carole r. mendelson - ut southwestern home · carole r. mendelson ... society for pediatric...

Revised, 7/3/2014

CURRICULUM VITAE

CAROLE R. MENDELSON

Professional Address: Department of Biochemistry The University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas, Texas 75390-9038 Telephone: (214) 648-2944 FAX: (214) 648-3214 E-Mail: [email protected] Education: Ph.D., Zoology, Rutgers University, 1970 B.S., Biology, City College of the City Univ. of New York, 1964

PROFESSIONAL EXPERIENCE:

2005 – Present Director, North Texas March of Dimes Birth Defects Center

1992 - Present Professor of Biochemistry and Obstetrics-Gynecology, The University of Texas Southwestern Medical Center at Dallas, TX.

1991 - Present Member, Training Programs in Cell Regulation, Biochemistry and Molecular Biology, and Integrative Biology, The University of Texas Southwestern Medical Center at Dallas, TX.

1987 - 1992 Associate Professor of Biochemistry and Obstetrics-Gynecology, The University of Texas Southwestern Medical Center at Dallas, TX.

1980 - 1987 Assistant Professor of Biochemistry and Obstetrics-Gynecology, The University of Texas Southwestern Medical Center at Dallas, TX.

1978 - 1980 Research Instructor in Biochemistry and Obstetrics-Gynecology, The University of Texas Southwestern Medical Center at Dallas, TX.

1976 - 1978 Postdoctoral Fellow in the laboratory of Dr. John M. Johnston, Departments of Biochemistry and Obstetrics-Gynecology, The University of Texas Southwestern Medical Center at Dallas, TX.

1974 - 1976 Postdoctoral Fellow in the laboratory of Dr. John Perkins, Department of Pharmacology, The University of Colorado Medical School, Denver, CO.

1973 - 1974 Staff Fellow in the laboratory of Drs. Maria Dufau and Kevin Catt, Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD.

1970 - 1973 Postdoctoral Fellow in the laboratory of Dr. Robert O Scow, Section on Endocrinology, NIAMDD, National Institutes of Health, Bethesda, MD.

1967 - 1969 Predoctoral Fellow in the laboratory of Dr. James H. Leathem, Rutgers University, New Brunswick, NJ.

1964 - 1966 Teaching Assistant in General Biology, Rutgers University, New Brunswick, NJ.

1963 - 1964 Research Assistant in the laboratory of Dr. Robert Ortman, The City College of the City University of New York, NY.

Curriculum Vitae Carole R. Mendelson, Ph.D.

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PROFESSIONAL INTERESTS:

Molecular mechanisms in the developmental, hormonal and tissue-specific regulation of surfactant protein gene expression in fetal lung tissue.

Molecular mechanisms in the regulation of aromatase in estrogen-producing cells.

Mechanisms in the maintenance of pregnancy and initiation of parturition.

HONORS/AWARDS:

1967 - 1969 Public Health Service Predoctoral Fellowship No. 4-FO2-GM 34272.

1970 - 1972 Public Health Service Postdoctoral Fellowship No. 1-FO2-AM 34272.

1975 - 1976 Public Health Service Postdoctoral Fellowship No. 1-F22-AM 05029.

1997 John E. Patrick Memorial Lecture, Univ. Western Ontario, London, Ontario

1997 The Earl R. Plunkett/Wyeth-Ayerst Lecture, Univ. Western Ontario, London, ON

1998 - 2008 NIH MERIT Award

2001 Roy O. Greep Award, The Endocrine Society

2002 Alpha Omega Alpha

2004 Anita Payne Lectureship, University of Michigan, Ann Arbor, MI

2006 31st Maryland-Hopkins Lectureship in Reproductive Biology, Baltimore, MD

2010 Mentor Award, Women in Endocrinology

2011 Harold R. Behrman Memorial Lectureship, Yale University

2011 Dr. Jacob Probstein Lecturer, Washington Univ. School of Medicine

2014 SGI-Pardi President's Distinguished Scientist Award, Society for Gynecologic Investigation

CURRENT GRANT SUPPORT:

NIH 5-RO1 DK31206 “Cellular Mechanisms in the Induction of Aromatase” Carole R. Mendelson, Principal Investigator 04/01/11 – 03/31/16

NIH 5-R01-HL50022 "Mechanisms in the Regulation of SP-A Gene Expression” Carole R. Mendelson, Principal Investigator 07/01/14 – 06/30/19

NIH 5-P01-HD11149 “Initiation of Human Labor: Prevention of Prematurity” Carole R. Mendelson, Program Director 02/05/11-01/31/16

NIH 5-P01-HD11149 "Role of the Fetus in the Inflammatory Response Leading to Labor" Carole R. Mendelson, Principal Investigator, Project 2 02/05/11-01/31/16


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March of Dimes Birth Defects Foundation, Prematurity Initiative Grant “Cellular Mechanisms in the Initiation of Labor” Carole R. Mendelson, Principal Investigator 3/01/14 – 2/28/17

PROFESSIONAL SOCIETIES, COMMITTEES AND OFFICES:

The Endocrine Society 1984 - 1991 Education Committee 1988 - 1991 Chair, Education Committee 1991 - 1992 Publications Committee 1992 - 1994 Nominating Committee 1993 - 1994 Chair, Nominating Committee 1994 - 1997 Chair, Publications Committee 1995 - 1996 Program Organizing Committee, Tenth International Congress of

Endocrinology 1997 - 2000 Annual Meeting Steering Committee

2000 – 2001 Council

2002 – 2004 President, Women in Endocrinology

2004 – 2005 Chair, Annual Meeting Steering Committee

2006 – 2008 Publications Core Committee

2008 – 2011. Research Affairs Core Committee

2008 – 2011 Vice President, Basic Scientists

FASEB

2010 – pres. Member, Board of Directors

2012 – pres. Member, Public Affairs Committee

The Perinatal Research Society 1988 - 1990 Council 1990 - 1991 President

The Society of Sigma Xi 1985 – 1986 President, UT Southwestern Chapter

American Society for Biochemistry and Molecular Biology

Society for Gynecologic Investigation 2006 – 2009 Council

Society for Pediatric Research

American Thoracic Society

SCIENTIFIC ADVISORY BOARDS:

Burroughs Wellcome Fund, Preterm Birth Initiative Scientific Advisory Board


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SCIENTIFIC MEETING ORGANIZATION:

2004 Co-organizer, FASEB Summer Conference on Lung Surfactant: Cellular and Molecular Biology

2005 Chair, Annual Meeting of The Endocrine Society 2006 Co-organizer, Keystone Conference on Nuclear Receptors: Steroid Sisters 2012 Co-organizer, FASEB Summer Conference on The Lung Epithelium in Health & Disease

EDITORIAL BOARDS:

1986 - 1989 Editorial Board, Molecular and Cellular Endocrinology.

1990 – 1999 Editorial Board, American Journal of Physiology: Lung Cellular and Molecular Physiology.

1989 - 1998 Executive Editor, Trends in Endocrinology and Metabolism.

1998 – pres. Editorial Board, Trends in Endocrinology and Metabolism

1999 – 2002 Editorial Board, Molecular Endocrinology

1999 – 2003 Section Editor on Respiratory Physiology, Annual Reviews of Physiology

2004 – 2007 Editorial Board, Endocrine Reviews

2004 – pres. Editorial Board, Journal of Steroid Biochemistry & Molecular Biology

2006 – 2011 Editorial Board, Molecular Endocrinology

2009 – pres. Editorial Board, Hormone Molecular Biology and Clinical Investigation

REVIEW COMMITTEES:

1979 National Institute of Child Health and Human Development; Reviewer of contract proposals for RFP, entitled "Preparation of gonadal cells and analysis of cellular functions.”

1980 National Institute of Child Health and Human Development; Reviewer of contract proposals in response to RFP-NICHD-IRP-80-16.

1986 National Heart, Lung and Blood Institute; Reviewer and member of site visit team for the NIH Specialized Centers of Research Concerned with Respiratory Disorders of Neonates and Children, University of Rochester School of Medicine, Rochester, NY.

1987 National Institutes of Child Health and Human Development Special Review Committee, University of Cincinnati Medical Center, Cincinnati, OH.

1988 National Institutes of Health Special Study Section on Surfactant Proteins and Respiratory Distress Syndrome.

1988 - 1991 American Heart Association, Texas Affiliate, Review Committee.

1990 National Institute of Child Health and Human Development Special Review Committee for contract proposal on Preparation of Gonadal Cells and Cell Fractions.


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1991 National Institute of Child Health and Human Development Special Review Committee for contract proposal on Preparation and Analysis of Pituitary and Adrenal Cells.

1991 National Institutes of Health Special Study Section on Cellular and Molecular Aspects of Respiratory Physiology.

1991 National Heart, Lung and Blood Institute, Special Study Section on Chronic Bronchitis: The Cellular and Biochemical Basis.

1991 - 1995 American Heart Association, Texas Affiliate, Inc.

1992 - pres. Reproductive Scientist Development Program Selection Committee.

1993 MRC, Interdisciplinary Research Group in Fetal and Neonatal Health and Development, Site Visit, University of Western Ontario.

1994 National Heart, Lung and Blood Institute, Special Study Section on Development and Control of Pulmonary Alveolar Stability.

1994 - 1998 Parker B. Francis Fellowship Program Review Committee.

1995 External Review Committee, Developmental Endocrinology Branch, National Institute of Child Health and Human Development.

1996 National Heart, Lung and Blood Institute, Pathobiology of Lung Development SCOR Review Subcommittee and Special Emphasis Panel.

1998 March of Dimes Birth Defects Foundation, ad hoc reviewer.

1999 NICHD Intramural Review, Reproduction Research Branch, National Institutes of Health.

1999 Special NHLBI Review Committees, Development and Control of Pulmonary Alveolar Stability, Surfactant Homeostasis in Health and Disease.

1991 - 1995 Research Allocations and Advisory Committee, American Heart Association, Texas Affiliate, Inc.

1994 – 1998 Member, Scientific Review Committee, Parker B. Francis Foundation 1999 – 2004 Member, Board of Scientific Counselors, National Heart, Lung and Blood

Institute, National Institutes of Health

2003 NICHD Intramural Review, Reproduction Research Branch, National Institutes of Health.

2005 – pres. Chair, Reproductive Scientist Development Program Selection Committee.

2008 – pres. Member, Basil O’Connor Starter Scholar Research Award Review Committee, March of Dimes Foundation.

2012 Ad hoc Reviewer, Lung Injury and Repair Study Section, NIH

INVITED PRESENTATIONS:

1973 "Lipoprotein Lipase and the Uptake of Chylomicron-Triglyceride and Cholesterol by Perfused Rat Mammary Tissue", Gordon Research Conference on Biology of Milk.


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1975 "Luteinizing Hormone and the Regulation of Steroid Biosynthesis by Leydig Cells", Departments of Obstetrics and Gynecology, University of Colorado Medical Center, Denver, CO.

1976 "Lipoprotein Lipase and Lipid Metabolism in Mammary Gland", American Dairy Science Association, Raleigh, NC.

1979 "Hormonal Regulation of Lung Development and Surfactant Synthesis", Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD.

1979 "Hormonal Regulation of Fetal Lung Development and Surfactant Synthesis", Department of Pediatrics, University of Texas Medical School, Houston, TX.

1982 "Regulation of Estrogen Formation by Human Adipose Cells in Culture", International Conference on the Adipocyte and Obesity, Toronto, Canada.

