ch 3: the molecules of cells. molecules of life the molecules of life are all organic...
TRANSCRIPT
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CH 3: The Molecules of CH 3: The Molecules of CellsCells
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Molecules of LifeMolecules of Life
The molecules of life are all organic The molecules of life are all organic compounds….meaning carbon containingcompounds….meaning carbon containing Carbohydrates: C, H, OCarbohydrates: C, H, O Lipids: C, H, OLipids: C, H, O Proteins: C, H, O, N, SProteins: C, H, O, N, S Nucleic acids: C, H, O, N, PNucleic acids: C, H, O, N, P
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Carbon Carbon (3.1)(3.1)
In compounds, C always forms 4 In compounds, C always forms 4 covalent bondscovalent bonds Diagramming C compounds Diagramming C compounds
C to C single bonds can rotate freelyC to C single bonds can rotate freely• Allows C compounds to form ringsAllows C compounds to form rings
C to C double bonds are rigidC to C double bonds are rigid
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HydrocarbonsHydrocarbons
Hydrocarbons – compounds Hydrocarbons – compounds containing only C and Hcontaining only C and H Are hydrocarbons polar or nonpolar?Are hydrocarbons polar or nonpolar? Are they hydrophilic or hydrophobic?Are they hydrophilic or hydrophobic?
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IsomersIsomers
Isomers – compounds with same formula, Isomers – compounds with same formula, but different arrangement of the atomsbut different arrangement of the atoms Isomers differ in properties and in biological Isomers differ in properties and in biological
activityactivity
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Functional GroupsFunctional Groups
Molecules of life are all substituted Molecules of life are all substituted hydrocarbonshydrocarbons (Most) functional groups contain atoms (Most) functional groups contain atoms
other than C and Hother than C and H• Many are polar and change properties of the Many are polar and change properties of the
compoundcompound
Substitute functional group(s) for Substitute functional group(s) for hydrogenshydrogens
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Six main functional groupsSix main functional groups are important are important in the chemistry of biological molecules:in the chemistry of biological molecules:
POLAR Functional groupsPOLAR Functional groups Hydroxyl group (OH)Hydroxyl group (OH) Carbonyl group (C=O)Carbonyl group (C=O)
• May be an aldehyde or ketoneMay be an aldehyde or ketone Carboxyl group (COOH) - Acidic Carboxyl group (COOH) - Acidic Amino group (NHAmino group (NH22) - basic) - basic
Phosphate group (OPOPhosphate group (OPO33))
NONPOLAR Functional GroupNONPOLAR Functional Group
• Methyl (CHMethyl (CH33))
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Estradiol
Male lion
TestosteroneFemale lion
Functional Groups Impact FunctionFunctional Groups Impact Function Differences in Differences in position and types of functional groupsposition and types of functional groups greatly impact greatly impact
the function of the moleculethe function of the molecule
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Classes of Chemical Classes of Chemical Reactions Reactions (3.3)(3.3)
1. Rearrangement1. Rearrangement• Convert one isomer to anotherConvert one isomer to another• Example Example
• Reaction that converts glucose to fructoseReaction that converts glucose to fructose• Reaction is used to make high fructose corn Reaction is used to make high fructose corn
syrupsyrup
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Making PolymersMaking Polymers
2. Dehydration* Reaction - 2. Dehydration* Reaction - links molecules links molecules togethertogether
• A covalent bond forms between molecules A covalent bond forms between molecules and water is removedand water is removed
• Reaction by which monomers are joined to form larger Reaction by which monomers are joined to form larger moleculesmolecules
• Examples:Examples:
• *Also called a condensation reaction*Also called a condensation reaction
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Breaking PolymersBreaking Polymers
3. Hydrolysis reaction – 3. Hydrolysis reaction – breaks down breaks down larger moleculeslarger molecules
• Water is added to a larger molecule to Water is added to a larger molecule to split off a smaller molecule.split off a smaller molecule.
