cancer principles & practice of oncology
TRANSCRIPT
Cancer Principles & Practice of OncologyCancer: Principles and Practice of Oncology 6th edition (July 2001): by Vincent T. Devita (Editor), Samuel Hellman, Steven A. Rosenberg (Editor) By Lippincott Williams & Wilkins Publishers
DeVita - Cancer: Principles and Practice of Oncology
CONTENTS
Editors
Dedication
PART 1
ESSENTIALS OF MODERN ONCOLOGIC SCIENCE
Chapter 1 Essentials of Molecular Biology: Basic Principles LANCE A. LIOTTA EDISON T. LIU
Chapter 2 Essentials of Molecular Biology: Genomics and Cancer LANCE A. LIOTTA EDISON T. LIU
Chapter 3 Essentials of Signal Transduction CHRISTOPHER L. CARPENTER LEWIS C. CANTLEY
Chapter 4 Essentials of Immunology NICHOLAS P. RESTIFO JOHN R. WUNDERLICH
PART 2
PRINCIPLES OF ONCOLOGY
Chapter 5 Molecular Biology of Cancer: Cytogenetics MAZIN B. QUMSIYEH PEINING LI
Chapter 6 Molecular Biology of Cancer: The Cell Cycle MICHAEL B. KASTAN STEPHEN X. SKAPEK
Chapter 7 Molecular Biology of Cancer: Apoptosis STANLEY J. KORSMEYER SANDRA S. ZINKEL
Chapter 8 Molecular Biology of Cancer: Invasion and Metastases WILLIAM G. STETLER-STEVENSON DAVID E. KLEINER, JR.
Chapter 9 Biology of Cancer: Angiogenesis ISAIAH J. FIDLER ROBERT S. KERBEL LEE M. ELLIS
Chapter 10 Etiology of Cancer: Viruses
Section 10.1 RNA Viruses ERIC M. POESCHLA GARY L. BUCHSCHACHER, JR. FLOSSIE WONG-STAAL
Section 10.2 DNA Viruses PETER M. HOWLEY DON GANEM ELLIOTT KIEFF
Chapter 11 Etiology of Cancer: Chemical Factors STUART H. YUSPA PETER G. SHIELDS
Chapter 12 Etiology of Cancer: Physical Factors ROBERT L. ULLRICH
Chapter 13 Etiology of Cancer: Cancer Genetics ALLEN E. BALE SUZANNE J. BROWN
Chapter 14 Epidemiology of Cancer
Section 14.1 Epidemiologic Methods MARGARET A. TUCKER
Section 14.2 Descriptive Epidemiology: Cancer Statistics PHILIP COLE BRAD RODU
Section 14.3 Analytic Epidemiology: Cancer Causes PHILIP COLE BRAD RODU
Chapter 15 Principles of Cancer Management: Surgical Oncology STEVEN A. ROSENBERG
Chapter 16 Principles of Cancer Management: Radiation Therapy SAMUEL HELLMAN
Chapter 17 Principles of Cancer Management: Chemotherapy EDWARD CHU VINCENT T. DEVITA, JR.
Chapter 18 Principles of Cancer Management: Biologic Therapy STEVEN A. ROSENBERG
Chapter 19 Pharmacology of Cancer Chemotherapy
Section 19.1 Pharmacokinetics and Pharmacodynamics MARK J. RATAIN
Section 19.2 Cancer Drug Development
Section 19.2.1 Cancer Drug Development: Identification and Screening of New Agents EDWARD CHU MICHAEL R. GREVER BRUCE A. CHABNER
Section 19.2.2 Cancer Drug Development: Combinatorial Chemistry DAVID J. AUSTIN
Section 19.3 Antitumor Alkylating Agents OLIVER MICHAEL COLVIN
Section 19.4 Cisplatin and Its Analogues STEVEN W. JOHNSON JAMES P. STEVENSON PETER J. O'DWYER
Section 19.5 Antimetabolites EDWARD CHU AUGUSTO C. MOTA MIKLOS C. FOGARASI
Section 19.6 Topoisomerase Interactive Agents CLINTON F. STEWART MARK J. RATAIN
Section 19.7 Antimicrotubule Agents ERIC K. ROWINSKY ANTHONY W. TOLCHER
Section 19.8 Miscellaneous Chemotherapeutic Agents BRUCE D. CHESON
Chapter 20 Pharmacology of Cancer Biotherapeutics
Section 20.1 Interferons JOHN M. KIRKWOOD
Section 20.2 Interleukin-2 JAMES W. MIER MICHAEL B. ATKINS
Section 20.3 Hormonal Therapies CHARLES ERLICHMAN CHARLES L. LOPRINZI
Section 20.4 Differentiation Agents RAYMOND P. WARRELL, JR.
