certificate of analysis 4-(1 h-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)...
TRANSCRIPT
Certificate of Analysis
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QA:
Jeff Park QC:
Zoey TsengDate:
Sep. 14, 2015
CAS 941685-27-4 Batch No. B15S0913
Product Name 4-(1H-pyrazol-4-yl)-7-((2-
(trimethylsilyl)ethoxy) methyl)-7H-pyrrolo[2,3-d]pyrimidine
Batch size 800 g
MFG. Date Sep.13, 2015 Retest Date Sep.13, 2017
TESTING ITEM SPECIFICATION RESULT
Appearance White powder Conforms
Identification 1H-NMR spectrum Conforms
Purity HPLC
≥95% 98.01%
Storage Keep in a cool and dry place at room temperature
Result Correspond
4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy) methyl)-7H-pyrrolo[2,3-d]pyrimidine
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=====================================================================Acq. Operator : 2015-09 Seq. Line : 11Acq. Instrument : Instrument 1 Location : Vial 92Injection Date : 9/14/2015 3:24:37 PM Inj : 1 Inj Volume : 1 µlDifferent Inj Volume from Sequence ! Actual Inj Volume : 0.7 µlAcq. Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.MLast changed : 9/6/2015 8:47:13 AM by 2015-09Analysis Method : D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\LC-12MIN-ACID.MLast changed : 9/14/2015 3:41:39 PM by 2015-09 (modified after loading)Method Info : Instrment: Agilent 1100HPLC Column:C18 4.6*150mm 5um Mobile phase:A=0.02% CF3COOH in Water B=ACN Gradient: 10%-90%B in 6min Flow Rate: 1mL/min
min0 2 4 6 8 10
mAU
0
200
400
600
800
1000
*DAD1 B, Sig=254,16 Ref=off (D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D - D:\DATA\RAW DATA\2015-09\DE
6.4
05
9.1
58
9.5
15
11.
242
===================================================================== Area Percent Report ===================================================================== Sorted By : SignalMultiplier : 1.0000Dilution : 1.0000Use Multiplier & Dilution Factor with ISTDs
Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D
Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 1 of 2
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Signal 1: DAD1 B, Sig=254,16 Ref=off Signal has been modified after loading from rawdata file! Peak RetTime Type Width Area Height Area # [min] [min] [mAU*s] [mAU] %----|-------|----|-------|----------|----------|--------| 1 6.405 BB 0.0619 4657.47656 1133.94214 98.0105 2 9.158 BB 0.0916 12.38730 1.91217 0.2607 3 9.515 BB 0.0860 22.02720 3.56841 0.4635 4 11.242 BB 0.1549 60.12518 5.70784 1.2653 Totals : 4752.01625 1145.13056 ===================================================================== *** End of Report ***
Data File D:\DATA\RAW DATA\2015-09\DEF_LC2015-09-1412-59-40\092-1101.D
Instrument 1 9/14/2015 3:41:50 PM 2015-09 Page 2 of 2
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01234567891011121314f1 (ppm)
-5.0E+07
0.0E+00
5.0E+07
1.0E+08
1.5E+08
2.0E+08
2.5E+08
3.0E+08
3.5E+08
4.0E+08
4.5E+08
5.0E+08
5.5E+08
6.0E+08
09-14-2015400MHz/DMSO-d6
9.00
2.00
2.12
2.01
0.99
1.00
0.95
1.95
0.94
-0.119
0.796
0.816
0.836
2.500
3.390
3.498
3.518
3.538
5.619
7.091
7.100
7.717
7.726
8.349
8.669
8.738
13.409
NN
NOSi
CH3CH3
CH3
NHN
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