• Reaction involves breaking a covalent Reaction involves breaking a covalent bond by adding waterbond by adding water• Reverse of a dehydration reactionReverse of a dehydration reaction
Example from lab this weekExample from lab this week
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MonomersMonomers Polymer FormedPolymer Formed Monosaccharides Monosaccharides Di & Di &
PolysaccharidesPolysaccharides Fatty acids Fatty acids TriglyceridesTriglycerides Amino acids Amino acids ProteinsProteins Nucleotides Nucleotides Nucleic acids Nucleic acids
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SUMMARYSUMMARY Monomers are linked by Monomers are linked by condensation reactions condensation reactions (also (also
called called dehydration reactionsdehydration reactions))• A water molecule is producedA water molecule is produced• A covalent bond is formed between monomer unitsA covalent bond is formed between monomer units
Polymers are broken down to monomers by the reverse Polymers are broken down to monomers by the reverse process, process, hydrolysishydrolysis• A water molecule is brokenA water molecule is broken• A covalent bond is broken between monomer unitsA covalent bond is broken between monomer units
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Carbohydrates Carbohydrates (3.4-3.7)(3.4-3.7)
Class of molecules with many Class of molecules with many hydroxyl groups (OH) and one hydroxyl groups (OH) and one carbonyl group (C=O)carbonyl group (C=O)
Consider 3 Classes of CarbohydratesConsider 3 Classes of Carbohydrates MonosaccharidesMonosaccharides Disaccharides Disaccharides
• and other moderate size carbohydratesand other moderate size carbohydrates PolysaccharidesPolysaccharides
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MonosaccharidesMonosaccharides
General Formula: CGeneral Formula: CnnHH2n2nOOnn
Typically 3-7 carbons longTypically 3-7 carbons long• Many –OH groups and one carbon is Many –OH groups and one carbon is
attached to an aldehyde or ketone groupattached to an aldehyde or ketone group• Form rings – see pg 37Form rings – see pg 37
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Common MonosaccharidesCommon Monosaccharides
Pentose monosaccharidesPentose monosaccharides:: Deoxyribose – Deoxyribose – sugar in DNAsugar in DNA Ribose – Ribose – sugar in RNAsugar in RNA
Hexose MonosaccharidesHexose Monosaccharides: : Glucose all isomers ofGlucose all isomers of Fructose CFructose C66HH1212OO66
GalactoseGalactose
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6 C - Hexose Sugars6 C - Hexose Sugars
All isomers of All isomers of CC66HH1212OO66
Glucose - Glucose - • Blood sugarBlood sugar• Primary source of energy for cellsPrimary source of energy for cells
FructoseFructose• ““Fruit” sugarFruit” sugar• Sweetest of all the sugarsSweetest of all the sugars
GalactoseGalactose• Formed when lactose is digestedFormed when lactose is digested
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Glucose is an aldehyde sugar
Aldose
Fructose is a ________ sugar
_____ose
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DisaccharidesDisaccharides
Formed when 2 monosaccharides are Formed when 2 monosaccharides are joined in a ___________ reaction.joined in a ___________ reaction. One sugar gives up a H and the other a -OHOne sugar gives up a H and the other a -OH
3 Disaccharides to know3 Disaccharides to know Sucrose = glucose - Sucrose = glucose - Lactose = glucose - Lactose = glucose - Maltose = glucose -Maltose = glucose -
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Synthesis of MaltoseSynthesis of Maltose
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DisaccharidesDisaccharides
Sucrose Sucrose = glucose covalently = glucose covalently bonded to a fructose bonded to a fructose Table sugarTable sugar In the small intestines the enzyme In the small intestines the enzyme
sucrase catalyzes the hydrolysis of the sucrase catalyzes the hydrolysis of the bond between glucose and fructose bond between glucose and fructose • In the lab this bond can be broken by…..?In the lab this bond can be broken by…..?
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DisaccharidesDisaccharides
Lactose = glucose-galactoseLactose = glucose-galactose Milk sugarMilk sugar The enzyme The enzyme lactaselactase catalyzes the catalyzes the
hydrolysis of the bond between glucose hydrolysis of the bond between glucose and galactose.and galactose.• Individuals who do not make the enzyme lactase Individuals who do not make the enzyme lactase
are lactose intolerant.are lactose intolerant.