Section 20.5 Therapeutic Monoclonal Antibodies: General Principles LOUIS M. WEINER GREGORY P. ADAMS MARGARET VON MEHREN
Section 20.6 Antiangiogenesis Agents JUDAH FOLKMAN
Chapter 21 Clinical Trials in Cancer
Section 21.1 Design and Analysis of Clinical Trials
RICHARD SIMON
Section 21.2 Research Data Management DOUGLAS HAGEMAN DIANNE M. REEVES
PART 3
Chapter 22 Cancer Prevention: Preventing Tobacco-Related Cancers HOWARD K. KOH CHRISTINE KANNLER ALAN C. GELLER
Chapter 23 Cancer Prevention: Diet and Chemopreventive Agents
Section 23.1 Fat WALTER C. WILLETT
Section 23.2 Dietary Fibers PETER GREENWALD
Section 23.3 Retinoids, Carotenoids, and Micronutrients SUSAN TAYLOR MAYNE SCOTT M. LIPPMAN
Section 23.4 Naturally Occurring Dietary Anticarcinogens PETER GREENWALD
Section 23.5 Dietary Carcinogens PETER GREENWALD
Section 23.6 Aspirin and Other Nonsteroidal Antiinflammatory Drugs and the Risk of Cancer Development MICHAEL J. THUN CHARLES H. HENNEKENS
Section 23.7 Physical Activity and Body Weight GRAHAM A. COLDITZ
Chapter 24 Cancer Prevention: Role of Surgery in Cancer Prevention RICHARD M. SHERRY
Chapter 25 Cancer Screening BARBARA K. RIMER JOELLEN SCHILDKRAUT ROBERT A. HIATT
Chapter 26 Cancer Diagnosis: Molecular Pathology JOSÉ COSTA CARLOS CORDON-CARDO
Chapter 27 Cancer Diagnosis: Imaging
Section 27.1 Computed Tomography ELLIOT K. FISHMAN BRUCE A. URBAN
Section 27.2 Magnetic Resonance Imaging ARTHUR E. LI DAVID A. BLUEMKE
Section 27.3 Functional and Metabolic Imaging MARTIN G. POMPER
Section 27.4 Interventional Radiology JEAN-FRANCOIS H. GESCHWIND
Section 27.5 Ultrasound ULRIKE M. HAMPER
Section 27.6 Radionuclide Imaging E. EDMUND KIM
Chapter 28 Cancer Diagnosis: Endoscopy ROBERT C. KURTZ ROBERT J. GINSBERG
Chapter 29 Specialized Techniques in Cancer Management
Section 29.1 Laparoscopy ALAN T. LEFOR
Section 29.2 Vascular Access and Specialized Techniques of Drug Delivery STEVEN K. LIBUTTI MCDONALD K. HORNE III
Section 29.3 Isolation Perfusion H. RICHARD ALEXANDER
Section 29.4 Intensity-Modulated Radiation Therapy C. CLIFTON LING CHEN CHUI THOMAS LOSASSO CHANDRA BURMAN
MARGIE HUNT GIGAS MAGERAS HOWARD IRA AMOLS MICHAEL J. ZELEFSKY ZVI Y. FUKS STEVEN A. LEIBEL
Chapter 30 Cancer of the Head and Neck
Section 30.1 Molecular Biology of Head and Neck Tumors DAVID SIDRANSKY
Section 30.2 Tumors of the Nasal Cavity and Paranasal Sinuses, Nasopharynx, Oral Cavity, and Oropharynx STIMSON P. SCHANTZ LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.3 Tumors of the Larynx and Hypopharynx ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.4 Tumors of the Salivary Glands and Paragangliomas ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.5 Rehabilitation after Treatment for Head and Neck Cancer SUSAN D. MILLER ROY B. SESSIONS
Chapter 31 Cancer of the Lung
Section 31.1 Molecular Biology of Lung Cancer YOSHITAKA SEKIDO KWUN M. FONG JOHN D. MINNA
Section 31.2 Non–Small Cell Lung Cancer ROBERT J. GINSBERG EVERETT E. VOKES KENNETH ROSENZWEIG
Section 31.3 Small Cell Lung Cancer JOHN MURREN ELI GLATSTEIN HARVEY I. PASS
Chapter 32 Neoplasms of the Mediastinum ROBERT B. CAMERON PATRICK J. LOEHRER CHARLES R. THOMAS, JR.
