cefeina universidad de barcelona
TRANSCRIPT
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A* A#* ,!
D>@<= %@M %===M CM<, <@ B@=< I<= I<O< < C@@=, C=<O< C=< (I3C)
P-& #$ D-. E#-# E''
CRM FH HJ
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A* A#* ,!
D>@<= %@M %===M CM<, <@ B@=< I<= I<O< < C@@=, C=<O< C=< (I3C)
P-& #$ D-. E#-# E''
ISBN: 978-84-695-1140-4
N R$&'-: 2012629
E!'$ %$& e" C$*- #$ I*%-"'* C% S#
M&!, 2012
*. F 171, 08035 BF, .E-: @I.I
CRM FH HJ
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E- #$'$- $ ''-D-. E#-# E''
D@=@ CM< 'N= E, '% I< <@@ D B@-=< C==@<=@ < 'N= H=> G<@ CN.
E FF G >G M GHF GFHG G H I JFG. E GH FH, GI T GIQG I I GIS FFF, G GF IGHF J.
*F HFF, GHP HHH F I I FJT FT GIS M IFH H I FIF G IF. EGH GHIT GFJG GIG; , HG IFG, TG M HFPGH G>G GH GH. G F GHG LHFG, HG GGHQ I G HG TG - QGHG, FG, H.- I IFF IGHF FF H I H J I GIG IGG FG.
E GH J G GI T I GIS I MH. E FF G I FG FFF, G HF FGHIFG H I G GH IFH R. APG, FNG H F.EGH HF IF I UF HF FG F GIF GIG>HJG. E G IHG, G GF I GH H G HF 7 M 8 FG. EG IFT R GIS I FHN IGHF FF GHF FFG
F FHF I IJ R GFHG.
E GH GF GIS FJ GF G.'I H GF HJR I FF G FF H. D , G -G G 90 SG, FG F 30 SG. HF IGHF J GHGH U GHFG I G FF, F I G FHN 60 SG IJ. I J G GHF GFHG, FH GF I JJG IFHIGHF R, G F FHF FHG RGG M HG.
F GIS IFH R, G LGH HR, G GI F F- G JH. HF GIS G I, H GHIG
H GHRIG I G H FH, FN GH GH GF IG G FF. EG FHH I G H GH H,FI I H G I G G H HJ F G;F G G F> M FH I GHIT GH, G IF, F HLHGG HFQG GIF JFGG IFFG, GF, GLT GIS G GI JH.
4
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CafE+na y rEndiMiEnto Cognitivo
5
PG FH I GH GJFT. E IFFH M GLT GIS. GIS... HF GIS. EGH FT, I F H JH, G U F HR I M G GHFF. E IFFH FII H HFT I GHG . CGIHH, G G F G FG GFG, GH H HFT M IFFHJFP IGHF FF FFG. *F HFF, G G F G FGGIHG, GI GFP I GFG HFG GG, GJFG HT I GHG , F G FFG.
D> IM F I F GIF I I GH FH G FGF F G FG GFG, HQ G F IG GF-G GF FHG GIGHG I G MIFP >FF GH J, GFI G IGG F JH.
R G I GHG GIGHG GHJG, IHN IH G I H, FGH G Q, HQ G. ELH HF> F F FGF A A, I H F F-F, G FH HG HRG IRJG GF GH GIGH, GIG FH-FRGHG M GIG G.
DGHG M MG G GIHG GFG, I F FH GIH HF> HR:
E =<= =@= M< >@= <= =@ @<<= =-<=, @ <O<. < L =<< 100 M<.
' < =<@@ = M< <@=@ 200 , =-@ <@ 200-400 >@=@ 400 .
! M< >== <=<@@ < , >, , @@ .
E < < <= @. ' =@ @><, << = = < < <@ >@@ = 30-45 <=.
' = < =@<= = <@ 3 6 =@.
E< >=@< @< < @= =O< <@ <=; @, < @O< =. E<@ , <<-@=. < = =@, 65-70 N= > @@ 8 =@ < -<@ =@<=. C <= =<=@ @O< M< < @>= @ < =<<.
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E < @= M< > <@ = >== < =@<=,<= >@= >=@ "<@= '< >N= O< == @-= <= >@ = =<=<, <, = =<= < -=, <= < L= >= M= == >M=.
A < L, M< >== <=<@@ = @= @- < @ = <L= =< < >=<@ = = @-=O= <= =. % @ <= =< =@M @== < < @<= <@= @<< >=O-. I<= =< = @<= >=@=O= <= < >@<> >=>=O (>@O<, >=, .) = <@ <@=O, == <, <= @ =<@<= = M<.
' =<= M< @ =@ =<@ = < >@@>O<L, =< <= >@ = 400 M (@= L).
! M< < >= =<@<=<, < < < @<< >=O < =< @ =<=. =< @=<@=@ @=<< @: >>, <=<=, < << >.
!= >= = @= M< =< >== < >@= >=<. E<@= @< <= < = @@, <=<= @@O<
@=<<. E< = >@ <= =, =< <@@>O< =<= >@= => @O< < >== >=.
E =<= M< >@= = <== @ =@ @<<==<=, <O<, @ =<<@O< <= =< = < = <=>@< = 400 (4 L M) < = <@ 3 6 =@ < <@ N= <=@<=.
!= <= =<= M< < =<O< =< > <@L,>= >@ >=O< < M= =@ = >=@.
E< <@, = <= < @ <=< /= >===@ =<= = M< =< >@=@ = <= < < =< L O<, == = = < @<@ <= <= >@O< N=. %=@ = <= @ >< P < = @-=@ @< @ @< >@== <=@<=.
