CbnœrResearchVOLUME 51 •NUMBER 1 •CNREA8 •PP 1-464

CONTENTS§

Asterisks * preceding page numbers refer to studies using human-derived material.

Editorial

1 Progress Report to the Readers of Cancer Research. Carlo M.Croce.

Perspectives in Cancer Research

2 The Inhibition of Tumor Growth by Tumor Mass. Richmond T.Prehn.

Special Lecture

5 The Chemical and Biological Route from Podophyllotoxin Glu-coside to Etoposide: Ninth Cain Memorial Award Lecture.Hartmann F. Stähelinand Albert von Wartburg.

16 Effects of Choline Deficiency and Methotrexate Treatment uponLiver Folate Content and Distribution. Jacob Selhub, EliasSeyoum, Elizabeth A. Pomfret, and Steven H. Zeisel.

22 Inhibition of Tumor-inducedAngiogenesis by Sulfated Chitin Derivatives. Jun Murata, Ikuo Saiki, Takashi Makabe. YasuhiroTsuta, Seiichi Tokura, and Ichiro Azuma.

* 27 Expression of Class I Major Histocompatibility Complex Antigens in Epstein-Barr Virus-carrying Lymphoblastoid Cell Linesand Burkitt Lymphoma Cells. Wolfgang Jilg, Raymond Voltz,Christine Markert-Hahn, Helga Mairhofer, Iris Münz,and HansWolf.

*33 Combined Analysis of DNA Ploidy Index and N-/nyc GenomicContent in Neuroblastoma. J. Bourhis, F. DeVathaire, G. D.Wilson, O. Hartmann, M. J. Terrier-Lacombe, L. Boccon-Gibod,N. J. McNally, J. Lemerle, G. Riou, and J. Bénard.

37 Concentration-dependent Increase of Murine P388 and B16 Population Doubling Time by the Acyclic Monoterpene Geranio!.Suzanne M. Shoff, Mary Grummer, Milton B. Yatvin, and CharlesE. Elson.

* 43 Some Antagonists of Platelet Activating Factor Are Cytotoxic forHuman Malignant Cell Lines. Susanne Danhauser-Riedl, StephanB. Felix, William J. Houlihan, Monica Zafferani, GabrielaSteinhauser, Dorothea Oberberg, Hildegard Kalvelage, RaymondeBusch, Johann Rastetter, and Wolfgang E. Berdel.

#49 Hepatitis B Virus Integration Event in Human Chromosome 17pnear the p53 Gene Identifies the Region of the ChromosomeCommonly Deleted in Virus-positive Hepatocellular Carcinomas.Betty L. Slagle, Yi-Zhong Zhou, and Janet S. Butel.

* 55 Protein Kinase C Activity and Multidrug Resistance in MOLT-3Human Lymphoblastic Leukemia Cells Resistant to Trimetrexate.Gary K. Schwartz, Hadara Arkin, James F. Holland, and TakaoOhnuma.

62 Participation of T-Lymphocytes in the Curative Effect of a NovelSynthetic Polyamine Analogue, A',A"-Bis|3-(ethylamino)propyl|-1,7-heptanediamine, against LI210 Leukemia in Vivo. Terry L.Bowlin, Nellikunja J. Prakash, Michael L. Edwards, and AlbertSjoerdsma.

$67 Effect of Buthionine Sulfoximine on Toxicity of Verapamil andDoxorubicin to Multidrug Resistant Cells and to Mice. James M.Ford, Jin-ming Yang, and William N. Hait.

#73 The Effects of Five Hematopoietic Growth Factors on HumanSmall Cell Lung Carcinoma Cell Lines: Interleukin 3 Enhancesthe Proliferation in One of the Eleven Cell Lines. Edo Vellenga,Bonne Biesma, Coby Meyer, Lex Wagteveld, Mariet Esselink, andElisabeth G. E. de Vries.

# 77 Tumor-dependentIncreased Plasma Nitrate Concentrations as anIndication of the Antitumor Effect of Flavone-8-acetic Acid andAnalogues in Mice. Lindy L. Thomsen, Lai-Ming Ching, LiZhuang, John B. Gavin, and Bruce C. Baguley.

82 Differential Activation and Inhibitionof Lymphocyte Proliferationby Phorbol Esters, Mezerein, Teleocidin, and Okadaic Acid.Deborah S. Grove and Andrea M. Mastro.

#89 Allelotype Study of Primary Hepatocellular Carcinoma. MinurtiFujimori, Takashi Tokino, Okio Hiño,Tomoyuki Kitagawa,Takayuki Imamura, Eizo Okamoto, Masao Mitsunobu. TakashiIshikawa, Hitoshi Nakagama, Hideharu Harada, MichiyasuYagura, Kenichi Matsubara, and Yusuke Nakamura.

#94 Sensitization of Human Melanoma Cells to the Cytotoxic Effectof Melphalan by the Glutathione Transferase InhibitorEthacrynicAcid. Johan Hansson, Kiflu Berhane, Victor M. Castro, UlfJungnelius, Bengt Mannervik, and Ulrik Ringborg.

99 Thy-1 as a Negative Growth Regulator in ras-transformedMouseFibroblasts. Yoshikazu Sugimoto, Yoji Ikawa, and HiromitsuNakauchi.

* 105 Variant Human Breast Tumor Estrogen Receptor with Constitutive Transcriptional Activity. Suzanne A. W. Fuqua, Saundra D.Fitzgerald, Gary C. Chamness, Atul K. Tandon, Donald P.McDonnell, Zafar Nawaz, Bert W. O'Malley, and William L.

