carbon ion depth-dose profile in hibmc facility
DESCRIPTION
18.Sep. 2007 @ Hebden Bridge. Carbon Ion depth-dose profile in HIBMC facility. Toshiyuki Toshito KEK. T. Yamashita 13-Sep. Medical / Gate Applications Geant4 simulation of HIBMC facility using DICOM Proton therapy at HIBMC facility - PowerPoint PPT PresentationTRANSCRIPT
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Carbon Ion depth-dose profile in HIBMC facility
Toshiyuki Toshito
KEK
18.Sep. 2007 @ Hebden Bridge
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T. Yamashita 13-Sep. Medical / Gate Applications Geant4 simulation of HIBMC facility using DICOMProton therapy at HIBMC facilityVisualization of CT image and dose in real patients were presented.
Study for Carbon therapy is also underway.We have realized that to reproduce depth-dose profile for carbon is much more difficult than for proton.
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Depth-dose profile
Normalized here !
20% simulation
measurement
4.9.0
•Width of bragg peakEM and hadron physics
•Tail doseHadron physics
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Nozzle for carbon at HIBMC facility in Hyogo, Japan
Ekine=320MeV/nΔP/P=0.1%(FWHM) in simulation In fact, it is estimated to be±0.02%
Z=0
r=10cm at Isocenter0.25cm thick Tantalum
simulation
(mm)
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Water phantom 30cmx30cmx50cm
320MeV/n 12C
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Dosimetry
Simulation
Cross section 2cmx2cm for speedup (~6hr with 20CPU) 6cmx6cm for further speedupThickness sensitive detector is sliced into 100micron thickness
experimentalr=0.25cmdepth 0.1cmvented to air
Moved along beam axis
320MeV/n 12C 30cm
6cm2cm
50cm100micron
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ConfigurationGeant4 version
4.8.2.p01/4.9.0
Physics ListElectromagnetics – LowE G4hLowEnergyionisation
Physics table of dE/dxSRIM2000p for E<10MeV/n
Physics tables for proton are used for Ions after scaled by mass and effective charge
Ion inelastic - Binary cascade with Shen’s total cross sectionHadron elastic - G4HadronElasticPhysics("elastic",0,false)No Ion elastic
Decay 8Be→2alpha
Production cut 1mm (30micron in water phantom)
theProtonIonisation->SetElectronicStoppingPowerModel(G4Proton::Proton(),"SRIM2000p");theProtonIonisation->SetHighEnergyForProtonParametrisation(10.*MeV);
/run/setCut 1. mm/run/SetCutForRegion WaterPhantom 30. micrometer
G4RADIOACTIVEDATA z4.a8
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electromagnetics
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6cmx6cm rightMLCpos
[0.1mm]
ICRU_R49p for E<2MeV/nvs. SRIM2000p for E<10MeV/n
ICRU_R49pSRIM2000p
measurement
4.9.0LowE
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Standard EM vs. LowE
[0.1mm]
4.9.0
standardLowE
4.9.0
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4.8.2.p01 LowE vs. 4.9.0 LowE
[0.1mm]
4.8.2.p01LowE4.9.0LowE
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Step length in LowE4.8.2.p01 4.9.0
Step length (mm) Step length (mm)
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4.8.2.p01 Std vs. 4.9.0 Std
[0.1mm]
4.8.2.p01standard 4.9.0standard
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Step length in Standard EM4.8.2.p01 4.9.0
Step length (mm) Step length (mm)
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Thickness of slice
4.8.2.p01
100micron
1micron
10micron
4.8.2.p01LowE
Step length is limited by thickness of slice
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Ion inelastic / elastic
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Total cross section
6cmx6cm rightMLCpos 4.9.0
[0.1mm]
Binary cascade4.9.0LowE
Shen
Shenx1.1
Enhanced at LowE
MeV/n
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[0.1mm]
Shen vs. Tripathi vs. TripathiLight
6cmx6cm rightMLCpos 4.9.0
Binary cascade4.9.0LowE
ShenTripathiTripathiLight
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BC vs. JQMD vs. PHITS
BCJQMD(3)PHITS
4.8.2.p01
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Ion elastic
JTri->SetEnhanceFactor(1.0); multiplication factor against Tripathi Cross Section
gionInelasticModel->SetSDMEMin(2*MeV); minimum excitation energy treated by statistical process
1MeV:defaultgionInelasticModel->SetPeripheralFactor(1.2);
multiplication factor against Tripathi Cross Section to derive maximum of impact parameter
gionInelasticModel->SetElasticParameter (2);region to judge the collision as elastic
2:default
Collaborative work with T.Koi
JQMD can treat elastic process as peripheral collision. A version to manipulate JQMD to simulate elastic processwas developed by T.Koi and tested.
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Elastic (150MeV proton)
[0.1mm]
[0.1mm]
Without elasticWith elastic 7.5%
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Ion elastic
Without elastic
With elastic
4.9.0LowE
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Summary
• No configuration to reproduce the height of Bragg peak in HIBMC facility has not been found so far.
• Both electromagnetics and Ion inelastic/elastic process significantly affect the depth-dose profile.
• More systematic study in electromagnetics is needed.• Ions elastic process will be improved.• We need more experimental data for cross check.• I welcome any idea or suggestion.
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Ion elastic
Without elastic
With elastic
Collaborative work with T.Koi
Without elasticWith elastic
4.9.0LowE
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Detector position
+2cm -2cm
2cmx2cm rightMLCpos
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[0.1mm]
Detector size
2cmx2cm6cmx6cm
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G4hLowEnergyIonisation.cc
G4double G4hLowEnergyIonisation::ElectronicLossFluctuation(const G4DynamicParticle* particle,const G4MaterialCutsCouple* couple,G4double meanLoss,G4double step) const
{………………………………………………………………………………………………………………………………………………// Gaussian fluctuationif(meanLoss > kappa*tmax || tmax < kappa*ipotFluct ){………………………….………………………….………………………….
return loss;}
// Non Gaussian fluctuation………………………….………………………….………………………….return loss;}
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Energy loss fluctuation
GaussianNon Gaussian
320MeV/n 42MeV/n
meanLoss (MeV) meanLoss (MeV)
loss
loss
loss loss0.4<meanLoss<0.5 0.4<meanLoss<0.5
mean0.4483 gaussian0.4454 non gaussian
mean0.4499 gaussian0.4453 non gaussian
0.4-0.5 0.4-0.5
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Gauss vs. non-gaussEnergy fluctuation model
[0.1mm]
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SOBP 10cm
4.8.2.p01
[0.1mm]
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Spread of beam momentumΔP/P=0.35%(FWHM) : far from realistic
4.8.2.p01
[0.1mm] [0.1mm]
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Wobbler
r=sqrt(x2+y2)10cm
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290 2x2
290 2x192
070723
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400 2x2
400 2x192
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290 2x2 BC
290 2x192 BC
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400 2x2 BC
400 2x192 BC