Chapter 11Cell Communication

Question?

How do cells communicate?

Why do cells communicate?

Cell Communication

Cell Signaling (C.S.)

Is a relatively “new” topic in Biology and AP Biology.

Appears to answer many questions in medicine.

Is a topic you’ll be hearing more about in your future.

Stages of C.S.

Reception

Transduction

Response

Reception

Direct Contact

Direct Contact

Signal Molecules

Signal Molecules

Receptor Molecules

Receptor Molecules

G-protein linked

G-protein

G-protein

G-protein linked receptors

G-protein linked receptors

G-protein linked receptors

Tyrosine-Kinase Receptors

Mechanism

Intracellular Proteins

Tyrosine-Kinase Receptors

Ion-channel Receptors

Ion-channel Receptors

Intracellular Signals

Intracellular Signals

Comment

Signal-Transduction Pathways

Protein Phosphorylation

Protein Kinase

Amplification

Secondary Messengers

Secondary Messengers

cAMP

Calcium Ions

Calcium Ions

Inositol Trisphosphate(IP3)

Start here Or Start here

Animation Link

http://entochem.tamu.edu/G-Protein/index.html

Cellular Responses

Cytoplasmic Regulation

Transcription Regulation

Question

If liver and heart cells both are exposed to ligands, why does one respond and the other not?

Alternate explanation

Comment

Chapter focused only on activating signals. There are also inactivation mechanisms to stop signals.

Summary Don’t get bogged down in

details in this chapter. Use the KISS principle.

Know - 3 stages of cell signaling.

Know - At least one example of a receptor and how it works (in detail).