McGuire.

Antitumor Activity of 7WV-||2-|[2-{7-L-Glutamylamino)ethyl|di-thio!ethyl)|mitomycin C. Makoto Morimoto, Tadashi Ashizawa,Hiroe Ohno, Mitsuhiko Azuma, Eiji Kobayashi, Masami Okabe,Katsushige Gomi, Motomichi Kono, Yutaka Saitoh, YutakaKanda. Hitoshi Arai, Akira Sato, Masaji Kasai, and TakashiTsuruo.

$ 116 A Double-Blind Placebo-controlled Study with Granulocyte-Mac-rophage Colony-stimulating Factor during Chemotherapy forOvarian Carcinoma. Elisabeth G. E. de Vries, Bonne Biesma, PaxH. B. Willemse, Nanno H. Mulder, Angelika C. Stern, Jan G.Aalders, and Edo Vellenga.

123 Sensitive Detection of DNA Modifications induced by Cisplatinand Carboplatin'in Vitro and in Vivo Using a Monoclonal Anti

body. Michael J. Tilby, Caroline Johnson, Richard J. Knox,Jacqueline Cordell, John J. Roberts, and Christopher J. Dean.

130 Reversible and Phorbol Ester-specific Defect of Protein Kinase CTranslocation in Hepatocytes Isolated from Phenobarbital-treatedRats. J. Scott Brockenbrough. Sharon A. Meyer, Chenxing Li.and Randy L. Jirtle.

§The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS. This On«

Q8JY-3NJ-XPGAResearch.

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137 Stereoselective Formation of in Vitro Nucleic Acid Adducts by2,3-Epoxy-4-hydroxynonanal. Rama S. Sodum and Fung-LungChung.

* 144 Effect of a Chimeric Anti-Ganglioside GDZAntibody on Cell-mediated Lysis of Human Neuroblastoma Cells. Edward Barker,Barbara M. Mueller, Rupert Handgretinger, Michael Herter, AliceL. Yu, and Ralph A. Reisfeld.

$ 150 Expression of Functional Epidermal Growth Factor Receptors ina Human Hematopoietic Cell Line. John Oval, Robert Hershberg,Bernd Gansbacher, Eli Gilboa, Joseph Schlessinger, and RaymondTaetle.

$157 Cellular Pharmacology of MX2, a New Morpholino Anthracy-cline, in Human Pleiotropic Drug-resistant Cells. MasahikoWatanabe, Nobuyasu Komeshima, Mikihiko Naito, ToshiyukiIsoe, Noboru Otake, and Takashi Tsuruo.

$ 162 ProgrammedCell Death during Regression of the MCF-7 HumanBreast Cancer following Estrogen Ablation. Natasha Kyprianou,Hugh F. English, Nancy E. Davidson, and John T. Isaacs.

167 Role of Asbestos and Active Oxygen Species in Activation andExpression of Ornithine Decarboxylase in Hamster Trachea! Epithelial Cells. Joanne P. Marsh and Brooke T. Mossman.

* 174 Cytotoxic Activity of a Recombinant Fusion Protein betweenInsulin-like Growth Factor I and Pseudomonas Exotoxin. TrevorI. Prior, Lee J. Helman, David J. FitzGerald, and Ira Pastan.

$ 181 Generation and Characterization of a Recombinant/ChimericB72.3 (Human y,). P. Hutzell, S. Kashmiri, D. Colcher. F. J.Primus, P. Horan Hand, M. Roselli, M. Finch, G. Yarranton,M. Bodmer, N. Whittle, D. King, C. C. Loullis, D. W. McCoy,R. Callahan, and J. Schlom.

$ 190 Urinary Excretion of Nitrate, jV-Nitrosoproline,3-Methyladenine,and 7-Methylguanine in a Colombian Population at High Risk forStomach Cancer. W. G. Stillwell, Joseph Glogowski, H-X. Xu,John S. Wishnok, Diego Zavala, G. Montes, Pelayo Correa, andSteven R. Tannenbaum.

195 Isolation of Two Chloroethylnitrosourea-sensitive Chinese Hamster Cell Lines. Hiroaki Hata, Masayuki Numata, Hiroko Tohda,Akira Yasui, and Atsushi Oikawa.

199 Selective DNA Interaction of the Novel Distamycin DerivativeFCE 24517. Massimo Broggini, Eugenio Erba, Mauro Ponti,DaríoBallinari, Cristina Ceroni, Federico Spreafico, and MaurizioD'Incaici.

* 205 Altered Protein Kinase C Activity in Biopsies of Human ColonieAdenomas and Carcinomas. R. Kopp, B. Noelke, G. Sauter, F. W.Schildberg, G. Paumgartner, and A. Pfeiffer.

#211 Preclinical in Vivo Activity of 2',2'-Difluorodeoxycytidine (Gem-

citabine) against Human Head and Neck Cancer. Boudewijn J.M. Braakhuis, Guus A. M. S. van Dongen, Jan B. Vermerken,and Gordon B. Snow.

$215 Combination Effect of Recombinant Human Interleukin la withAntitumor Drugs on Syngeneic Tumors in Mice. ShinichiNakamura, Shigeki Kashimoto, Fumie Kajikawa, and KatsuhisaNakata.

$222 A Complex between Prostate-specific Antigen and «,-Vmidiy-motrypsin Is the Major Form of Prostate-specific Antigen inSerum of Patients with Prostatic Cancer: Assay of the ComplexImproves Clinical Sensitivity for Cancer. Ulf-HàkanStenman,Jari Leinonen, Henrik Alfthan, Sakari Rannikko, Kari Tuhkanen,and Olof Alfthan.

