canterpene for-lifespan-healthspan-4dec2010
TRANSCRIPT
REBRANDING HEMP FOR THE NUTRACEUTICAL MARKET
CANTERPENE AS A HEALTHSPAN EXTENSION SUPPLEMENT
Terry Grossman, M.D., Medical Director
Morris Johnson, CTO, Founder
Silas Kanning,
Co-founders of:
Lifespan Pharma Inc.
Morris/Greg/Leah/Erin Rod Fisher Steve Burnside
OUR SHAREHOLDERS HAIL FROM AGRICULTURE, MEDICINE AND PHARMACY
REBRANDING HEMP AS CANTERPENE MAKES SENSE FOR THE NATURAL HEALTH PRODUCT / DSHEA FOOD SUPPLEMENT MARKETS
35 YEARS AGO RAPESEED EXPERIENCED THE SAME PROBLEMS AFFECTING HEMP TODAYGrowers needed to rebrand something that was associated with a machine oil regarded as too toxic for humans to consume
Low Erucic Acid Rapeseed (LEAR)?
“CANadian source of OLeic Acid” became CANOLA
It was promoted as a safe, nutritious, multi-purpose human and animal food ingredient
Hemp is undergoing a similar identity crisisHemp is undergoing a similar identity crisis iin the minds of many todayn the minds of many today
When you Google “hemp” you get recreational you Google “hemp” you get recreational and medicinal marijuana “Hits” because “pot and medicinal marijuana “Hits” because “pot people” use “hemp” indiscriminately when people” use “hemp” indiscriminately when speaking about marijuanaspeaking about marijuana
SOME MARIJUANA PRODUCTS associate cannabis with health benefits
and socially “sexy” memes such as
organic or chemical free
SOME CANADIAN HEMP PRODUCTS SOME CANADIAN HEMP PRODUCTS ASSOCIATE HEMP WITH MARIJUANAASSOCIATE HEMP WITH MARIJUANA
ASSOCIATING HEMP WITH MARIJUANA IS CREATING CONSUMER CONFUSION
• Solutions:• Litigate?
• Regulate?
• Educate?
• Ignore?
AFTER MUCH CONSIDERATION WE AFTER MUCH CONSIDERATION WE CONCLUDED NONE OF THE ABOVE CONCLUDED NONE OF THE ABOVE SOLUTIONS ARE PRACTICAL OR COST SOLUTIONS ARE PRACTICAL OR COST EFFECTIVEEFFECTIVE
Some hemp manufacturers Some hemp manufacturers want to capitalize on the science want to capitalize on the science which has popularized the which has popularized the term “Medical Marijuana” term “Medical Marijuana”
The best solution: The best solution: REBRANDING REBRANDING
REBRAND CANADIAN HEMP AS REBRAND CANADIAN HEMP AS CANTERPENECANTERPENE
We link Canadian Hemp with the message
“Extend Health-span and Lifespan naturally with cannabis chemistry”
Canterpene expands the functional chemistry beyond arginine and omega3’s to include cannabinoids and terpenes
WE HAVE PATENTED CANTERPENE WE HAVE PATENTED CANTERPENE AS A PROPRIETARY FORMULATION AS A PROPRIETARY FORMULATION OF MILLED HEMPSEEDOF MILLED HEMPSEED
DOES CANTERPENE HAVE A MARKET?
-Healthspan and lifespan extension are new unmet needs
-Personalized /Individualized Medicine
is an emerging Industry
-”Bockbuster” Pharma is migrating towards “mega-Niche” Pharma
AGING CAN BE BRUTAL
IT IS POSSIBLE TO GROW OLDER WITHOUT AGING AT ANY AGE
60 yrs old 80 yrs old
ANTIAGING IS AN ENORMOUS MARKET
76 million baby boomers in the US
6 million “boomies” in Canada
Boomers now 48 – 64 and have begun to experience the “aging process” firsthand
This generation has redefined each stage of their lives and is currently redefining aging
BOOMERS REGARD AGING IS A DISEASE …
… THAT AFFECTS EVERYONE
… AND IS 100 PERCENT FATAL
THIS IS THE NEW VIEW OF AGING
Bob Delmonteque, age 84
THE TWO PILLARS OF HEALTH
Prevention EarlyDetection
CANTERPENE CAN HELP AS A PREVENTIVE ANTIAGING STRATEGY
Science has linked numerous Cannabis Science has linked numerous Cannabis compounds found in Canterpene with compounds found in Canterpene with beneficial effects on the diseases resulting beneficial effects on the diseases resulting from “normal” agingfrom “normal” aging
Canterpene captures much that other Canterpene captures much that other conventional hemp supplements have conventional hemp supplements have ignoredignored
A toolbox for slowing aging & regenerating damage is emerging:
e.g. Plastoquinine..targeting oxidative stressPlastoquinine..targeting oxidative stress
pp
And “TA65” targeting telomerase gene activation
* GREGORY BENFORD UNVEILS STEMCELL100.COM, A NUTRACEUTICAL DEVELOPED BY GENESCIENT WHICH HAS BEEN TESTED ON HUMANS.
AFTER SEVERAL YEARS OF DEVELOPMENT STEM CELL 100 WILL BE AVAILABLE FOR SALE 03 DEC 2010. IT EXTENDS FRUIT FLY LIFESPAN BY 20%.
