case reports, infectious diseases and the developing world - geoffrey pasvol
TRANSCRIPT
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Case Reports, Infectious Diseases and the Developing WorldGeoffrey Pasvol
Professor of Infection & Tropical MedicineConsultant in Infection & Tropical Medicine
Associate Editor, Transactions of the Royal Society of Tropical Medicine & HygieneDirector, Imperial Wellcome Centre for Clinical Tropical Medicine
Imperial College London
Celebrating Case Reports, Friday May 15, 2009
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Out of the Tropics/Developing World …………
‘ex Africa semper aliquid novi’Pliny the Elder
Infectious Diseases, Tropical Medicine a truly fertile ground- rich in variety, complexity and intrigue
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The Triad in Case Reports
The Reader
The Author
The Editor
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So why NOT Case Reports?
• The Reader
»Anecdotal
»Unsubstantiated
»Unedifying
»Unscientific
• The Author
»Lengthy review process
»Pot luck!
• The Editor
»Impact factor
»Who will review
»Titles/keywords to confuse or reveal?
• “CR remain CR”
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So why Case Reports?
• The Reader
»Aids clinical practice
»Stimulating
»Interesting
»Challenging
• The Author
»A step on the publication ladder
»Source of research ideas
»Important eg ADR
• The Editor
»Readable
»Space-filler
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Transactions of the Royal Society of Tropical Medicine & Hygiene
•One of the top ranked Journals in Tropical Medicine
•Impact Factor 2-3
•Published since 1907
•Online submission free of page charges
•Manuscripts - peer-reviewed online
•Accepted papers - published electronically on ScienceDirect® and immediately indexed by PubMed
•8 Case reports Jan 2008- May 2009
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From Bhubaneswar, India
A successful outcome of gross haematuria (due to lymphatic filariasis) treated with diethylcarbamazine and ivermectin.
Kerketta et al, 2008
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From New Delhi, India
Cutaneous leishmaniasis in Nepal:
Leishmania major as a cause.
Kumar et al, 2008
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From New Delhi, India
Immune response following miltefosine therapy in a patient with post-kala-azar dermal leishmaniasis.
Ansari et al, 2008
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From Alexandroupolis, Greece
Maggot infestation (myiasis) of external fixation pinsites in diabetic patients.
Verettasa et al, 2008
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From Piaui, Brazil
Myiasis in the uterine cavity of an elderly woman with a complete uterine prolapse.
Lopes-Costa et al, 2008
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From Lima, Peru
Cervical tumor caused by the sexually mature stage of Fasciola hepatica.
Luis et al, 2009
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From Cape Town, South Africa
First case report of pharyngeal cysticercosis.
Sobnach et al, 2009
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From Khon Kaen, Thailand
Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication.
Sawanyawisutha et al, 2009Gnathostoma spinigerum
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Case Reports and the Developing World• The Reader
»Access: Internet, CD, DVD, paper, laminated cards»A repository of knowledge»‘Small Is Beautiful’
• The Author»Disadvantaged: Lacks diagnostic tools (esp dev countries) »Language»Open access?»Encouraging»Inclusive
• The Editor»Colour; powerful image»Reviewing- what allowances»Copyediting
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Confessions…………
1. 1984 Pneumonia due to Legionella bozemanii first report of a case in Europe. Journal of Infection 8: 251-255.
2. 1996 Leptospirosis in pregnancy: an unusual and relatively unrecognised cause of death in man. Journal of Obstetrics and Gynaecology 16: 163-165
3. *1996 Fatal quinine cardiotoxicity in the treatment of falciparum malaria. Transactions Royal Society of Tropical Medicine 90: 305-307.
4. 2000 Acute adrenal insufficiency precipitated by isolated involvement of the adrenal gland by tuberculosis. Journal of Infection. 39: 244-245.
5. *2002 Malarone ® treatment failure and in vitro confirmation of resistance of P falciparum isolate from Lagos, Nigeria. Malaria Journal 1(1) 1-4
6. 2002 Severe acute symptomatic hyponatraemia in falciparum malaria. Transactions of the Royal Society of Tropical Medicine 96: 647-648
7. 2003 Amoebic abscess in the left lobe of the liver masquerading as pyelonephritis. Journal of Infection 46: 249-250
8. *2005 Kikuchi's disease: a rare cause of meningitis? Clinical Infectious Diseases. 41:e80-2.
9. *2005 Pneumococcal meningitis and etanercept--chance or association? Journal of Infection. 51:E49-51.
10. (2005) Images in clinical medicine Chromoblastomycosis. New England Journal of Medicine. 352: e19.
11. (2005) Successful treatment of severe Kikuchi’s disease with intravenous immunoglobulin. Rheumatology. 235-236
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“From Case Report to Clinic……”
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“From Case Report to Clinic……”
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“From Case Report to Clinic……”
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So for all……….
• Raises questions
• Ambivalence
• The best- the worst
• Just because they are fun, harmless but possess potential
• Teach, research and practice
• So why not celebrate?
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Lest anyone doubt ………………….
‘I come to celebrate case reports, not to bury them!’
Plenty the Wiser
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Acknowledgements
Bo Drasar (Editor) and The Transactions of the Royal Society of Tropical Medicine and Hygiene
www.rstmh.org/transactions.asp
Healthcare Information for all by 2015
www.hifa2015.org
The Organisers