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CARDIAC ENZYM

CARDIOVASCULAR

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CK (CREATININE KINASE)

AST(ASPARTATE TRASAMINAE)

LDH(LACTAT DEHIDROGNASE)

 THE MOST COMMONLY MEASUREDMARKERS OF MYOCARDIAL INFARCTION

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CREATINE KINASE IS FOUND INHEART MUSCLESKELETAL MUSCLEBRAIN

CK EXIST AS DIMER MADE FROM THEMONOMER M AND B.THESE MONOMER CANCOMBINE TO FORM THREE ISOENZYM

MB (FOUND PRINCIPALLAY IN HEART)MM(IN SKELETAL MUSCLE)BB ( IN BRAIN)

CK 

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Creat!e "!a#e

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 THE PLASMA ACTIVITY OF CK BEGINS TO RISEBEFORE THAT THE OTHER CARDIAC ENZYM$SOIT IS THE MOST %IDELY USED MARKER MI.

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I! t&e 'a#a r#e# t* +*!+e!trat*! *, ,*-r t*/e te# t&e -''er te *, t&e re,ere!+era!0e a,ter MI.

A# AST # ,*-!1 ! t##-e *t&er t&a! &eart$*t&er ,a+t*r# +-+& a# /er 1#ea#e *r&ae*2## a2 1e+rea#e t&e -#e,-!e## *,t&e te#t.

A#'artate tra!#a!a#e

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A#'artat Tra!#a!a#e(AST)

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A#'artate # ,*re1 ! a tra!#a!at*!rea+t*! +ata23e1 42 a#'artate tra!#a!a#e$AST

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A+t/t2 a2 4e ee/ate1 t&ree t* ,*-r te#a4*/e t&e -''er et *, t&e re,ere!+e ra!0ea,ter MI.

F*-!1 !HeartEr2tr*+2te#L/erS"eeta -#+e

LDH5 # a4e t* +ata2#e +*!/er#*! *, a6&21r*724-t2rate $t&# "!*8! a# HBD a+t/t2(#'e#+ ar"er *, 2*+ar1a 1aa0e)

La+tate 1e&21r*0e!a#e

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 T&e a+tate 'r*1-+e1 1-r!0 a!aer*4+02+*2## 19-#e# ,r* t&e t##-e# a!1 #tra!#'*rte1 t* &0&2 aer*4+ t##-e# #-+& a#+ar1a+ -#+e a!1 /er.

 T&e a+tate # t&e! *713e1 t* '2r-/ate !t&e#e +e# 42 LDH a!1 t&e '2r-/ate # ,-rt&er*713e1 ! t&e TCA +2+e. I, t&e e!er02 e/e !

t&e#e +e# # &0& t&e +ar4*!# *, '2r-/ate 84e 1/erte1 4a+" t* 0-+*#e /a t&e0-+*!e*0e!e## 'at&8a2.

http://themedicalbiochemistrypage.org/gluconeogenesis.htmlhttp://themedicalbiochemistrypage.org/gluconeogenesis.htmlhttp://themedicalbiochemistrypage.org/gluconeogenesis.htmlhttp://themedicalbiochemistrypage.org/gluconeogenesis.html

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Maaa! +e# +*!ta! t8* 1#t!+t t2'e# *,LDH #-4-!t#$ tere1 M a!1 H

C*4!at*!# *, t&e#e 19ere!t #-4-!t#

0e!erate# LDH #*32e# 8t& 19ere!t+&ara+ter#t+#.

 T&e H t2'e #-4-!t 're1*!ate# ! aer*4+t##-e# #-+& a# &eart -#+e (a# t&e H:

tetraer) 8&e t&e M #-4-!t 're1*!ate# !a!aer*4+ t##-e# #-+& a# #"eeta -#+e a#t&e M: tetraer).

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G2+*##

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Enzym Activity

Strat *, r#e(&*-r#)

Pea"(&*-r#)

D-rat*!(DAYS)

CK :6; 5