6
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E =<= < =<@= L, , < < O< <=< <-= =@ =@<=. ! O< = <=< @=<= =< > >@< >@O< L =<= == <-<= == , < >, @=@= =<= >=O= == >@=-= < <@ A@. ! > <=< L <=>@=@ < C.
! <=< >= >@ >@<@ @L == @-= =@<=, <@ = ' #@== C<@. E=@ < =@ >@==@ >@ <<=.
#=@< L = == =< P@ (=). ! = < <= >=< < >@<> <@M <@= ' #@== C<@ < = >== =@ =<O<, < > >@ O< @ >@< =@.
! M< = =< << = <L@= < =>@O< =< <@O< < =. != <= =@< ><< @ <O< =<, >@< =@.
! @=<O< =<@ L = < = (= P@ >=<< < =@ @= >@>=< @@=@ = M<-@= O= @= @@=@ < >@O< = =<=) -
<= >@ <@= =@<=.
G G, IG, FH J FNG HRG I M IG -F Q, GI F F HJ: R.
E H LIGHJ GIGH, GHIG HRG IG MFFG J I, G FH FF GI IG, FH G GHIGGFHG HFFH M GI G FG I G.
E H F FH T F G IG M FHFRGHG Q, >IH G G FG GI IG, G FH GF HGHG
I IHNT F, IQG FJF HG G G I FJ GI GI FN.
CafE+na y rEndiMiEnto Cognitivo
7
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8
\
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CR M FH HJ
1 #HFIT ..........................................................................................................................%*!# 10
2 FR R .........................................................................................%*!# 13
3 EHG R GH FJG CHF (C)...............%*!# 16
4 EJIT FH HJ.................................................................%*!# 21
5 EHG R HFG HT M GHFG ..............%*!# 24
6EHG R HFG F
M IG >IHJG ....................................................................................................%*!# 29
7 CR M GH GI>HJ ..........................................................................................%*!# 33
8 CR HFG GIGHG ........................................................%*!# 39
9 G F I IG FGG .................................................%*!# 43
10 FG .............................................................................................................................%*!# 46
CafE+na y rEndiMiEnto Cognitivo
9
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10
#HFIT1
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CafE+na y rEndiMiEnto Cognitivo
11
R F FH IGHF J H M, H F, G GIG-H GHJ PG IHN. 'G FGG I GI
F >IGHF GI HJT JG IG I THG.
R G FGH I JF G, Q, HQ G F-
FGG . IFGG GHIG G HFG F NF G HG
R T M HFG GHG IHIG. BI FH G HF-
>G LGHHG I GI R FI G GF
FH HJ, G G UHG QG G IH FG
UHG HFG I I IF G FGIHG M LF IG G
NG GGHHG. EHF G, GG M F GHFT R,
G FHFRGHG G FHHG IH GI R (PH GI R M JG GI) M G FIGHG GRG G
I G HU G G (J HJT, FJT GIS, H.).
C G, H M F GHFT R G I H
J. GI GFF GG >G R IG FFG 200 , -
FG HF 200-400 M JG IG GIFFG 400 . ,
LGH I GG FG IHG FH
HFNT G GG. *F I PI FP
G GH I I Q H 100 R,
II G IM JF H
Q M GI F FFT. MFR HF-
>G HRG G GIG GHIG GG
HF 100-400 . F PG HI GHFF R G I U
GHFT (F I), M G GG G F J GH I
T G GI GIF R G HIFRGHG T.
APG, G JGHG G IHN FF FFG G,
PGIG, HHG, FFG M G R IF I Q (GFGG, HF,
GHHP, H.), I HQ I FFG , I G G FG PG IG GI. *F HF , G IM HI I GG G G HF>G -
HRG G GHF I U H, HFG I G GIFG R GI-
F GIG FHG IFH R. EGHG GHG HTG H
FNT G FGIHG G G J F.
GF GI F
I GG 200-400 R(HF 2-4 HNG R)
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12
*IGH I GI R G IM HI J H, HF JFFHH G PH GI I H G FHHG. EGH
FI HFJFG GF G FH LGH HG GG HFIG
GI R. AGR, G GFF THGG ZFIFT
GRF GH[ I GH I G GIFG HIG -
R F HG HJG HJG M IHIG FFG FG
S FIG F IG GI IFH FR HIF. G
GIFG GH THGG G I GI R GH
GFF GH HJ GH HFG I H G FG
GHF, FGHIF G G HJG FH GIG JG F-
G (FG H ., 2003; $G & FG 2005; FG 2007).
MFR GHIG, G F, GIGHH THGG ZFIFT
GRF GH[. OGHG J HG GHJG R
U IG FRG FG G GI GIFG HIG
(CFGHF H ., 2005; G H ., 2005; CG & H, 2006; KHH & H,
2006, 2007; F HF IG HF>G I GH
GH GH GIG GIGG). E JF I
GI R FI HG GG
HG FG GF FH HJ HG
HFG JG. FF, F GHIG
FRG G FHF I G
GH F R G I GI GHFT FI HG
GHJG FH. GI, G I GI R IG
GIFG HIG HQ J HG GHJG GI >IT.
HFF IF, GHFT R JIG GIFG HIG
I G GH GH G F GR G HG -
GG. *F FINF GH GH I GIHFG LH FJGT
H (2002).
ELGH JG HRG I GI R FI HG
GG HG FG GF FH HJ
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CafE+na y rEndiMiEnto Cognitivo
13
FR R
2
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14
G FHFRGHG FTG R I GIGH P -> M J GIF (A & *FH, 2011). I GFT, HFG GHFT
F JR F, G FP M H NPG G PLG JG GF
(PL) FHF G 30-45 IHG HFG GI M IFT GI H
FG (H1/2) G HF G 3 M G 6 FG.