$ 227 Metabolic Inactivation: A Mechanism of Human Tumor Resistance to Bleomycin. Said M. Sebti, Jitesh P. Jani, Jehangir S.Mistry, Eli Gorelik, and John S. Lazo.

$ 233 Preclinical Study of Sequential Tumor Necrosis Factor and Interleukin 2 in the Treatment of Spontaneous Canine Neoplasms.Antony S. Moore, Gordon H. Theilen, Arthur D. Newell, BruceR. Madewell, and Alfred R. Rudolf.

$ 239 Immunocytochemical Determination of Estrogen Receptor, Progesterone Receptor, and 1,25-Dihydroxyvitamin I), Receptor inBreast Cancerand Relationship to Prognosis. Uta Berger,RichardA. McClelland, Patricia Wilson. Geoffrey L. Greene, Mark R.Haussler, J. W. Pike, Kay Colston, Douglas Easton, and R. CharlesCoombes.

# 245 Direct in Vitro Lysis of Metastatic Tumor Cells by Cytokine-activated Murine Vascular Endothelial Cells. Limin Li, Garth L.Nicolson, and Isaiah J. Fidler.

$255 Preclinical Assessments of ""Y-labeled C110 Anti-Carcinoem-

bryonic Antigen Immunotoxin: A Therapeutic Immunoconjugatefor Human Colon Cancer. Tsunao Ito, Helena Qiu, Jeffrey A.Collins, A. Bertrand Brill, David K. Johnson, and Thomas W.Griffin.

$261 Interleukin 4 Receptor Expression on Human Lung Tumors andNormal Lung. Muhammad F. Tungekar, Helen Turley, MichaelS. Dunnill, Kevin C. Gatter, Mary A. Ritter, and Adrian L. Harris.

265 Microvascular Architecture in a Mammary Carcinoma:BranchingPatterns and Vessel Dimensions. Joanne R. Less, Thomas C.Skalak, Eva M. Sevick, and Rakesh K. Jain.

$ 274 Inhibition of Urokinase-type Plasminogen Activator by Antibodies: The Effect on Dissemination of a Human Tumor in the NudeMouse. Liliana Ossowski, Helen Russo-Payne, and Elaine L.Wilson.

282 Karyotypic Changes Associated with Loss of Prolactin Dependency of Rat Nb2 Node Lymphoma Cell Cultures. Douglas E.Horsman, Sharon Masui, and Peter W. Gout.

$ 288 DNA Damage Inducedby 193-nm Radiation in Mammalian Cells.Irene E. Kochevar, Agnes A. Walsh, Howard A. Green, MargaretSherwood, Alice G. Shih, and Betsy M. Sutherland.

$ 294 Loss of Heterozygosity for the Short Arm of Chromosome 11(llplS) in Human Milk Epithelial Cells Immortalized by Mi-croinjectionof SV40 DNA. IreneGarcia, Daniel Brandt,JonathanWeintraub, Weigong Zhou, and Matti Aapro.

301 Expression and Inducihility of Drug-metabolizing Enzymes inNovel Murine Liver Epithelial Cell Lines and Their Ability toActivate Procarcinogens. Moreno Paolini, Enrico Barone, ClaudioCorsi, Carla Paganin, and Roberto Paolo Revoltella.

310 Antitumor Activity of Idiirubidii-Monoclonal Antibody Conjugates in a Disseminated Thymic Lymphoma Model. M. J. Smyth,M. Bogdanovski, I. F. C. McKenzie, and G. A. Pietersz.

318 RapidRegression of SquamousCell Hyperplasia and Slow Regression of Basal Cell Hyperplasia in the Forestomach of F344 RatsTreated with ALMethyl-/V'-nitro-A'-nitrosoguanidineand/or Bu-

tylated Hydroxyanisole. Masae Tatematsu, Kumiko Ogawa,Mamoru Mutai, Toyohiko Aoki, Toru Hoshiya, and NobuyukiIto.

$324 Increased Sensitivity of Nontumorigenic Fibroblasts Expressingras or myc Oncogenes to Malignant Transformation Induced by5-Aza-2'-deoxycytidine. Donata Rimoldi, Vasantha Srikantan,

Vincent L. Wilson, Robert H. Bassin, and Dvorit Samid.

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•(•331Characterization of Mucin Antigens Recognized by MonoclonalAntibodies Raised against Human Colon Cancer Cells. ShigeyukiFukui, Tomoyo Hone. Yoshito Numata, Hiroshi Kitagawa,Hiroshi Nakada, Toshisuke Kawasaki, Ikuo Funakoshi, and IkuoYamashina.

* 336 Biochemical and Genetic Characterizationof the HBA71 Ewing'sSarcoma Cell Surface Antigen. Erich J. Fellinger. Pilar Garin-Chesa, Sai L. Su, Paula DeAngelis, Joseph M. Lane, and WolfgangJ. Rettig.

#341 Establishment and Characterization of a Human Leukemia CellLine with Megakaryocytic Features: Dependency on Granulocyte-Macrophage Colony-stimulating Factor, Interleukin 3, or Eryth-ropoietin for Growth and Survival. Norio Komatsu, HiromitsuNakauchi, Akiyoshi Miwa, Toshiki Ishihara, Mitsuoki Eguchi,Masaaki Moroi, Masayuki Okada, Yuko Sato, Hideho Wada,Yoshihito Yawata, Toshio Suda, and Yasusada Miura.