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Lactose IntoleranceLactose Intolerance
Populations at greatest risk: Populations at greatest risk: Asian - ~ 90% Asian - ~ 90% African descent - ~ 75%African descent - ~ 75% Hispanic, Native Americans - ~ 75%Hispanic, Native Americans - ~ 75%
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Last DisaccharidesLast Disaccharides
Maltose = glucose-glucoseMaltose = glucose-glucose Found in germinating grains, malt Found in germinating grains, malt
productsproducts Formed when starch is hydrolyzed Formed when starch is hydrolyzed
(digested)(digested)
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OligosaccharidesOligosaccharides ~20- 30 monosaccharides long~20- 30 monosaccharides long
found on the outside of the plasma found on the outside of the plasma membrane, Often branched, Help cells membrane, Often branched, Help cells recognize each otherrecognize each other
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PolysaccharidesPolysaccharides
All polymers of glucoseAll polymers of glucose Differ in:Differ in:
• FunctionFunction• Type of bonding between glucoseType of bonding between glucose• Length of the glucose chainLength of the glucose chain• Frequency of branchingFrequency of branching• Incidence of coilingIncidence of coiling
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Major PolysaccharidesMajor Polysaccharides
Glycogen Starch CelluloseGlycogen Starch Cellulose
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GlycogenGlycogen
Function – animal storage form of glucoseFunction – animal storage form of glucose Made and stored in:Made and stored in:
LiverLiver• Source of glucose for the entire bodySource of glucose for the entire body
Muscle cells Muscle cells • Source of glucose for muscle cells onlySource of glucose for muscle cells only
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GlycogenGlycogen StructureStructure
~ 1 million glucose joined by covalent bonds ~ 1 million glucose joined by covalent bonds called alpha glycosidic bondscalled alpha glycosidic bonds• We have the enzymes needed to hydrolyze the We have the enzymes needed to hydrolyze the
alpha bonds in glycogenalpha bonds in glycogen Highly branchedHighly branched
• Branch every 5-6 glucoseBranch every 5-6 glucose
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StarchStarch Function – plant storage form of glucoseFunction – plant storage form of glucose
Structure – ~100, 000 glucose joined by Structure – ~100, 000 glucose joined by covalent bonds called alpha glycosidic covalent bonds called alpha glycosidic bondsbonds• Molecules are either coiled or branched – Molecules are either coiled or branched –
depending on type of starchdepending on type of starch
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CelluloseCellulose
Function – structural polysaccharideFunction – structural polysaccharide• Component of cell wallsComponent of cell walls
StructureStructure• Long chains of glucose joined by covalent bonds Long chains of glucose joined by covalent bonds
called called betabeta glycosidic bonds glycosidic bonds• We do not have the enzymes needed to hydrolyze We do not have the enzymes needed to hydrolyze
beta bondsbeta bonds
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CelluloseCellulose
StructureStructure Hydrogen bonds link chains to each other to Hydrogen bonds link chains to each other to
form fibersform fibers The fibers then form bundlesThe fibers then form bundles
• See page 39See page 39 The resulting structure is VERY strong. The resulting structure is VERY strong.
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CelluloseCellulose
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Lipids Lipids (3.8 – 3.10)(3.8 – 3.10)
Water insoluble components of cellsWater insoluble components of cells Primarily hydrocarbon, nonpolar Primarily hydrocarbon, nonpolar
substancessubstances Classes of Lipids:Classes of Lipids:
• Triglycerides (fats) and fatty acidsTriglycerides (fats) and fatty acids• PhospholipidsPhospholipids• SterolsSterols• Waxes (no coverage)Waxes (no coverage)
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Triglycerides and Fatty Acids
Triglycerides are made by linking 3 fatty acids to a glycerol molecule
Triglyceride
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Fatty AcidsFatty Acids
Fatty Acids Fatty Acids (FA)(FA) Long hydrocarbon chains with a Long hydrocarbon chains with a
carboxylic acid head.carboxylic acid head.• Saturated FA: all carbon to carbon single Saturated FA: all carbon to carbon single
bondsbonds• Unsaturated FA: at least one carbon to Unsaturated FA: at least one carbon to
carbon double bondcarbon double bond
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Fatty AcidsFatty Acids
Red = polar head Black = nonpolar tail
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Triglycerides: Triglycerides: (TG)(TG)
Function: storage form of energyFunction: storage form of energy Structure: 3 fatty acids covalently Structure: 3 fatty acids covalently
bonded to a glycerol backbonebonded to a glycerol backbone• 3 FA are often different from each other3 FA are often different from each other• FA determine the properties of the TGFA determine the properties of the TG
Mostly unsaturated FA => liquid (oil), healthierMostly unsaturated FA => liquid (oil), healthier Mostly saturated FA => solid, heatlh issuesMostly saturated FA => solid, heatlh issues Trans FA => health issues, formed in Trans FA => health issues, formed in
hydrogenation reactionhydrogenation reaction
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TriglycerideTriglyceride
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Phospholipids (3.9)Phospholipids (3.9)
Function: major component of Function: major component of plasma membraneplasma membrane Structure: ………….Structure: ………….
