cannabis and autism - dr christian bogner, md

Autism & Cannabis

Christian Bogner, MDDenver, Colorado

2016

DECLARATION

• There is no conflict of interest in this lecture• I received no monetary benefit from this lecture• No implied sponsorship by any company to the speaker• No affiliation with the pharmaceutical or cannabis industry• All patients in this presentation had an informed consent for photography

and publication

AUTISM TREATMENT WITH CANNABIS

• I will not speak about

• Dosage recommendations• Ratios• Strains

AUTISM TREATMENT WITH CANNABIS

• I will speak about

• Primary cause of disordered endocannabinoid tone: neurotoxins• Endocannabinoid pathophysiology in autism spectrum

disorders

AUTISM FACTS

-70% of the children with ASD have GI Issues compared to 42% of the children with developmental disorder other than ASD

-Toxic overload (aluminum, mercury, copper)

-Vitamin D deficiency

-Systemic Inflammation

AUTISM

Known facts-70% of the children with ASD have GI Issues compared to 42% of the children with developmental disorder other than ASD

-Toxic overload (aluminum, mercury, copper)

-Vitamin D deficiency

-Systemic Inflammation

WHAT CAUSES THIS ?

MONSANTO’S ROUNDUP


Roundup=Glyphosate= N-(Phosphonomethyl)-glycine

GLYPHOSATE

• Enzyme inhibitor• Antifungal agent• Herbicide• Uncoupling agent

-National Center for Biotechnology Information

GLYPHOSATE

-Glycine [a potent neurotransmitter / non-essential amino acid]

-Formaldehyde [known neurotoxin affecting memory,learning,behavior]

-Phosphorous Acid [white phosphorous used in chemical warfare]

-Ullmann's Encyclopedia of Industrial Chemistry 7th ed

GLYPHOSATE

pH (1% solution in water) 2.5.

EPA: excretion of glyphosate is Feces (~70%) and Kidneys (~30%)

-Ullmann's Encyclopedia of Industrial Chemistry 7th ed

GLYPHOSATE

EVIDENCE OF DISEASE

GLYPHOSATE STUDIES

•"Despite its relatively benign reputation, Roundup was among the most toxic herbicides and insecticides tested.”

- University of Caen, Institute of Biology, Paris, France

•"Case control studies in the USA, Canada and Sweden reported increased risk for NHL (Non-Hodgkin's lymphoma) associated with exposure to glyphosate.

-International Agency for Research on Cancer, World Health Organization [WHO]

GLYPHOSATE GI TRACT

•"Taken together, these data suggest that Roundup exposure may affect human reproduction and fetal development in case of contamination."

-University of Caen, Institute of Biology, Paris, France

•. Ingestion of >85 mL of the concentrated formulation is likely to cause significant toxicity in adults. Gastrointestinal corrosive effects. Renal and hepatic impairment are also frequent and usually reflect reduced organ perfusion.

-Bradberry SM et al; Toxicol Rev 23 (3): 159-67 (2004)

GLYPHOSATE GI TRACT

•Effects at 30,000 ppm included central lobular hepatocyte hypertrophy in males, central lobular hepatocyte necrosis in males, chronic interstitial nephritis in males, and proximal tubule epithelial basophilia and hypertrophy in females.

-California Environmental Protection Agency/Department of Pesticide Regulation

•The results/ suggest that acute toxicity at lethal doses may occur as a result of the uncoupling of oxidative phosphorylation.

-WHO/International Programme on Chemical Safety; Environmental Health Criteria 159, Glyphosate, (1994).

GLYPHOSATE GI TRACT

• "...in a long term combined study of toxicity and carcinogenicity in rats given glyphosate at normal doses, inflammation was observed in the stomach mucosa..."

-International Agency for Research on Cancer, World Health Organization

GLYPHOSATE BRAIN

•Taken together, these results demonstrated that Roundup might lead to excessive extracellular glutamate levels and consequently to glutamate excitotoxicity and oxidative stress in rat hippocampus. -Cattani D et al; Toxicology 320: 34-45 (2014)

GLYPHOSATE ENDOCRINE

•The study tested the effects of glyphosate and Roundup at lower nontoxic concentrations on aromatase, the enzyme responsible for estrogen synthesis. The glyphosate-based herbicide disrupts aromatase activity and mRNA levels...