*3-l(» Fibrinogen Deposition without Thrombin Generation in PrimaryHuman Breast Cancer Tissue. Vincenzo Costantini, Leo R.Zacharski, Vincent A. Memoli, Walter Kisiel, Bohdan J. Kudryk,and Sandra M. Rousseau.

* 354 Occurrence of Components of Fibrinolysis Pathways in Situ inNeoplastic and Nonneoplastic Human Breast Tissue. VincenzoCostantini, Leo R. Zacharski. Vincent M. Memoli, Bohdan J.Kudryk, Sandra M. Rousseau, and David C. Stump.

$359 Hyperthermia Effects on Cytosolic |( :r*|: Analysis at the Single

Cell Level by Digitized Imaging Microscopy and Cell Survival.Ross B. Mikkelsen, Leslie Reinlib. Mark Donowitz, and DavidZahniser.

$365 Establishment and Characterization of SV40 T-Antigen Immortalized Human Esophageal Epithelial Cells. Gary D. Stoner, M.Edward Kaighn, Roger R. Reddel, James H. Resau, DouglasBowman, Zenya Naito, Norio Matsukura, Ming You, Anthony J.Calati, and Curtis C. Harris.

* 372 Characterization of New Pancreatic Cancer-Reactive MonoclonalAntibodies Directed against Purified Mucin. Jenny J. L. Ho, NingBi, Pei-sha Yan, Mei Yuan, Kristine A. Norton, and Young S.Kim.

$ 381 Establishment and Characterization of Human Signet Ring CellGastric Carcinoma Cell Lines with Amplification of the v-mycOncogene. Kazuyoshi Yanagihara, Toshio Seyama, MasaruTsumuraya, Nanao Kamada. and Kenjiro Yokoro.

* 387 Increased Content of an Endogenous Lactose-binding Lectin inHuman Colorectal Carcinoma Progressed to Metastatic Stages.Tatsuro Irimura, Yoshifumi Matsushita, Regina C. Sutton, DuniaCarralero, David W. Ohannesian, Karen R. Cleary, David M.Ota, Garth L. Nicolson, and Reuben Lotan.

394 Endothelial Cell Membrane Vesicles in the Study of Organ Preference of Metastasis. Robert C. Johnson, Hellmut G. Augustin-Voss, Duzhang Zhu, and Bendicht U. Pauli.

$400 Cytogenetic Abnormalities and Overexpression of Receptors forGrowth Factors in Normal Bronchial Epithelium and TumorSamples of Lung Cancer Patients. Gabriella Sozzi, MonicaMiozzo, Elda Tagliabue, Carla Calderone, Luciano Lombardi,Silvana Pilotti, Ugo Pastorino, Marco A. Pierotti. and GiuseppeDella Porta.

$405 Invasion of Reconstituted Basement Membrane Matrix Is NotCorrelated to the Malignant Metastatic Cell Phenotype. AgnèsC.Noel, Aleth Callé,HervéP. Emonard, Betty V. Nusgens, LéonSimar, Jacqueline Foidart, Charles M. Lapiere, and Jean-MichelFoidart.

415 Role of Endogenous Tumor Necrosis Factor a and Interleukin 1for Experimental Tumor Growth and the Development of CancerCachexia. Johan Gelin, Lyle L. Moldawer, Christina Lönnroth,Barbara Sherry, Richard Chizzonite, and Kent Lundholm.

$422 Cytogenetic Profile of 109 Lipomas. Chandrika Sreekantaiah,Stanley P. L. Leong, Constantine P. Karakousis, Daniel L. McGee,William D. Rappaport, Hugo V. Villar, David Neal, SusanFleming, Albert Wankel, Peter N. Herrington, Richard Carmona,and Avery A. Sandberg.

434 Early Lesion of Ar-Nitroso-/V-ethylurea-inducedHamster Neuro-fibromatosis Model. Takuro Nakamura, Mitsuru Hará,andTsutomu Kasuga.

$439 Increased Expression of the M, 72,000 Type IV Collagenase inHuman Colonie Adenocarcinoma. Anna T. Levy, Vittoria Cioce,Mark E. Sobel, Spiridione Garbisa, Walter F. Grigioni, Lance A.Liotta, and William G. Stetler-Stevenson.

Advances in Brief

445 Identification of a Second Human nm23 Gene, nm23-H2. JohnA. Stahl, Alvaro Leone, Ariella M. Rosengard, Laura Porter,C. Richter King, and Patricia S. Steeg.

Meeting Report

450 Mouse Pulmonary Carcinogenesis: A Symposium to Honor theMemory of Dr. Michael B. Shimkin. Alvin M. Malkinson.

454 AnnouncementsEighty-second Annual Meeting of the AACRTravel Grants for the AACR and ASCO Annual Meetings for

Young Minority ScientistsAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRAmerican Cancer Society Call for Grant Applications—

Nutrition and CancerCalendar of Events

456 Instructions for Authors

463 Author Index

NOTE: AACR forms available in the back of this issue—•1991 Employment Register Forms and Instructions•Application for Active and CorrespondingMembership•Application for Associate Membership•AdvanceRegistration Form for the 82nd Annual Meeting

Also available in the back of this issue—GUIDELINES FOR SUBMITTING DISKETTES TO

CANCER RESEARCH

Research. on September 26, 2020. © 1991 American Association for Cancercancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 51 •NUMBER 1

CONTENTS Arranged by Subject Category

Editorial

1 Progress Report to the Readers of Cancer Research. Carlo M.Croce.

Perspectives in Cancer Research

2 The Inhibition of Tumor Growth by Tumor Mass. Richmond T.Prehn.

Special Lecture

5 The Chemical and Biological Route from Podophyllotoxin Glu-coside to Etoposide: Ninth Cain Memorial Award Lecture.Hartmann F. Stähelinand Albert von Wartburg.

