cbc interpretation

Download CBC interpretation

Post on 21-Jul-2015

177 views

Category:

Education

2 download

Embed Size (px)

TRANSCRIPT

Slide 1

hgd

In the name of ALLAH

DIAGRAMATIC REPRESENTATION OF BONE MARROW PLURIPOTENT

PCV or Hematocrit57% Plasma

1% Buffy coat WBC

42% RBCs

Blood componentsInterpretation of

CBC- complete blood count

Results of lab.testsMay be affected byActivityDietStressGeographymedicationsTime of the day

Component of the CBC White Blood Cells (WBCs) Red Blood Cells (RBCs) Hemoglobin (Hgb) Hematocrit (Hct)Mean Corpuscular Volume (MCV)mean corpuscular hemoglobin(MCH) Mean Corpuscular Hemoglobin Concentration (MCHC) Red cell distribution width (RDW)Platelet ( PLT )

6

RBCRBC (varies with altitude):

M: 4.7 to 6.1 x10^12 /L F : 4.2 to 5.4 x10^12 /L In : 4.8 to 7.1 x10^12 /L

Function: - transport hemoglobin which carries oxygen from the lung to the tissues -acid base buffer.

7(Hgb/Hb)

M: 14 to 18 g/dL F : 12 to 16 g/dLIn: 14 to 24 g/dl

5>Hgb>20 Emergency

Hemoglobin8Hematocrit(HCT /PCV)

It is ratio of the volume of red cell to the volume of whole blood.

M: 42 to 52 % F : 37 to 47 % In: 44 to 64 %

15>Hct>60 Emergency

MCV = mean corpuscular volume HCT/RBC count = 80-100fLsmall = microcyticnormal = normocyticlarge = macrocyticMCHC= mean corpuscular hemoglobin concentration HB/RBC count = 26-34%decreased = hypochromicnormal = normochromic

MCV&MCHC

10MCH (mean corpuscular hemoglobin) HB/HCT = 27-32 pg

RDW (red cell distribution width)

It is correlates with the degree of anisocytosis

_ Normal range from 10-15%MCH & RDW 11ADULT REFERENCES OF RED BLOOD CELLS_________________________________________________ Male Female_________________________________________________Hemoglobin (g/dl) 14 18 12 16

Hematocrit ; PCV (%) 42 -52 37 47

RBC count(X1012/l) 4.5 6.2 4 5.5

Mean Cell Volume 80 -95 80 - 95 MCV (fl)

Mean Cell Hemoglobin 27 -34 27 - 34 MCH (pg)

Mean Cell Hemoglobin 30 -35 30 -35 Concentration(MCHC)

Normal CBC

RBC

Physiological responseHypoxiaPOLYCYTHEMIA VERAAcute dehydration

RBC

AnemiaHemorrhage.nutritional deficiency Kidney diseaseLeukemiaAnaemia

HypoproliferativeHemolyticRetics < 2Retics > 2Hb% < 12, Hct < 38%Anaemia Workup - MCVMicrocyticMCVNormocyticMacrocyticIron Deficiency -IDAChronic InfectionsThalassemiasSideroblastic Anemia

Chronic diseaseEarly IDAHemoglobinopathiesPrimary marrow disordersCombined deficienciesIncreased destructionMegaloblastic anemiasLiver disease/alcoholMetabolic disorders

The causes of a hypochromic microcytic anaemia. These include lack of iron (iron deficiency), or of iron release from macrophages to serum (anaemia of chronic inflammation or malignancy). Failure of protoporphyrin synthesis (sideroblastic anaemia) or of globin synthesis (Alpha or Beta Thalassaemia). RDW

Megaloblastic anemias

IDA

Hemoglobinopathies

Hemolotic anemia

Microcytic Hypochromic - IDA

Macrocytosis -MBA

Norms of leukocytes(WBC) A :4-11000/mm3 In:9-30000/mm3

30000