CancerResearchVOLUME 48 •NUMBER 3 •CNREA8 •PP 493-758

CONTENTSf

Asterisks * preceding page numbers refer to studies using human-derived material.

Perspectives in Cancer Research

493 Oncogenes of DNA Tumor Viruses. Arnold J. Levine.

BASIC SCIENCES

497 Effects of Acute pH 6.6 and 42.1) C Heating on the IntracellularpH of Chinese Hamster Ovary Cells. John A. Cook and MichaelH. Fox.

* 503 Uptake and Intracellular Distribution of Doxorubicin Metabolitesin B-Lymphocytes of Chronic Lymphocytic Leukemia. EmmanuelN. Dessypris, Dean E. Brenner, Maria R. Baer, and Kenneth R.Hande.

507 De Novo Guanylate Synthesis in the Commitment to Replicationin Hepatoma 3924A Cells. Yutaka Natsumeda, Tadashi Ikegami.Kimie Murayama, and George Weber.

512 Sister Chromatid Exchanges, Chromosomal Aberrations, and Cy-totoxicity Produced by AntirumorTopoisomerase II Inhibitors inSensitive (DC3F) and Resistant (DC3F/9-OHE) Chinese HamsterCells. Yves Pommier, Donna Kerrigan,Joseph M. Covey. Chien-Song Kao-Shan, and Jacqueline Whang-Peng.

*517 Bromodeoxyuridine Enhancement of l-/8-D-Arabinofuranosylcy-tosine Metabolic Activation and Toxicity in HL-60 LeukemicCells. Douglas D. Ross, ChristopherC. Joneckis, Tae Heun Song,and Richard K. Wu.

522 Decontamination and Disposal of Nitrosoureas and Related ,\!-

Nitroso Compounds. George Lunn, Eric B. Sansone, A. W.Andrews, and Larry K. Keefer.

*527 Identification of an Anionic Form of Glutathione TransferasePresent in Many Human Tumors and Human Tumor Cell Lines.Thomas C. Shea, Susan L. Kelley, and William D. Henner.

Effect of Lymphokine-activated Killer Cell Fraction on the Development of Human Hematopoietic Progenitor Cells. YoshihiroFujimori, Hiroshi Hará,and Kiyoyasu Nagai.

539 Partial Reversal of Doxorubicin Resistance by Forskolin and 1,9-Dideoxyforskolin in Murine Sarcoma S180 Variants. Scott Wadlerand Peter H. Wiernik.

Immunomodulatory Properties of Recombinant Murine and Human Tumor Necrosis Factor. James E. Talmadge, HamblinPhillips, Mark Schneider, Tammy Rowe, Robin Pennington,Orville Bowersox, and Barbara Lenz.

551 Lectin-binding Proteins in Nuclear Preparations from Rat Liverand Malignant Tumors. George R. Burrus, Warren N. Schmidt,Judith A. Briggs, Lubomir S. Hnilica, and Robert C. Briggs.

556 Mechanism of II-ras Oncogene Activation in Mouse SquamousCarcinoma Induced by an Alkylating Agent. Anne E. Hochwalt,Jerome J. Solomon, and Seymour J. Garte.

* 559 Therapeutic Efficacy of Antiglioma Mesenchymal ExtracellularMatrix '"I-Radiolabvled Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Yi-Sheng Lee, Dennis E. Bullard,Michael R. Zalutsky, R. Edward Coleman, Carol J. Wikstrand,Henry S. Friedman, Edward V. Colapinto, and Darell D. Bigner.

:':567 Individual and Combined Tumoricidal Effects of Dexamethasone

and Interferonson Human Leukocyte Cell Lines. Luying Pan andPaul M. Guyre.

572 Marker Polypeptides Distinguishing between Cancer Cell Cloneswith High and Low Potential for Spontaneous Metastasis inMurine FibrosarcomaCells. IvarAmund Grimstad, Anne KarineThorsrud. and Egil Jellum.

578 Selective Cytotoxicity of Phospholipids and Diacylglycerols to Rat3Y1 Fibrilblasts Transformed by Adenovirus Type 12 or Its EIAGene. Hideo Shimura, Masumi Ohtsu, Akinobu Matsuzaki,Tetsuya Mitsudomi, Kazukiyo Onodera, and Genki Kimura.

* 584 Augmented Antitumor Effect of Recombinant Human Interleukin-la by Indomethacin. Katsuhisa Nakata, Shigeki Kashimoto.Hiroaki Yoshida, Tohru Oku, and Shinichi Nakamura.