STEM CELL 100 DOES NOT STIMULATE STEM CELLS TO DIFFERENTIATE OR DIVIDE; IT JUST PROMOTES THE STABILITY AND VITALITY OF ADULT STEM CELLS SO THEY HAVE THE CAPACITY TO DIVIDE WHEN THE BODY SIGNALS A NEED FOR MORE STEM CELLS. WHEN AN ORGAN OR TISSUE IS DAMAGED, IT WILL SEND OUT NATURAL SIGNALS THAT NEW CELLS ARE NEEDED TO REPLACE OLD OR DAMAGED CELLS. STEM CELL 100TM ALLOWS THE ADULT STEM CELLS TO RESPOND TO THE DAMAGE SIGNAL BY PROVIDED NEW DIFFERENTIATED CELLS TO REPLACE THE OLD OR DAMAGED CELLS AND ALSO MAKE MORE ADULT STEM CELLS TO SUPPORT THE YOUTHFUL STEM CELL POPULATION. THE STEM CELL STABILITY AND VITALITY COMES IN PART FROM ACTIVATING TELOMERASE, WHICH IS REQUIRED FOR GENETIC STABILITY, AND IN PART FROM ACTIVATING INSULIN SENSITIVITY USING A POTENT RESVERATROL ANALOGUE, WHICH ENHANCES METABOLIC STABILITY. TWO OTHER SUBSTANCES (THEANINE AND PINE TREE OLIGO PROANTHOCYANIDINS) IN STEM CELL 100TM PROVIDE NICHE SUPPORT FOR STEM CELLS BY LOWERING INFLAMMATION AND STRESS AND BY PROMOTING VASCULAR STRUCTURE AND HORMONE SUPPORT
THERE ARE FOUR COMPONENTS THAT MAKE UP THE PATENT-PENDING COMBINATION IN STEM CELL 100. THE FIRST INGREDIENT IS A PSYCHOACTIVE AMINO ACID 5-N-ETHYL-GLUTAMINE FROM CAMELLIA SINESIS THAT REDUCES MENTAL STRESS AND INFLAMMATION WHILE IMPROVING LEARNING AND PROTECTING BRAIN CELLS FROM ISCHEMIC OR TOXIC INJURY. THREE OF THE ACTIVE COMPONENTS ARE HIGHLY EXTRACTED NATURAL HERBS THAT ARE STANDARDIZED FOR ACTIVE COMPONENTS THAT PROMOTE ADULT STEM CELLS AND LOWER INFLAMMATION: 1) OLIGO-PROANTHOCYANIDINS FROM THE PINE BARK OF THE PINUS TREE ; 2) PTEROSTILBENE, WHICH IS A LONG HALF-LIFE RESVERATROL ANALOG (SOME 14X LONGER LASTING THAN RESVERATROL) FROM PTEROCARPUS MARSUPIUM, 3) ASTRAGALOSIDES EXTRACTED FROM ASTRAGALUS MEMBRANACEUS, WHICH HAS MANY POSITIVE EFFECTS ON STEM CELLS AND THE CARDIOVASCULAR AND IMMUNE SYSTEMS.
CAN CANTERPENE WORK AS A
HEALTHSPAN AND
LIFESPAN EXTENSION TOOL?
THE MEDICAL BENEFITS
CANTERPENE
NUMEROUS BIOCHEMICAL BENEFITS OF CANNABINOIDS IN HEMP
Canterpene contains terpenes with significant health benefits
WHILE AGING IS NOT LEGALLY CLASSED AS A DISEASE…..
SOME DISEASES/CONDITIONS ASSOCIATED WITH AGING ARE
Oxidative stress
Arthritis
Central nervous system degeneration
Parkinson’s
Alzheimer’s
Cannabidiol (CBD) the major cannabinoid in hemp has been shown to be of benefit in each of these and many other conditions
OXIDATIVE STRESSCBD treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina. Consistent with these effects, CBD treatment also significantly inhibited p38 MAP kinase in the diabetic retina. These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals.
EL Remessey AB et al. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol. 2006 Jan;168(1):235-44.
ARTHRITIS
These potentially anti-inflammatory properties of CBD, together with the lack of psychotropic effect and low toxicity prompted us to test the potential of CBD as a therapeutic agent in collagen-induced arthritis (CIA).
RESULTS: “We report that CBD has a beneficial therapeutic action on established CIA.”
Malfait AM et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9561-6.
PARKINSON’S DISEASEEvidence suggests that cannabinoids may prove useful in Parkinson's disease by inhibiting the excitotoxic neurotransmitter glutamate and counteracting oxidative damage to dopaminergic neurons
Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs. 2003;17(3):179-202.
It seems that cannabinoids could delay or even stop progressive degeneration of brain dopaminergic systems, a process for which there is presently no prevention. In combination with currently used drugs, cannabinoids might represent, qualitatively, a new approach to the treatment of PD, making it more effective.
Sevcik J, Masek K Potential role of cannabinoids in Parkinson's disease DRUG AGING 16 (6): 391-395 JUN 2000
ALZHEIMER’S DISEASEMemory loss, the first and primary symptom of Alzheimer’s disease, can be slowed down significantly in mice by cannabidiol.
In a study at the Cajal Institute in Madrid, Spain, mice were injected with a molecule found in the brain of humans suffering from Alzheimer’s disease, and then treated for one week with cannabidiol.
Those mice injected with cannabidiol successfully performed the task within 25-30 seconds, compared to control mice, who took almost double the amount of time, 45-50 seconds, to complete the task.
See also: Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004
CANTERPENE AS AN ANTIAGING STRATEGY
GOOD SCIENCE WITHOUT A METHOD TO GOOD SCIENCE WITHOUT A METHOD TO COMMERCIALIZE IT WILL NOT BENEFIT COMMERCIALIZE IT WILL NOT BENEFIT ANYONEANYONE
The name of the game is to “beat the clock”
Presented at Canadian Hemp Trade Alliance Nov
15-17, 2010Annual Conference
Winnipeg , Manitoba , Canada
Lifespan Pharma IncSW34-01-16-W2nd meridian
Box 10 Beaubier, Sk., [email protected]
701-240-9411