GHFIM MFR H>G FFG M
HFJG FFF HP I -
, I L GI HIF
GH FJG CHF (C). HN
F HG R, FIQG GH
FG GIGHG HQ HJ FT, GI JFGT H, I F IFT H FG. ELGH FHHG
FG FH HNT HF JIG, HF G GH
I GI HF. *F T FG G IHN F-
H JR LFT F, HFJQG F.
FH I R I HF HG GHJG F-
G, PG F F 'GHF GS GI IHNT
PF F GHG G, GH, H HH
IHG, HH G QGHG H RG GRI (A & *FH, 2011). AGR,
LGH FFG FQIHG I H F T LIG-
JH R (*FFHV DIFJH FHFV). GG GHFF PF G
IM >, I PL F GH 1200 , FHF FG-
FHF GU GF FHI. APG, G IFGG G PFG -
T HHF, QG, HFS, F>H IGIF HQH I
H R S, HF G HG FTG
I G (JF IF 1). R FGH G HFG, G
G GI GI >IH MFR PFG IHNG HIH
HFHH IFGG FIGHG HTG. #IG G HFH-
HG GFTG G G FG GHTG (FGT,GGG, H.) FG IFTG, G G, GI FG
HF IG R.
E PL J GFT R G N G 30-45 IHG
M GI H IF HF 3-6 FG
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CafE+na y rEndiMiEnto Cognitivo
15
F'&- 1. A<= >@>@= @L= =@= < E>N =< M<< = =< =< =@= >@<>= = (<<=@=, <L-
=, <@N, @< @ = <L=) >@ >=<@ O<.
G$*-'" C$-"' D' (&/#)
CR DIFJH FHFV, *FFHV 'PL. 1200
CR AV, AGV, BF CRV, 'IM JF
(S CFHV,CGFV, FV, GU FF
HFG FG FV, #JV, IFFV, '>FV,
HJG) HV, *V, V
GI R G FN F IHGHF G FGFT
Q G G> I G GIF GG 400 R. E GI -
R GG >G FG IHG G GF FGG, G FGG
F GI M I G I HF G G G HJG
HH FH M F N, G HFG FIGH-
G, JFG F GH HF>.
R H G HFG, G LGH IG FIGHG
HTG G I G G> JHF GI GI. OGHG G G HFG
FJGIFG M GHFHGHG FJG, G, G, G M
GI PH. Q G F JHF IG R FG
12 SG M G G GI F, HH FI G M FH
HG F>IG G F H GHIG G GG I FH HG
FIGHG GI GIF. E IG HG FIGHG, GI -
F R I HF HG GG GF J HH
JIG >TJG G JN. G GG HG JFGG
R G G M G F H, HF G PG FIHG G
IHI FFH, G M FFHT GHFHGH. E G IFN I G, HFFIT GI G FI H
FGT H.
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16
EHG R GH FJG
CHF (C)
3
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CafE+na y rEndiMiEnto Cognitivo
17
R FI G FH HJ FI G I GIGHGHJ. EGH G, H HIF C, G G G-
HFIHIFG M LG FGGG FGH HG G G
HJG. WIQ G/G T HJ C I G LI GIG -
G?
E G T R GGH I G FHFG
G H A1 M A2A (F H ., 1999). G G I GIGH
HFGGF C I I HU HFGH G>G GIF HJ
R GHN IG. G FHFG G GHP -
H GHFIG F Q, I F H GHFIHIFG FI-G F >IT G G HJG G ,
FHN FF, FHN F M HP. E I G FHFG
G, F HH, I QGH G I G
FHFG M HU C. E FJFH F-
HG FG HFGGT HJ
G GGHG IFHFGGT I G
FHFG GRG. OGHG G FFQF-
, QF, QF M GFHQF
(F H ., 2005). E FH, I HG IR GF G
FHFG A1, I G GHIG G IFG FGPHG GFG, G
HFI I MF FT GHG IFHFGGFG I G FI
I IT (JF IF 2). E I HG IR GF G F-
HFG A2A, GHIG IFG GHGPHG FHFG, H I G
FHFG H 2 FH GI HJ (JF IF 3) M FG
PG FT.
GHIT G GGHG FFQF M QF G F F-
HG FH, HT M FGF FT IJ (F-
N>), G GH GH GHIG HFG F> GHG FJT GIS. T GF HJ QF-
G G GHP G H FJHJ IFFHHF GFFF
F *FG, HH JFG I>FG GF I QGHG
G M GH HFHH F GHFTG (FFQ, 2009).
R I G FHFG G, GHI IF-
HFGGT M >F GH FH, HT M FN>
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F'&- 2. "<= O< M< =@ = @>=@ <=< >= A1 < ' #@== C<@ @>=< <@<@ < = <-
@=@<=@ <=@@<< (#A), =< (AC), =>< (DA) @==<<
(5-H). "== A< & %@ (2011).
F'&- 3. "<= O< M< =@ = @>=@ <=< >=
A2A < ' #@== C<@ @>=< <@<@ =<O<
=>< (DA), =<= @>=@ >= 2 (D2). "==
A< & %@ (2011).
18
Neurona postsináptica
Cafeína(Antagonista químico A1)
Respuesta NA, DA,5-HT y ACh
DA
DA
DA
NA
NANA
NA
ACh
ACh ACh
ACh
5-HT
5-HT
5-HT
Neurona presináptica
Receptor presináptico A1
Neurona postsináptica
Respuesta DA
DA
D2
Receptorpostsináptico A2A
Receptorpostsináptico A2A
Cafeína(Antagonista químico A2A)
+
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CafE+na y rEndiMiEnto Cognitivo
19
HT HJ QF G G T G G I G GIGHG GHJG HU GF G GHFIHIFG FFG
FGGG FIFN M T, I FIF GR M IG.