-Richard S et al; Environ Health Perspect 113 (6): 716-20 (2005)]

GLYPHOSATE GENOTOXICITY

•Glyphosate also caused DNA and chromosomal damage in human cells […] one study in community residents reported increases in blood markers of chromosomal damage (micronuclei) after glyphosate formulations were sprayed nearby.

-WHO; IARC Monographs Volume 112: evaluation of five organophosphate insecticides and herbicides (March 20, 2015)

GLYPHOSATE MORE

• Roundup exposure may affect human reproduction and fetal development in case of contamination [1]

• Glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use [2]

• Maternal exposure to glyphosate disturbed the masculinization process in the offsping and promoted behavioral changes and histological and endocrine problems in reproductive parameters [3]

• Roundup […] could contribute to Sertoli cell disruption in spermatogenesis that could have an impact on male fertility [4]

EPA STATEMENT

• “Given increased public interest in glyphosate, EPA may recommend sampling for glyphosate in the future”.

– Environmental Protection Agency, 2015

5.2 PPM GLYPHOSATE

GLYPHOSATE EFFECTS

• Oral glyphosate

• Destruction of gastrointestinal bacteria via Shikimate pathway disruption • Malabsorption of tyrosine, tryptophan, phenylalanine• Gastrointestinal inflammation and leaky gut• Systemic absorption of protein• Systemic inflammation • Liver P450 enzyme destruction Stephanie Seneff, Senior Research Scientist,MIT

GLYPHOSATE SOURCES

170 PPB GLYPHOSATE IN ENFAMIL PROSOBEE LIQUID CONCENTRATE

SENEFF, SAMSEL, GLYPHOSATE, PATHWAYS TO MODERN DISEASES III: MANGANESE, NEUROLOGICAL DISEASES, AND ASSOCIATED PATHOLOGIES

0.390 PPB GLYPHOSATE

VACCINES

MMR VACCINE

2.671 ppm Glyphosate

FROM GLYPHOSATE TO AUTISM

FOODBABE.COM

Picture by Dr. Hagmeyer

MOLECULAR EVIDENCE OF BRAIN INJURY

Glutamate Glycine

Glutamate

Glutamate Glycine

AUTISM BRAIN


Roundup=Glyphosate= N-(Phosphonomethyl)-glycine

Glyphosate = Glycine


Glutamate

?

Accelerated and abnormal brain growth in the Autistic

MSG Used to Trigger Epileptic SeizuresMSG Used to Trigger CNS and Brain DamageMSG Used to Damage Eye Cells in Vivo and in Vitro


Glutamate

?

IN 1949 DR. MALHERBE TESTED A GROUP OF

MENTALLY DISABLED CHILDREN

TO SEE IF GLUTAMATE WOULD IMPROVE THEIR

MENTAL CAPACITY. IT MADE THEM WORSE.


Glutamate


Glutamate

ADHD

WHERE CAN WE FIND MASSIVE AMOUNT OF GLUTAMATE ?

MMR VACCINE

2.671 ppm Glyphosate0.4mg monosodium-L-

Glutamate


Glutamate AUTISM

WHY CBD IS NEEDED

US patent 6630507

US department of Health and Human Services

‘Cannabinoids as antioxidants and neuroprotectants’

‘Cannabinoids have been found to have antioxidantproperties, unrelated to NMDA receptor antagonism’

"In the presence of glutamate alone, and in the presence of glutamate and cannabidiol (CBD) or THC, it was demonstrated that CBD and THC were similarly protective."


Glutamate

THE CASE FOR THC

• Endocannabinoid system

• Memory consolidation• Memory Extinction

• Disrupt aspects of short-term (i.e. working) memory• Leave retrieval of well-

learned information (i.e. long-term or reference memory) largely intact.