BASIC SCIENCES

Biochemistry and Biophysics

16 Effects of Choline Deficiency and Methotrexate Treatment uponLiver Folate Content and Distribution. Jacob Selhub, EliasSeyoum. Elizabeth A. Pomfret, and Steven H. Zeisel.

*55 Protein Kinase C Activity and Multidrug Resistance in MOLT-3Human Lymphoblastic Leukemia Cells Resistant to Trimetrexate.Gary K. Schwartz. Hadara Arkin. James F. Holland, and TakaoOhnuma.

82 Differential Activation and Inhibitionof Lymphocyte Proliferationby Phorbol Esters, Mezerein, Teleocidin, and Okadaic Acid.Deborah S. Grove and Andrea M. Mastro.

$222 A Complex between Prostate-specific Antigen and a,-Antichy-motrypsin Is the Major Form of Prostate-specific Antigen inSerum of Patients with Prostatic Cancer: Assay of the ComplexImproves Clinical Sensitivity for Cancer. Ulf-HâkanStenman,Jari Leinonen, Henrik Alfthan, Sakari Rannikko, Kari Tuhkanen,andOlof Alfthan.

*33I

*359

Characterization of Mucin Antigens Recognized by MonoclonalAntibodies Raised against Human Colon Cancer Cells. ShigeyukiFukui, Tomoyo Horie. Yoshito Numata, Hiroshi Kitagawa,Hiroshi Nakada, Toshisuke Kawasaki, Ikuo Funakoshi, and IkuoYamashina.Hyperthermia Effects on Cytosolic |< :i'*|: Analysis at the Single

Cell Level by Digitized Imaging Microscopy and Cell Survival.Ross B. Mikkelsen, Leslie Reinlib, Mark Donowitz, and DavidZahniser.

Carcinogenesis

130 Reversible and Phorbol Ester-specific Defect of Protein Kinase CTranslocation in Hepatocytes Isolated from Phenobarbital-treatedRats. J. Scott Brockenbrough, Sharon A. Meyer. Chenxing Li.and Randy L. Jirtle.

137 Stereoselective Formation of in Vitro Nucleic Acid Adducts by2,3-Epoxy-4-hydroxynonanal. Rama S. Sodum and Fung-LungChung.

167 Role of Asbestos and Active Oxygen Species in Activation andExpression of Ornithine Decarboxylase in Hamster Trachea! Epithelial Cells. Joanne P. Marsh and Brooke T. Mossman.

* 205 Altered Protein Kinase C Activity in Biopsies of Human ColonieAdenomas and Carcinomas. R. Kopp. B. Noelke, G. Sauter, F. W.Schildberg, G. Paumgartner, and A. Pfeiffer.

* 288 DNA Damage Induced by 193-nm Radiation in Mammalian Cells.Irene E. Kochevar, Agnes A. Walsh. Howard A. Green, MargaretSherwood, Alice G. Shih, and Betsy M. Sutherland.

301 Expression and Inducibility of Drug-metabolizing Enzymes inNovel Murine Liver Epithelial Cell Lines and Their Ability toActivate Procarcinogens. Moreno Paolini, Enrico Barone. ClaudioCorsi, Carla Paganin, and Roberto Paolo Revoltella.

318 RapidRegression of SquamousCell Hyperplasia and Slow Regression of Basal Cell Hyperplasia in the Forestomach of F344 RatsTreated with A'-Methyl-jV'-nitro-A'-nitrosoguanidineand/or Bu-

tylated Hydroxyanisole. Masae Tatematsu, Kumiko Ogawa,Mamoru Mutai, Toyohiko Aoki, Toru Hoshiya, and NobuyukiIto.

*324 Increased Sensitivity of Nontumorigenic Fibroblasts Expressingras or myc Onocogenes to Malignant Transformation Induced by5-Aza-2'-deoxycytidine. Donata Rimoldi, Vasantha Srikantan,

Vincent L. Wilson, Robert H. Bassin, and Dvorit Samid.

*3f>5 Establishment and Characterization of SV40 T-Antigen Immortalized Human Esophageal Epithelial Cells. Gary D. Stoner.M. Edward Kaighn, Roger R. Reddel, James H. Resau,Douglas Bowman, Zenya Naito, Nono Matsukura, Ming You,Anthony J. Calati, and Curtis C. Harris.

434 Early Lesion of /V-Nitroso-yV-ethylurea-inducedHamster Neuro-fibromatosis Model. Takuro Nakamura, Mitsuru Hará,andTsutomu Kasuga.

Endocrinology

* 239 Immunocytochemical Determination of Estrogen Receptor, Progesterone Receptor, and 1,25-Dihydroxyvitamin I), Receptor inBreast Cancerand Relationship to Prognosis. Uta Berger.RichardA. McClelland, Patricia Wilson, Geoffrey L. Greene, Mark R.Haussler, J. W. Pike, Kay Colston, Douglas Easton, and R. CharlesCoombes.

282 Karyotypic Changes Associated with Loss of Prolactin Dependency of Rat Nb2 Node Lymphoma Cell Cultures. Douglas E.Horsman, Sharon Masui, and Peter W. Gout.

