chapter 5 - personal.tcu.edupersonal.tcu.edu/yryu/50133/gene_expression_overview.pdfchapter 5 part...
TRANSCRIPT
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Chapter 5Part II. Gene expression and
replication (overview)
• Replication (DNA synthesis)• Transcription (RNA synthesis)• Translation (Protein synthesis)
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The central dogma of molecular biology
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DNA synthesis: Replication
(DNA)n + dNTP (DNA)n+1 + PPiDNA Polymerase
RNA primer
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Leading and Lagging Strands
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Removal of RNA primer
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DNA ligase
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Gene expression
Transcription
Translation
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RNAs
• Messenger RNA (mRNA): Carrier of the genetic information (codons)
• Transfer RNA (tRNA): Deciphering genetic codes (anticodons-amino acids)
• Ribosomal RNA (rRNA): Component of ribosome (ribozyme, protein synthesis)
• Small nuclear RNA (snRNA), Micro RNA (miRNA), small activating RNA (saRNA)
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RNA secondary and tertiary structure
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RNA Synthesis: Transcription
(RNA)n + NTP (RNA)n+1 + PPiRNA Polymerase
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Transcription bubble
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Control of transcription
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Post-transcriptional processing
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Structure of tRNA
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Aminoacyl tRNA synthetases (aaRSs)
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rRNA
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Ribosome
(E Site)
(P Site)
(A Site)
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Protein Synthesis: Translation
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Ribosomal reaction
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Ribosome in action
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The “Standard” Genetic Codes
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