case study€¦ · cholelithiasis dvt ... case continues … the operation ... retrospective study...
TRANSCRIPT
![Page 1: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/1.jpg)
Case Study Laparoscopic Gastric Bypass Surgery & Obesity
![Page 2: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/2.jpg)
Pathology Associated with Obesity
Coronary Artery Disease
Atherosclerosis
Hypertension
Diabetes mellitus
Obstructive Sleep Apnea
Systemic and pulmonary hypertension
Gastroesophageal reflux disease
Non alcoholic fatty liver disease
Cholelithiasis
DVT
Degenerative disk disease
![Page 3: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/3.jpg)
Preoperative Evaluation
61” tall
151 kg/334 lbs. (BMI = 63.3)
EKG: NSR with nonspecific ST segment abnormalities
ECHO: EF 67% LVH
CXR and Labs WNL
• 56 year old woman • Type 2 Diabetes • Hypertension • ↑ Chol • OSA • GERD • 25 pack year smoker • No PSH •Uses a walker frequently
![Page 4: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/4.jpg)
Absolute contraindications to bariatric surgery?
A lack of understanding of the procedural risk
Severe liver disease with accompanying portal hypertension.
Uncontrolled severe OSA with pulmonary hypertension.
Unstable or terminal illness
![Page 5: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/5.jpg)
Airway Plan
Patient was induced and intubated with the Glidescope after adequate pre-oxygenation and ramping of the patient
Rapid-sequence induction
Ramp
Glidescope intubation.
![Page 6: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/6.jpg)
Doop Doop Doop Doop…
You notice that your pulse ox is slowly dropping and your peak airway pressures are rising.
Maintaining adequate oxygenation for this morbidly obese patient is becoming a challenge.
![Page 7: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/7.jpg)
Goals
Prevent Atelectasis
Recruitment maneuver by using sustained (8-10 seconds) pressure ≥ 40cm/H2O.
Restrict the use of FiO2 to less than 0.8 during maintenance of anesthesia.
Maintain Lung Recruitment
Use PEEP (10-12 cmH2O)
Increase I:E ratio to 1:1
Improves arterial oxygenation
![Page 8: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/8.jpg)
Avoid lung overdistension
Use tidal volume of 6-10 mL/kg of IDEAL body weight.
Keep peak inspiratory pressure <30cm/H2O Change to pressure control.
Consider mild hypercapnia if necessary.
Maintain postoperative lung
expansion
Use CPAP or BiPAP immediately after tracheal extubation.
Keep upper body elevated.
Maintain good pain control using multimodal approach
Use incentive spirometry
Encourage early ambulation
![Page 9: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/9.jpg)
Case continues…
The operation takes longer than expected due to the patient’s body habitus.
Total time on the table 6 hours
Extubation successful and you take your patient to PACU, glad to be done!
![Page 10: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/10.jpg)
POD 1 Visit
C/O gluteal and lumbar myalgia
Oliguria
Overnight hospitalist had ordered CPK & Myoglobin levels
CPK >30,000 (Normal is <250)
Myoglobin: >400 (Normal 0-85)
![Page 11: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/11.jpg)
What’s the Significance?
Creatine Phosphokinase Enzyme (CPK) –found in skeletal muscle
The patient’s level was over 5x’s the normal value, which is diagnostic for Rhabdomyolisis (RML)
Pharmacologic causes of elevated CPK are: ETOH, Amphotericin B, cocaine, steroids such as dexamethasone, and statins
![Page 12: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/12.jpg)
This patient’s creatine phosphokinase level was 38,700 U/L
![Page 13: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/13.jpg)
Rhabdomyolysis
Rhabdomyolysis (RML) is a rare complication of surgical procedures, and is caused by injury and destruction of skeletal muscles.
It is accompanied by pain in the region of the referred muscle group, an increase in CPK (5x’s or more of the normal value), and myoglobinuria. This can lead to varying levels of renal dysfunction, and if not recognized and treated, multi-organ system failure and death.
![Page 14: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/14.jpg)
Rhabdomyolysis
Morbidly obese patients who undergo laparoscopic bariatric operations should be considered high-risk for RML
extended immobilization and pressure phenomena in the lumbar and gluteal regions.
![Page 15: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/15.jpg)
Significant correlation between postop CPK, Myoglobin, surgical duration, and patients’ BMI.
Forfori, et al (2013)
Retrospective study of 100 patients undergoing laparoscopic gastric bypass
6 out of 100 found to have acute kidney dysfunction secondary to RML
![Page 16: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/16.jpg)
RML ranges in severity from asymptomatic to life-threatening
Electrolyte disturbances
Kidney injury
Cardiac arrest
DIC
Multi-organ failure
![Page 17: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/17.jpg)
Increasing population of bariatric surgical patients
Awareness of identified risk factors for RML is key
Surgical time > 4 hours
BMI > 40
HTN (presence of comorbities)
ASA status III-IV
Lithotomy position
![Page 18: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/18.jpg)
Precautions
Awareness of comorbidities
Positioning and padding
Adequate intraoperative fluid administration
Postoperative CPK monitoring in high-risk patients can hasten diagnosis and prevent further complications If untreated, 33% of patients develop AKI secondary
to RML (Forfori, et al 2013)
![Page 19: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/19.jpg)
Treatment after Diagnosis
Adequate fluid resuscitation to prevent further renal damage by flushing myoglobin
Mannitol and Sodium Bicarbonate to maintain urine pH > 6.5
Postulated to minimize breakdown of myoglobin into its nephrotoxic metabolites
![Page 20: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/20.jpg)
Summary
RML in this patient population most likely caused by prolonged muscle pressure, resulting in a compartment-like syndrome
Early detection can mitigate RML’s deleterious effects
CPK is a sensitive marker for the diagnosis of RML
![Page 21: Case Study€¦ · Cholelithiasis DVT ... Case continues … The operation ... Retrospective study of 100 patients undergoing laparoscopic gastric bypass 6 out of 100 found to have](https://reader033.vdocuments.mx/reader033/viewer/2022052310/5f04ef237e708231d4106f8c/html5/thumbnails/21.jpg)
References
Elisha, Sass., (2011), Case studies in nurse anesthesia. pp. 74-83
Thompson, J., Bordi, S., Boytim, M., Elisha, S., Heiner, J., Nagelhout, J., Anesthesia case management for bariatric surgery. (2011) AANA Journal, Vol. 79, No. 2
Filis, D, Daskalakis, M., Askoxylakis, I., Metaxari, M., Melissas, J., Rhabdomyolysis Following Laparoscopic Gastric Bypass. (2005) Obesity Surgery, Vol. 15, Issue 10, pp 1496-1500