chapter 24 chapter 24 spirochetes spirochetes chapter 24 chapter 24 spirochetes spirochetes

Download chapter 24 chapter 24 spirochetes spirochetes chapter 24 chapter 24 spirochetes spirochetes

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<ul><li> Slide 1 </li> <li> Slide 2 </li> <li> chapter 24 chapter 24 spirochetes spirochetes chapter 24 chapter 24 spirochetes spirochetes </li> <li> Slide 3 </li> <li> thin-walled, flexible, spiral rods motile through the undulation of axial filaments </li> <li> Slide 4 </li> <li> Cause disease in human Treponema : Leptospira : Borrelia: </li> <li> Slide 5 </li> <li> Histology: Treponema pallidum Histology: Treponema pallidum - testis infected rabbit </li> <li> Slide 6 </li> <li> Treponema pallidum transmission genital placenta 0.1-0.2 x 6-15um; 8-14 small, regular spirals syphilis syphilis </li> <li> Slide 7 </li> <li> characteristics spirochetes not seen on Gram-stained smear seen only by darkfield microscopy, silver impregnation or immunofluorescence not cultured in vitro </li> <li> Slide 8 </li> <li> habitat and transmission habitat: the human skin or mucous membranes intimate contact intimate contacttransmission from mother to fetus from mother to fetus across the placenta across the placenta </li> <li> Slide 9 </li> <li> Pathogenesis Produce no important toxins or emzymes multiplies at site of inoculation spread widely via the blood stream </li> <li> Slide 10 </li> <li> Early syphilis Primary syphilis: 2-10 weeks, local, nontender ulcer (chancre) Secondary lesions: maculopapular rash or moist papules rich in spirochetes and highly infectious rich in spirochetes and highly infectious 1st &amp; 2nd lesions heal spontaneously 1st &amp; 2nd lesions heal spontaneously some remain latent </li> <li> Slide 11 </li> <li> I II III </li> <li> Slide 12 </li> <li> Tertiary syphilis (late phase) Gummas , aortitis , central nervous system involvement, cardiovascular lesions Treponemas are rarely seen, noninfectious </li> <li> Slide 13 </li> <li> Congenitial syphilis Infected woman fetus Stillbirth Multiple fetal abnormalities </li> <li> Slide 14 </li> <li> Treatment Penicillin is effective in the treatment of Penicillin is effective in the treatment of all stages </li> <li> Slide 15 </li> <li> Leptospira interrogans Disease leptospirosis leptospirosis </li> <li> Slide 16 </li> <li> Leptospira </li> <li> Slide 17 </li> <li> Slide 18 </li> <li> characteristics characteristics tightly coiled, fine spirochete Not stained, can be seen on dark-field microscopy Grow in bacteriologic media containing serum (Korthoff media) </li> <li> Slide 19 </li> <li> Habitat and transmission habitat: rats, domestic livestock habitat: rats, domestic livestock transmission: via animal urine---- contaminate water and soil transmission: via animal urine---- contaminate water and soil (human contact contaminated environment) (human contact contaminated environment) </li> <li> Slide 20 </li> <li> pathogenesis High risk population: peasant, person who fight a flood, or fishing Ingested or pass through mucous membranes or skin Circulate in the blood Multiply in various organs </li> <li> Slide 21 </li> <li> Clinical findings Initial bacteremic phase: fever, chills and intense headache (conjunctivae congestion, pain of gastrocnemius, (conjunctivae congestion, pain of gastrocnemius, lymphadenectasis) lymphadenectasis) Subsequent immunopathologic phase: meningitis (stiff neck), liver damage (jaundice) and impaired kidney function </li> <li> Slide 22 </li> <li> diagnosis History of possible exposure Suggestive clinical signs Detect Ab Isolation of leptospiras </li> <li> Slide 23 </li> <li> Treatment Penicillin G </li> <li> Slide 24 </li> <li> avoid contact with the contaminated environment vaccination of livestock and pets rat control prevention </li> <li> Slide 25 </li> <li> Slide 26 </li> </ul>