CardioInspectCardioInspect

Diagnostic and Monitoring SystemsDiagnostic and Monitoring Systemsfor Congestive Heart Failure (CHF) for Congestive Heart Failure (CHF)

PatientsPatients

TAU Future Technology Development L.PTAU Future Technology Development L.P . .

The TechnologyThe Technology EIT – Electrical Impedance TomographyEIT – Electrical Impedance Tomography

• Electrical Impedance tissue property is imaged Electrical Impedance tissue property is imaged non invasivelynon invasively

Chest belt with Chest belt with disposable electrodesdisposable electrodes

Current Source Unit

Voltage Measurement

Unit

Control and Acquisition Unit

Reconstruction Algorithm

CardioInspect Standalone CardioInspect Standalone PrototypePrototype

Clinical TrialsClinical Trials

Clinical ResultsClinical ResultsMonitoring Lung Edema Monitoring Lung Edema

LevelLevelEdema Improvement

+35%

+16%

Significant increase in resistivity values reflect improvement of lung

fluid level

Lung

Res

istiv

ity [O

hm*c

m]

Measurement #

The Telemedicine Home The Telemedicine Home SystemSystem

Recording Phase Transmitting Phase

Clinical data as received at the medical center

The Telemedicine Home The Telemedicine Home SystemSystem

Healthy Subject

CHF Patient

Confidential

Diagnostic and Monitoring EIT Systemfor Osteoporosis

Confidential

Vision Statement

8

Revolutionize the diagnostics and monitoring of Osteoporosis in the clinic and

at home by introducing an EIT based technology that can be integrated within a

hand wristband

Confidential

Proposed Solution

9

Deliver a novel Electrical Impedance Tomography (EIT) based technology as an alternative to the DEXA solution:Inexpensive relative to other existing techniquesDoes not utilize ionizing radiation and well suited for long-term tracking that is often required in Osteoporosis managementUtilized using simple and compact hardware; Can be applied in small clinics and at home

Current Source Unit

Voltage Measurement

Unit

Control and Acquisition Unit

Reconstruction Algorithm

Utilizing EIT:Provides information about the spatial electrical conductivity distribution within the human bodyBased on applying small magnitude alternating electric currents to the body and measuring developing electric potentials on the body surfaceThe large variation in bone tissue electric and dielectric properties during Osteoporosis, makes EIT a promising technique for monitoring and diagnosing

Confidential

10

Technical Background (1 of 4)

Forward formulation - Calculation of the spatial electrical potential due to known current sources and conductivity distribution

source

source

J

:conductor volumea in equations fields EM sMaxwell'by Solution

Jf

),(

Mathematical Formulation

Inverse formulation - Calculation of the spatial conductivity distribution due to known current sources and surface voltages

algorithmRaphson -Newton iterativeby Solution

),( surfacesourceJf

Confidential

11

Technical Background (2 of 4)

The Newton-Raphson algorithm

Initial Guess - 0

Forward Solver

Calculated surface potentials

Measured surface potentials Cost

function

<yes

Endno

k+1=k+k+1

Confidential

12

Technical Background (3 of 4)

Displayed above are human body computerized model cross section results of the wrist and forearm as received from our preliminary numerical study, using a set of 5 electrodes on the surface of the wrist and measuring the surface potentials. Very strong correlation was found between the Impedance and BMD

Numerical computational simulation

Confidential

13

Technical Background (4 of 4)

Preliminary real measurements using the developed prototype

Results of 7 real tests from 5 healthy subjects and 2 patients with documented osteoporosis

The prototype during measurement

Good correlation was obtained between the measured impedance and age