Chapter 33 Cancers of the Gastrointestinal Tract
Section 33.1 Molecular Biology of Gastrointestinal Cancers ERIC R. FEARON
Section 33.2 Cancer of the Esophagus DAVID S. SCHRUMP NASSER K. ALTORKI ARLENE A. FORASTIERE BRUCE D. MINSKY
Section 33.3 Cancer of the Stomach MARTIN S. KARPEH DAVID P. KELSEN JOEL E. TEPPER
Section 33.4 Cancer of the Pancreas DOUGLAS B. EVANS JAMES L. ABBRUZZESE CHRISTOPHER G. WILLETT
Section 33.5 Cancer of the Liver and Biliary Tree YUMAN FONG NANCY KEMENY THEODORE S. LAWRENCE
Section 33.6 Cancer of the Small Intestine DANIEL G. COIT
Section 33.7 Cancer of the Colon JOHN M. SKIBBER BRUCE D. MINSKY PAULO M. HOFF
Section 33.8 Cancer of the Rectum JOHN M. SKIBBER PAULO M. HOFF BRUCE D. MINSKY
Section 33.9 Cancer of the Anal Region BRUCE D. MINSKY JOHN P. HOFFMAN DAVID P. KELSEN
Chapter 34 Cancers of the Genitourinary System
Section 34.1 Molecular Biology of Genitourinary Cancers W. MARSTON LINEHAN BERTON ZBAR FREDRICK LEACH CARLOS CORDON-CARDO WILLIAM ISAACS
Section 34.2 Cancer of the Kidney and Ureter W. MARSTON LINEHAN BERTON ZBAR SUSAN E. BATES MICHAEL J. ZELEFSKY JAMES C. YANG
Section 34.3 Cancer of the Bladder HARRY W. HERR WILLIAM U. SHIPLEY DEAN F. BAJORIN
Section 34.4 Cancer of the Prostate PETER R. CARROLL KEITH L. LEE ZVI Y. FUKS PHILIP W. KANTOFF
Section 34.5 Cancer of the Urethra and Penis HARRY W. HERR GUIDO DALBAGNI DEAN F. BAJORIN WILLIAM U. SHIPLEY
Chapter 35 Cancer of the Testis GEORGE J. BOSL DEAN F. BAJORIN JOEL SHEINFELD ROBERT J. MOTZER R. S. K. CHAGANTI
Chapter 36 Gynecologic Cancers
Section 36.1 Molecular Biology of Gynecologic Cancers SETSUKO KUKI CHAMBERS
Section 36.2 Cancer of the Cervix, Vagina, and Vulva PATRICIA J. EIFEL JONATHAN S. BEREK JAMES T. THIGPEN
Section 36.3 Cancers of the Uterine Body THOMAS W. BURKE PATRICIA J. EIFEL FRANCO M. MUGGIA
Section 36.4 Gestational Trophoblastic Diseases FRANCO M. MUGGIA PATRICIA J. EIFEL THOMAS W. BURKE
Section 36.5 Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma ROBERT F. OZOLS PETER E. SCHWARTZ PATRICIA J. EIFEL
Chapter 37 Cancer of the Breast
Section 37.1 Molecular Biology of Breast Cancer ROBERT B. DICKSON MARC E. LIPPMAN
Section 37.2 Malignant Tumors of the Breast ERIC P. WINER MONICA MORROW C. KENT OSBORNE JAY R. HARRIS
Section 37.3 Rehabilitation after Treatment for Cancer of the Breast JOSEPH J. DISA JEANNE A. PETREK
Chapter 38 Cancer of the Endocrine System
Section 38.1 Molecular Biology of Endocrine Tumors TERRY C. LAIRMORE SAMUEL A. WELLS, JR. JEFFREY F. MOLEY
Section 38.2 Thyroid Tumors DOUGLAS L. FRAKER MONICA SKARULIS VIRGINIA LIVOLSI
Section 38.3 Parathyroid Tumors DOUGLAS L. FRAKER
Section 38.4 Adrenal Tumors
JEFFREY A. NORTON HOP N. LE
Section 38.5 Pancreatic Endocrine Tumors H. RICHARD ALEXANDER ROBERT T. JENSEN
Section 38.6 Carcinoid Tumors and the Carcinoid Syndrome ROBERT T. JENSEN GERARD M. DOHERTY
Section 38.7 Multiple Endocrine Neoplasias GERARD M. DOHERTY ROBERT T. JENSEN
Chapter 39 Sarcomas of the Soft Tissue and Bone
