May 8, 2013

Brian S. Appleby, M.D.Cleveland Clinic Lou Ruvo Center for Brain Health

Hope vs Optimism

Hope (verb, noun): “to desire with expectation of fulfillment”

Optimism (noun)/Optimistic (adjective)

Celebrate (verb): “to perform publicly”

Trainee: “Why do you do this, you always have bad news to give?”

• Quality vs Quantity of Life (psychiatry)• Comprehensive Model (geriatric psych)• Caregiver/Family dyad (dementia care)• Unmet Need (CJD, young-onset dementia)• 5 days/week (Cleveland Clinic)

-80

-60

-40

-20

0

20

Heart Disease Cancer Stroke Lung disease Accidents Diabetes Influenza Alzheimer’s Kidney disease Septicemia

Change in Death Rate (1999 vs 2010) of Top 10 Causes of Death in U.S.A.

Does NOT take age into account

#1 Risk for Alzheimer’s?AGE

Thies W, Alzheimers Dement 2013

Thies W, Alzheimers Dement 2013

Estimated aggregate costs of care by payer for Americans age 65 years and older with Alzheimer’s disease and other dementias for 2013

Thies W, Alzheimers Dement 2013

Thies W, Alzheimers Dement 2013

“I'm Givin' Her All She's Got Captain! If I Push It Any Harder the Whole Thing's Gonna' Blow”

New and Better Disease Models

Aguzzi A, Nature 2009

A

B

C

Google searches for “dementia” over time

Appleby BS, Prion 2012

U.S. Alzheimer’s Related Publications Over Time

What IS Alzheimer’s Disease?

What is the Best Way to Treat/Prevent Alzheimer’s Disease?

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