Bridging Research, Development & Clinical Application

Wound Health Research&

Clinical Innovation DaysJune 19th & July 24th, 2015

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Exciton Technologies is a Canadian based medical device company engaged in the development, manufacturing & commercialization of advanced wound care products to address the growing global demand in the areas of hospital acquired infection, acute & chronic wounds and burn care.

Wounds & Exciton...EDMONTON Company

•20+ years leadership in silver technology and medical device commercialization•Co-inventor & developer of Acticoat® silver wound care product line

Rod Precht, President & Founder

Ag+, Ag2+, Ag3+

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‘Genius is 1% inspiration

and 99% perspiration’

-Thomas Edison

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Ag Oxysalts – Ag7NO11

Ag+, Ag2+, Ag3+

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Exsalt® Wound Dressings

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Silver Wound Dressing Requirements

Fast, powerful & long lasting efficacyFlexible shape, size & absorbency Safe, comfortable & user friendly

The Patient’s Voice

“No pain, comfortable”“No problems, no stinging”“Less painful than previous silver dressing”“Less expensive than the other silver dressings”

The Clinician's Voice

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Silver dressings are used to:

Prevent - where there is a high risk of infection in:• Contaminated wounds • Partial- or full-thickness burns• Large and/or deep wounds • Reduced healing because of patient-related factors

Restore Wound Balance - where there is increased bioburden:• local infection• local infection that is associated with a widespread (systemic) infection

Ayello, E.A, et al., Appropriate Use of Silver Dressings in Wounds, International Consensus, Wounds International, 2012, 1-20

Silver dressing on the market today have different types of silver.

• Most products offer Ag0 or Ag1+

• New products offer Ag2+ & Ag3+ (1st - AgOxysalts)

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•Adapted from the respective product documentation/marketing materialsSpina, Carla J., Lischuk, David, Motta, Glenda, Silver Dressings 101: Silver Science

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Silver Type Oxidation State Silver in Dressing (mg Ag/100 cm2)

Silver Release (4h in SWF)

Silver Oxysalts Ag3+, Ag2+, Ag1+ 40 107

Metallic Silver, Silver (I) Oxide Ag1+, Ag0 160 28

Metallic Silver Ag1+, Ag0 440 5

Silver Na H Zr Phosphate Ag1+ 210 4

Silver Sulfate Ag1+ 120 18

Silver Chloride Ag1+ 12 28

Silver Wound DressingsHighest Oxidation State = Potent & powerful

Low concentration on dressing = less expensive

Effective amount into wound

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Day 0

Day 6

Chronic  to  acute  wounds  Mul2-­‐disciplinary  use

Hospital  se7ng

Community  CareHome  care  &  Assisted  livingLong  term  &  extended  care

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exsalt® Wound Dressing Indications

Partial and full thickness wounds

Decubitus ulcers

Venous stasis ulcers & diabetic ulcers

First and second degree burns

Grafts and donor sites

Other acute & chronic wounds

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Exsalt ® Meeting Clinical NeedsEffective

FastPowerful Long lasting

VersatileFlexibleSize Absorbency

User friendly SafeComfortable Cost efficient

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Rapid release of silver Ag2+ & Ag3+

Sustained release

Conformable dressing Cut & Shape Absorbent

Low pH Non-adherent Potential cost savings

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Meeting Clinical Needs:

High concentration of silver released

Potency

Low total silver content

Cost

Minimal pH shift

Pain

Silver Oxysalts - Ag7O8NO3

Strong AbsorbentSustained Dosing

‘Chronic wounds’

StrongThin & conformable Sustained Dosing

‘Acute wounds’

“No pain, comfortable”“No problems, no stinging”“Less painful than previous

silver dressing”“Less expensive than the

other silver dressings”

The Patient’s Voice

FDA/Health  Canada/European  CE  ApprovedSilver  Type:  Silver  Oxysalt    (NEW  and  ONLY  Silver  with  high  oxida2on  state  Ag3+, Ag2+, Ag1+)  

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Product  Development

2015

2016

Educa8on  &  Support

Marke8ng Canadian  Clinical  Sales/Distribu8on

Evidence  Base  and  Designed  with  Scien8fic  &  Clinical  Exper8se    Considera8on  to  policy/proceduresMonitored  &  Controlled  Product  Sampling

Discre8on

ary  Use  /  S

pecial  Req

uest

Healthpro

 discre8on

ary  allowa

nce

AHS  CPSM

 past  appr

ovals  (disc

re8onary  

requests)

exsalt  wou

nd  dressin

gs  listed  in

 AHS  Orac

le

Grant  MacEwan  University  Wound  Management  HLST352:  Clinical  prac8cum  Course

Alberta  Innovators  2012

One  of  the  new  AHS  Health  Technology  Assessment  &  Innova8on  (HTAI)  Project

Con8nued  clinical  research  &  product  trialsMo8vated  to  design,  test,  launch  new  configura8ons  

AHS purchases through discretionary use (<20%):Grey Nuns Covenant Hospital (Edmonton, AB)Foothills Hospital (Calgary, AB)Dr. Vernon Fanning Carewest Centre (Calgary, AB)Father Lacombe Care Centre (Calgary, AB)Medicine Hat Hospital (Alberta)Westview Health Centre (Stony Plain, AB)Drumheller Regional Health CentreUniversity of Alberta

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Global News (Su-Ling Goh, health reporter) featured the Edmonton company Exciton Technologies and the exsalt silver wound dressings.  Jan 21, 2015  http://globalnews.ca/video/1786293/an-invention-to-help-care-for-wounds

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