Section 39.1 Soft Tissue Sarcoma MURRAY F. BRENNAN KALED M. ALEKTIAR ROBERT G. MAKI
Section 39.2 Sarcomas of Bone MARTIN M. MALAWER MICHAEL P. LINK SARAH S. DONALDSON
Chapter 40 Benign and Malignant Mesothelioma
Section 40.1 Molecular Biology of Mesothelioma JOSEPH R. TESTA HARVEY I. PASS MICHELE CARBONE
Section 40.2 Management of Mesothelioma KAREN H. ANTMAN HARVEY I. PASS PETER B. SCHIFF
Chapter 41 Cancer of the Skin
Section 41.1 Molecular Biology of Skin Cancer DOUGLAS E. BRASH ALLEN E. BALE
Section 41.2 Management of Skin Cancer DAVID J. LEFFELL JOHN A. CARUCCI
Section 41.3 Skin Cancer Atlas DAVID J. LEFFELL
Chapter 42 Melanoma
Section 42.1 Molecular Biology of Cutaneous Melanoma MEENHARD HERLYN KAPAETTU SATYAMOORTHY
Section 42.2 Cutaneous Melanoma MICHAEL T. LOTZE RAMSEY M. DALLAL JOHN M. KIRKWOOD JOHN C. FLICKINGER
Section 42.3 Intraocular Melanoma JOSÉ A. SAHEL ARTHUR S. POLANS MINESH P. MEHTA RICHARD M. AUCHTER DANIEL M. ALBERT
Chapter 43 Neoplasms of the Central Nervous System
Section 43.1 Molecular Biology of Central Nervous System Neoplasms DAVID N. LOUIS WEBSTER K. CAVENEE
Section 43.2 Neoplasms of the Central Nervous System VICTOR A. LEVIN STEVEN A. LEIBEL PHILIP H. GUTIN
Chapter 44 Cancers of Childhood
Section 44.1 Molecular Biology of Childhood Cancers LEE J. HELMAN DAVID MALKIN
Section 44.2 Solid Tumors of Childhood DAVID H. EBB DANIEL M. GREEN ROBERT C. SHAMBERGER
NANCY J. TARBELL
Chapter 45 Lymphomas
Section 45.1 Molecular Biology of Lymphomas RICCARDO DALLA-FAVERA GIANLUCA GAIDANO
Section 45.2 Leukemias and Lymphomas of Childhood HOWARD J. WEINSTEIN NANCY J. TARBELL
Section 45.3 Non-Hodgkin’s Lymphomas JAMES O. ARMITAGE PETER M. MAUCH NANCY LEE HARRIS PHILIP BIERMAN
Section 45.4 Cutaneous T-Cell Lymphomas LYNN D. WILSON GLENN W. JONES BARRY M. KACINSKI RICHARD L. EDELSON PETER W. HEALD
Section 45.5 Primary Central Nervous System Lymphoma LISA M. DEANGELIS JOACHIM YAHALOM
Section 45.6 Hodgkin’s Disease VOLKER DIEHL PETER M. MAUCH NANCY LEE HARRIS
Chapter 46 Leukemias
Section 46.1 Molecular Biology of Leukemias CLARA D. BLOOMFIELD MICHAEL A. CALIGIURI
Section 46.2 Acute Leukemias DAVID A. SCHEINBERG PETER MASLAK MARK WEISS
Section 46.3 Chronic Leukemias
Section 46.3.2 Chronic Leukemias: The Chronic Lymphocytic Leukemias BRUCE D. CHESON
Section 46.4 Plasma Cell Neoplasms NIKHIL C. MUNSHI GUIDO TRICOT BART BARLOGIE
Section 46.5 Myelodysplastic Syndromes HAGOP M. KANTARJIAN ELIHU ESTEY
Chapter 47 Paraneoplastic Syndromes SUSANNE M. ARNOLD ROY PATCHELL ANDREW M. LOWY KENNETH A. FOON
Chapter 48 Cancer of Unknown Primary Site FRANK A. GRECO JOHN D. HAINSWORTH
Chapter 49 Peritoneal Carcinomatosis DAVID L. BARTLETT
Chapter 50 Immunosuppression-Related Malignancies
Section 50.2 Transplantation-Related Malignancies STANLEY R. RIDDELL
Chapter 51 Oncologic Emergencies
Section 51.1 Superior Vena Cava Syndrome JOACHIM YAHALOM
Section 51.2 Spinal Cord Compression BRIAN G. FULLER JOHN D. HEISS EDWARD H. OLDFIELD
Section 51.3 Metabolic Emergencies RAYMOND P. WARRELL, JR.