* 589 Feasibility of Drug Screening with Panels of Human Tumor CellLines Using a Microculture Tetrazolium Assay. Michael C. Alley,Dominic A. Scudiero. Anne Monks, Miriam L. Hursey, Maciej J.Czerwinski, Donald L. Fine, Betty J. Abbott. Joseph G. Mayo,Robert H. Shoemaker, and Michael R. Boyd.

602 Energy Substrate Utilization in Freshly Isolated Morris Hepatoma 7777 Cells. Julie A. Mares-Perlman and Earl Shrago.

609 Testosterone-mediated Increase in 5a-Dihydrotestosterone Content, Nuclear Androgen Receptor Levels, and Cell Division in anAndrogen-independentProstate Carcinoma of Noble Rats. Shuk-Mei Ho. Irwin Leav, David Damassa. Paul W. L. Kwan, FrederickB. Merk, and Henry S. K. Seto.

615 Effect of Blennivan on Murine Tumor Cells at Elevated Temperatures and Two Different pH Values. Muneyasu Urano, JuliaKahn, and Lydia A. Kenton.

620 Enhancement of Chemical Carcinogenesis in Mice by SystemicEffects of Ultraviolet Irradiation. Helen L. Gensler.

*624 Antibody-mediated Killing of Human Tumor Cells by AttachedEffector Cells. Ingegerd Hellström,Ursula Garrigues, EfraimLavie, and Karl Erik Hellström.

628 Proton Stoichiometry of Electron Transport in Rodent TumorMitoplasts. Jorge Ferreira, Baltazar Reynafarje, Lidia E. Costa,and Albert L. Lehninger.

*635 Alteration of Human Lymphokine-activated Killer Cell Activityby Manipulation of Protein Kinase C and Cytosolic Ca2*.Carl W.

McCrady, Fei Li. Angus J. Grant, Randall E. Merchant, andRichard A. Carchman.

641 Tumorigenicityof the cyc~ Variant of the S49 Murine Lymphoma

Deficient in the G,-a Subunit of Adenylate Cyclase. Jeffrey M.Stadel, Randall K. Johnson, Christopher K. Mirabelli, David A.Powers, Chiù-MeiSung, Leo F. Faucette. Francis L. McCabe, andStanley T. Crooke.

645 Expression of Two Different Endogenous Galactoside-bindingLectins Sharing Sequence Homology. Avraham Raz. PninaCarmi, and Galit Pazerini.

t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

on July 20, 2021. © 1988 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 589 Feasibility of Drug Screening with Panels of Human Tumor CellLines Using a MicrocultureTetrazolium Assay. Michael C. Alley,Dominic A. Scudiere, Anne Monks, Miriam L. Hursey, Maciej J.Czerwinski, Donald L. Fine, Betty J. Abbott, Joseph G. Mayo,Robert H. Shoemaker, and Michael R. Boyd.

615 Effect of Bleomycin on Murine Tumor Cells at Elevated Temperatures and Two Different pH Values. Muneyasu Urano, JuliaKahn, and Lydia A. Kenton.

* 650 Synergistic Cytotoxic and Antitumor Effects of Recombinant Human Tumor Necrosis Factor and Hyperthermia. Naoki Watanabe,Yoshiro Niitsu, Hiroshi Umeno, Hisao Soné,Hiroshi Neda,Naofumi Yamauchi, Masahiro Maeda, and Ichiro Urushizaki.

Synergistic Effects of Recombinant Human Tumor Necrosis Factor and Hyperthermia on in Vitro Cytotoxicity and ArtificialMetastasis. Yoshiro Niitsu, Naoki Watanabe, Hiroshi Umeno,Hisao Soné,Hiroshi Neda, Naofumi Yamauchi, Masahiro Maeda,and Ichiro Urushizaki.

671 Denaturation and Renaturation of a /3-l,6;l,3-Glucan, Lentinan,Associated with Expression of T-Cell-mediated Responses.Yukiko Y. Maeda, Sumiyo T. Watanabe, Chie Chihara, andMakoto Rokutanda.

694 Pharmacokinetics of Tumor Cell Exposure to |MC]Methotrexate

after IntracarotidAdministration without and with HyperosmoticOpening of the Blood-Brain and Blood-Tumor Barriers in RatBrain Tumors: A Quantitative Autoradiographic Study. WilliamR. Shapiro, Rand M. Voorhies, Emile M. Hiesiger, Peter B. Sher,George A. Basler, and Lauren E. Lipschutz.

* 725 Reduction of Doxorubicin Cytotoxicity by Ouabain: Correlationwith Topoisomerase-induced DNA Strand Breakage in Humanand Hamster Cells. Theodore S. Lawrence.