1982 "The Effects of Hormones on Human Fetal Lung Development and Surfactant Synthesis" Department of Biology, Southern Methodist University, Dallas, TX.

1982 "Regulation of Aromatase Activity in Human Adipose Tissue", Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD.

1982 "Role of Prolactin, Cortisol and Insulin in the Regulation of Surfactant Synthesis by the Human Fetal Lung", NIH Workshop on Fetal Lung Development, Val David, Canada.

1982 "Steroid Hormones, Receptors and Breast Cancer", Ob-Gyn Grand Rounds, UTHSCD, Dallas, TX.

1983 "Regulation of Aromatase Activity of Human Adipose Stromal Cells in Culture", Division of Endocrinology, University of Texas Medical School, Houston, TX.

1983 "Hormonal Regulation of Aromatase in Estrogen-Producing Cells", Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD.

1984 "Hormonal Regulation of Surfactant Synthesis in Fetal Lung Tissue", Department of Biology, Texas Women's University, Denton, TX.

1985 "Regulation of Estrogen Formation in Human Adipose Tissue", Endocrine Rounds, UTHSCD, Dallas, TX.

1986 "Regulation of Aromatase in Estrogen-Producing Cells", Clinical Oncology Group, Ludwig Institute for Cancer Research, St. George's Hospital, London, England.

1986 "cDNA Probes and Fetal Lung Development", Symposium on Fetal Physiology, Victoria, Canada.

1986 "Regulation of Aromatase in Estrogen-Producing Cells", Institute of Animal Physiology, Agricultural Research Council, Babraham, Cambridge, England.

1986 "Pulmonary Surfactant", Symposium on Pathogenetic Mechanisms in Perinatal Disease, Society for Pediatric Pathology, Dallas, TX.

1986 "Isolation and Characterization of a cDNA Specific for Aromatase Cytochrome P-450", Aromatase Workshop, Irvine, CA.

1986 "Mechanisms in the Regulation of Estrogen Biosynthesis", International Congress on Hormonal Steroids, Madrid, Spain.


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1986 "Estrogen Production in Human Adipose Tissue: Molecular and Clinical Aspects", NIH Interinstitute Endocrine Grand Rounds, National Institutes of Health, Bethesda, MD.

1987 "Pulmonary Surfactant: A Developmentally- and Hormonally-Regulated Lipoprotein", University Lecture Series, UTHSCD, Dallas, TX.

1987 "Developmental and Hormonal Regulation of Surfactant Apoprotein Synthesis in Fetal Lung Tissue", Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY.

1987 "Molecular Mechanisms in the Regulation of Aromatase in Estrogen-Producing Cells", International Conference on Aromatase: Future Perspectives, Miami, FL.

1987 "Multifactorial Regulation of Surfactant Apoprotein Gene Expression in Fetal Lung Tissue", Gordon Research Conference on Hormone Action, Meriden, NH.

1988 "The Aromatase Cytochrome P-450 Gene and its Regulation", 8th International Congress of Endocrinology, Kyoto, Japan.

1988 "Gonadotropin and Growth Factor Regulation of Aromatase Cytochrome P-450 Gene Expression", International Symposium on Growth Factors, Oncogenes, Receptors and Gonadal Peptides, Beijing, The People's Republic of China.

1988 "Hormonal and Developmental Regulation of Synthesis of the Surfactant-Associated Protein, SP-A, in Fetal Lung Tissue", Department of Pediatrics, Saitama Medical School, Saitama, Japan.

1988 "Hormonal and Developmental Regulation of Synthesis of the Surfactant-Associated Protein, SP-A, in Fetal Lung Tissue", Department of Pathology, Kyoto University, Kyoto, Japan.

1989 "Regulation of Surfactant Protein A Gene Expression in Fetal Lung Tissue", Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA.

1989 "Developmental and Hormonal Regulation of Surfactant Protein Gene Expression in Fetal Lung", Physiology Department, UT Southwestern Medical Center at Dallas, TX.

1989 "Regulation of Surfactant Protein A Gene Expression in Fetal Lung: The Dallas Perspective", Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH.

1989 "The Aromatase Cytochrome P-450 Gene and its Regulation", 8th Workshop on Development and Function of the Reproductive Organs, Domain de Seillac, Touraine, France.

1989 "Use of Molecular Probes to Study Regulation of Aromatase Cytochrome P-450", Society for the Study of Reproduction, Columbia, MO.

1989 "Regulation of Aromatase Cytochrome P-450 Gene Expression in Estrogen-Producing Cells", Department of Veterinary Anatomy, Texas A&M University, College Station, TX.

1990 "Hormonal and Developmental Regulation of Surfactant Protein Gene Expression in Fetal Lung", Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA.


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1990 "Controls of Surfactant Production", John Elgin Patrick Memorial Symposium, The Lawson Research Institute, St. Joseph's Health Centre, London, Ontario, Canada.

1990 "Developmental and Hormonal Regulation of Surfactant Protein A Gene Expression in Fetal Lung", Department of Biochemistry, University of Western Ontario, London, Ontario, Canada.

1990 "Aromatase Cytochrome P-450 Gene and its Regulation", Department of Biochemistry, Washington State University, Pullman, WA.

1990 "Hormonal, Developmental and Cell-Specific Regulation of Surfactant Protein A Gene Expression in Fetal Lung", Department of Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX.

1990 "Hormonal Control of Fetal Lung Development," Endocrine Rounds, University of Texas Southwestern Medical Center, Dallas, TX.

1991 "Hormonal, Developmental and Tissue-Specific Regulation of Surfactant Protein A Expression in Fetal Lung," Diabetes Center Conference, University of Texas Southwestern Medical Center, Dallas, TX.

1991 "Developmental, Hormonal and Tissue-Specific Regulation of Surfactant Protein Gene Expression in Fetal Lung," Endocrine Grand Rounds, National Institutes of Health, Bethesda, MD.

1991 "Regulatory Mechanisms in Surfactant Protein Gene Expression in Fetal Lung," Symposium on Regulatory and Functional Aspects of Pulmonary Surfactant Proteins, American Thoracic Society Meeting, Anaheim, CA.

1991 "Stress Factors and the Regulation of Surfactant Protein Genes in Fetal Lung," Serono Symposium on Stress and Reproduction, Port Douglas, Australia.

1991 "Developmental and Hormonal Regulation of Surfactant Protein-A Gene Expression in Fetal Lung," Department of Physiology, Monash University, Melbourne, Australia.

1991 "Regulation of Surfactant Protein Gene Expression in Fetal Lung," Department of Pharmacology, State University of New York Health Science Center, Syracuse, New York.

1991 "Developmental, Hormonal and Tissue-Specific Regulation of Surfactant Protein Gene Expression in Fetal Lung," Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock, TX.

1992 "Regulatory Elements of the Rabbit Surfactant Protein-A Gene," Department of Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada.

1992 "Identification of Cis-Acting Elements that Mediate Developmental, Hormonal and Tissue-Specific Regulation of the Pulmonary Surfactant Protein-A Gene," Department of Pharmacology, University of Texas Medical School, Houston, Texas.

1992 "Mechanisms in the Regulation of Surfactant Protein-A Gene Expression in Fetal Lung." International Surfactant Symposium, Marburg, Germany

1993 "Genomic Elements Involved in Transcriptional Regulation of the Rabbit Surfactant Protein A Gene," American Thoracic Society International Conference, San Francisco, California.


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1993 "Molecular Mechanisms in the Regulation of Surfactant Protein A Gene Expression - It's Elemental!," Perinatal Research Society Meeting, L'Esterel, Quebec, Canada.

1994 "Mechanisms in the Regulation of Surfactant Protein A Gene Expression," Reproductive Research Branch, NICHD, NIH, Bethesda, Maryland.

1994 "Mechanisms in the Regulation of Surfactant Protein Gene Expression in Fetal Lung," IX International Congress on Hormonal Steroids, Dallas, Texas.

1994 "Mechanisms of Gene Regulation in Eukaryotic Cells" and "Developmental and Hormonal Regulation of Surfactant Protein-A Gene Expression,", Mead Johnson Symposium on Perinatal and Developmental Medicine - Regulators of Fetal Development and Postnatal Function, Marco Island, FL

1995 “Molecular Mechanisms in the Regulation of Surfactant Protein-A (SP-A) Gene Expression in Fetal Lung,” International Symposium on New Technologies in Perinatal Medicine and Human Reproduction, Rome, Italy

1996 “Mechanisms in the Regulation of Surfactant Protein-A (SP-A) Gene Expression in Fetal Lung,” Department of Pathology, University of Texas Southwestern Medical Center, Dallas,TX

1996 “Mechanisms for Transcriptional Activation of the Surfactant Protein-A Gene,” Magee Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.

1996 “Estrogen: Mechanisms of Synthesis and Action,” Grand Rounds, Department of Obstetrics-Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

1996 “Use of Transgenic Mice and Transfected Cells to Define Genomic Elements Involved in Tissue-Specific Expression of the Human Aromatase Gene,” IV International Aromatase Conference, Granlibakken, Tahoe City, CA.

1996 , “Transcriptional Regulation of SP-A,” 39th Annual Aspen Lung Conference, State of the Art presentation, Given Institute of Pathobiology, Apen, CO.

1996 “Regulation of Placental Aromatase Gene Expression,” Banff 96: The 13th Rochester Trophoblast Conference and The Thomas G. Wegmann Memorial Symposium, Banff, Alberta, Canada.

1997 “Surfactant Protein Gene Expression in Fetal Lung,” Division of Cellular Biology, Brigham Young University, Provo, Utah

1997 John E. Patrick Memorial Lecture, “Pulmonary Surfactant: An Essence of Life,” University of Western Ontario, London, Ontario

1997 The Earl R. Plunkett/Wyeth-Ayerst Lecture, “Mechanisms in the Regulation of Tissue-Specific Expression of the Human Aromatase Gene,” Department of Obstetrics-Gynaecology, University of Western Ontario, London, Ontario

1997 “Characterization of Genomic Elements Involved in Tissue-Specific Expression of the Human Aromatase Gene,” International Symposium on Signal Transduction in Health and Disease, Tel Aviv, Israel

1998 “Molecular Mechanisms in the Regulation of Surfactant Protein Gene Expression in Fetal Lung,” Shionogi Trans-Pacific Symposium, The Endocrine Society Meeting, New Orleans, LA


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1998 “Aromatase: Lessons from Transgenic Animals and Other Model Systems,” Aromatase and its Inhibitors: New Biology and Clinical Perspectives, Prague

1998 “Mechanisms in the Regulation of Surfactant Protein-A Gene Expression,” Environmental Health Institute, University of Pennsylvania School of Medicine, Philadelphia, PA

1998 “Mechanisms in Developmental, Hormonal and Cell-Specific Regulation of Surfactant Protein Gene Expression,” Department of Pharmacology, Cornell Medical School, NY

1999 “Regulation of Surfactant Protein-A Gene Expression in Fetal Lung,” Department of Cell Biology and Physiology, Louisiana State University, Shreeveport, LA

1999 “Mechanisms in the Regulation of Surfactant Protein Gene Expression in Fetal Lung,” Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX

1999 “Mechanisms in SP-A Gene Transcription,” American Thoracic Society meeting, San Diego, CA.

2000 “Mechanisms in the Regulation of SP-A Gene Expression During Fetal Lung Development,” Department of Cell and Molecular Biology, Baylor College of Medicine, Houston, TX.