F, F HJ QF GF I HI
IM GIFF I FI R, IG GHF GG JG. A JG
HQFG IG G T Q R, F U -
GIG JG LGJG G FGG IGHF
QF HF FHH IGJ,
I G GH HFH T. A -
F I GI IG HFG GIGHG
GHJG (, H, G, H.), -GI R G FJ GIG HJG RGG, GTG GG
G IG G G G TGHG RG T. AGR, G IG
TGHG I HI IHN G FGG GI -D'-#- M C#E-
10- H TGH GRF GH
R M H ' (FNT 'I I) GF R -
HF HFR G G. E G I FPH R G GF-
J FG T FG GH R, F J I QGH
G. C GIF JFGG LFHG H, GI F R
GFFG I I PH M I T.
H, HJT GGH GFHQF G L G GG G
GI R GH P. F, QGHG G GHG M
I HG GHIG JG HT H M G GF G -
G I G H H HG R G G IHN PF
H GIG FGHG FQIHG. GHFT R FIG-
HG RG PG GJFG, I GF FGT MF, FGIH I GHFH
HFQIH GIH F GIF FJFHF GHHR G HG.
E GI FH Q, PG, H T HLH GF FG I G J HH HF>G LFHG GHIG RG
(H H ., 2002; !F & GFH, 2010). T G HLHG, HQ
G THFG FR, G F FJ-
HJ FT QHG HJG GG J>H LHG M, IM
G, HFF HJ HT FI F
' GF R HF HFR G
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20
Polaridad
No polaridad
Radicales libres“peligrosos”
Radicales libres“amigos”
Moléculas establessin actividad
Antioxidantes
ANF. HLH Q G IG GIFF JH CM GF IHHT, HLH I IGHF FG FI F
HIF F HFF FIT LGJ FG FG (JF IF 4). G F-
G FG G G GHFQG LHJ, I F>I I I-
H GHHG GGHG FG, HF G I GH F GI MF
JIF C M GIG IG IG, G IFG. GHFQG LHJ
G J, GT I F>IF HJ G IFG, G FIF GI
IFH G GIG JGHFG I G I FJF. E HG
G FG IFFHJG, IP G GI F M H,
G GG JNG G FI IFH IF (IFFT) GJ F-
I F GHFQG LHJ.
APG, GI HLHG FGIH G GHIG PG H-
G I G I HJF GHFQG LHJ, IG G I LGH
I J FH HJ (. >. Q LPG) RG
(FPH FHJ HG). HJ HLH Q, >IH F -
G T HGH G FHFG G (F, 2009), H-
Q GFR G LHJ G HG I F GI GI I F
FG GIFF JFGG HG PF (F, GT, R M ).
F'&- 4. AO< = <=<. != <=< <@< = @ @
@>=< @L ==, ><= M =< >=@ << <-
@= @@ @, = <= >@-
< L. E @L == < ' #@== C<@ >@
@<<= =<= , < = @=, = =< >==M <@=<@.
"== A< & %@ (2011).
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EJIT FH HJ
4
CafE+na y rEndiMiEnto Cognitivo
21
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G JGHG I HFI GHI FH HJ G-F HFG FH I G GGG M G JIF J-
HH >IT. E FGIH P F IFGG HJG. >IT
HJ GI GIF IGH F JFGG G (.>. HT,
HF HF, FN>, F, IG >IHJG) M FNT I
HF, F G I G, F JFG G. JIT >-
IT G I FNF FHF FGHF J (H FGIGH)
M/ FGT (FGIGHG FFHG, FFFG M GIG), G IG H FIQ
FG F I GHFT R.
APG, II M HG HFG IFGTG GHFNG G-G HI, GF LGH GG FGH GI GG. IH-
NT GHG HFG FGIH LHFH GG F JIT G
G HT, F M FN> IG >IHJG F -
HHF G HTG I G G FNF I L R. -
F, I G JIG GG QGHG GI FHF JG
FH GFG HF F F. IHNT HFG G-
RG I G IHN JGHT GFT FGIH PG GG M
UH F JIF G HG GG GI
R FH HJ. *F I F-
FH GHG HFG G I GI GF
IM GG, I IH LHFT G
FGIHG HG G G HJG
IG M GG G I G J GHG
G JIG GI J F. E IHIF GFR HFGH F I GIFN
GH GHI F HFIF HFG PG FRGHG, FR GF -
IG J>IG GHFN IT, G IG, PG, FH J-
IT FFN FH (H FGH M FGIGH,
FGT, FHT, H).
*F HF , JF JI G IM FHH I JIG G-
HG IHIG M FH HJ. OGH I FIF I J
JF GFGT G HG, I G IH HT FGIHG
GHRGHH GHJG II G GHIG G F I I
HF IFGG HFG JIG (, GL, J GHIG, H.) I
22
*F GHIF G HG R FH HJ G IHN
HFG GRG GGG MG JIF >IT
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G I IF FH HJ G JIG. JF- JI G N IHNT GSG G FHG. OGHG
G I T LH I FNG G FPHFG TG,
F F FHG GG >IT HJ I HFIF HG
H M/ FN> GG HFF GHFF M I GI I JF-
F F F HT FGIHG JPG M G (H H .,
2007; A H ., 2008).
LGH FHG FG I FH GHHG IG IFG -
HJ I FG F G HF IH S-
GH GHI (A H ., 2008; H H ., 2007). GH I JFT HF-JI FH HJ, H
F R, I JFF I 20% HF F M >F FGHF. D I
F, F R IM FR MFR GIGHG M, F
HH, R. F, G GHIG I H IH F
R I G GHF R G H IG I JU GIG GG
HG GF GHG H FJT GIS. E G UHG QG, H-
R F (HIHG, HFG M JGFHG) G GHF FI
HFF GHHG HFG IH T M HJ (A H
., 2008,) M G GF GI GFT JGHT G HG
R FH HJ.