Section 51.4 Urologic Emergencies McCLELLAN M. WALTHER
Chapter 52 Treatment of Metastatic Cancer
Section 52.1 Metastatic Brain Cancer PATRICK Y. WEN PETER MCLAREN BLACK JAY S. LOEFFLER
Section 52.2 Metastatic Cancer to the Lung JOE B. PUTNAM, JR.
Section 52.3 Metastatic Cancer to the Liver H. RICHARD ALEXANDER CARMEN J. ALLEGRA THEODORE S. LAWRENCE
Section 52.4 Metastatic Cancer to the Bone HOLLY K. BROWN JOHN H. HEALEY
Section 52.5 Malignant Pleural and Pericardial Effusions DAO M. NGUYEN DAVID S. SCHRUMP
Section 52.6 Malignant Ascites FRANCESCO M. MARINCOLA DOUGLAS J. SCHWARTZENTRUBER
Chapter 53 Hematopoietic Therapy
Section 53.1 Transfusion Therapy PETER L. PERROTTA EDWARD L. SNYDER
Section 53.2 Autologous Stem Cell Transplantation DENNIS L. COOPER STUART SEROPIAN
Section 53.3 Allogeneic Stem Cell Transplantation RICHARD W. CHILDS
Section 53.4 Hematopoietic Growth Factors JAMES D. GRIFFIN
Chapter 54 Infections in the Cancer Patient BRAHM H. SEGAL THOMAS J. WALSH STEVEN M. HOLLAND
Chapter 55 Adverse Effects of Treatment
Section 55.1 Nausea and Vomiting ANN M. BERGER REBECCA A. CLARK-SNOW
Section 55.2 Oral Complications ANN M. BERGER THOMAS J. KILROY
Section 55.3 Pulmonary Toxicity DIANE E. STOVER ROBERT J. KANER
Section 55.4 Cardiac Toxicity LAUREL J. STEINHERZ JOACHIM YAHALOM
Section 55.5 Hair Loss CLAUDIA A. SEIPP
Section 55.6 Gonadal Dysfunction MARVIN L. MEISTRICH RENA VASSILOPOULOU-SELLIN LARRY I. LIPSHULTZ
Section 55.7 Second Cancers FLORA E. VAN LEEUWEN LOIS B. TRAVIS
Section 55.8 Miscellaneous Toxicities RAYMOND B. WEISS
Chapter 56 Supportive Care and Quality of Life
Section 56.1 Management of Cancer Pain KATHLEEN M. FOLEY
Section 56.2 Nutritional Support J. STANLEY SMITH WILEY W. SOUBA
Section 56.3 Sexual Problems PATRICIA A. GANZ MARK S. LITWIN BETH E. MEYEROWITZ
Section 56.4 Genetic Counseling ELLEN T. MATLOFF ALLEN E. BALE
Section 56.5 Psychological Issues MARY JANE MASSIE LISA CHERTKOV ANDREW J. ROTH
Section 56.6 Community Resources BONNIE A. INDECK PHYLLIS M. SMITH
Section 56.7 Specialized Care of the Terminally Ill FREDERICK A. FLATOW SCOTT LONG
Chapter 57 Rehabilitation of the Cancer Patient LYNN GERBER JEANNE HICKS JAY SHAH
Chapter 58 Advanced Practice Nurses and Physician Assistants in Oncology Care M. TISH KNOBF SUSAN ANDERSON
Chapter 59 Ethical Issues in Oncology and Clinical Trials CHRISTOPHER DAUGHERTY MARK SIEGLER
Chapter 60 Information Systems in Oncology SUSAN MOLLOY HUBBARD
Chapter 61 Complementary, Alternative, and Unproven Methods of Cancer Treatment JEFFREY D. WHITE
PART 4
Chapter 62 Genetic Therapy
Section 62.1 Gene Therapy PATRICK HWU
Section 62.2 Molecular Therapy ALBERT B. DEISSEROTH AMANDA PSYRRI DAVID J. AUSTIN
Chapter 63 Cancer Vaccines
Section 63.1 Preventive Cancer Vaccines DOUGLAS R. LOWY JOHN T. SCHILLER
Section 63.2 Therapeutic Cancer Vaccines NICHOLAS P. RESTIFO MARIO SZNOL WILLEM W. OVERWIJK
Chapter 64 Image-Guided Surgery NICK BRYAN STEVEN K. LIBUTTI
Chapter 65 Proton Beam Radiation Therapy IRA J. SPIRO ALFRED R. SMITH ANTHONY LOMAX JAY S. LOEFFLER
CONTRIBUTING AUTHORS
Annie Laurie Howard Research Distinguished Professor Department of Gastrointestinal Medical Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas
Gregory P. Adams, PhD
Assistant Member Department of Medical Oncology Fox Chase Cancer Center Philadelphia, Pennsylvania