2000 “Transcriptional Regulation of Surfactant Protein A,” FASEB Conference on Lung Surfactant: Cellular and Molecular Biology, Saxtons River, VT

2000 “Mechanisms in the Regulation of SP-A Expression,” Eighth Woods Hole Conference on Lung Cell Biology, Woods Hole, MA

2000 “Mechanisms in Tissue-Specific Expression of Aromatase,” International Aromatase Conference, Port Douglas, Australia

2000 “Mechanisms in Tissue-Specific Expression of the Human Aromatase Gene,” International Symposium on Signal Transduction in Health and Disease, Tel Aviv, Israel

2001 “Mechanisms in the Regulation of Surfactant Protein Gene Expression in Developing Lung” Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC

2001 “Transcriptional Mechanisms in Developmental and Hormonal Regulation of Lung Surfactant Protein Gene Expression,” University of Iowa College of Medicine, Iowa City, IA

2001 “Mechanisms in the Regulation of Estrogen Biosynthesis in Placenta,” Symposium on Estrogen Production and Action in Health and Disease, Society for Gynecologic Investigation Meeting, Toronto, CA.

2001 “Transcriptional Mechanisms in Developmental and Hormonal Regulation of Gene Expression in the Lung,” Plenary Greep Award Lecture, The Endocrine Society meeting, Denver, CO.

2001 “Mechanisms in Developmental and Hormonal Regulation of Gene Expression in the Lung,” Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL.


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2002 “Transcriptional Regulation of Surfactant Protein A,” FASEB Conference on Lung Surfactant: Cellular and Molecular Biology, Saxtons River, VT

2002 “Coactivators in Lung Development and Surfactant Protein Gene Expression” Keystone Symposium on Nuclear Receptor Superfamily, Snowbird, UT.

2002 “Mechanisms in Tissue-Specific Regulation of Estrogen Biosynthesis” International Congress on Hormonal Steroids and Hormones and Cancer, Fukuoka, Japan

2003 “Mechanisms in the Regulation of Surfactant Protein Gene Expression in Fetal Lung: A Role for Inflammatory Mediators,” National Institute for Environmental Health Sciences, Research Triangle Park, NC

2003 “Mechanisms in Tissue-Specific Regulation of Estrogen Biosynthesis in Humans,” Oregon National Primate Research Center, Beaverton, OR

2003 “Mechanisms in the Initiation of Labor: The Fetal Lung Connection,” NICHD, National Institutes of Health, Bethesda, MD

2004 “Fetal-Maternal Signaling in the Initiation of Parturition,” Harvard-Wide Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, MA

2004 “Regulation of Mammalian Parturition by Nuclear Receptors and Coregulators,” Keystone Symposium on Nuclear Receptors, Keystone, CO

2004 “Fetal-Maternal Signaling in the Initiation of Parturition,” Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA

2004 “Oxygen Regulation of Tropphoblast Differentiation and Aromatase Expression,” FASEB Experimental Biology 2004, Washington, D.C.

2004 FASEB Conference on Lung Surfactant: Cellular and Molecular Biology, Saxtons River, VT

2004 “Transcriptional Regulation of Aromatase in Ovary and Placenta,” Aromatase 2004, Edinburgh Scotland

2004 “New Insights into the Molecular Endocrinology of Parturition,” 16th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology, Seefeld, Tyrol, Austria

2004 “Aromatase Expression in Ovary and Placenta,” Aromatase 2004, Edinburgh, Scotland.

2004 Anita Payne Lectureship, University of Michigan, Ann Arbor, MI

2004 Department of Pharmacology and Cancer Biology, Duke University Medical Center

2005 Center for Reproductive Science, Northwestern University, Evanston, IL

2005 Endocrinology Grand Rounds, Northwestern University Medical Center, Chicago, IL

2005 Department of Physiology & Biophysics, University of Iowa, Iowa City, IA

2005 Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

2005 3rd International Conference on Biomarkers and Preterm Birth, UCLA Lake Arrowhead Conference Center


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2005 Myometrial Satellite Symposium, Soc. for Gynecologic Investigation, Los Angeles, CA

2005 8th Frontiers in Nuclear Receptor Action, Phoenix Arizona

2005 Selective Progesterone Receptor Modulators – Classification and Mechanisms of Action, Chicago, Illinois

2005 1st SGI International Summit on Preterm Birth, Siena, Italy

2005 March of Dimes Prematurity Symposium, Washington, D.C.

2005 State of the Art Lecture Series: “Preterm Birth, a National Health Issue,” American Academy of Pediatrics, Washington, D.C.

2005 Department of Biochemistry & Molecular Biology and The Mayo Clinic Cancer Center, Rochester, MN

2006 Department of Experimental Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX

2006 Keystone Symposium on Nuclear Receptors, Banff, Canada

2006 31st Maryland-Hopkins Lectureship in Reproduction Biology, Baltimore, MD

2006 17th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology, Seefeld, Tyrol, Austria

2006 Gordon Research Conference on Reproductive Tract Biology, New London, CT

2006 Intl. Congress on Hormonal Steroids and Hormones & Cancer, Athens, Greece

2006 VIII International Aromatase Conference, Baltimore, MD

2006 Causes and Consequences of Preterm Birth Conference, Columbus Ohio

2007 The Academy of Medicine, Engineering and Science of Texas (TAMEST), Austin

2007 The 10th Frontiers in Nuclear Receptor Action, Braselton, GA

2007 Program in Reproductive Science, Univ. Colorado Health Scis Center, Denver, CO

2007 4th International Conference on the Reproductive Tract, Frauenchiemsee, Germany

2007 4th Annual Gilbert S. Greenwald Symposium, University of Kansas Medical Center

2007 Wyeth, Collegeville, Pennsylvania

2007 Nuclear Hormone Receptor Modulators, Cambridge Healthtech Institute, Boston, MA

2008 13th World Congress of Gynecological Endocrinology, Florence, Italy

2008 McArdle Cancer Center, University of Wisconsin, Madison, WI

2008 Magee Women’s Research Institute, 8th Annual Postdoctoral Fellowship Research Day, Keynote Lecture, University of Pittsburgh Medical Center

2008 NICHD Roundtable: The Role of Progestins in the Prevention of Preterm Birth, Perinatology Research Branch, Detroit, MI

2009 18th Annual Meeting of the Triangle Consortium for Reproductive Biology: Pregnancy and Fetal Development, Keynote Lecture, NIEHS, Research Triangle, N.C.

2009 Estrogens, SERMs, and TSECs Scientific Meeting, Fort Myers, FL


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2009 NICHD Grand Rounds, NIH, Bethesda, MD

2009 Endocrinology and Reproduction Research Branch seminar, NIH, Bethesda, MD

2010 Department of Biochemistry, Molecular Biology, & Biophysics seminar, University of Minnesota School of Medicine

2010 Keystone Symposium on Nuclear Receptors, invited speaker, Keystone Colorado

2010 Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine, Urbana, IL

2010 FASEB Summer Research Conference on The Lung Epithelium in Health and Disease, Saxtons River, VT

2010 10th International Aromatase Conference, Edinburgh, Scotland

2010 UT Obesity Alliance, UT Southwestern Medical Center

2010 3rd Biennial Symposium, Preventing Prematurity: Establishing a Network for Innovation and Discovery, March of Dimes, Burroughs Wellcome Fund, Newport Beach, CA

2011 Harold Behrman Memorial Lecture, Yale University, New Haven, CT

2011 Obstetrics & Gynecology Grand Rounds, Yale University, New Haven, CT

2011 Plenary Lecture, Endocrine Society Annual Meeting, Boston, MA

2011 Dr. Jacob Probstein Lecturer, Washington Univ. School of Medicine, St. Louis, MO

2011 Markey Pathway Lecture, Washington Univ. School of Medicine, St. Louis, MO

2011 Obstetrics & Gynecology Grand Rounds, Washington Univ. School of Medicine, St. Louis, MO

2011 Frontiers in Pregnancy Research Symposium, Univ. Colorado Medical Center, Denver

2011 Department of Pharmacology, UT Southwestern Medical Center

2012 Department of Obstetrics & Gynecology, Medical College of Georgia, Augusta, GA

2012 XI International Aromatase Congress, Houston, TX,

2012 International Congress on Physiological Sciences, Suzhou, China

2012 Department of Physiology, Second Military University, Shanghai, China

2012 Burroughs Wellcome Fund/March of Dimes 4th Biennial Symposium on Preventing Premature Birth, Newport Beach, CA

2013 Pediatrics Grand Rounds UT Southwestern Medical Center

2013 Department of Pediatrics, UT Medical School Houston

2013 Myometrial Satellite, Society for Gynecologic Investigation Meeting, Orlando, FL

2013 Interdisciplinary Faculty of Reproductive Biology (IFRB), Texas A&M University

2013 2013 Rocky Mountain Reproductive Sciences Symposium, Keynote Lecture

2013 Dept. of Pathology & Cell Biology, University of South Florida College of Medicine

2014 Magee Women’s Research Institute, University of Pittsburgh School of Medicine


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2014 Symposium on microRNAs and Female Reproduction, Society for Gynecologic Investigation Annual Meeting, Florence, Italy

2014 Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY

2014 84th Perinatal Medicine and Developmental Medicine Symposium, Aspen, CO

UT SOUTHWESTERN – CURRENT AND PAST TRAINEES:

Postdoctoral Trainees:

1. Vijayakumar Boggaram, Ph.D., 1985-1987; Mechanisms in the regulation of surfactant protein-A gene expression. Dr. Boggaram currently is Professor, Department of Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas.

2. Mikal Janelle Odom, M.D., 1985-1988; Studies of the regulation of surfactant apoprotein synthesis in human fetal lung in vitro. Centre for Reproductive Medicine, Lubbock, Texas.

3. Claudia T. Evans, Ph.D., 1984-1986, in conjunction with Dr. Evan R. Simpson; Molecular cloning of a cDNA for human aromatase cytochrome P-450.

4. Michael Steinkampf, M.D., 1985-1987, in conjunction with Dr. Evan R. Simpson; Studies of the regulation of aromatase in human granulosa cells. Dr. Steinkampf is currently a Professor of Obstetrics-Gynecology, University of Alabama, Birmingham.

5. Jill Merrill, Ph.D., 1986-1988, in conjunction with Dr. Evan R. Simpson; Molecular mechanisms of aromatase regulation in estrogen-producing cells. Dr. Merrill is currently at the Institute for In Vitro Sciences, Bethesda, MD.

6. Sandra Graham, Ph.D., 1986 - 1990, in conjunction with Dr. Evan R. Simpson; Dr. Graham currently is a Research Instructor at The University of Texas Southwestern Medical Center, Dallas, Texas.

7. Joseph Alcorn, Ph.D., 1987 - 1992; Cellular localization and targeting of the expressed surfactant protein A gene product in eukaryotic cells. Dr. Alcorn currently is an Associate Professor of Pediatrics and Biochemistry, University of Texas Medical School at Houston.

8. William Green, M.D., Ph.D., Resident in Pediatrics, 12/88 - 2/89; Effect of cyclic AMP on SP-A mRNA stability in human fetal lung. Dr. Green currently is an anesthesiologist.

9. Erwei Gao, Ph.D., 1989 - 1991; Molecular mechanisms in the regulation of surfactant protein A gene expression in fetal lung. Dr. Gao currently is in private practice in Anesthesiology, Iowa.