A GF G IHG I GI JGHT FH HJ
F M G HG R QGH FHIF, GI HFQG, HH G
FGHJ H PG , G I HFQG M
GFF I IHIF G G JFH GIFNG M FIFGG F JNF
GH GHI.
CafE+na y rEndiMiEnto Cognitivo
23
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24
EHG R HFG HT
M GHFG
5
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CafE+na y rEndiMiEnto Cognitivo
25
G HFG HT GGH FIG FHHJG M THG I F GIFNT IGH F G FHIG M HJG.
OGHG H F U I FFN
J FGIGH (H FT). E
G GHIG G J HT GG-
H, I G F FIFF
HF I GH HT FHG JHG
GHRIG IFH I H F (. >.
UGI JGI, GIGHHIT RHG, H.), M G H FT (G M
T). MFR HF>G I FF HFG HT GIG G-
HIG H G HFG GHFT R FT (FF G F HJ). E F GHG HFG G G I G-
MF J I GI FH >F HFG GI R.
E G HFG HT GGH G GFJ PG J HH F -
T IJ FT FGIGH, GR I FGT GIFF
(PG FIGHG FFHG, G GG FFFG) HFG GI R.
EGH G, R HFT F >IT GH
H HFG M F I G IH FH
HT JGI (BFIMQ H ., 2010). E G GFJ HH GG >G -
FG JG (BF & H, 2001; CG & H, 2006; KHH &
H, 2007; FJFHG H ., 2008; H, 2009), GR GIFG -
HIG R (CFGHF H ., 2005; AHHK H ., 2007; FF & $I
2009) M GIFG (CFGHF H ., 2005; G H ., 2005).
R HQ GHF HG GG G HFG H
FT, HH G (HT GHRIG FGHG I I)
T (F H FGHT JFG GHRIG I), G
FPHF >IT PG GG J FGIGH (J DI
H ., 2005; AHHK H ., 2007; H, 2009; A & FF-!FIG, 2010). EG GFJ I G FHHG G GIFG -
HIG HIG R (G H ., 2005). GHFT -
R, , FH HG H FHT G HFG
HT YGFT FT G I G H GHJ-
HY (BFIMQ H ., 2010,) H HFG I FIF
IFGG GHIG HRG J- I GI R >F
FH HFG HT
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JGI-G (A & FF-!FIG 2010). EGH FGIH G H GG GHF M GI HI R G FHHG.
E G HFG I FIF J HT GHFT R
GG FF 200 GI FIF G FHG JIG
GIFG GIFG >G HG R (FJFHG H .,
2008; A & FF !FIG 2010; BFIMQ H ., 2010). E GIFG -
HIG GG HJ F I G GFJ HG GHJG G 400
(BFIMQ H ., 2010). A GHG GG, G G >IT HFG
HT G GIFFG G GIFG HIG JG HG
R I IG GIFG GG FG (AHHK H .,2007), II HJR I F IF IH LHJ GH F-
GIH.
G HG R GF HT G JIG H HQG
IFGTG M IF, I FF FT GF G -
GG IFG I GIM G HG IHIG GFJG. E F-
F GHI I G IHNT FG QH
I (') F JIF G HG FFG
GI R GG > (100 ) I-
FH >IT I HF HT GGH-
, G GFJT I HJ
IF IFH FH II FIR >F FH
HF (GHHHF H ., 2008). EGH G, II G JIG HFG GI
R FNF HF I I G , HJ FF
I F GFFF F GI >IT, GI FIFGG, I F.
G HFG GHFG G IG I F GH GHFN
I, , F >, F HG G G F GGH (H-
) HGH Z*IFI F[, I GGH GF NG I HF PG FP G. LGH IG GHIG LFHG I L
H R GHF FHHG GG. MFR
JIG HFG G F H FT JH IFH
>IT HFG HGH HT. AIG HF>G H FG G-
HJG >IG HFG GHFT R JFGG GG
26
R >F IT M >IT HFG GRG FH-
JG M HFG JIG GG
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CafE+na y rEndiMiEnto Cognitivo
27
FT >TJG GG (CG & H 2006; A & FF-!FIG 2010), II FF & $I (2009) GFJ I >F >IT
I HF H GI 280 R FT -
. APG, R >F FH HF HFG FRGHG
GFHIF JIG IHG HFG (I H ., 2006), IT
JIG GG (BF & H 2001; * H ., 2006) M >IT HFG
GRG FHJG M HFG (!GH H ., 2010).
G G GI R IT G G HFQG -
F T I > JRIG F HI GFP. BF
& H (2001) GHIF GH GH I HF IT GI FHF. GFJF I HFG GI R G JIG FN
I IT G JHG J-
H, PG GH, FG M GIF FT
IG I GI . APG,
GHF I H G FT H
F GH IFH 1 F (JF IF 5). E G-
HI PG FH * H . (2006) G JT
G FG IT HIF
I IHGH IFH 200 , F G HG GHFT
I HN Q (200 ) FNT I GGH FJ 30 IHG
GH I Q G. G FFFG IT (FINF R
HF FFG) G FI> 75% FHHG I HF Q
FT 66% G I F GGH M GT 13% G I GI-
F Q G.
FG GH R G JIGFN I IT PG GH,
FG M GIF FT
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F'&- 5. %@O< < < @ =<O< 10 < @<< =@ @ =<= M< = >=. *=@ >=@< <@=@
100 << =@ >@O< (<= @@=@) @>= M< . "==
B@ & ' (2001).
