1 Type II Type III Type IV All

Q43. The primary vascular changes in Type I hypersensitivity following mast cell degranulation A. B. C. D. E. Edema Vascular dilation Vascular leakage Vascular constriction None of the above

Q44. The antibody that mediates most of the Type I hypersensitivity reactions A. B. C. D. E. IgA IgD IgM IgE All

General pathology 2008-2009 Compiled by Bhupinder Bawa Q45. Mast cell degranulation occurs by A. B. C. D. E. Cross linking of soluble IgE antibodies in the vicinity of Mast cells Binding of Allergin to IgE bound to Fc receptor of mast cell Cross linking of IgE bound to Fc receptor on mast cells Binding of IgE to Fc receptor on mast cell All the above

Q46. Which of the following is a ligand for NK cell inhibitory receptor? A. B. C. D. E. CD 94 MHC I Self proteins Viral proteins None of the above Q47. Which of the following are markers for NK cells? A. B. C. D. E. CD 3 CD 4 CD 16 CD 56 C and D Q48. Which of the following is not expected in the acute phase of a type I hypersensitivity reaction? A. B. C. D. E. Cell lysis Vasodilation Mucu