10. Michael Acarregui, M.D., 1988 - 1991; Role of prostaglandins in the regulation of surfactant protein A gene expression in fetal lung. Dr. Acarregui is currently chief medical officer for Providence Health & Services, Anchorage, Alaska.

11. David Breed, M.D., 1992 - 1995; Role of the C/EBP family of transcription factors in fetal lung development and surfactant protein gene expression. Dr. Breed currently is in private practice, Austin, Texas.


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12. Amrita Kamat, Ph.D., 1994 - 1999; Cis-acting elements in placenta-specific expression of the human aromatase cytochrome P-450 gene. Dr. Kamat currently is an Assistant Professor, UT Health Science Center at San Antonio.

13. Anu Bansal, Ph.D., 1995 - 98; Role of C/EBP in type II cell differentiation and surfactant synthesis in fetal lung. Dr. Bansal currently is a Research Scientist at Dupont, Wilmington, DE.

14. Susan Howe, D.V.M., Ph.D., 1996 - 1997; Transcriptional control of trophoblast differentiation. Dr. Howe currently is a toxicologist for the Health Department in Fort Worth, TX.

15. Bing Jiang, Ph.D., 1996 - 2001; Transcription factors involved in placenta-specific expression of the human aromatase P450 gene. Dr. Jiang is currently Assistant Director of Research at Detroit R&D, Inc. in Detroit, MI.

16. Guo-Xia Tong, Ph.D., 1997 – 1999; Identification of transcription factors that interact the nuclear receptor binding site in the SP-A gene. Dr. Tong currently is an Assistant Professor of Clinical Pathology, Columbia University, College of Physicians & Surgeons, NY.

17. Ming Yi, Ph.D., 1998 – 2002; Transcription factor interactions in the regulation of SP-A gene expression. Dr. Yi is currently a Contractor, Cancer Research Technology Program Leidos Biomedical Research, Inc., National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland.

18. Kazi N. Islam, Ph.D., 1998 – 2005; Epigenetic mechanisms in the regulation of SP-A gene expression in fetal lung. Dr. Islam is currently an Assistant Professor, Department of Pharmacology and Experimental Therapeutics, Louisiana State University School of Medicine, New Orleans, LA.

19. Achim Bell, Ph.D., 1999 – 2002; Differentiation-induced changes in type II cell nuclear protein bind to the SP-A promoter. Adjunct Faculty – Biology, Lone Star College

20. Jennifer Condon, Ph.D., 2000 – 2006; Mechanisms in the initiation of human labor. Dr. Condon is currently Associate Professor (with tenure), Department of Cell Biology & Physiology, University of Pittsburgh School of Medicine

21. Lydia Conner, Ph.D., 2001 – 2003; Mechanisms in regulation of SP-A expression.

22. Dongyuan Liu, Ph.D., 2002 – 2008; Transcription factor interactions in the regulation of SP-A gene expression.

23. Daniel B. Hardy, Ph.D., 2002 – 2007; Mechanisms in the initiation of labor. Dr. Hardy is Associate Professor (with tenure) in the Departments of Obstetrics and Gynaecology, Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario

24. Elizabeth Rabbitt, Ph.D., 2003 – 2005; Role of coactivators in the initiation of labor. Current position – Educator, Birmingham, UK

25. Julie Huh, M.D., 2003 – 2004, Reproductive Scientist Development Program awardee. Regulation of aromatase in brain. Currently in private practice, San Francisco, CA

26. Premlata Kumar, Ph.D., 2005 – 2013; Mechanisms in aromatase expression in human placenta.


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27. Orhan Bukulmez, M.D. 2005 – 2007; Mechanisms of aromatase upregulation in endometriosis. Currently an Associate Professor of Obstetrics & Gynecology, University of Texas Southwestern Medical Center.

28. Nurit Winkler, M.D. 2006 – 2009; Mechanisms of aromatase regulation in the human ovary. Reproductive endocrinologist in Los Angeles, CA.

29. LaKeitha Foster, M.D. 2006 – 2008; Mechanisms in progesterone regulation of uterine quiescence. Neonatologist in Plano, TX.

30. Houda Benlhabib, Ph.D. 2007 – present; Histone modification in the regulation of SP-A gene expression in fetal lung.

31. Chien-Cheng Chen, Ph.D. 2007 – present; Progesterone regulation of MAPK phosphatase 1 (MKP-1/DUSP1) and aromatase in breast cancer cells.

32. Maria Afanador, M.D. 2008 – 2009, Mechanisms in progesterone regulation of uterine quiescence.

33. Alina Montalbano, Ph.D. 2010 – present; Progesterone regulation of genes that regulate myometrial quiescence.

34. Yanmin Luo, M.D. 2011 – 2013., Sun Yat-Sen Visiting Scholar, Role of estrogen related receptor in in human trophoblast. Currently, Associate Professor, Sun Yat-Sen University, Guanzhou, China.

35. Lu Gao, Ph.D., 2011 – 2014. Roles of steroid receptor coregulators in pregnancy and labor

36. Patricia Jimenez, M.D. 2012 – pres. Reproductive Scientist Development Program Scholar, MicroRNAs and implantation.

37. Ming Zhang, M.D., 2013 – pres. Roles of miRNAs in trophoblast differentiation and function.

Predoctoral Trainees:

1. Christen M. Anderson, M.D/Ph.D. Degree, 1987 (completed Ph.D. in 1985). Dissertation title: “Regulation of Steroidogenesis in the Fetal Gonad.” Dr. Anderson currently is an independent consultant, Tulsa, OK.

2. Kuang Qing Chen, Ph.D. Degree, 1991. Dissertation title: “Developmental and Hormonal Regulation of Surfactant Apoprotein Gene Expression in Fetal Lung Tissue.”

3. Li Peng, Ph.D. Degree. Dissertation title: “Trans-acting Factors and Cis-acting Elements Involved in Developmental Regulation of Surfactant Protein A (SP-A) Gene Expression in Fetal Rabbit Lung”; graduate work was completed in the Eukaryotic Molecular Biology Program, University of California at San Diego.

4. Susan McCormick, Ph.D. Degree, 1992. Dissertation title: “Characterization of the Human Surfactant Protein A (SP-A) Genes and their Regulation.” Dr. McCormick currently is an Assistant Professor, Department of BioEngineering, University of Illinois at Chicago.

5. Pampee Young, M.D./Ph.D. Degree, 1998. Dissertation title: “Identification of Hormonal Response Elements in the Human SP-A2 Gene.” Dr. Young is currently an Associate Professor of Pathology, Vanderbilt University School of Medicine.


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6. Laura Michael, Ph.D. Degree, 1997. Dissertation title: “Mechanisms in the Regulation of the Rabbit SP-A Gene by Cyclic AMP.” Dr. Michael currently is Principal Research Scientist at Eli Lilly, Indianapolis, IN.

7. Jinxing Li, Ph.D. Degree, 1997. Dissertation title: “Role of Thyroid Transcription Factor-I in Surfactant Protein-A Gene Expression.” Dr Li is an oncologist in St. Louis, MO.

8. Liuhua Wang, M.S. Degree, 2001. Dissertation title: “Role of BTEB2 in Surfactant Protein-A Gene Expression.” Dr. Wang is currently enrolled in the Computer Science graduate program at UT Dallas.

9. Jennifer Jaworski, M.S. Degree, 2002 – 2004. “Transcriptional Regulation of SP-A Gene Expression by TTF-1.”

10. Alina Montalbano, Ph.D. Degree, 2005 – 2010. “Mechanisms in Macrophage Activation and Migration Leading to Parturition.”

11. Nora Renthal, M.D./Ph.D. Degree, 2007 – 2010. “Role of miRNAs in Pregnancy and Labor.”

12. Koriand’r C. Williams, M.D./Ph.D. Degree, 2010 – 2012. “Role of miRNAs in Pregnancy and Labor.”

13. Wei Guo, Ph.D. degree, 2012 – pres. Roles of miRNAs in fetal lung development and surfactant synthesis.

UT SOUTHWESTERN –TEACHING AND SERVICE:

Teaching:

1990 – pres. Co-Director, Medical School Biochemistry Course (5680)

2006 – pres. Leader and lecturer for Metabolism II Section, Medical Biochemistry Course (5680)

1994 – pres. Human Biology and Disease Course, lecturer

Institutional Committees:

1987 - 2000 Member, Medical Education and Curriculum Committee

1988 - 1994 Member of the UT Southwestern Faculty Senate

1992 - 1993 President, UT Southwestern Faculty Senate

1989 - 1994 Member, Medical School Admissions Committee

1990 - 2000 Member, Student Promotions Committee

1991 - pres. Medical Scientist Training Program Steering Committee

1991 - pres. Member, Student Assistance Committee

1993, ‘96, ‘99 Chair, Administration Committee, UT Southwestern Six Year Plan

1993 - 1994 Chair, University Lecture Series

1993 – pres. Member, Women in Science and Medicine Advisory Committee

1994 -1995 Member, Curriculum Review Task Force


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1994 - 2001 Member, Faculty Promotions and Tenure Committee

1996 Chair, Subcommittee on Organization and Administration, for SACs Self-Study Committee on Administrative Processes

1996 - pres. Friend, Medical School Admissions Committee

1997 - pres. Chair, Committee on the Advancement of Women

2000 – 2010 Nominata Award Selection Committee

2000 – 2010 Ida M. Green Award Selection Committee

2001 Member, Administration Committee, Six-Year Plan

2001 Member, Steering Committee, Six-Year Plan

2002 Member, LCME Committee on “Educational Program leading to the MD Degree”

2002 Member, Childcare Advisory Committee

2003 – pres. Co-chair, Women in Science and Medicine Advisory Committee

2004 – pres. Postdoctoral Advisory Committee

2005 Committee on Guidelines for Appointment, Compensation, Promotion & Tenure

2006 Search Committee, Chair of Obstetrics & Gynecology

2006 – 2009 Faculty Senate

2007 - 2009 Search Committee, Director, Cecil H. and Ida Green Center for Reproductive Biology Sciences

2009 Faculty Diversity Task Force

2011 – pres. Conflict of Interest Committee

2011 Chair, Search Committee for Assistant Dean for Women’s Careers

2011 – 2012 Member, Basic Science Committee, Six Year Plan

PUBLICATIONS:

Journal Publications with Editorial Review:

1. Mendelson, C.R., and Scow, R.O. Uptake of chylomicron triglyceride by perfused lactating rat mammary gland. Am. J. Physiol. 223:1418-1423, 1972.

2. Dufau, M.L., Mendelson, C.R., and Catt, K.J. A highly sensitive in vitro bioassay for luteinizing hormone and chorionic gonadotropin: Testosterone production by isolated Leydig cells. J. Clin. Endocrinol. Metab. 39:620-623, 1974.

3. Mendelson, C.R., Dufau, M., and Catt, K. Gonadotropin binding and stimulation of cyclic AMP and testosterone production by isolated Leydig cells. J. Biol. Chem. 250:8818-8823, 1975.

4. Mendelson, C.R., Dufau, M., and Catt, K. Dependence of gonadotropin stimulation of testosterone synthesis in Leydig cells upon RNA and protein synthesis. Biochim. Biophys. Acta 411:222-230, 1975.


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5. Zinder, O., Mendelson, C.R., and Scow, R.O. Lipoprotein lipase and uptake of chylomicron-triglyceride and cholesterol by perfused mammary tissue. Biochim. Biophys. Acta 431:526-537, 1976.