E F, G G G HFG HG M/ GHFG GI
GG >G R G GIFFG G G JIG G GHIG
QH HJT, G G GI>HG HG (H H ., 2005;
J DI H ., 2005; FJFGH H ., 2008; !GH H ., 2010) I
FF GH FJT GIS
(MHH H ., 2004; GGH H ., 2005; F
H ., 2006; F H ., 2006; ' H ., 2007;
I H ., 2007). C GIF MHH H . (2004)
GFFFG PG HF>G G
(. >. IHFG, HF>FG HIF -
HIF FHHF), JI IH M GIF F N IG R GHFH F GF G QHG FH FJG F
GIS GIH M G HFGHFG FH F.
28
C a m b i o
e n l a p r e c i s i ó n
Tarea de conducción
Cafeína
90
10 min 20 min 30 min 40 min 50 min 60 min
94
98
102
106
Placebo
G HG GHJG RG GIFFG GI>HG HG
I FF GHG FJT GIS
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CafE+na y rEndiMiEnto Cognitivo
29
EHG R HFG F
M IG >IHJG
6
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G HFG F GGH FGHT I HF I GI>H FFF HFGIFF I HF H, IGF F FGF
I >F I G I FGHF F IH ( FIHG FHG)
F. EGHG HFG G F IT
M IFT Q F-
T. E G HFG F H FH
N HFJ H HF FGHT M
FIF G FH M -
H H (. >. FIF GHG FG
UFG). G HFG F HF> G IG I FIF I MF
IFT Q FT, II QGH G HQ H, M - FT G F FH N F F FGJF U
FIFH G HF (. >. FHQH, FNH JF M F-
GT). H, HG G HFG F F N, G I HF-
J HF FGHT M FIF G G JFGG FG RG IG
GG; IFT Q FT G F M H.
EGHG UHG GI IFG G HFRG HFG HJG GG
G HF>G I GHI HG GI R, F G IHG
HTG I FH GI JIT.
MFR HF>G IG GFJ I GHFT R
>F J FGT G HFG FN> M F GI-
>HG GG FGHFG G IG HJT ( & FHM,
2005; G H ., 2005; CG & HH, 2006; FJFGH H ., 2008; A &
FF-!FIG 2010). E G H GG IHN
M I G FHHG G GIFG HIG HIG R.
F, JIG I G G HFG HJT
GHIG GHFGHG GR G H HG GHJG GI R
GHG HFG (F H ., 2002; !GH H ., 2010).
D G , G FGIHG H FH G GHFT
R GI>HG GG >IT HFG F HF>
HF JF M G (G H ., 2005; FG H ., 2009). E ,
G HF>G I LF H R >IT HFG F
HF> HF IQF GR H HG GHJG GI GHFT
30
E G HFG HJT GHIG GHFGHG R H HG GHJG
G HFG F
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(G H ., 2005; G H ., 2009), HH FHHG GIFG -HIG HIG R (JF IF 6). *I I
HF GHG HFG G I H J IH GHFF FGIHG G-
HJG. G GHIG I IHN ' J IG G
HJ IF FG GH R IFH FNT
HFG F HF> (GHHHF H ., 2010). AGR, IG
HG GHJG R GHG >IT (J M F-
GT), G GFJ I HJ FF G FG FG -
F HF> M G IG >IHJG (FHN FFH FGHF M
I GF F) I F GIFN F FF F
LHG (GHHHF H ., 2008, 2010).
F'&- 6. E= M< < = @> < @ =@
@= =< @ <L@= = < =<=@ <= =<=@ -
. ' @>@< = <@ @<<= < >L =<= >-
= = M< (75 150 ), = < <=. "== H .
(2005).
CafE+na y rEndiMiEnto Cognitivo
31
C a m b i o e n e l t i e m p o d e r e a c c i ó n
Memoria de trabajo
Consumidores
-50
-30
-40
Placebo
75 mg
150 mg
-20
-10
0
No consumidores
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G IG >IHJG G GF FGG F GIFF I G F HF HJ, GIT M FT IH (BFIMQ H .,
2010). H FHH G G F F G -
FG, GR F FIF I FT I G HFF.
DG FIG IFGTG I JU HF F G HF HF
M HGH FHG GG. E GHG HFG GHFT GG >G
R FGH G FH HFT
GI R G JIG (I H ., 2007; FJFGH H ., 2008; -
G H ., 2009; A & FF-!FIG 2010; BFIMQ H ., 2010). T G GFJ
I JH> GHFT R GG FHF 200 -
GIFG HIG (BFIMQ H 2010) M 400 GIFG -HIG (BFIMQ H 2010).
32
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CafE+na y rEndiMiEnto Cognitivo
33
CR MGH GI>HJ
7
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34
JIT GH GI>HJ G JIG I FNFG H IF JF IGHFG IHJIT. EHF G GHFIHG PG IH-
NG GHI G HG R G EG
HF (E), *F ' HHG (*') M G GG T-JGIG
(EA). G G G GHF GGG G HG GI R.
G EA G I GHFIH FGIGH FP I H F F-
T, G G G FN G FHG. IHNT I >IH
8 EA (JF IF 7), IHF G I F FT GT
HJT GI>HJ (FH, JFG, G M F) M IHF G I
F H GI>HJ (HH, , FG M HG), FHF F I M H GH GI>HJ (A H ., 2008). C
G G 100 HI M G GH JI I FI HF
"" (NIF) M "IM" (F) GI FT GH I G IHF
H FGF (IHIG I I GF HF 0 M 100). C
FI IHF GG G H I IHIT , IM G -
IF, G GIHG TFIG: HJT = (FH) + (JFG) + 200 -
(G) - (F)/4; H = (HH) + () + 200 - (F) -
(HG)/4. C G I HQ GFFG JIH F HF-
F GI GG FGH JF T I G GHI.