Daniel M. Albert, MD, MS
F. A. Davis Professor and Chair; Lorenz E. Zimmerman Professor Department of Ophthalmology and Visual Sciences University of Wisconsin Center for Health Sciences Madison, Wisconsin
Kaled M. Alektiar, MD
H. Richard Alexander, MD
Carmen J. Allegra, MD
Chief, Medicine Branch National Cancer Institute, National Institutes of Health Bethesda, Maryland
Nasser K. Altorki, BCh, MB
Professor of Cardiothoracic Surgery Weill Medical College of Cornell University New York, New York
Howard Ira Amols, PhD
Professor of Physics in Radiology Weill Medical College of Cornell University Memorial Sloan-Kettering Cancer Center New York, New York
Susan Anderson, BSN, MFA
Director, Clinical Trials Office Yale Cancer Center Yale University School of Medicine New Haven, Connecticut
Karen H. Antman, MD
Wu Professor of Medicine and Pharmacology Herbert Irving Comprehensive Cancer Center Columbia University College of Physicians and Surgeons New York, New York
James O. Armitage, MD
Professor of Medicine Dean of the College of Medicine University of Nebraska Medical Center Omaha, Nebraska
Susanne M. Arnold, MD
Assistant Professor of Medicine Department of Hematology and Oncology Lucille P. Markey Cancer Center University of Kentucky Chandler Medical Center Lexington, Kentucky
Michael B. Atkins, MD
Richard M. Auchter, MD
Clinical Assistant Professor of Human Oncology University of Wisconsin Medical School Madison, Wisconsin
David J. Austin, PhD
Assistant Professor of Chemistry Yale University School of Medicine New Haven, Connecticut
Dean F. Bajorin, MD
Professor of Medicine Weill Medical College of Cornell University Attending Physician Memorial Sloan-Kettering Cancer Center New York, New York
Allen E. Bale, MD
Associate Professor of Genetics Yale University School of Medicine New Haven, Connecticut
Bart Barlogie, MD, PhD
Professor of Medicine and Pathology Director, Arkansas Cancer Research Center University of Arkansas for Medical Sciences Little Rock, Arkansas
David L. Bartlett, MD
Susan E. Bates, MD
Jonathan S. Berek, MD
Professor and Chair of Applied Anatomy Vice Chair and Chief, Division of Gynecologic Oncology University of California, Los Angeles, UCLA School of Medicine Los Angeles, California
Ann M. Berger, RN, MSN, MD
Chief of Pain and Palliative Care Service National Institutes of Health Bethesda, Maryland
Philip Bierman, MD
Associate Professor of Medicine Department of Internal Medicine Section of Oncology/Hematology University of Nebraska Medical Center Omaha, Nebraska
Peter McLaren Black, MD, PhD
Franc D. Ingraham Professor of Neurosurgery Harvard Medical School Brigham and Women’s Hospital Children’s Hospital Boston, Massachusetts
Clara D. Bloomfield, MD
Professor of Medicine Ohio State University College of Medicine and Public Health Department of Internal Medicine Division of Hematology/Oncology The Comprehensive Cancer Center Columbus, Ohio
David A. Bluemke, MD, PhD, MSB
Associate Professor of Radiology Johns Hopkins University School of Medicine Baltimore, Maryland
George J. Bosl, MD
Chair, Department of Medicine Memorial Sloan-Kettering Cancer Center New York, New York
Douglas E. Brash, PhD
Professor of Therapeutic Radiology and Genetics Yale University School of Medicine New Haven, Connecticut
Murray F. Brennan, MD