6. Mendelson, C.R., MacDonald, P.C., and Johnston, J.M. Estrogen binding in human fetal lung tissue cytosol. Endocrinology 106:368-374, 1980.

7. Mendelson, C.R., Brown, P.K., MacDonald, P.C., and Johnston, J.M. Characterization of a cytosolic estrogen binding protein in lung tissue of fetal rats. Endocrinology 109:210-217, 1981.

8. Mendelson, C.R., Johnston, J.M., MacDonald, P.C., and Snyder, J.M. Multi-hormonal regulation of surfactant synthesis by human fetal lung in vitro. J. Clin. Endocrinol. Metab. 53:307-317, 1981.

9. Snyder, J.M., Mendelson, C.R., and Johnston, J.M. Development of fetal rabbit lung tissue in organ culture: Effect of cortisol. Dev. Biol. 85:129-140, 1981.

10. Ackerman, G.E., Smith, M.E., Mendelson, C.R., MacDonald, P.C., and Simpson, E.R. Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J. Clin. Endocrinol. Metab. 53:412-417, 1981.

11. Simpson, E.R., Ackerman, G.E., Smith, M.E., and Mendelson, C.R. Estrogen formation in adipose tissue stromal cells of women: Regulation by glucocorticosteroids. Proc. Natl. Acad. Sci. USA 78:5690-5694, 1981.

12. Longmuir, K.J., Snyder, J.M., Mendelson, C.R., and Johnston, J.M. Phospholipid composition of lamellar bodies formed by fetal rabbit lung type II cells in organ culture. Arch. Biochem. Biophys. 212:491-500, 1981.

13. Snyder, J.M., Johnston, J.M., and Mendelson, C.R. Differentiation of human fetal lung type II cells in vitro. Cell Tissue Res. 220:17-25, 1981.

14. Ackerman, G.E., MacDonald, P.C., Gudelsky, G., Mendelson, C.R., and Simpson, E.R. Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives. Endocrinology 109:2084-2088, 1981.

15. Molsberry, R.L., Carr, B.R., Mendelson, C.R., and Simpson, E.R. hCG binding to human fetal testes as a function of gestational age. J. Clin. Endocrinol. Metab. 55:791-794, 1982.

16. Mendelson, C.R., Cleland, W.H., Smith, M.E., and Simpson, E.R. Regulation of aromatase activity of stromal cells derived from human adipose tissue. Endocrinology 111:1077-1085, 1982.

17. Snyder, J.M., Longmuir, K.J., Johnston, J.M., and Mendelson, C.R. Hormonal regulation of the synthesis of lamellar body phosphatidylglycerol and phosphatidylinositol in fetal lung tissue. Endocrinology 112:1012-1018, 1983.

18. Cleland, W.H., Mendelson, C.R., and Simpson, E.R. Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes. Endocrinology 113:2155-2160, 1983.

19. Mitchell, M.D., Cleland, W.H., Smith, M.E., Simpson, E.R., and Mendelson, C.R. Inhibition of prostaglandin biosynthesis in human adipose tissue by glucocorticosteroids. J. Clin. Endocrinol. Metab. 57:771-776, 1983.


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20. Ng, V.L., Herndon, V.L., Mendelson, C.R., and Snyder, J.M. Characterization of rabbit surfactant associated proteins. Biochim. Biophys. Acta 754:218-226, 1983.

21. Mendelson, C.R., Smith, M.E., Cleland, W.H., and Simpson, E.R. Regulation of aromatase activity of cultured adipose stromal cells by catecholamines and adrenocorticotropin. Mol. Cell. Endocrinol. 37:61-72, 1984.

22. Cleland, W.H., Mendelson, C.R., and Simpson, E.R. Effects of aging and obesity on aromatase activity of human adipose cells. J. Clin. Endocrinol. Metab. 60:174-177, 1985.

23. Durham, C.R., Zu, H., Masters, B.S.S., Simpson, E.R., and Mendelson, C.R. Regulation of aromatase in rat granulosa cells: Indication of synthesis of NADPH-cytochrome P-450 reductase by FSH and dibutyryl cyclic AMP. Mol. Cell. Endocrinol. 40:211-219, 1985.

24. Anderson, C.M., and Mendelson, C.R. Regulation of steroidogenesis in rat Leydig cells in culture: Effect of human chorionic gonadotropin and dibutyryl cyclic AMP on the synthesis of cholesterol side-chain cleavage and adrenodoxin. Arch. Biochem. Biophys. 238:378-387, 1985.

25. Mendelson, C.R., and Snyder J.M. Effect of cortisol on the synthesis of lamellar body glycerophospholipids in fetal rabbit lung tissue in vitro. Biochim. Biophys. Acta 834:85-94, 1985.

26. Lanoux, M.J., Cleland, W.H., Mendelson, C.R., Carr, B.R., and Simpson, E.R. Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture. Endocrinology 117:361-368, 1985.

27. Mendelson, C.R., Wright, E.E., Evans, C.T., Porter, J.C., and Simpson, E.R. Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450AROM), and their use in its purification. Arch. Biochem. Biophys. 243:480-491, 1985.

28. Mendelson, C.R., Corbin, C.J., Smith, M.E., Smith, J., and Simpson, E.R. Growth factors suppress and phorbol esters potentiate the action of dibutyryl adenosine 3',5'-monophosphate to stimulate aromatase activity of human adipose stromal cells. Endocrinology 118:968-973, 1986.

29. Mendelson, C.R., Chen, C., Boggaram, V., Zacharias, C., and Snyder, J.M. Regulation of the synthesis of the major surfactant apoprotein in fetal rabbit lung tissue. J. Biol. Chem. 261:9938-9943, 1986.

30. Evans, C.T., Ledesma, D.B., Schulz, T.Z., Simpson, E.R., and Mendelson, C.R. Isolation and characterization of a complementary DNA specific for human aromatase cytochrome P-450 mRNA. Proc. Natl. Acad. Sci. USA 83:6387-6391, 1986.

31. Snyder, J.M., and Mendelson, C.R. Insulin inhibits the accumulation of the major lung surfactant apoprotein in human fetal lung explants maintained in vitro. Endocrinology 120:1250-1257, 1987.

32. Snyder, J.M., and Mendelson, C.R. Induction and characterization of the major surfactant apoprotein during rabbit fetal lung development. Biochim. Biophys. Acta 920:226-236, 1987.


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33. Steinkampf, M.P., Mendelson, C.R., and Simpson, E.R. Regulation by FSH of the synthesis of aromatase cytochrome P-450 in human granulosa cells. Mol. Endocrinol. 1:465-471, 1987.

34. Evans, C.T., Corbin, C.J., Saunders, C.T., Simpson, E.R., and Mendelson, C.R. Regulation of estrogen biosynthesis in human adipose stromal cells: Effects of Bt2cAMP, EGF and phorbol esters on the synthesis of aromatase cytochrome P-450. J. Biol. Chem. 262:6914-6920, 1987.

35. Odom, M.J., Snyder, J.M., and Mendelson, C.R. Cyclic AMP analogues and -adrenergic agonists stimulate the synthesis of the major surfactant apoprotein in human fetal lung in vitro. Endocrinology 121:1155-1163, 1987.

36. Fournet, N., MacLusky, N.J., Leranth, C.Z., Todd, R.G., Mendelson, C.R., Simpson, E.R., and Naftolin, F. Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. J. Clin. Endocrinol. Metab. 65:757-764, 1987.

37. Simpson, E.R., Evans, C.T., Corbin, C.J., Powell, F.E., Ledesma, D.B., and Mendelson, C.R. Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P450AROM). Mol. Cell. Endocrinol. 52:267-272, 1987.

38. Anderson, C.M., and Mendelson, C.R. Developmental and hormonal regulation of cholesterol side chain cleavage cytochrome P-450 in the fetal rabbit testis. Mol. Cell. Endocrinol. 55:121-130, 1988.

39. Boggaram, V., Qing, K., and Mendelson, C.R. Rabbit pulmonary surfactant apoprotein: Elucidation of primary sequence and hormonal and developmental regulation. J. Biol. Chem. 263:2939-2947, 1988.

40. Odom, M.J., Snyder, J.M., Boggaram, V., and Mendelson, C.R. Glucocorticoid regulation of the major surfactant associated protein (SP-A) and its mRNA and of morphologic development of human fetal lung in vitro. Endocrinology 123:1712-1720, 1988.

41. Steinkampf, M.P., Mendelson, C.R., and Simpson, E.R. Effects of epidermal growth factor and insulin-like growth factor-I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells. Mol. Cell. Endocrinol. 59:93-99, 1988.

42. Corbin, C.J., Graham-Lorence, S., McPhaul, M., Mason, J.I., Mendelson, C.R., and Simpson, E.R. Isolation of a full-length cDNA insert encoding human aromatase cytochrome P-450 and its expression in non-steroidogenic cells. Proc. Natl. Acad. Sci. USA 85:8948-8952, 1988.

43. Boggaram, V., and Mendelson, C.R. Transcriptional regulation of the gene encoding the major surfactant-associated protein (SP-A) in rabbit fetal lung. J. Biol. Chem. 263:19060-19065, 1988.

44. McPhaul, M.J., Noble, J.F., Simpson, E.R., Mendelson, C.R., and Wilson, J.D. The expression of a functional cDNA encoding the chicken cytochrome P-450AROM (aromatase) that catalyzes the formation of estrogen from androgen. J. Biol. Chem. 263:16358-16363, 1988.


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45. Boggaram, V., Smith, M.E., and Mendelson, C.R. Regulation of expression of the gene encoding the major surfactant protein (SP-A) in human fetal lung in vitro. J. Biol. Chem. 264:11421-11427, 1989.

46. Sasano, H., Okamoto, M., Mason, J.I., Simpson, E.R., Mendelson, C.R., Sasano, N., and Silverberg, S.G. Immunolocalization of aromatase, 17-hydroxylase and side-chain-cleavage cytochromes P-450 in the human ovary. J. Reprod. Fertil. 85:163-169, 1989.

47. Sasano, H., Okamoto, M., Mason, J.I., Simpson, E.R., Mendelson, C.R., Sasano, N., and Silverberg, S.G. Immunohistochemical studies of steroidogenic enzymes (aromatase, 17-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. Hum. Pathol. 20:452-457, 1989.

48. Means, G.D., Mahendroo, M.S., Corbin, C.J., Powell, F.B., Mendelson, C.R., and Simpson, E.R. Structural analysis of the gene encoding human aromatase, the enzyme responsible for estrogen biosynthesis. J. Biol. Chem. 264:19385-19391, 1989.

49. Acarregui, M.J., Snyder, J.M., Mitchell, M.D., and Mendelson, C.R. Prostaglandins regulate surfactant protein A (SP-A) gene expression in the human fetal lung in vitro. Endocrinology 127:1105-1113, 1990.

50. Boggaram, V., Smith, M.E., and Mendelson, C.R. Posttranscriptional regulation of surfactant protein A (SP-A) mRNA in human fetal lung in vitro by glucocorticoids. Mol. Endocrinol.5:414-423, 1991.

51. Mahendroo, M.S., Means, G.D., Mendelson, C.R., and Simpson, E.R. Tissue-specific expression of human P-450AROM: The promoter responsible for expression in adipose tissue is different from that utilized in placenta. J. Biol. Chem. 266:11276-11281, 1991.

52. Graham-Lorence, S., Khalil, M.W., Lorence, M.C., Mendelson, C.R., and Simpson, E.R. Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis. J. Biol. Chem. 266:11939-11946, 1991.