F'&- 7. C=<<= A<O= * (EA*) >@ O< O<
= =. ! =< = <= @ < 100 .
!= = @, =@==, <= =@= >@<< <O< -
O< , <@ = =<<=, =, >@= <= =.
C $ $*"$*- $* $$ $*?
'IMAFH
DFG
FG
CHH
CG
C
DF
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G HG R GH GI>HJ IG G GHI I-FGG HF>G M FIGHG. G FGIHG G JGHG IGHF
I GI R G G F G. G GI>HG -
GH I G IHF PG FH, HG M JFGG, GR PG G
HFFG M HJG F HF>. *F -
HF, G FT GI>HJ G-
, H, G M H HJ. E G
GFJ GHFIH
T IHN F JIF GH GI>HJ M
I F JF GG (BF & H 2001;
CFGHF H ., 2005; G H ., 2005; CG & HH 2006; KHH & H2007; H 2002; 2009; A H ., 2008; BFIMQ H ., 2010,). E F -
G F I G FI I H GG-H, MF GG H GIFF,
G F GG PG HJ HF 100-400 .
G HG GG R GF G JIG GI>HJG G GIFFG
GHFT GG >G G G JIG G HFG HJT,
G G GI>HG HG (H H ., 2005; FJFGH H ., 2008) M HF-
>FG GHIT FJT GIS (MHH H ., 2004; * H
., 2006; GGH H ., 2005; F H ., 2006; F H ., 2006). APG, I-
I G HG GHJG R GF HJT GI>HJ M H G F-
I HH GIFG HIG HIG, G GIFG
HG JG R G G I GH FF MFG G
GG GI (FG H ., 2003; KHH & H 2006; AHHK H ., 2007).
G JF G I GI R FIN HG -
JFGG FT GH GI>HJ, G H GFF
FR R. EHF G GH PG FIHG H
FHF G, HGT M FJGG, M GF. Q I F-
IF I HF F I GH FNT G HFG HG, FGR I F>IF FH G G JU HFG H HF F-
GT. G HG JFGG G GFJ GG GHFT GG -
JG R JIG JIFG FT GHG HG JFGG
(H 2002; CG & H 2006; AHHK H ., 2007).
CafE+na y rEndiMiEnto Cognitivo
35
FG GH R G JIGG IHF PG FH, HG,
JFGG M HJG F HF>
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JGHT A H . (2008) FGIH HFQG FI FH LGH I H GHJ GH GI>HJ FP HFG GI HH I Q
R (100 ) I G (G 5 ) JIG
GG. APG, GHI G JT G HIFRGHG FGH
GHFT R, IHNPG Q GFGG HH F I HR R
F G. G G G HIF HG M GIQG (10, 20 M
30 ) GI. GHFT Q
R FI> HG GHIHG (F G-
M MF HJT) HG G FGHFG GH-
GI, HFG I Q G GT
FI> >FRG FGHF H GHFF GI (10 ). C G , R -
N L FF G 30-45 HFG GI GI. OGH G H I G
GH HFGIFFF F F JF GIG HG FG, F I
MFR GHIG G FGHFG GH-GI HFGIFFG HF 30-120
. F, 50% L G N M G 10 GH-GI M
I GF GIH F I I FFG HG FG M, F HH,
I FGIGH FP. G FGIHG IGHF HFQG JIF G HG HG
G 30 IHG HFG GI R GR G Q G M
I, II F , HQ FH U GH GI>HJ.
Q GFFFG HF>G I JU G LGH FGIGH FP
FH HFG >IT >HJG.
E FGIGH GI>HJ FP G HG HJFG GI HH Q
R G LGH FG HF GLG (A H ., 2008).
FGIGH Q R G GIFF G FG M Q G G
I>FG. IF 8 IGHF FGH T FJ GI
G M IF 9 HJT GI>HJ F G 3 FGHFG GH-GI
HIG (10, 20 M 30 ) F M I>FG. AII GL G I HF I
HF IFGG FG FH HJ, MFR HF>GGF G HG IHIG R II IM FHHG G
GLG N G GG FG HF G. PG HG IH
I G I>FG IGHF F FT GHFT GIG-
HG GHIHG ('IF H ., 2006) M F GG G HG GHJG
R GF FH HFG HJG (BFIMQ H ., 2010), G JH
36
GHFT Q RFI> HG GHIHG (FG M MF HJT)
HG G FGHFG GH-GI
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CafE+na y rEndiMiEnto Cognitivo
37
I G FINF GH GH. *F G G HF IH GHFI G I>FG, M I LGH J I FH HJ G
>F IFH G IH G HFG HT M G JIHF G
F (G-FHN & CFG-CFF 2008).
F'&- 8. C= < O< =<=< <@ < =<= =
10, 20 30 < >L =<= < L >@= =< M< (A) = <=
(B) < =@ @ O<. ' O E '=<=< '<=@
><O< = S1- " <= =, , @, =>< >@=T
S7- C < N=, =<= <= N=, <> >@ >@<@ -
>@=T. D= @=@= A< . (2008).
C a m b i o d e p u n t u a c i ó n
Figura 8A. Café con cafeína
Hombres
-1,15
Post-10 Post-20 Post-30
-0,65
-0,9
-0,4
0,1
-0,15
Mujeres
C a m b i o
d e p u n t u a c i ó n
Figura 8B. Café descafeinado
Hombres
-1,15
Post-10 Post-20 Post-30
-0,65
-0,9
-0,4
0,1
-0,15
Mujeres
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F'&- 9. C= < O< O< <@ < =<= = 10, 20 30 < >L =<= < L >@= =< M< (A) = -
<= (B) < =@ @ O<. ! O< O =< @-
> 4 E A<O= * <= = < O@: (@)
+ (=@==) + 200 - (<=) - (=@=)/4. D= @=@= A< . (2008).