Tumor Biology497 Effects of Acute pH 6.6 and 42.0°CHeating on the Inrracellular

pH of Chinese Hamster Ovary Cells. John A. Cook and MichaelH. Fox.

609 Testosterone-mediated Increase in 5a-Dihydrotestosterone Content, Nuclear Androgen Receptor Levels, and Cell Division in anAndrogen-independent Prostate Carcinoma of Noble Rats. Shuk-Mei Ho, Irwin Leav, David Damassa, Paul W. L. Kwan, FrederickB. Merk, and Henry S. K. Seto.

* 665 Isolation and Characterization of Spontaneous Wheat Germ Ag-glutinin-resistant Human Melanoma Mutants Displaying Remarkably Different Metastatic Profiles in Nude Mice. MakotoIshikawa, James W. Dennis, Shan Man, and Robert S. Kerbel.

676 In Vivo 3IP Nuclear Magnetic Resonance Spectroscopy of Sub

cutaneous 9L Gliosarcoma: Effects of Tumor Growth and Treatment with l,3-Bis(2-chloroethyl)-l-nitrosourea on Tumor Bioen-ergetics and Histology. R. Grant Steen, Rafael J. Tamargo, KathyA. McGovern, S. Sunder Rajan, Henry Brem, Janna P. Wehrle,and Jerry D. Glickson.

* 686 Surface Antigens of Human Melanoma Cells Cultured in Serum-free Medium: Inductionof Expression of Major Histocompatibil-ity Complex Class II Antigens. Francisco X. Real, Bettina Fliegel,and Alan N. Houghton.

702 Cytogenetic Changes in Rat Trachea! Epithelial Cells during EarlyStages of Carcinogen-induced Neoplastic Progression. MitsuoOshimura, D. James Fitzgerald, Hitoshi Kitamura, PaulNettesheim, and J. Carl Barrett.

* 715 Optimization and Characterizationof the Capillary Human TumorClonogenic Cell Assay. Francis Ali-Osman and Patricia A. Beltz.

* 731 Biological and Karyotypic Characterization of a New Cell LineDerived from Human Gliosarcoma. Manfred Westphal, MarianneHaensel, Dieter Mueller, Rudolf Laas, Regina Kunzmann, EvaRohde, Albrecht Koenig, Fritz Hoelzel, and Hans-DietrichHerrmann.

741 Progressive Growth of Fish Tumors after Transplantation intoThymus-aplastic (nu/nu) Mice. Manfred Schartl and Ralf U.Peter.

* 745 Spontaneous Sister ChromatidExchange in Normal Bone Marrowand Ph-positive Chronic Myelocytic Leukemia. Reinhard Becher,Gabriele Zimmer, Gabriele Prescher, and Carl G. Schmidt.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

The Clinical and Epidemiológica!Investigations section contains afurther article presented at the Fifth Symposium on Epidemiologyand Cancer Registries in the Pacific Basin, November 16-21, 1986,Kauai, Hawaii.

751 Cancer in Migrants to Australia: Extending the Descriptive Epidemiológica!Data. Anthony J. McMichael and Graham G. Giles.

757 Announcements

758 Author Index

NOTE: Advance registration form for 79th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.

on July 20, 2021. © 1988 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

CanœrResearchVOLUME 48 •NUMBER 3 •CNREA8 •PP 493-758

CONTENTSf

Asterisks * preceding page numbers refer to studies using human-derived material.

Perspectives in Cancer Research

493 Oncogene«of DNA Tumor Viruses. Arnold J. Levine.

BASIC SCIENCES

497 Effects of Acute pH 6.6 and 42.0°CHeating on the Intracellular

pH of Chinese Hamster Ovary Cells. John A. Cook and MichaelH. Fox.

* 503 Uptake and Intracellular Distribution of Doxorubicin Metabolitesin B-Lymphocytes of Chronic Lymphocytic Leukemia. EmmanuelN. Dessypris, Dean E. Brenner, Maria R. Baer, and Kenneth R.Hande.

507 De Novo Guanylate Synthesis in the Commitment to Replicationin Hepatoma 3924A Cells. Yutaka Natsumeda, Tadashi Ikegami,Kimie Murayama, and George Weber.

512 Sister Chromâtid Exchanges, Chromosomal Aberrations, and Cy-totoxicity Produced by Antitumor Topoisomerase II Inhibitors inSensitive (DC3F) and Resistant (DC3F/9-OHE) Chinese HamsterCells. Yves Pommier, Donna Kerrigan,Joseph M. Covey, Chien-Song Kao-Shan, and Jacqueline Whang-Peng.