Immunology

62 Participation of T-Lymphocytes in the Curative Effect of a NovelSynthetic Polyamine Analogue, /V,/V'-Bis|3-(ethylamino)propyI|-1,7-heptanediamine, against LI 210 Leukemia in i irò.Terry L.Bowlin, Nellikunja J. Prakash, Michael L. Edwards, and AlbertSjoerdsma.

* 144 Effect of a Chimeric Anti-Ganglioside GDI Antibody on Cell-mediated Lysis of Human Neuroblastoma Cells. Edward Barker.Barbara M. Mueller. Rupert Handgretinger, Michael Herter, AliceL. Yu, and Ralph A. Reisfeld.

* 181 Generation and Characterization of a Recombinant/ChimericB72.3 (Human 7,). P. Hutzell, S. Kashmiri, D. Colcher, F. J.Primus, P. Horan Hand, M. Roselli, M. Finch, G. Yarranton,M. Bodmer, N. Whittle, D. King, C. C. Loullis, D. W. McCoy,R. Callahan, and J. Schlom.

$255 Preclinical Assessments of ""Y-labeled C110 Anti-Carcinoem-

bryonic Antigen Immunotoxin: A Therapeutic Immunoconjugatefor Human Colon Cancer. Tsunao Ho, Helena Qiu, Jeffrey A.Collins, A. Bertrand Brill, David K. Johnson, and Thomas W.Griffin.

* Indicates studies using human-derived material.

Research. on September 26, 2020. © 1991 American Association for Cancercancerres.aacrjournals.org Downloaded from

* 261 Interleukin 4 Receptor Expression on Human Lung Tumors andNormal Lung. Muhammad F. Tungekar, Helen Turley, MichaelS. Dunnill, Kevin C. Gatter, Mary A. Ritter, and Adrian L. Harris.

310 Antitumor Activity of Idarubicin-Monoclonal Antibody Conjugates in a Disseminated Thymic Lymphoma Model. M. J. Smyth,M. Bogdanovski, I. F. C. McKenzie. and G. A. Pietersz.

* 336 Biochemical and Genetic Characterization of the HBA71 Ewing'sSarcoma Cell Surface Antigen. Erich J. Fellinger. Pilar Garin-Chesa. Sai L. Su. Paula DeAngelis, Joseph M. Lane, and WolfgangJ. Rettig.

$ 372 Characterization of New Pancreatic Cancer-Reactive MonoclonalAntibodies Directed against Purified Mucin. Jenny J. L. Ho, NingBi, Pei-sha Van, Mei Yuan, Kristine A. Norton, and Young S.Kim.

Molecular Biology and Genetics

* 89 Allelotype Study of Primary Hepatocellular Carcinoma. MinoniFujimori, Takashi Tokino, Okio Hiño,Tomoyuki Kitagawa,Takayuki Imamura, Eizo Okamoto, Masao Mitsunobu, TakashiIshikawa, Hitoshi Nakagama, Hideharu Harada, MichiyasuYagura, Kenichi Matsubara, and Yusuke Nakamura.

* 105 Variant Human Breast Tumor Estrogen Receptor with Constitutive Transcriptional Activity. Suzanne A. W. Fuqua. Saundra D.Fitzgerald, Gary C. Chamness, Atul K. Tandon. Donald P.McDonnell, Zafar Nawaz, Bert W. O'Malley. and William L.

McGuire.

*174 Cytotoxic Activity of a Recombinant Fusion Protein betweenInsulin-like Growth Factor I and Pseudomonas Exotoxin. TrevorI. Prior, Lee J. Helman, David J. FitzGerald, and Ira Pastan.

19S Isolation of Two Chloroethylnitrosourea-sensitive Chinese Hamster Cell Lines. Hiroaki Hâta.Masayuki Numata, Hiroko Tohda,Akira Yasui, and Atsushi Oikawa.

$ 294 Loss of Heterozygosity for the Short Arm of Chromosome 11(llplS) in Human Milk Epithelial Cells Immortalized by Mi-croinjectionof SV40 DNA. IreneGarcia. Daniel Brandt.JonathanWeintraub, Weigong Zhou, and Matti Aapro.

$422 Cytogenetic Profile of 109 Lipomas. Chandrika Sreekantaiah,Stanley P. L. Leong, Constantine P. Karakousis, Daniel L. McGee,William D. Rappaport, Hugo V. Villar, David Neal, SusanFleming. Albert Wankel. Peter N. Herrington, Richard Cannona,and Avery A. Sandberg.

$439 Increased Expression of the M, 72,000 Type IV Collagenase inHuman Colonie Adenocarcinoma. Anna T. Levy, Vittoria Cioce.Mark E. Sobel, Spiridione Garbisa, Walter F. Grigioni. Lance A.Liotta, and William G. Stetler-Stevenson.

Preclinical Pharmacology and Experimental Therapeutics

* 43 Some Antagonists of Platelet Activating Factor Are Cytotoxic forHuman Malignant Cell Lines. Susanne Danhauser-Riedl. StephanB. Felix, William J. Houlihan, Monica Zafferani. GabrielaSteinhauser, Dorothea Oberberg, Hildegard Kalvelage, RaymondeBusch, Johann Rastetter, and Wolfgang E. Berdel.

$67 Effect of Buthionine Sulfoximine on Toxicity of Verapamil andDoxorubicin to Multidrug Resistant Cells and to Mice. James M.Ford, Jin-ming Yang, and William N. Hait.

