cat thorax riy
TRANSCRIPT
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CAT
(Critical Appraisal of the Topics)
OPUS 12 Scientist 2009 Vol. 3, No. 3
Submitted 09/2010; Revised 10/2010; Re-evised11/2010; Publis!ed 11/2010
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SCREEN FOR INITIAL VALIDITY ANDRELEVANCE
"!is #oun$l %$s $le$d& evie%ed b& OPUS 12Scientist US' ()ee-evie%ed electonic #oun$l*
"!e stud& %$s not s)onsoed b& $n& o+$ni$tiont!$t mi+!t inuence t!e stud& desi+n o esults
"!is inom$tion %ill !$ve $ diect im)$ct on t!e!e$lt! o ou )$tients
"!e )oblem $ddessed in t!is #oun$l is todetemine benets o e)idu$l (epid) vesus
int$venous/int$muscul$ (iv/im) $n$l+esi$ ot$um$tic ib $ctues (RFs) b& )eomin+ $ met$$n$l&sis stud&
"!is inom$tion, %ill euie us to c!$n+e ou
cuent )$ctice.
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DETERMINE THE INTENT OF THE ARTICLE
"!e investi+$tos %ee intended benets oe)idu$l (epid) vesus int$venous/int$muscul$(iv/im) $n$l+esi$ o t$um$tic ib $ctues (RFs)
b& )eomin+ $ met$ $n$l&sis stud&
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Cliicalcate!or"
Descriptio #referre$ St%$"Desi!
"!e$)& "ests t!e eectiveness o $
te$tment, suc! $s $ du+,su+ic$l )ocedue, o ot!eintevention
R$ndomied, double-
blinded, )l$cebo-contolled ti$l
i$+nosis e$sues t!e v$lidit& (is itde)end$ble4* $nd eli$bilit&(%ill t!e s$me esults be
obt$ined eve& time4* o $di$+nostic test, o ev$lu$test!e eectiveness o $ test indetectin+ dise$se $t $ )es&m)tom$tic st$+e %!en$))lied to $ l$+e )o)ul$tion
5oss-section$lsuve& (com)$in+t!e ne% test %it! $
eeence st$nd$d*
5$us$tion 'ssesses %!et!e $ subst$nceis el$ted to t!e develo)mento $n illness o condition
5o!ot o c$se-
contol
Po+nosis etemines t!e outcome o $
dise$se
6on+itudin$l co!ot
stud&
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7vidence
6evel
"!e$)&/Pevention,'etiolo+&/8$m
Po+nosis i$+nosis
1$ SR (%it!!omo+eneit&* o
R5"s
SR (%it!!omo+eneit&* oince)tion co!ot
studies; 5R:v$lid$ted in
dieent)o)ul$tions
SR (%it! !omo+eneit&*o 6evel 1 di$+nostic
studies; 5R: %it!1b studies omdieent clinic$l
centes
&' ndividu$l R5" (%it!n$o% 5ondence
ntev$l0? ollo%-u);
5R: v$lid$ted in$ sin+le
)o)ul$tion
V$lid$tin+ co!otstud& %it! +ood:::
eeence st$nd$ds;
o 5R: tested%it!in one clinic$l
cente
1c 'll o none 'll o none c$se-seies
'bsolute S)Pins $ndSnNouts
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6evel
"!e$)&/Pevention,'etiolo+&/8$m
Po+nosis i$+nosis
2$ SR (%it!!omo+eneit&* o
co!ot studies
SR (%it!!omo+eneit&* o
eit!e etos)ectiveco!ot studies ounte$ted contol
+ou)s in R5"s
SR (%it! !omo+eneit&*o 6evel =2 di$+nostic
studies
2b ndividu$l co!ot stud&(includin+ lo% u$lit&
R5"; e.+., @>0?ollo%-u)*
Retos)ectiveco!ot stud& o
ollo%-u) ounte$ted contol
)$tients in $n R5";eiv$tion o 5R:
o v$lid$ted ons)lit-s$m)leAAA onl&
7B)lo$to& co!otstud& %it! +ood:::
eeence st$nd$ds;5R: $te deiv$tion,
o v$lid$ted onl& ons)lit-s$m)leAAA o
d$t$b$ses
2c "OutcomesC Rese$c!;7colo+ic$l studies
"OutcomesCRese$c!
6evel 2 o7vidence
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6evel
"!e$)&/Pevention,'etiolo+&/8$m
Po+nosis i$+nosis
3$ SR (%it!!omo+eneit&* o
c$se-contol studies
SR (%it! !omo+eneit&*o 3b $nd bette studies
3b ndividu$l 5$se-
5ontol Stud&
Non-consecutive stud&;
o %it!out consistentl&$))lied eeence
st$nd$ds
4 5$se-seies ($nd )oou$lit& co!ot $nd
c$se-contol studiesA*
5$se-seies ($nd)oo u$lit&
)o+nostic co!ot
studies*
5$se-contol stud&,)oo o non-
inde)endent eeence
st$nd$d5 7B)et o)inion %it!out
eB)licit citic$l$))$is$l, o b$sed on
)!&siolo+&, benc!ese$c! o Cst
)inci)les"
7B)et o)inion%it!out eB)licit
citic$l $))$is$l, ob$sed on
)!&siolo+&, benc!
ese$c! o Cst)inci)les"
7B)et o)inion %it!outeB)licit citic$l
$))$is$l, o b$sed on)!&siolo+&, benc!
ese$c! o Cst
)inci)les"
6evel 3,D,E o7vidence
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ra$es ofRecoe$atio
' consistent level 1 studies
F consistent level 2 o 3 studies o
eBt$)ol$tions om level 1 studies5 level D studies o eBt$)ol$tions om
level 2 o 3 studies
level E evidence o toublin+l&inconsistent o inconclusive studies o$n& level
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HANK YOU