53. Means, G.D., Kilgore, M.W., Mahendroo, M.S., Mendelson, C.R., and Simpson, E.R. Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5:2005-2013, 1991.

54. Kilgore, M.W., Means, G.D., Mendelson, C.R., and Simpson, E.R. Alternate promotion of aromatase cytochrome P-450 expression in human fetal tissues. Mol. Cell. Endo. 83:R9-R16, 1992.

55. Alcorn, J.L., Chen, Q., Boggaram, V., and Mendelson, C.R. Expression and transport of rabbit surfactant protein A (SP-A) in COS1 cells. Am. J. Physiol.: Lung Cell. Mol. Physiol.262:L437-L445 1992.

56. Chen, Q., Boggaram, V., and Mendelson, C.R. Rabbit surfactant protein A (SP-A) gene: Identification of a lung-specific DNaseI hypersensitive site in the 5'-flanking region. Am. J. Physiol.: Lung Cell. Mol. Physiol.262:L662-L671, 1992.

57. Alcorn, J.L., and Mendelson, C.R. Trafficking of surfactant protein A (SP-A) in fetal rabbit lung in organ culture. Am. J. Physiol.:Lung Cell. Mol. Physiol.264:L27-L35, 1993.

58. Acarregui, M.J., Snyder, J.M., and Mendelson, C.R. Oxygen modulates the differentiation of human fetal lung in vitro and its responsiveness to cyclic AMP. Am. J. Physiol.: Lung Cell. Mol. Physiol. 264:L465-L474, 1993.


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59. Alcorn, J.L., Gao, E., Chen, Q., Smith, M.E., Gerard, R.D., and Mendelson, C.R. Genomic elements involved in transcriptional regulation of the rabbit surfactant protein-A (SP-A) gene. Mol. Endocrinol.7:1072-1085, 1993.

60. Gao, E., Alcorn, J.L., and Mendelson, C.R. Identification of enhancers in the 5'-flanking region of the rabbit surfactant protein-A (SP-A) gene and characterization of their binding proteins. J. Biol. Chem.268:19697-19709, 1993.

61. Mahendroo, M.S., Mendelson, C.R., and Simpson, E.R. Tissue-specific and hormonally-controlled alternative promoters regulate aromatase cytochrome P-450 gene expression in adipose tissue. J. Biol. Chem. 268:19463-19470, 1993.

62. McCormick, S.M., Boggaram, V., and Mendelson, C.R.: Characterization of mRNA transcripts and exon-intron organization of the human surfactant protein (SP)-A1 and SP-A2 genes. Am. J. Physiol.: Respir. Cell Mol. Physiol. 266:L354-L366, 1994.

63. McCormick S.M., and Mendelson, C.R.: The human SP-A1 and SP-A2 genes are differentially regulated during development and by cyclic AMP and glucocorticoids. Am. J. Physiol.: Respir. Cell Mol. Physiol. 266:LL367-L374, 1994.

64. Toda K., Simpson, E.R., Mendelson, C.R., Shizuta, Y., and Kilgore, M.W.: Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. Mol. Endocrinol. 8:210-217, 1994.

65. Weissler, J.C., Mendelson, C., Moya, F., and Yarbrough, W.C.: Effect of interstitial lung disease macrophages on T-cell signal transduction. Am. J. Respir. Crit. Care Med. 149:191-196, 1994.

66. Zhao, Y., Mendelson, C.R., and Simpson, E.R.: Characterization of sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol. Endocrinol. 9:340-349, 1995.

67. Zhao, Y., Nichols, J.E., Bulun S.E., Mendelson, C.R., and Simpson, E.R.: Aromatase P450 gene expression in human adipose tissue: Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J. Biol. Chem. 270:16449-16457, 1995.

68. Seidner, S.R., Smith, M.E., and Mendelson, C.R. Developmental and hormonal regulation of surfactant protein-A (SP-A) gene expression in baboon fetal lung. Am. J. Physiol.: Lung Cell. Mol. Physiol 15:L609-L616, 1996.

69. Gao, E., Wang, Y., McCormick, S.M., and Mendelson, C.R. Characterization of two baboon surfactant protein-A (SP-A) genes. Am. J. Physiol.: Lung Cell. Mol. Physiol 15:L617-L630, 1996.

70. Young, J., Bulun, S.E., Agarwal, V., Couzinet, B., Mendelson, C.R., Simpson, E.R., and Schaison, G. Aromatase expression in a feminizing adrenocortical tumor. J. Clin. Endocrinol. Metab. 81:3173-3176, 1996.

71. Young, P.P., and Mendelson, C.R. A CRE-like element plays an essential role in cyclic AMP regulation of the human surfactant protein-A2 (SP-A2) gene. Am. J. Physiol.: Lung Cell. Mol. Physiol., 271:L287-L299, 1996.

72. Michael, L.F., Alcorn, J.L., Gao, E., and Mendelson, C.R. Characterization of the cyclic AMP response element of the rabbit surfactant protein-A gene: Evidence for


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transactivators distinct from CREB/ATF family members. Mol. Endocrinol., 10:159-170, 1996.

73. Zhao, Y., Nichols, J.E., Valdez, R., Mendelson, C.R., and Simpson, E.R. TNF stimulates aromatase gene expression in adipose stromal cells through use of an AP-1 binding site upstream of promoter I.4. Mol. Endocrinol 10:1350-1357, 1996.

74. Zhao, Y., Agarwal, V.R., Mendelson, C.R., and Simpson. E.R. Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137:5739-5746, 1996

75. Alcorn, J.L., Smith, M.E., Smith, J.F., Margraf, L.R., and Mendelson, C.R. Primary cell culture of human type II pneumonocytes: Maintenance of a differentiated phenotype and transfection with recombinant adenoviruses. Am. J. Respir. Cell Mol. Biol 17:672-682, 1997.

76. Young, P.P., and Mendelson, C.R. A GT box is essential for basal and cyclic AMP regulation of the human SP-A2 gene in alveolar type II cells: Evidence for the binding of lung nuclear factors distinct from Sp1. Mol. Endocrinol 11:1082-1093, 1997.

77. Michael, L.F., Lazar, M.A., and Mendelson, C.R. PPAR1 expression is induced during cyclic AMP-stimulated differentiation of alveolar type II pneumonocytes. Endocrinology 138:3695-3703, 1997.

78. Gao, E., Wang, Y., Alcorn, J.L., and Mendelson, C.R. The basic helix-loop-helix-zipper transcription factor USF1 regulates expression of the surfactant protein-A gene. J. Biol. Chem. 272:23398-23406, 1997.

79. Breed, D.R., Margraf, L.R., Alcorn, J.L., and Mendelson, C.R. Transcription factor C/EBP in fetal lung: Developmental regulation and effects of cyclic AMP and glucocorticoids. Endocrinology, 138:5527-5534, 1997.

80. Li J., Gao, E., and Mendelson, C.R. Cyclic AMP-responsive expression of the surfactant protein-A gene is mediated by increased DNA binding and transcriptional activity of thyroid transcription factor-1. J. Biol. Chem. 273:4592-4600, 1998.

81. Kamat, A., Alcorn, J.L., Kunczt, C., and Mendelson, C.R. Characterization of the regulatory regions of the human aromatase (P450arom) gene involved in placenta-specific expression. Mol. Endocrinol. 12:1764-1777, 1998.

82. Li, J., Gao, E., Seidner, S.R., and Mendelson, C.R. Differential regulation of expression of the baboon SP-A1 and SP-A2 genes and structural and functional analysis of their 5’-flanking regions. Amer. J. Physiol.: Lung Cell. Mol. Physiol. 275:L1078-1088, 1998.

83. Alcorn. J.A., Hammer, R.E., Graves, K.H., Smith M.E., Maika, S.D., Michael, L.F., Gao, E., Wang, Y., and Mendelson, C.R. Identification of regulatory regions involved in lung cell-specific, developmental, and hormonal regulation of expression of the rabbit surfactant protein-A (SP-A) gene in transgenic mice. Amer. J. Physiol.: Lung Cell. Mol. Physiol. 277:L349-L361, 1999.

84. Kamat, A., Graves, K.H., Smith, M.E., Richardson, J.A., and Mendelson, C.R. A 500 bp region, ~40 kb upstream of the human CYP19 (aromatase) gene mediates placenta-specific expression in transgenic mice. Proc. Natl. Acad. Sci. USA, 96:4575-4580, 1999.


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85. Hinshelwood, M.M., Graves, K.H., Smith, M.E., and Mendelson, C.R. A 278 bp region just upstream of the human CYP19 (aromatase) gene mediates ovary-specific expression in transgenic mice. Endocrinology 141:2050-2053, 2000.

86. Jiang, B., Kamat, A. and Mendelson, C.R. Hypoxia prevents induction of aromatase expression in human trophoblast cells in culture: Potential role of the hypoxia-inducible transcription factor Mash-2. Mol. Endocrinol 14:1661-1673, 2000.

87. Islam, K., and Mendelson, C.R. Potential role of nuclear factor B and reactive oxygen species (ROS) in cyclic AMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells. Mol. Endocrinol. 16:1428-1440, 2002.

88. Yi, M., Tong, G-X., Murry BA, and Mendelson, C.R. Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1). J. Biol. Chem. 277:2997-3005, 2002.

89. Gao, E.M., Wang, Y., Alcorn, J.L., and Mendelson, C.R. Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce surfactant protein-A (SP-A) gene expression. Am. J. Physiol.: Lung Cell. Mol. Biol. 284:L1027-L1036, 2003.

90. Jiang, B. and Mendelson, C.R. USF1 and 2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression. Mol. Cell. Biol. 23:6117-6128, 2003.

91. Condon, J.C., Faust, J.M., Wilson, J.W., and Mendelson, C.R. The decline in coactivators in the pregnant myometrium at term may antagonize progesterone receptor function and contribute to the initiation of labor. Proc. Natl. Acad. Sci. USA 100:9518-9523, 2003.

92. Hinshelwood, M.M., Repa, J.J., Shelton, J.M., Richardson, J.A., Mangelsdorf, D.J., and Mendelson, C.R. Expression of SF-1 and LRH-1 in the mouse ovary: localization in different cell types correlates with differing function. Mol. Cell. Endocrinol. 207:39-45, 2003.

93. Alcorn, J.L., Islam, K.N., Young, P.P., and Mendelson, C.R. Glucocorticoid inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated via the TTF-1 binding element. Am. J. Physiol. Lung Cell. Mol. Biol. 286:L767-L776, 2004.

94. Condon, J.C., Pancharatnam, J., Faust, J.M., and Mendelson, C.R. Expression of surfactant protein by the fetal lung signals the initiation of labor. Proc. Natl. Acad. Sci. USA 101:4978-4983, 2004.

95. Kamat, A., Smith, M.E., Shelton, J., Richardson, J.A. and Mendelson, C.R. Genomic regions that mediate placental cell-specific and developmental regulation of human CYP19 (aromatase) gene expression in transgenic mice. Endocrinology 146:2481-2488, 2005.

96. Jiang, B. and Mendelson, C.R. O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2. Mol. Cell. Biol.25:8824-8833, 2005.

97. Hinshelwood, M.M., Shelton, J.M. Richardson, J.A., and Mendelson, C.R. Temporal and spatial expression of liver receptor homologue-1 (LRH-1) during embryogenesis suggest a potential role in gonadal development. Dev. Dyn. 234:159-68, 2005.