* 77 Tumor-dependentIncreased Plasma Nitrate Concentrationsas anIndication of the Antitumor Effect of Flavone-8-acetic Acid andAnalogues in Mice. Lindy L. Thomsen. Lai-Ming Ching. LiZhuang. John B. Gavin, and Bruce C. Baguley.

* 94 Sensitizaron of Human Melanoma Cells to the Cytotoxic Effectof Melphalan by the Glutathione Transferase InhibitorEthacrynicAcid. Johan Hansson. Kiflu Berhane, Victor M. Castro, UlfJungnelius. Bengt Mannervik. and Ulrik Ringborg.

*110 Antitumor Activity of 7-JV-||2||2-(-y-i.-Glutamylamino)ethyl|di-

thio}ethyl}jmitomycin C. Makoto Morimoto, Tadashi Ashizawa,Hiroe Ohno. Mitsuhiko Azuma. Eiji Kobayashi. Masami Okabe.Katsushige Gomi, Motomichi Kono, Yutaka Saitoh, YutakaKanda, Hitoshi Arai, Akira Sato. Masaji Kasai. and TakashiTsuruo.

#116 A Double-Blind Placebo-controlled Study with Granulocyte-Macrophage Colony-stimulating Factor during Chemotherapy forOvarian Carcinoma. Elisabeth G. E. de Vries, Bonne Biesma, PaxH. B. Willemse. Nanno H. Mulder, Angelika C. Stern, Jan G.Aalders. and Edo Vellenga.

123 Sensitive Detection of DNA Modifications induced by ( '¡spiaihi

and Carboplatin in Vitro and in Vivo Using a Monoclonal Antibody. Michael J. Tilby. Caroline Johnson. Richard J. Knox,Jacqueline Cordell. John J. Roberts, and Christopher J. Dean.

* 157 Cellular Pharmacology of MX2, a New Morpholino Anthracy-cline, in Human Pleiotropic Drug-resistant Cells. MasahikoWatanabe, Nobuyasu Komeshima, Mikihiko Naito, ToshiyukiIsoe, Noboru Otake, and Takashi Tsuruo.

199 Selective DNA Interaction of the Novel Distamycin DerivativeFCE 24517. Massimo Broggini, Eugenio Erba, Mauro Ponti,DaríoBallinari, Cristina Ceroni, Federico Spreafico. and MaurizioD'Incaici.

* 211 Preclinical in Vivo Activity of 2',2'-Difluorodeoxycytidine (Gem-

citabine) against Human Head and Neck Cancer. BoudewijnJ. M. Braakhuis. Guus A. M. S. van Dongen, Jan B. Vermorken,and Gordon B. Snow.

$215 Combination Effect of Recombinant Human Interleukin la withAntitumor Drugs on Syngeneic Tumors in Mice. ShinichiNakamura. Shigeki Kashimoto, Fumie Kajikawa, and KatsuhisaNakata.

* 227 Metabolic Inactivation: A Mechanism of Human Tumor Resistance to Bleomycin. Said M. Sebti, Jitesh P. Jani, Jehangir S.Mistry, Eli Gorelik, and John S. Lazo.

$ 233 Preclinical Study of Sequential Tumor Necrosis Factor and Interleukin 2 in the Treatment of Spontaneous Canine Neoplasms.Antony S. Moore, Gordon H. Theilen, Arthur D. Newell. BruceR. Madewell, and Alfred R. Rudolf.

Tumor Biology

22 Inhibition of Tumor-induced Angiogenesis by Sulfated Chitin Derivatives. Jun Murata. Ikuo Saiki, Takashi Makabe. YasuhiroTsuta. Seiichi Tokura, and Ichiro Azuma.

37 Concentration-dependentIncrease of Murine P388 and B16 Population Doubling Time by the Acyclic Monoterpene Geraniol.Suzanne M. ShofT,Mary Grummer, Milton B. Yatvin, and CharlesE. Elson.

$73 The Effects of Five Hematopoietic Growth Factors on HumanSmall Cell Lung Carcinoma Cell Lines: Interleukin 3 Enhancesthe Proliferation in One of the Eleven Cell Lines. Edo Vellenga,Bonne Biesma, Coby Meyer, Lex Wagteveld, Mariet Esselink, andElisabeth G. E. de Vries.

99 Tin-1 as a Negative Growth Regulator in ras-transformcdMouseFibroblasts. Yoshikazu Sugimoto, Yoji Ikawa. and HiromitsuNakauchi.

$ 150 Expression of Functional Epidermal Growth Factor Receptors ina Human Hematopoietic Cell Line. John Oval. Robert Hershberg,Bernd Gansbacher, Eli Gilboa, Joseph Schlessinger, and RaymondTaetle.

$ 162 ProgrammedCell Death during Regression of the MCF-7 HumanBreast Cancer following Estrogen Ablation. Natasha Kyprianou,Hugh F. English, Nancy E. Davidson, and John T. Isaacs.

Research. on September 26, 2020. © 1991 American Association for Cancercancerres.aacrjournals.org Downloaded from

#245 Direct in Vitro Lysis of Metastatic Tumor Cells by Cytokine-activated Murine Vascular Endothelial Cells. Limin Li, Garth L.Nicolson, and Isaiah J. Fidler.

265 Microvascular Architecture in a Mammary Carcinoma:BranchingPatterns and Vessel Dimensions. Joanne R. Less, Thomas C.Skalak, Eva M. Sevick, and Rakesh K. Jain.

* 274 Inhibition of Urokinase-type Plasminogen Activator by Antibodies: The Effect on Dissemination of a Human Tumor in the NudeMouse. Liliana Ossowski, Helen Russo-Payne, and Elaine L.Wilson.