CB1 AGONISTS

-Cannabinoids as Therapeutics, Mechoulam

ECS REFRESHER

• Disrupt aspects of short-term (i.e. working) memory

• Leave retrieval of well-learned information (i.e. long-term or reference memory) largely intact.

CB1 AGONISTS • Attentional mechanisms• Associational processes• Consolidation processes• Encoding processes• Retrieval processes

SKYWALKER

Endocannabinoids, phytocannabinoids and synthetic cannabinoids effects on memory

CONDITIONAL DISCRIMINATION


AUDITORY OR VISUAL STIMULUS (KNOWN)

REFERENCE (LONG TERM) MEMORY


AUDITORY OR VISUAL STIMULUS (UNKNOWN)

WORKING (SHORT TERM) MEMORY



SR-141716



METHANANDAMIDE



ESTROGEN



ESTROGENAUTISM

BOYS 4.5 : 1 GIRLS

RELEVANCE

• Without proper short term memory, long term memory formation is impaired• It would make sense that repetitive CB1 stimulation

would cause the desired effect,e.g. with ABA therapy? Unfortunately, often limited to no effect in severe autism !

GLYPHOSATE VS BRAIN P450

BRAIN CYTOCHROME P450 D6 [CYP2D6]

- Metabolizes many psychoactive compounds in the brain• implicated in neurodegeneration, psychosis,

schizophrenia, and personality traits- involved in the oxidation of 20-30% of the most

commonly prescribed drugs

BRAIN CYTOCHROME P450D6

• Endocannabinoid anandamide is metabolized by CYP2D6, resulting in the formation of multiple mono- and deoxygenated products

•Oxidation of anandamide may result in the formation of novel signaling mediators

BRAIN

• Increase in CYP2D6 in 13 different brain regions of alcoholics including the frontal cortex temporal cortex hippocampus substantia nigra

all of which are areas of high CB1 expression and where anandamide is known to be produced.

P450D6

ANANDAMIDE

5,6EET-EAs

CB1 CB2

P450D6

ANANDAMIDE

5,6EET-EAs

CB1 CB2

During inflammationupregulated in 13 different brain regions (e.g.alcoholics)

P450D6

ANANDAMIDE

5,6EET-EAs

CB1 CB2

300 fold selectivity1000 fold affinity

CB2 receptors on Microglia [brain macrophages]

CYP2D6

ANANDAMIDE

5,6EET-EAs

CB1

300 fold selectivity1000 fold affinity

CYP2D6

ANANDAMIDE

5,6EET-EAs

CB1

[AEA]

5,6EET-EAs

CYP2D6

ANANDAMIDE

5,6EET-EAs

CB1

GLYPHOSATE

‘Cannabinoids have been found to have antioxidantproperties, unrelated to NMDA receptor antagonism’

CB2 receptors on Microglia [brain macrophages]Also have TRVP receptors that CB2 activate

CYP2D6

ANANDAMIDE

5,6EET-EAs

CB1

GLYPHOSATE

CBD

TRVP

CYP2D6

ANANDAMIDE

5,6EET-EAs

CB1

GLYPHOSATE

CBD

TRVP

delta9THC

THE BRADSTREET REVELATION

GCMAF – 85% IMPROVEMENT IN AUTISM

GCMAF

P450Activated vitamin D GCMAF

Vitamin D3

GCMAF


Vitamin D3glyphosate

BRADSTREET FAMILY REVELATION

‘85% IMPROVEMENT WITH CANNABIS ONLY’

IMPOSSIBLE TO PROFIT IN U.S. MARKET

?DATA OMITTED?

SUMMARY

Protect brain from further toxic injury – THC/CBD OILRestore the gastrointestinal system – PROBIOTICSProper testingProper educationProper diet (non-GMO, organic)Share information

THE FUTURE OF AUTISM

GCMAF


Vitamin D3glyphosate

GCMAF


Vitamin D3

www.mammausa.org

http://uf4a.org/

The Unconventional Foundation for Autism

www.drbogner.com

cannabis and autism - dr christian bogner, md

Health & Medicine