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SteroidsSteroids
Steroids (sterols)Steroids (sterols) Functions varyFunctions vary Examples of sterols include:Examples of sterols include:
• Hormones – testosterone, estrogenHormones – testosterone, estrogen• Vitamin DVitamin D• CholesterolCholesterol
Structure: 4 linked rings……..Structure: 4 linked rings……..
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SteroidsSteroids
Cholesterol
General steroid structure
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ProteinsProteins
Functions/examples of proteins:Functions/examples of proteins: EnzymesEnzymes AntibodiesAntibodies HemoglobinHemoglobin InsulinInsulin Component of cell membranesComponent of cell membranes Hair, nails, cartilageHair, nails, cartilage
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ProteinsProteins
StructureStructure:: Chain of covalently bonded amino acids Chain of covalently bonded amino acids
(a.a)(a.a) Bond between a.a. called a Bond between a.a. called a peptide peptide
bondbond 20 different amino acids…………..20 different amino acids…………..
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Carboxyl (acid)group
Aminogroup
Amino Acid Structure
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The structure of the The structure of the R groupR group determines the specific determines the specific properties of each amino acidproperties of each amino acid
Leucine (Leu) Serine (Ser)
Hydrophobic R Group
Aspartic acid (Asp)
Hydrophilic R groups
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ProteinsProteins Synthesis of proteins:Synthesis of proteins:
a.a. + a.a a.a. + a.a dipeptide + H dipeptide + H22OO
What type of reaction is this?What type of reaction is this?
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ProteinsProteins
Order of the a.a. in a protein determines Order of the a.a. in a protein determines the:the: 3D shape of the protein3D shape of the protein Function of the proteinFunction of the protein
Any change in protein structure may Any change in protein structure may impact the ability of the protein to function.impact the ability of the protein to function. More to come on this.More to come on this.
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Describing Protein StructureDescribing Protein Structure
Primary structure: 1Primary structure: 100
Order of amino acids in a proteinOrder of amino acids in a protein
Bonding: peptide bonds between amino Bonding: peptide bonds between amino acidsacids• Peptide bonds are _________ bondsPeptide bonds are _________ bonds
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Protein StructureProtein Structure
Example of a Primary structure: Example of a Primary structure:
Methonine-proline-serine-asparagine-tryptophan-leucine-tyrosine-Methonine-proline-serine-asparagine-tryptophan-leucine-tyrosine-
valine-proline-alanine-glycine…….valine-proline-alanine-glycine…….
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Secondary Structure: 2Secondary Structure: 200
The polypeptide (protein) chain coils or The polypeptide (protein) chain coils or folds to form:folds to form:• Alpha helix or beta pleated sheetsAlpha helix or beta pleated sheets
Bonding: H bondsBonding: H bonds
Alpha helix Beta-sheet
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Tertiary Structure: 3Tertiary Structure: 300
Folding of the secondary structure to Folding of the secondary structure to form domains form domains • order of aa determines how the protein order of aa determines how the protein
foldsfolds• Domain = self-organized, stable, functional Domain = self-organized, stable, functional
unitunit
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Describing Protein StructureDescribing Protein Structure
Tertiary Structure Bonding: Tertiary Structure Bonding: • R group interactionsR group interactions
H bondsH bonds Hydrophilic R groups on the outside and Hydrophilic R groups on the outside and
hydrophobic R groups are on the inside hydrophobic R groups are on the inside of the proteinof the protein
Disulfide bonds between S containing Disulfide bonds between S containing a.a.a.a.
