chapter 13 meiosis and sexual life cycles "you're unique. just like everyone else..."


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  • CHAPTER 13 MEIOSIS AND SEXUAL LIFE CYCLES "You're unique. Just like everyone else..."
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  • Heredity transmission of traits from one generation to the next Variation offspring differ from parent Genetics study of heredity and variation Introduction
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  • Karyotypes- ordered displays of an individuals chromosomes
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  • Offspring acquire genes from parents by inheriting chromosomes 23 pairs Somatic cell 23Germ cell (sperm) 23Germ cell (egg) 23 pairs Somatic cell
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  • Sex, at what cost????? Sex is production of gametes by meiosis (halving the chromosome number), and then syngamy (fusion of gametes)
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  • Sex, at what cost????? asexual sexual reproduction Pass genes on twice as fast! No forfeiting of genes Forfeit half their genes - (in the trash!) BUT SEX HAS BEEN PRESERVED - WHY?
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  • More number of organisms Less variation Like begets like, more or less: asexual rep. sexual rep. More variation due to genetic recombination Increases fitness
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  • A life cycle is the generation-to-generation sequence of stages in the reproductive history of an organism. Fertilization and meiosis alternate in sexual life cycles A cell with a single chromosome set is haploid. A cell with a double chromosome set is diploid.
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  • The timing of meiosis and fertilization does vary among species.
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  • Most fungi and some protists have a second type of life cycle.
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  • Plants and some algae have a third type of life cycle, alternation of generation. This life cycle includes both haploid (gametophyte) and diploid (sporophyte) multicellular stages.
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  • Homologous chromosomes- are inherited one from mom and one from dad MOM DAD There are 23 pairs of homologous chromosomes A a BB
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  • Homologous chromosome pairs carry the genes that control the same inherited trait. How many homologous chromosomes do you have?
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  • Autosomes and Sex Chromosomes in body cells 22 pairs + XX = 22 pairs + XY= Autosomes Sex Chromosomes
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  • Homologous chromosome pairs are separated during MEIOSIS phase 1. A B C D E F G a b c d e f g A B C D E F G a b c d e f g A B C D E F G a b c d e f g Sister chromatids will separate during 2nd phase of meiosis. 2 of each type; so 4 gametes total But, the story does not end here. Johnny Johnnys sperm Sister chromatids still attached
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  • a b c d e f g Homologous chromosome pairs line up and undergo crossing over during meiosis. A B C D a b c d e f g E F G A B C D E F G a b c d e f g Johnnys sperm Johnny Johnny makes many, many recombinations of his parental genes in his sperm Each chromosome can cross over 2-3 times - lots of recombinations of genes!
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  • Two consecutive cell divisions, meiosis I and meiosis II, which results in four daughter cells. Each daughter cell has HALF the number of chromosomes as the parent cell Meiosis reduces chromosome number from diploid to haploid: Meiosis I Meiosis II
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  • Meiosis reduces chromosome number by copying the chromosomes once, but dividing twice. The first division, meiosis I, separates homologous chromosomes. The second, meiosis II, separates sister chromatids. Hence reduction division
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  • Meiosis I : includes prophase I, metaphase I, anaphase I, and telophase I. Interphase: (before Meiosis I) the chromosomes are replicated to form sister chromatids.
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  • Prophase I: chromosomes condense and homologous chromosomes pair up to form tetrads. Synapsis: special proteins -synaptonemal complex attach homologous chromosomes tightly together. Chiasmata: At several sites the chromatids of homologous chromosomes are crossed (chiasmata) and segments of the chromosomes are traded.
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  • Metaphase I, the tetrads/homologous chromosomes are arranged at the metaphase plate. Microtubules from poles are attached to homologous chromosomes (at centromeres)
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  • Anaphase I, the homologous chromosomes separate and are pulled toward opposite poles.
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  • In telophase I, movement of homologous chromosomes continues until there is a haploid set at each pole. Each chromosome consists of linked sister chromatids. Cytokinesis occurs
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  • Meiosis II is very similar to mitosis. Prophase II a spindle apparatus forms, attaches to kinetochores of each sister chromatids, and moves them around.
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  • Metaphase II, the sister chromatids are arranged at the metaphase plate. The kinetochores of sister chromatids face opposite poles. Fig. 13.7
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  • At anaphase II, the centomeres of sister chromatids separate and the now separate sisters travel toward opposite poles. Fig. 13.7
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  • In telophase II, separated sister chromatids arrive at opposite poles. Nuclei form around the chromatids. Cytokinesis separates the cytoplasm. At the end of meiosis, there are four haploid daughter cells.
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  • Mitosis produces two identical daughter cells, but meiosis produces 4 very different cells.
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  • Three mechanisms contribute to genetic variation: independent assortment crossing over random fertilization Sexual life cycles produce genetic variation among offspring
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  • Independent Assortment - 50% chance that gamete will get the maternal chromosome and a 50% chance it will get the paternal chromosome
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  • Independent Assortment - genes on different chromosomes can be assorted or mixed up to produce all combinations in gametes Aa Bb A AA A aa a a B B BB bb bb b b b bb B B BB B AA A A Aa aa a a A -Normal a - Albino B - Normal b - Bald Normal, baldAlbino, Hair Albino, bald Normal, Normal
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  • Independent Assortment Independent assortment - due to the random orientation of chromosomes at the metaphase plate. Chance of getting a chromosome from mom = Chance of getting a chromosome from dad = 50%
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  • The number of combinations possible when chromosomes assort independently into gametes is 2 n, where n is the haploid number of the organism. n = 23, there are 2 23 or about 8 million possible combinations of chromosomes from Independent assortment alone
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  • oIn crossing over, homologous portions of two nonsister chromatids trade places. For humans, this occurs two to three times per chromosome pair. oAlso, any sperm can fuse with any egg - random fertilization.
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  • So all in all variation resuls because - A zygote produced by mating of a woman and man has a unique genetic identity. An ovum is one of approximately 8 million possible chromosome combinations (actually 2 23 ). The successful sperm represents one of 8 million different possibilities (actually 2 23 ). The resulting zygote is composed of 1 in 70 trillion (2 23 x 2 23 ) possible combinations of chromosomes. Crossing over adds even more variation to this
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  • The three sources of genetic variability in a sexually reproducing organism are: Independent assortment of homologous chromosomes during meiosis I and of nonidentical sister chromatids during meiosis II. Crossing over between homologous chromosomes during prophase I. Random fertilization of an ovum by a sperm. All three mechanisms reshuffle the various genes carried by individual members of a population. Mutations, still to be discussed, are what ultimately create a populations diversity of genes.
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  • Darwin recognized the importance of genetic variation in evolution via natural selection. A population evolves through the differential reproductive success of its variant members. Those individuals best suited to the local environment leave the most offspring, transmitting their genes in the process. This natural selection results in adaptation, the accumulation of favorable genetic variations. Evolutionary adaptation depends on a populations genetic variation
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  • As the environment changes or a population moves to a new environment, new genetic combinations that work best in the new conditions will produce more offspring and these genes will increase. The formerly favored genes will decrease. Sex and mutations are two sources of the continual generation of new genetic variability. Gregor Mendel, a contemporary of Darwin, published a theory of inheritance that helps explain genetic variation. However, this work was largely unknown for over 40 years until 1900.
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  • Mitosis and meiosis have several key differences. The chromosome num


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