*5I7 Bromodeoxyuridine Enhancement of 1-0-D-Arabinofuranosylcy-tosine Metabolic Activation and Toxicity in HL-60 LeukemicCells. Douglas D. Ross. ChristopherC. Joneckis, Tae Heun Song,and Richard K. Wu.

522 Decontamination and Disposal of Nitrosoureas and Related ,V-Nitroso Compounds. George Lunn, Eric B. Sansone, A. W.Andrews, and Larry K. Keefer.

*527 Identification of an Anionic Form of Glutathione TransferasePresent in Many Human Tumors and Human Tumor Cell Lines.Thomas C. Shea, Susan L. Kelley, and William D. Henner.

*534 Effect of Lymphokine-activated Killer Cell Fraction on the Development of Human Hematopoietic Progenitor Cells. YoshihiroFujimori, Hiroshi Hará,and Kiyoyasu Nagai.

539 Partial Reversal of Doxorubicin Resistance by Forskolin and 1,9-Dideoxyforskolin in Murine Sarcoma S180 Variants. Scott Wadlerand Peter H. Wiernik.

* 544 Immunomodulatory Properties of Recombinant Murine and Human Tumor Necrosis Factor. James E. Talmadge, HamblinPhillips, Mark Schneider, Tammy Rowe, Robin Pennington,Orville Bowersox, and Barbara Lenz.

551 Lectin-binding Proteins in Nuclear Preparations from Rat Liverand Malignant Tumors. George R. Burrus, Warren N. Schmidt,Judith A. Briggs, Lubomir S. Hnilica, and Robert C. Briggs.

556 Mechanism of \\-ras Oncogene Activation in Mouse SquamousCarcinoma Induced by an Alkylating Agent. Anne E. Hochwalt,Jerome J. Solomon, and Seymour J. Garte.

* 559 Therapeutic Efficacy of Antiglioma Mesenchymal ExtracellularMatrix '"I-Radiolabflcd Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Yi-Sheng Lee, Dennis E. Bullard,Michael R. Zalutsky, R. Edward Coleman, Carol J. Wikstrand,Henry S. Friedman, Edward V. Colapinto, and Darell D. Bigner.

:'c567 Individualand Combined Tumoricidal Effects of Dexamethasone

and Interferons on Human Leukocyte Cell Lines. Luying Pan andPaul M. Guyre.

572 Marker Polypeptides Distinguishing between Cancer Cell Cloneswith High and Low Potential for Spontaneous Metastasis inMurine FibrosarcomaCells. IvarAmund Grimstad, Anne KarineThorsrud, and Egil Jellum.

578 Selective Cytotoxicity of Phospholipids and Diacylglycerols to Rat3Y1 Fibroblasts Transformed by Adenovirus Type 12 or Its EIAGene. Hideo Shimura, Masumi Ohtsu, Akinobu Matsuzaki.Tetsuya Mitsudomi, Kazukiyo Onodera, and Genki Kimura.

* 584 Augmented Antitumor Effect of RecombinantHuman Interleukin-la by Indomethacin. Katsuhisa Nakata, Shigeki Kashimoto,Hiroaki Yoshida, Tohru Oku, and Shinichi Nakamura.

* 589 Feasibility of Drug Screening with Panels of Human Tumor CellLines Using a Microculture Tetrazolium Assay. Michael C. Alley,Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J.Czerwinski, Donald L. Fine, Betty J. Abbott, Joseph G. Mayo,Robert H. Shoemaker, and Michael R. Boyd.

602 Energy Substrate Utilization in Freshly Isolated Morris Hepatoma 7777 Cells. Julie A. Mares-Perlman and Earl Shrago.

609 Testosterone-mediated Increase in 5a-Dihydrotestosterone Content, Nuclear Androgen Receptor Levels, and Cell Division in anAndrogen-independentProstate Carcinoma of Noble Rats. Sliuk-Mei Ho, Irwin Leav, David Damassa, Paul W. L. Kwan, FrederickB. Merk, and Henry S. K. Seto.

615 Effect of Bleomycin on Murine Tumor Cells at Elevated Temperatures and Two Different pH Values. Muneyasu Urano, JuliaKahn, and Lydia A. Kenton.

620 Enhancement of Chemical Carcinogenesis in Mice by SystemicEffects of Ultraviolet Irradiation. Helen L. Gensler.

*624 Antibody-mediated Killing of Human Tumor Cells by AttachedEffector Cells. Ingegerd Hellström,Ursula Garrigues, EfraimLavie, and Karl Erik Hellström.

628 Proton Stoichiometry of Electron Transport in Rodent TumorMitoplasts. Jorge Ferreira, Baltazar Reynafarje, Lidia E. Costa,and Albert L. Lehninger.