Ionic bonds between charged R groupsIonic bonds between charged R groups
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Tertiary Structure: 3Tertiary Structure: 300
Tertiary structure descries the overall 3D Tertiary structure descries the overall 3D shape of single polypeptideshape of single polypeptide
Most polypeptides can be described as either:Most polypeptides can be described as either:
GlobularGlobular FFibrousibrous
most enzymes hair, spider silkmost enzymes hair, spider silk
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Describing Describing Protein Structure
Quaternary Structure: 4Quaternary Structure: 400
Arrangement of 2 or more protein Arrangement of 2 or more protein chains.chains.
Bonding – same R group interactions as Bonding – same R group interactions as 330 0 structurestructure
Collagen – fibrous protein with 40 structure
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Simple Diagram of Levels of Simple Diagram of Levels of Protein StructureProtein Structure
Identify the stabilizing forces at each levelIdentify the stabilizing forces at each level
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Protein denaturation - change in the Protein denaturation - change in the 3D structure of a protein3D structure of a protein Changes occur to 2Changes occur to 200 -4 -400 structure structure Causes a loss of protein functionCauses a loss of protein function
Functional protein
Protein isno longerfunctional
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Partially denatured proteinsPartially denatured proteins Minor changesMinor changes to active site(s) to active site(s) Can still function but very Can still function but very reduced ratereduced rate
Fully denatured proteinsFully denatured proteins Major changesMajor changes to active site(s) to active site(s) Protein Protein cannot cannot function at allfunction at all
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Denaturing AgentsDenaturing Agents
pH changes pH changes - changes ionic interactions - changes ionic interactions between charged amino acids between charged amino acids
Salt concentration increased- Salt concentration increased- interferes interferes with ionic bonds between charged aawith ionic bonds between charged aa
Higher temperatures Higher temperatures – break hydrogen – break hydrogen bondsbonds
Heavy metals Heavy metals - break S-S bonds between - break S-S bonds between cysteinescysteines
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Nucleotides & Nucleic AcidsNucleotides & Nucleic Acids Nucleotides - Nucleotides - General compositionGeneral composition
5 Carbon sugar5 Carbon sugar 1 or more phosphate groups1 or more phosphate groups Nitrogenous baseNitrogenous base
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NucleotidesNucleotides
Examples of nucleotides:Examples of nucleotides: ATP - ATP - major energy carrier in cells major energy carrier in cells
NADH/NADNADH/NAD+ + - - Coenzyme that transports HCoenzyme that transports H+ +
and electrons and electrons
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Nucleic AcidsNucleic Acids
Nucleic AcidsNucleic Acids Long chain(s) of covalently bonded Long chain(s) of covalently bonded
nucleotidesnucleotides 2 types of nucleic acids:2 types of nucleic acids:
• RNA – single stranded, shorterRNA – single stranded, shorter
• DNA – double stranded, very longDNA – double stranded, very long
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DNA DNA RNA RNA
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Nucleic Acids - RNANucleic Acids - RNA
RNA – RNA – ribonucleic acidribonucleic acid 1 strand of covalently bonded nucleotides1 strand of covalently bonded nucleotides
Composition of RNA nucleotides:Composition of RNA nucleotides: RiboseRibose PhosphatePhosphate 1 of 4 possible nitrogenous bases1 of 4 possible nitrogenous bases
• AdenineAdenine• GuanineGuanine• UracilUracil• CytosineCytosine
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Nucleic Acids - DNANucleic Acids - DNA
DNA – deoxyribonulceic acidDNA – deoxyribonulceic acid 2 strands of covalently bonded nucleotides2 strands of covalently bonded nucleotides
DNA nucleotides:DNA nucleotides: DeoxyriboseDeoxyribose PhosphatePhosphate 1 of 4 Nitrogenous bases1 of 4 Nitrogenous bases
• AdenineAdenine• GuanineGuanine• ThymineThymine• CytosineCytosine
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Nucleic AcidsNucleic Acids DNA – deoxyribonucleic acidDNA – deoxyribonucleic acid
Double strandedDouble stranded
• Hydrogen bonds between bases join Hydrogen bonds between bases join the two strandsthe two strands
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DNADNA