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98. Janowski, B.A., Kaihatsu, K., Huffman, K.E., Schwartz, J.C., Ram, R., Hardy, D., Mendelson, C.R., and Corey, D.R. Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nature Chem. Biol. 1:210-215, 2005.

99. Islam, K.N. and Mendelson, C.R. Permissive effects of oxygen on cyclic AMP and interleukin-1 (IL-1) stimulation of surfactant protein-A (SP-A) gene expression are mediated by epigenetic mechanisms. Mol. Cell. Biol. 26:2901-2912, 2006.

100. Condon, J.C., Hardy, D.B., Kovaric, K. and Mendelson, C.R. Upregulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of NF-B may contribute to the onset of labor through inhibition of PR function. Mol. Endocrinol., 20:764-775, 2006.

101. Hardy, D.B., Janowski BA, Corey DR, and Mendelson CR. Progesterone receptor (PR) plays a major anti-inflammatory role in human myometrial cells by antagonism of NF-B activation of cyclooxygenase 2 (COX-2) expression. Mol. Endocrinol., 20:2724-33, 2006.

102. Liu, D., Hinshelwood M.M., Giguère, V. and Mendelson, C.R. Estrogen Related Receptor (ERR) enhances surfactant protein-A (SP-A) gene expression in fetal lung type II cells. Endocrinology, 147:5187-95, 2006.

103. Coyle, Y.M., Xie, X.J., Hardy, D.B., Ashfaq, R., Mendelson, C.R. Progesterone receptor expression is a marker for early stage breast cancer: Implications for progesterone receptor as a therapeutic tool and target. Cancer Lett. 258:253-61, 2007.

104. Bukulmez, O., Hardy, D.B., Carr, B.R., Word, R.A, and Mendelson, C.R. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology 149:1190-1204, 2008.

105. Islam K.N. and Mendelson, C.R. Glucocorticoid/GR Inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A Promoter. Mol. Endocrinol. 22:585-96, 2008.

106. Hardy, D.B. Janowski, B.A. and Mendelson, C.R. Progesterone receptor (PR) inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms. Mol. Endocrinol. 22:1812-24, 2008.

107. Liu, D., Yi, M., Smith, M. and Mendelson, C.R. TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:L264-71, 2008.

108. Bukulmez, O., Hardy, D.B, Carr, B.R., Auchus, R.J., Toloubeydokhti, T. Word, R. A. Mendelson, C.R. Androstenedione, via local conversion to estrogen, plays a positive feedback role in upregulation of aromatase expression in human endometrium: potential relevance to pathogenesis of endometriosis. J. Clin. Endocrinol. Metab. 93:3471-3477, 2008.

109. Liu, D., Benlhabib H. and Mendelson, C.R. Cyclic AMP enhances estrogen related receptor (ERR) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2). Mol. Endocrinol. 23:772-83, 2009.


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110. Kumar, P., Kamat, A. and Mendelson, C.R. Estrogen receptor (ER) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in placenta. Mol. Endocrinol. 23:784-93, 2009.

111. Maitra, M., Wang, Y., Gerard, R.D., Mendelson, C.R., Garcia, C.K, Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and ER stress. J. Biol. Chem. 285:22103-13, 2010.

112. Renthal, N.E., Chen, C.-C., Williams K.C., Gerard, R., Prange-Kiel, Mendelson, C.R. The miR-200 family and targets ZEB1 and ZEB2 are novel, progesterone-regulated modulators of uterine quiescence and contractility during pregnancy and labor. Proc. Natl. Acad. Sci. U S A 107:20828-20833, 2010.*

*Article Featured on PNAS cover, and in Nature News: “MicroRNAs mediate an early birth” November 2010 Nature doi:10.1038/news.2010.613, and in N Engl J Med 364:972-973: “How does progesterone relax the uterus in pregnancy?” 2010.

113. Benlhabib, H. and Mendelson, C.R. Epigenetic regulation of surfactant protein A (SP-A) gene expression in fetal lung reveals a critical role of SUV39H methyltransferases during development and with hypoxia. Mol. Cell. Biol. 31:1949-1958, 2011

114. Kumar, P. and Mendelson, C.R. Estrogen-related receptor (ERR) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Mol. Endo. 25:1513-26, 2011.

115. Chen, C.-C., Hardy, D.B. and Mendelson, C.R. Progesterone receptor (PR) inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1). J. Biol. Chem. 286:43091-43102, 2011.

116. Williams, K.C., Renthal, N.E., Gerard, R. and Mendelson, C.R. miR-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor. Proc. Natl. Acad. Sci. U S A, 109:7529-34, 2012.

117. Williams, K.C., Renthal, N.E., Gerard, R. and Mendelson, C.R. The microRNA (miR)-199a/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor. Mol. Endocrinol., 26:1857-1867, 2012.

*Article featured on Molecular Endocrinology cover.

118. Montalbano, A.P., Hawgood, S. and Mendelson, C.R. Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Endocrinology, 154:483-98, 2013.

119. Kumar, P., Luo, Y. Tudela C., Alexander J.M. and Mendelson, C.R. The c-Myc regulated microRNA (miR)-17~92 and miR-106a~363 clusters target CYP19A1 and hGCM1 to inhibit human trophoblast differentiation. Mol. Cell. Biol., 33:1782-96, 2013.

120. Luo, Y., Kumar, P. and Mendelson, C.R. Estrogen-related receptor (ERR) regulates oxygen-dependent expression of voltage-gated potassium (K+) channels and tissue kallikrein during human trophoblast differentiation. Mol. Endocrinol., 27:940-52, 2013.

121. Luo, Y., Kumar, P., Chen, C-C., Latham, J., Wang, L., Tudela, C., Alexander, J.M., Shelton, J.M., McKown, L. and Mendelson, C.R. Estrogen-related receptor (ERR) serves a role in blood pressure homeostasis during pregnancy. Mol. Endocrinol 28:965-75, 2014.


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Chapters in Books and Invited Articles

122. Scow, R.O., Mendelson, C.R., Zinder, O., Hamosh, M., and Blanchette-Mackie, E.J. Role of lipoprotein lipase in the delivery of dietary fatty acids to lactating mammary tissue. In: Dietary Lipids and Postnatal Development (Galli, C., Jacini, G., and Pecile, A., eds.) pp. 91-114, Raven Press, New York, 1973.

123. Catt, K.J., Tsuruhara, T., Mendelson, C.R., Ketelslegers, J.M., and Dufau, M.L. Gonadotropin binding and activation of the interstitial cells of the testis. In: Hormone Binding and Target Cell Activation (Dufau, M.L., and Means, A.R., eds.) pp. 1-30, Plenum Press, New York, 1974.

124. Scow, R.O., Blanchette-Mackie, E.J., Mendelson, C.R., Hamosh, M., and Zinder, O. Incorporation of dietary fatty acids into milk triglyceride: Mechanism and regulation. Modern Prob. Pediatr. 15:31-45, 1975.

125. Mendelson, C.R., Zinder, O., Chernick, S., Blanchette-Mackie, E.J., and Scow, R.O. Lipoprotein lipase and lipid metabolism in mammary gland. J. Dairy Sci. 60:666-676, 1977.

126. Mendelson, C.R., Cleland, W.H., and Simpson, E.R. Regulation of estrogen formation by human adipose stromal cells in culture. In: The Adipocyte and Obesity (Angel, A., Hollenberg, C.H., and Roncari, D.A.K., eds.) pp. 211-215, Raven Press, New York, 1983.

127. Simpson, E.R., Cleland, W.H., and Mendelson, C.R. Aromatization of androgens by human adipose tissue in vitro. J. Steroid Biochem. 19:707-713, 1983.

128. Anderson, C.M., and Mendelson, C.R. Regulation of the synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin in rat Leydig cells. Ann. N.Y. Acad. Sci. 438:259-268, 1984.

129. Mendelson, C.R., and Snyder, J.M. Role of prolactin, cortisol, and insulin in the regulation of surfactant synthesis by the human fetal lung. Pediatr. Pulmonol. 1:S91-S98, 1985.

130. Snyder, J.M., Mendelson, C.R., and Johnston, J.M. The morphology of lung development in the human fetus. In: Pulmonary Development (Nelson, G.H., ed.), Vol. 27, pp. 19-46, Marcel Dekker, Inc., New York, 1985.

131. Simpson, E.R., and Mendelson, C.R. Effect of aging and obesity on aromatase activity of human adipose cells. Am. J. Clin. Nutr. 45:290-295, 1987.

132. Mendelson, C.R., Evans, C.T., and Simpson, E.R. Regulation of aromatase in estrogen-producing cells. J. Steroid Biochem. 27:753-757, 1987.

133. Mendelson, C.R., and Simpson, E.R. Regulation of estrogen biosynthesis by human adipose cells in vitro. Mol. Cell. Endocrinol. 52:169-176, 1987.

134. Mendelson, C.R. Mechanisms of hormone action. In: Textbook of Endocrine Physiology (Griffin, J.E., and Ojeda, S.R., eds.) pp. 28-55, Oxford University Press, New York, 1988.

135. Mendelson, C.R., Corbin, C.J., Means, G.D., Mathis, J.M., Graham-Lorence, S., Merrill, J.C., and Simpson, E.R. The aromatase cytochrome P-450 gene and its regulation. In:


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Progress in Endocrinology (Imura, H., Shizume, K., and Yoshida, S., eds.) Elsevier Science Publishers B.V., Amsterdam, 1988.

136. Mendelson, C.R., Merrill, J.C., Steinkampf, M.P., and Simpson, E.R. Regulation of synthesis of aromatase cytochrome P-450 in human adipose stromal and ovarian granulosa cells. Steroids 50:51-59, 1988.

137. Simpson, E.R., Evans, C.T., and Mendelson, C.R. Aromatase cytochrome P-450: Preparation of polyclonal and monoclonal antibodies and a cDNA insert. Steroids 50:3-9, 1988.

138. Simpson, E.R., Mason, J.I., Mendelson, C.R., Estabrook, R.W., and Waterman, M.R. In: Molecular and Cellular Endocrinology of the Testis, Serono Symposia, Vol. 50 (Cooke, B.A., and Sharpe, R.M., eds.) pp. 73-84, Raven Press, New York, 1988.

139. Mendelson, C.R., Corbin, C.J., Means, G.D., Mahendroo, M.S., Graham-Lorence, S., Steinkampf, M.P., and Simpson, E.R. Gonadotropin and growth factor regulation of aromatase cytochrome P-450 gene expression. In: Proceedings of the International Symposium on Frontiers in Reproduction Research: The Role of Growth Factors, Oncogenes, and Gonadal Peptides (Li, Wei-Xiong, Chen, Hao-Chia, Hahn Do Won and McGuire, John L., eds.) NIH, NICHD, pp. 165-187, 1988.

140. Simpson, E.R., Merrill, J.C., Hollub, A.J., Graham-Lorence, S., and Mendelson, C.R. Regulation of estrogen biosynthesis by human adipose cells. Endo. Rev. 10:136-148, 1989.

141. Mendelson, C.R., and Boggaram, V. Regulation of pulmonary surfactant protein synthesis in fetal lung: A major role of glucocorticoids and cyclic AMP. Trends Endocrinol. Metab. 1:20-25, 1989.

142. Simpson, E.R., and Mendelson, C.R. The regulation of oestrogen biosynthesis in human adipose tissue. Proc. Royal Soc. Edin. 95B:153-159, 1989.