*635 Alteration of Human Lymphokine-activated Killer Cell Activityby Manipulation of Protein Kinase C and Cytosolic Ca2*.Carl W.

McCrady, Fei Li, Angus J. Grant, Randall E. Merchant, andRichard A. Carchman.

641 Tumorigenicity of the eye Variant of the S49 Murine LymphomaDeficient in the G.-<*Subunit of Adenylate Cyclase. Jeffrey M.Stadel, Randall K. Johnson, Christopher K. Mirabelli, David A.Powers, Chiù-MeiSung, Leo F. Faucette, Francis L. McCabe, andStanley T. Crooke.

645 Expression of Two Different Endogenous Galactoside-bindingLectins Sharing Sequence Homology. Avraham Raz, PninaCarmi, and Galit Pazerini.

t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

on July 20, 2021. © 1988 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 650 Synergistic Cytotoxic and Ant¡tumorEffects of Recombinant Human Tumor Necrosis Factor and Hyperthermia. Naoki Watanabe,Yoshiro Niitsu, Hiroshi Umeno, Hisao Soné,Hiroshi Neda,Naofumi Yamauchi, Masahiro Maeda, and Ichiro Urushizaki.

*654 Synergistic Effects of Recombinant Human Tumor Necrosis Factor and Hyperthermia on in Vitro Cytotoxicity and ArtificialMetastasis. Yoshiro Niitsu, Naoki Watanabe, Hiroshi Umeno,Hisao Soné,Hiroshi Neda, Naofumi Yamauchi, Masahiro Maeda,and Ichiro Urushizaki.

658 Phorbol Ester Induction of 8-Lipoxygenase in Inbred SENCAR(SSIN) but not C57BL/6J Mice Correlated with Hyperplasia,Edema, and Oxidant Generation but not Ornithine DecarboxylaseInduction. Susan M. Fischer, James K. Baldwin, Daniel W.Jasheway. Kelly E. Patrick, and Gregory S. Cameron.

* 665 Isolation and Characterization of Spontaneous Wheat Germ Ag-glutinin-resistant Human Melanoma Mutants Displaying Remarkably Different Metastatic Profiles in Nude Mice. MakotoIshikawa, James W. Dennis, Shan Man, and Robert S. Kerbel.

671 Denaturation and Renaturation of a /9-l,6;l,3-Glucan, Lentinan,Associated with Expression of T-Cell-mediated Responses.Yukiko Y. Maeda, Sumiyo T. Watanabe, Chie Chihara, andMakoto Rokutanda.

676 In Vivo 31P Nuclear Magnetic Resonance Spectroscopy of Sub

cutaneous 9L Gliosarcoma: Effects of Tumor Growth and Treatment with l,3-Bis(2-chloroethyl)-l-nitrosourea on Tumor Bioen-ergetics and Histology. R. Grant Steen, Rafael J. Tamargo, KathyA. McGovern, S. Sunder Rajan, Henry Brem, Janna P. Wehrle,and Jerry D. Glickson.

* 682 ei-6/i-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21-3p25 and Deleted in SmallCell Lung Carcinoma. Alexander Dobrovic, Benoit Houle,Abdelmajid Belouchi, and W. E. C. Bradley.

* 686 Surface Antigens of Human Melanoma Cells Cultured in Serum-free Medium: Induction of Expression of Major Histocompatibil-ity Complex Class II Antigens. Francisco X. Real, Bettina Fliegel,and Alan N. Houghton.

694 Pharmacokinetics of Tumor Cell Exposure to (uC]Methotrexate

after IntracarotidAdministration without and with HyperosmoticOpening of the Blood-Brain and Blood-Tumor Barriers in RatBrain Tumors: A Quantitative Autoradiographic Study. WilliamR. Shapiro, Rand M. Voorhies, Emile M. Hiesiger, Peter B. Sher,George A. Basler, and Lauren E. Lipschutz.

702 Cytogenetic Changes in Rat Trachea! Epithelial Cells duringEarlyStages of Carcinogen-induced Neoplastic Progression. MitsuoOshimura, D. James Fitzgerald, Hitoshi Kitamura, PaulNettesheim, and J. Carl Barrett.

709 Mechanisms of Induction of Ornithine Decarboxylase Activity inTrachea! Epithelial Cells by Asbestiform Minerals. Joanne P.Marsh and Brooke T. Mossman.

* 715 Optimization and Characterizationof the Capillary Human TumorClonogenic Cell Assay. Francis Ali-Osman and Patricia A. Beltz.