$341 Establishment and Characterization of a Human Leukemic CellLine with Megakaryocytic Features: Dependency on Granulocyte-Macrophage Colony-stimulating Factor, Interleukin 3, or Eryth-ropoietin for Growth and Survival. Nono Komatsu, HiromitsuNakauchi, Akiyoshi Miwa, Toshiki Ishihara, Mitsuoki Eguchi,Masaaki Moroi, Masayuki Okada, Yuko Sato, Hideho Wada,Yoshihito Yawata, Toshio Suda, and Yasusada Miura.

$349 Fibrinogen Deposition without Thrombin Generation in PrimaryHuman Breast Cancer Tissue. Vincenzo Costantini, Leo R.Zacharski, Vincent A. Memoli, Walter Kisiel, Bohdan J. Kudryk,and Sandra M. Rousseau.

$354 Occurrence of Components of Fibrinolysis Pathways in Situ inNeoplastic and Nonneoplastic Human Breast Tissue. VincenzoCostantini, Leo R. Zacharski, Vincent A. Memoli, Bohdan J.Kudryk, Sandra M. Rousseau, and David C. Stump.

$381 Establishment and Characterization of Human Signet Ring CellGastric Carcinoma Cell Lines with Amplification of the c-mycOncogene. Kazuyoshi Yanagihara, Toshio Seyama, MasaruTsumuraya, Nanao Kamada, and Kenjiro Yokoro.

$387 Increased Content of an Endogenous Lactose-binding Lectin inHuman Colorectal Carcinoma Progressed to Metastatic Stages.Tatsuro Irimura, Yoshifumi Matsushita. Regina C. Sutton, DuniaCarralero, David W. Ohannesian, Karen R. Cleary, David M.Ota, Garth L. Nicolson, and Reuben Lotan.

394 Endothelial Cell Membrane Vesicles in the Study of Organ Preference of Metastasis. Robert C. Johnson, Hellmut G. Augustin-Voss, Duzhang Zhu, and Bendicht U. Pauli.

$400 Cytogenetic Abnormalities and Overexpression of Receptors forGrowth Factors in Normal Bronchial Epithelium and TumorSamples of Lung Cancer Patients. Gabriella Sozzi, MonicaMiozzo, Elda Tagliabue, Carla Calderone, Luciano Lombardi,Silvana Piloni, Ugo Pastorino, Marco A. Pierotti, and GiuseppeDella Porta.

$405 Invasion of Reconstituted Basement Membrane Matrix Is NotCorrelated to the Malignant Metastatic Cell Phenotype. AgnèsC.Noel, Aleth Callé,HervéP. Emonard, Betty V. Nusgens, LéonSimar, Jacqueline Foidart, Charles M. Lapiere, and Jean-MichelFoidart.

415 Role of Endogenous Tumor Necrosis Factor a and Interleukin 1for Experimental Tumor Growth and the Development of CancerCachexia. Johan Gelin, Lyle L. Moldawer, Christina Lönnroth,Barbara Sherry, Richard Chizzonite, and Kent Lundholm.

Virology

$ 27 Expression of Class I Major Histocompatibility Complex Antigens in Epstein-Barr Virus-carrying Lymphoblastoid Cell Linesand Burkitt Lymphoma Cells. Wolfgang Jilg, Raymond Voltz,Christine Markert-Hahn, Helga Main»ofer,Iris Münz,and HansWolf.

$49 Hepatitis B Virus Integration Event in Human Chromosome 17pnear the p53 Gene Identifies the Region of the ChromosomeCommonly Deleted in Virus-positive Hepatocellular Carcinomas.Betty L. Slagle, Yi-Zhong Zhou, and Janet S. Butel.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Clinical

33 Combined Analysis of DNA Ploidy Index and N-wye GenomicContent in Neuroblastoma. J. Bourhis, F. DeVathaire, G. D.Wilson, O. Hartmann, M. J. Terrier-Lacombe, L. Boccon-Gibod,N. J. McNally, J. Lemerle, G. Riou, and J. Bénard.

Epidemiológica!

190 Urinary Excretion of Nitrate, ,/V-Nitrosoproline,3-Methyladenine,and 7-Methylguanine in a Colombian Population at High Risk forStomach Cancer. W. G. Stillwell, Joseph Glogowski, H-X. Xu,John S. Wishnok, Diego Zavala, G. Montes, Pelayo Correa, andSteven R. Tannenbaum.

Advances in Brief

445 Identification of a Second Human nm2i Gene, nm23-H2. JohnA. Stahl, Alvaro Leone, Ariella M. Rosengard, Laura Porter,C. Richter King, and Patricia S. Steeg.

Meeting Report

450 Mouse Pulmonary Carcinogenesis: A Symposium to Honor theMemory of Dr. Michael B. Shimkin. Alvin M. Malkinson.

454 AnnouncementsEighty-second Annual Meeting of the AACRTravel Grants for the AACR and ASCO Annual Meetings for

Young Minority ScientistsAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRAmerican Cancer Society Call for Grant Applications—

Nutrition and CancerCalendar of Events

456 Instructions for Authors

463 Author Index

NOTE: AACR forms available in the back of this issue—•1991 Employment Register Forms and Instructions•Application for Active and Corresponding Membership•Application for Associate Membership•Advance Registration Form for the 82nd AnnualMeeting

Also available in the back of this issue—GUIDELINES FOR SUBMITTING DISKETTES TO

CANCER RESEARCH

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