143. Simpson, E.R., Graham-Lorence, S., Corbin, C.J., Merrill, J.C., Means, G.D., Mahendroo, M.S., and Mendelson, C.R. Regulation of expression of the gene encoding aromatase cytochrome P-450. Horm. Cell Regulat. 14:49-55, 1989.

144. Mendelson, C.R., Corbin, C.J., Means, G.D., Mahendroo, M., Graham-Lorence, S., Merrill, J.C., and Simpson, E.R. The aromatase cytochrome P-450 gene and its regulation. In: Development and Function of Reproductive Organs, Vol. III, (Josso, N., ed.) Serono Symposia, Vol. 21, pp. 5-19, 1989.

145. Mendelson, C.R., Means, G.D., Mahendroo, M.S., Corbin, C.J., Steinkampf, M.P., Graham-Lorence, S., and Simpson, E.R. Use of molecular probes to study regulation of aromatase cytochrome P-450. Biol. Reprod. 42:1-10, 1990.

146. Mendelson, C.R., and Boggaram, V. Hormonal and developmental regulation of pulmonary surfactant synthesis in fetal lung. Bailliere's Clin. Endocrinol. Metab. 4:351-378, 1990.

147. Simpson, E.R., and Mendelson, C.R. The role of adipose tissue in estrogen biosynthesis in the human. In: Adipose Tissue and Reproduction (Frisch RE, ed.), Karger Basel, pp. 86-106, 1990.


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148. Mendelson, C.R., and Boggaram, V. Hormonal control of the surfactant system in fetal lung. Ann. Rev. Physiol. 53:415-440, 1991.

149. Simpson, E., Lauber, M., Demeter, M., Stirling, D., Rodgers, R., Means, G., Mahendroo, M., Kilgore, M., Mendelson, C.R., and Waterman, M. Regulation of expression of genes encoding steroidogenic enzymes. J. Steroid Biochem. Mol. Biol. 40:45-52, 1991.

150. Simpson, E.R., Means, G.D., Mahendroo, M.S., Kilgore, M.W., Corbin, C.J., and Mendelson, C.R. Analysis of the gene encoding human aromatase cytochrome P-450. In: The New Biology of Steroid Hormones, (Hochberg, R.B. and Naftolin, F., eds.), Serono Symposia, Vol. 74, 1991.

151. Mendelson, C.R., Acarregui, M.J., Odom, M.J., and Boggaram, V. Developmental and hormonal regulation of surfactant protein A (SP-A) gene expression in fetal lung. J. Devel. Physiol. 15:61-69, 1991.

152. Mendelson, C.R., and Boggaram, V. Hormonal and developmental regulation of surfactant-associated proteins in fetal lung. In: Hormones and Fetal Pathophysiology, (Pasqualini, J.R., ed.), Chapter 3, pp. 87-118, Marcel Dekker, New York, 1992.

153. Mendelson, C.R., Acarregui, M.J., Odom, M.J., and Boggaram, V. Stress factors and the regulation of surfactant protein-A (SP-A) gene expression in fetal lung. In: Stress and Reproduction, (Sheppard, K.E., Boublik, J.H., and Funder, J.W. eds.), Serono Symposia, Vol. 86, pp. 51-83, 1992.

154. Mendelson, C.R. Mechanisms of hormone action. In: Textbook of Endocrine Physiology, 2nd edition, (Griffin, J.E., and Ojeda, S.R., eds.) pp. 28-60, Oxford University Press, New York, 1992.

155. Simpson, E., Lauber M., Demeter, M., Means, G., Mahendroo, M., Kilgore, M., Mendelson, C., and Waterman, M. Regulation of genes encoding steroidogenic enzymes in the ovary. J. Steroid Biochem. Mol. Biol. 41:409-413, 1992.

156. Simpson, E.R., and Mendelson, C.R. The molecular basis of hormone action. In: Textbook of Reproductive Medicine, (Carr, B.R., and Blackwell, R.E., eds.), pp. 121-139, Appleton and Lange, Connecticut, 1993.

157. Mendelson, C.R., Gao, E., Smith, M.E., Gerard, R.D., and Alcorn, J.L. Hormonal regulation of surfactant protein gene expression in fetal lung. In: Progress in Endocrinology. The Proceedings of the Ninth International Congress of Endocrinology, Nice, 1992, (R. Mornex, C. Jaffiol, and J. LeClerc, eds.), pp. 669-674, Parthenon Publishing, London, 1993.

158. Mendelson, C.R., Alcorn, J.L., and Gao, E. The pulmonary surfactant protein genes and their regulation in fetal lung. Sem. Perinatol., 17:223-232, 1993.

159. Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J., and Mendelson, C.R. Tissue-specific regulation of aromatase cytochrome P450 expression. In: Handbook of Experimental Pharmacology. (J.B. Schenkman, ed.), pp. 611-625, Springer-Verlag, Berlin, 1993.

160. Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J., and Mendelson, C.R. Tissue-specific promoters regulate aromatase cytochrome P450 expression. Clin. Chem. 39:317-324, 1993.


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161. Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J., and Mendelson, C.R. Tissue-specific promoters regulate aromatase cytochrome P450 expression. J. Steroid Biochem. Mol. Biol. 44:321-330, 1993.

162. Rooney, S.A., Young, S.L., and Mendelson, C.R. Molecular and cellular processing of lung surfactant. FASEB J. 8:957-967, 1994.

163. Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Hinshelwood, M.M., Graham-Lorence, S., Amarneh, B., Ito, Y., Fisher, C.R., Michael, M.D., Mendelson, C.R., and Bulun, S.E.: Aromatase cytochrome P450: The enzyme responsible for estrogen biosynthesis. Endo Rev 15:342-355, 1994.

164. Mendelson, C.R., Alcorn, J.L., and Gao, E. Mechanisms in the regulation of SP-A gene expression in fetal lung. In: Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders. Prog. Respir. Res. (Müller, B., Wichert, P., eds.), pp. 44-50, Karger, Basel, 1994.

165. Mendelson, C.R. Mechanisms of hormone action. In: Textbook of Endocrine Physiology, 3rd edition, (Griffin, J.E., and Ojeda, S.R., eds.) pp. 29-65, Oxford University Press, New York, 1996.

166. Simpson, E.R., Mahendroo, M.S., Kilgore, M.W., Means, G.D., Bulun, S.E., Hinshelwood, M.M. and Mendelson, C.R. Advances in Mol. Cell. Biol. 14:225-244, 1996.

167. Bissonnette, J., Chambers, S., Collins, P., Lockwood, C., Mendelson, C., Myatt, L., Polan, M.L., Shen, W.H., and Szal, S. Strengthening research in departments of Obstetrics and Gynecology. J. Soc. Gynecol. Investig. 4:115-122, 1997.

168. Simpson, E.R., Zhao, Y., Agarwal, V., Michael, M.D., Bulun, S.E., Hinshelwood, M.M., Graham-Lorence, S., Sun, T., Fisher, C.R., and Mendelson, C.R. Aromatase expression in health and disease. In: Rec. Prog. Hormone Res. 52:185-213, 1997.

169. Mendelson, C.R., Young, P.P, Michael, L.F., Alcorn, J.L., and Gao, E.E. Transcriptional regulation of the surfactant protein-A gene. Chest, 111:96S-104S, 1997.

170. Zhao, Y., Agarwal, V.R., Mendelson, C.R., and Simpson, E.R. Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture. J. Steroid Biochem. Mol. Biol. 61:203-210, 1997.

171. Mendelson, C.R., Young, P.P., Michael, L.F., Gao, E., and Alcorn, J.L. The surfactant protein A gene and its regulation. In: Lung Surfactant: Cellular and Molecular Processing. (Rooney, S.A., ed.) pp. 47-73, R.G. Landes, Co., 1998.

172. Mendelson, C.R., Gao, E., Li, J., Young, P.P., Michael, L.F., and Alcorn, J.L. Regulation of expression of surfactant protein-A. Biochim. Biophys. Acta 1408:132-149, 1998.

173. Mendelson, C.R. Role of transcription factors in fetal lung development and surfactant protein gene expression. Annu. Rev. Physiol. 62:875-915 2000.

174. Mendelson, C.R., Li, J., Michael, L.F., Young, P.P., and Alcorn, J.L. Cyclic AMP and glucocorticoid regulation of surfactant protein A (SP-A) gene expression. In: Endocrinology of the Lung (Mendelson, C.R., ed.), pp. 59-80, Humana Press, Totowa, New Jersey, 2000.


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175. Mendelson, C.R. Mechanisms of hormone action. In: Textbook of Endocrine Physiology, 4th edition, (Griffin, J.E., and Ojeda, S.R., eds.) pp. 51-88, Oxford University Press, New York, 2000.

176. Kamat, A. and Mendelson, C.R. Identification of regulatory regions of the human aromatase gene involved in placenta-specific expression. J. Steroid Biochem. Mol. Biol. 79:173-80, 2001.

177. Hinshelwood, M.M. and Mendelson, C.R. Tissue-specific expression of the human CYP19 (aromatase) gene in transgenic mice. J. Steroid Biochem. Mol. Biol 79:193-201, 2001.

178. Kamat, A., Hinshelwood M.M., Murry, B.A., and Mendelson, C.R. Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans. Trends Endocrinol. Metab. 13:122-128, 2002.

179. Kamat, A., and Mendelson, C.R. Placental gene expression. In: Encyclopedia of Hormones. (H. Henry and A.W. Norman, eds.), 2003.

180. Mendelson, C.R., and Condon, J.C. 2005 New insights into the molecular endocrinology of parturition. J. Steroid Biochem. Mol. Biol. 93:113-119. 2005.

181. Mendelson, C.R., Jiang, B., Shelton, J.M., Richardson, J.A., and Hinshelwood, M.M. Transcriptional regulation of aromatase in placenta and ovary. J. Steroid Biochem. Mol. Biol. 95:25-33, 2005.

182. Jiang, B. and Mendelson, C.R. Adenoviral-mediated gene delivery to trophoblast cells. Meth Mol Med 121:451-61, 2006.

183. Mendelson, C.R. and Hardy, D.B. Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast. J. Steroid Biochem. Mol. Biol. 102:241-249. 2006.

184. Hardy, D.B. and Mendelson, C.R. Progesterone receptor antagonism of the inflammatory signals leading to labor. Fetal Maternal Med. Rev. 17:1-19, 2006.

185. Mendelson, C.R., Condon. J.C. and Hardy, D.B. Regulation of inflammatory response pathways during pregnancy and labor. In: Preterm Birth: Mechanisms, Mediators, Prediction and Interventions (Petraglia, F., Strauss, J.F. III, Gabbe, S.G. and Weiss, G., eds), Informa Healthcare, Abingdon, Oxfordshire. 60-69, 2006.

186. Mendelson, C.R. and Kamat, A. Mechanisms in the regulation of aromatase in developing ovary and placenta. J. Steroid Biochem. Mol. Biol.106:62-70, 2007.

187. Mendelson, C.R. Fetal-maternal hormonal signaling in pregnancy and labor. Mol. Endocrinol. 23:947-54, 2009.

188. Renthal, N.E., Williams, K.C. and Mendelson, C.R. MicroRNAs as critical mediators of myometrial contractility during pregnancy and labor. Nature Rev. Endocrinol. 9:391-401, 2013.

189. Mendelson, C.R. GRTH: a key to understanding androgen-mediated germ cell signaling. Endocrinology, 154:1967-1969.

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