"'"725 Reduction of Doxorubicin Cytotoxicity by Ouabain: Correlation

with Topoisomerase-induced DNA Strand Breakage in Humanand Hamster Cells. Theodore S. Lawrence.

*731 Biological and Karyotypic Characterization of a New Cell LineDerived from Human Gliosarcoma. Manfred Westphal, MarianneHaensel, Dieter Mueller, Rudolf Laas, Regina Kunzmann, EvaRohde, Albrecht Koenig, Fritz Hoelzel, and Hans-DietrichHerrmann.

741 Progressive Growth of Fish Tumors after Transplantation intoThymus-aplastic (nu/nu) Mice. Manfred Schartl and Ralf U.Peter.

* 745 Spontaneous Sister ChromatidExchange in Normal Bone Marrow

and Ph-positive Chronic Myelocytic Leukemia. Reinhard Becher,Gabriele Zimmer, Gabriele Prescher, and Carl G. Schmidt.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

The Clinical and Epidemiológica!Investigations section contains afurther article presented at the Fifth Symposium on Epidemiologyand Cancer Registries in the Pacific Basin, November 16-21, 1986,Kauai, Hawaii.

751 Cancer in Migrants to Australia: Extending the Descriptive Epidemiológica!Data. Anthony J. McMichael and Graham G. Giles.

757 Announcements

758 Author Index

NOTE: Advance registration form for 79th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.

on July 20, 2021. © 1988 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 48 •NUMBER 3

CONTENTS Arranged by Subject Category

Perspectives in Cancer Research

493 Oncogenes of DNA Tumor Viruses. Arnold J. Levine.

BASIC SCIENCES

Biochemistry and Biophysics

507 De Novo Guarniate Synthesis in the Commitment to Replicationin Hepatoma 3924A Cells. Yutaka Natsumeda, Tadashi Ikegami.Kimie Murayama, and George Weber.

*527 Identification of an Anionic Form of Glutathione TransferasePresent in Many Human Tumors and Human Tumor Cell Lines.Thomas C. Shea, Susan L. Kelley. and William D. Henner.

539 Partial Reversal of Doxorubicin Resistance by Forskolin and 1,9-Dideoxyforskolin in Murine Sarcoma S180 Variants. Scott Wadlerand Peter H. Wiernik.

572 Marker Polypeptides Distinguishing between Cancer Cell Cloneswith High and Low Potential for Spontaneous Metastasis inMurine FibrosarcomaCells. IvarAmund Grimstad, Anne KarineThorsrud, and Egil Jellum.

602 Energy Substrate Utilization in Freshly Isolated Morris Hepatoma 7777 Cells. Julie A. Mares-Perlmanand Earl Shrago.

628 Proton Stoichiometry of Electron Transport in Rodent TumorMitoplasts. Jorge Ferreira. Baltazar Reynafarje, Lidia E. Costa,and Albert L. Lehninger.

641 Tumorigenicity of the eye'"Variant of the S49 Murine Lymphoma

Deficient in the G,-«Subunit of Adenylate Cyclase. Jeffrey M.Stadel, Randall K. Johnson, Christopher K. Mirabelli, David A.Powers, Chiù-MeiSung, Leo F. Faucette, Francis L. McCabe, andStanley T. Crooke.

Carcinogenesis

522 Decontamination and Disposal of Nitrosoureas and Related Y-Nitroso Compounds. George Lunn. Eric B. Sansone, A. W.Andrews, and Larry K. Keefer.

551 Lectin-binding Proteins in Nuclear Preparations from Rat Liverand Malignant Tumors. George R. Burrus. Warren N. Schmidt.Judith A. Briggs, Lubomir S. Hnilica, and Robert C. Briggs.

620 Enhancement of Chemical Carcinogenesis in Mice by SystemicEffects of Ultraviolet Irradiation. Helen L. Gensler.

65!. Phorbol Ester Induction of 8-Lipoxygenase in Inbred SENCAR(SSIN) but not C57BL/6J Mice Correlated with Hyperplasia,Edema, and Oxidant Generation but not Ornithine DecarboxylaseInduction. Susan M. Fischer, James K. Baldwin. Daniel W.Jasheway. Kelly E. Patrick, and Gregory S. Cameron.

709 Mechanisms of Induction of Ornithine Decarboxylase Activity inTrachea! Epithelial Cells by Asbestiform Minerals. Joanne P.Marsh and Brooke T. Mossman.

Immunology* 534 Effect of Lymphokine-activated Killer Cell Fraction on the De

velopment of Human Hematopoietic Progenitor Cells. YoshihiroFujimori, Hiroshi Hará,and Kiyoyasu Nagai.