38
C a m b i o d e
p u n t u a c i ó n
Figura 9A. Café con cafeína
Hombres
1,5
Post-10 Post-20 Post-30
4,5
3
6
7,5
10,5
9
Mujeres
C a m b i o d e p u n t u a c i ó
n
Figura 9B. Café descafeinado
Hombres
Post-10 Post-20 Post-30
Mujeres
1,5
4,5
3
6
7,5
10,5
9
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CafE+na y rEndiMiEnto Cognitivo
39
CR HFG GIGHG
8
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LFG IR G G FQHG, M I QGHG H >IH R HFG GIGHG GGHIHG, HIF, G
HG FTH FJHG F GIF HG GH-
IHG GRIG M RGG GIFFG, F HQ FGG FHG
G GI G J M/ HI H. CHFFG GH FH
IG, F GF I H FGH IGHF H I GI IH
F FR C (F & FMGH, 1992), G F GI I
IH, M IM GH T R GI GF IM F-
IH. F HI GIF R G H FFGG I
GI MFR H JG JG IG M R >G GG (42 F
NUF + 30 R F H). Q GI SFG NUF G FFG Q M HQ II H >, HF 8 M 20 F. GG HJ F J-
F HG IG T GHF LIGJH G > (<25
F) IHG >TJG M J (50-75 F) G ('GGF, 2004). IG
H HG GHJG GF T, G F >IT HFG
FN> M F (H H ., 2005; M H ., 2006).
*FT>H, LGH IM G HF>G IG I JGHI H
T R M IG FH HJ G -
MFR T QGH G F HI GIF R. AGR, GHI
T ZPHG M HHIG G GSG FH GI Q[, F-
N 2011 F CHF #FT CQ M I I IGHF 3.000
FGG H EGS, G J I 90% G GIFG
Q IF M G 66% H F NUF (HH://KKK.G.G/). G
FGIHG GHIG GI>HG IHG GG, G THG HJ-
T, I R M IG G H HG GQFG -
FT GHFT GIGH G. G G G GFJ
GH HFG HT GGH, FN> M F (M &
M, 2004; H H ., 2006; A & FF-!FIG 2010).
AGG, H IHNT HQ G HG JG, G
J I F R M IG FI I >F HJ -
FF FH HFG HT ( H ., 2005). *F HF , IH-
N HQ ', G GFJ HG GG GI
G GIGHG HFG HT GGH H (FF-!FI-
40
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G H ., 2010), IH G PFG FFG I GIGHH HT M F HF> (F HJT FHN FH HF
M FHN FFH NIF) FGH GI>HG I HF ,
R IG GG (JF IF 10). G GHG >IT HF,
, IF GFG H GI.
F'&- 10. V@ =< @@ =@ < >@ @-
O< < @ <O< =< =>@<= @@= = >@=
=<= =< @= @ =<= >=, =, M< = = + -
M<. "== '@@-G@= . (2010).
CafE+na y rEndiMiEnto Cognitivo
41
P"$!
%@
%=
G"
%@
%=
C%$*
%@
%=
G" + C%$*
%@
%=
0
5
10
15
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42
F, GFFFG PG JGHG F JIF F HG GHG FTG GHFT R M IG M GI H
GF IH. *I I H G JH>G GIF G I -
H J H NUF M > R. AGR, AFG & F (2006)
GFJF I GHG G FH G HFG I FR LHG
FH IF JF. APG, T HQ I F-
IF HG GQFG GF HJ G FIHG QFG, I-
H G FG FFNHG GI M FG GFFF I HFT
LGJ GI ( H ., 2009).
I, PG, I I GH LGJ NUF GI I HF FGI FG GFFF G M GRF HT. A GF HG
FHG GHIG GG-FGIGH I JU R GG IG
IHNF F GIF G HG GQFG, FT G GH
U G I F IG GG >G (<25 F) R I GF T
PG G G G IG F IHF IGHF FH HJ,
G IHG >TJG. I GI I GMI I G S Q F
S, HF I Q HQ I FN Q HFG HG
R. EGHG G UHG, PG, GI I I T G G FIFF -
HF I I FHT FG G HG -
JFGG, G HJ RG (JF RGG PG, IFG HF> IFGG
M/ UG), G GIFG GHFQG, I G I HF I F GFHT.
FHH GH I I GIH FHT F>I F-
H HJ IHG >TJG M GG M, MF , SG M G
I IGHF MF JIF GFHFG (!F> & !F>, 2007;
F, 2007). I GH FHT G I HF FHHF FH FG
GIFF HG FG GFFF HRG, FIJ I GFF
HH HFG RGG HG M >F FT GHF G -
JIG (HN & BFFIH, 2005; & K, 2007). AII IG PGIJFG F HFG FH G I, JG IHNF HFG G I
H HG G (GG, FFHG, R, H.) I FIF
HG PG GG JN I FGIH PG HFHJ GI GI F GF,
F I HFG IG. E G HF F G GG JG IG,
FT G I G I IGF H F GI.
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CafE+na y rEndiMiEnto Cognitivo
43
GF I IG FGG
9
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44
E IG R GG GH 400 , IJH 4 QG, I GFI GHFH N M GIF >FF IGHF HJ, M I GI
H FG FI FHG FH, HT M -
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CafE+na y rEndiMiEnto Cognitivo
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$, A. & H@, !.. (2005). = < < >< =< <=< < =@. H< %=>@==. C< < E>@<, 20, 193-202.
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