#5-1-1 ImmunomodulatoryProperties of Recombinant Murine and Human Tumor Necrosis Factor. James E. Talmadge. HamblinPhillips, Mark Schneider. Tammy Rowe, Robin Pennington.Orville Bowersox, and Barbara Lenz.

•^624Antibody-mediated Killing of Human Tumor Cells by Attached

Effector Cells. Ingegerd Hellström,Ursula Garrigues, EfraimLavie, and Karl Erik Hellström.

*635 Alteration of Human Lymphokine-activated Killer Cell Activityby Manipulation of Protein Kinase C and Cytosolic (a"*. Carl W.

McCrady, Fei Li, Angus J. Grant, Randall E. Merchant, andRichard A. Carchman.

Molecular Biology and Genetics

556 Mechanism of H-ru.vOncogene Activation in Mouse SquamousCarcinoma Induced by an Alkylating Agent. Anne E. Hochwalt.Jerome J. Solomon, and Seymour J. Garte.

645 Expression of Two Different Endogenous Galactoside-bindingLectins Sharing Sequence Homology. Avraham Raz. PninaCarmi, and Galit Pazerini.

#682 rrA.f-related Sequence Coding for DNA-binding Hormone Receptor Localized to Chromosome 3p21-3p25 and Deleted in SmallCell Lung Carcinoma. Alexander Dobrovic. Benoit Houle,Abdelmajid Belouchi, and W. E. C. Bradley.

Preclinical Pharmacology and Experimental Therapeutics•*•503 Uptake and Intracellular Distribution of Doxorubicin Metabolites

in B-Lymphocytes of Chronic Lymphocytic Leukemia. EmmanuelN. Dessypris, Dean E. Brenner. Maria R. Baer. and Kenneth R.Hande.

512 Sister Chromatid Exchanges, Chromosomal Aberrations, and Cy-totoxicity Produced by Antitumor Topoisomerase II Inhibitors inSensitive (DC3F) and Resistant (DC3F/9-OHE) Chinese HamsterCells. Yves Pommier. Donna Kerrigan,Joseph M. Covey, Chien-Song Kao-Shan, and Jacqueline Whang-Peng.

*517 Bromodeoxyuridine Enhancement of 1-0-D-Arabinofuranosylcy-tosine Metabolic Activation and Toxicity in III -611LeukemicCells. Douglas D. Ross. ChristopherC. Joneckis, Tae Heun Song,and Richard K. Wu.

* 559 Therapeutic Efficacy of Antiglioma Mesenchymal ExtracellularMatrix '"I-Radiolabek'd Murine Monoclonal Antibody in a Human Glioma Xenograft Model. Yi-Sheng Lee. Dennis E. Bullard.Michael R. Zalutsky. R. Edward Coleman. Carol J. Wikstrand,Henry S. Friedman, Edward V. Colapinto, and Darei! D. Bigner.

* 567 Individualand Combined Tumoricidal Effects of Dexamethasoneand Interferons on Human Leukocyte Cell Lines. Luying Pan andPaul M. Guyre.

578 Selective Cytotoxicity of Phospholipids and Diacylglycerols to Rat3Y1 Fibroblasts Transformed by Adenovirus Type 12 or Its EIAGene. Hideo Shimura, Masumi Ohtsu, Akinobu Matsuzaki,Tetsuya Mitsudomi, Kazukiyo Onodera, and Genki Kimura.

* 584 Augmented Antitumor Effect of RecombinantHuman Interleukin-la by Indomethacin. Katsuhisa Nakata, Shigeki Kashimoto,Hiroaki Yoshida, Tohru Oku, and Shinichi Nakamura.

1Indicates studies using human-derived material.

on July 20, 2021. © 1988 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

* 589 Feasibility of Drug Screening with Panels of Human Tumor CellLines Using a Microculture Tetrazolium Assay. Michael C. Alley,Dominic A. Scudiere, Anne Monks, Miriam L. Hursey, Maciej J.Czerwinski, Donald L. Fine, Betty J. Abbott, Joseph G. Mayo,Robert H. Shoemaker, and Michael R. Boyd.

615 Effect of Biconi) ein on Murine Tumor Cells at Elevated Temperatures and Two Different pH Values. Muneyasu Urano, JuliaKahn, and Lydia A. Kenton.

* 650 Synergistk- Cytotoxic and Antitumor Effects of Recombinant Hu

man Tumor Necrosis Factor and Hyperthermia. Naoki Watanabe,Yoshiro Niitsu, Hiroshi Umeno, Hisao Soné,Hiroshi Neda,Naofumi Yamauchi, Masahiro Maeda, and Ichiro Urushizaki.

Synergistic Effects of Kecombinant Human Tumor Necrosis Factor and Hyperthermia on in Vitro Cytotoxicity and ArtificialMetastasis. Yoshiro Niitsu, Naoki Watanabe, Hiroshi Umeno,Hisao Soné,Hiroshi Neda, Naofumi Yamauchi, Masahiro Maeda,and Ichiro Urushizaki.

671 Denaturali"!) and Renaturation of a /ff-l,6;l,3-Glucan, Lentinan,Associated with Expression of T-Cell-mediated Responses.

Yukiko Y. Maeda, Sumiyo T. Watanabe, Chie Chihara, andMakoto Rokutanda.

694 Pharmacokinetics of Tumor Cell Exposure to [uC|Methotrexate

after IntracarotidAdministration without and with HyperosmoticOpening of the Blood-Brain and Blood-Tumor Barriers in RatBrain Tumors: A Quantitative Autoradiographic Study. WilliamR. Shapiro, Rand M. Voorhies, Emile M. Hiesiger, Peter B. Sher,George A. Basler, and Lauren E. Lipschutz.

*725 Reduction of Doxorubicin Cytotoxicity by Ouabain: Correlationwith Topoisomerase-induced DNA Strand Breakage in Humanand Hamster Cells. Theodore S. Lawrence.

Tumor Biology

497 Effects of Acute pH 6.6 and 42.IIT Heating on the IntracellularpH of Chinese Hamster Ovary Cells. John A. Cook and MichaelH. Fox.

609 Testosterone-mediated Increase in 5a-Dihydrotestosterone Content, Nuclear Androgen Receptor Levels, and Cell Division in anAndrogen-independentProstate Carcinoma of Noble Rats. Shuk-Mei Ho, Irwin Leav, David Damassa, Paul W. L. Kwan, FrederickB. Merk, and Henry S. K. Seto.

*(>65 Isolation and Characterization of Spontaneous Wheat Germ Ag-glutinin-resistant Human Melanoma Mutants Displaying Remarkably Different Metastatic Profiles in Nude Mice. MakotoIshikawa, James W. Dennis, Shan Man, and Robert S. Kerbel.

676 In Vivo "P Nuclear Magnetic Resonance Spectroscopy of Sub

cutaneous 9L Gliosarcoma: Effects of Tumor Growth and Treatment with l,3-Bis(2-chloroethyl)-l-nitrosourea <>nTumor Bioen-ergetics and Histology. R. Grant Steen, Rafael J. Tamargo, KathyA. McGovern, S. Sunder Rajan, Henry Brem, Janna P. Wehrle,and Jerry D. Glickson.

* 686 Surface Antigens of Human Melanoma Cells Culturedin Serum-free Medium: Inductionof Expression of Major Histocompatibil-ity Complex Class II Antigens. Francisco X. Real, Bettina Fliegel,and Alan N. Houghton.

702 Cytogenetic Changes in Rat Trachea! Epithelial Cells duringEarlyStages of Carcinogen-induced Neoplastic Progression. MitsuoOshimura, D. James Fitzgerald, Hitoshi Kitamura, PaulNettesheim, and J. Carl Barrett.

* 715 Optimization and Characterizationof the Capillary Human TumorClonogenicCell Assay. Francis Ali-Osmanand Patricia A. Beltz.

Biological and Karyotypic Characterization of a New Cell LineDerived from Human Gliosarcoma. Manfred Westphal, MarianneHaensel, Dieter Mueller, Rudolf Laas, Regina Kunzmann, EvaRohde, Albrecht Koenig, Fritz Hoelzel, and Hans-DietrichHerrmann.

741 Progressive Growth of Fish Tumors after Transplantation intoThymus-aplastic (nu/nu) Mice. Manfred Schartl and Ralf U.Peter.

* 745 Spontaneous Sister ChromatidExchange in Normal Bone Marrowand Ph-positive Chronic Myelocytic Leukemia. Reinhard Becher,Gabriele Zimmer, Gabriele Prescher, and Carl G. Schmidt.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

The Clinical and Epidemiológica!Investigations section contains afurther article presented at the Fifth Symposium on Epidemiologyand Cancer Registries in the Pacific Basin, November 16-21, 1986,Kauai, Hawaii.

751 Cancer in Migrants to Australia: Extending the Descriptive Epidemiológica!Data. Anthony J. McMichael and Graham G. Giles.

757 Announcements

758 Author Index

NOTE: Advance registration form for 79th Annual Meeting of the American Association for Cancer Research available in the back ofthis issue.

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