Chair, Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York
Holly K. Brown, MD
Suzanne J. Brown, MD
Fellow in Oncology Yale Comprehensive Cancer Center Yale University School of Medicine New Haven, Connecticut
Nick Bryan, MD, PhD
Gary L. Buchschacher, Jr., MD, PhD
Department of Medicine Division of Hematology/Oncology University of California, San Diego, School of Medicine La Jolla, California
Thomas W. Burke, MD
Professor of Gynecologic Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas
Chandra Burman, PhD
Michael A. Caligiuri, MD
Professor of Medicine Ohio State University College of Medicine and Public Health Arthur James Cancer Hospital and Research Institute Columbus, Ohio
Robert B. Cameron, MD
Assistant Professor of Surgery University of California, Los Angeles, UCLA School of Medicine Los Angeles, California
Lewis C. Cantley, PhD
Professor of Cell Biology Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts
Michele Carbone, MD, PhD
Christopher L. Carpenter, MD, PhD
Assistant Professor of Medicine Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts
Peter R. Carroll, MD
Professor and Chair, Department of Urology University of California, San Francisco, School of Medicine San Francisco, California
John A. Carucci, MD, PhD
Clinical Instructor of Dermatology Yale University School of Medicine New Haven, Connecticut
Webster K. Cavenee, PhD
Professor of Medicine University of California, San Diego, School of Medicine Director, Ludwig Institute for Cancer Research Center for Molecular Genetics; University of California Laboratory of Tumor Biology La Jolla, California
Bruce A. Chabner, MD
R. S. K. Chaganti, PhD
Member and William E. Snee Chair Human Genetics Memorial Sloan-Kettering Cancer Center New York, New York
Setsuko Kuki Chambers, MD
Professor of Obstetrics and Gynecology Division of Gynecologic Oncology Yale University School of Medicine New Haven, Connecticut
Lisa Chertkov, MD
Bruce D. Cheson, MD
Clinical Professor of Medicine Georgetown University School of Medicine Vincent T. Lombardi Cancer Research Center Washington, DC Head, Medicine Section Cancer Therapy Evaluation Program National Cancer Institute, National Institutes of Health Bethesda, Maryland
Richard W. Childs, MD
Senior Investigator Hematology Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland
Edward Chu, MD
Chen Chui, PhD
Rebecca A. Clark-Snow, RN, BSN, OCN
Director of Clinical Services Oncology and Hematology Associates of Kansas City Kansas City, Missouri
Daniel G. Coit, MD
Chief of Gastric and Mixed Tumor Service Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York
Graham A. Colditz, MD, DrPH
Professor of Medicine Harvard Medical School Brigham and Women’s Hospital Boston, Massachusetts
Philip Cole, MD, PhD
Professor Emeritus Department of Epidemiology University of Alabama School of Medicine Birmingham,…
DeVita - Cancer: Principles and Practice of Oncology
CONTENTS
Editors
Dedication
PART 1
ESSENTIALS OF MODERN ONCOLOGIC SCIENCE
Chapter 1 Essentials of Molecular Biology: Basic Principles LANCE A. LIOTTA EDISON T. LIU
Chapter 2 Essentials of Molecular Biology: Genomics and Cancer LANCE A. LIOTTA EDISON T. LIU
Chapter 3 Essentials of Signal Transduction CHRISTOPHER L. CARPENTER LEWIS C. CANTLEY
Chapter 4 Essentials of Immunology NICHOLAS P. RESTIFO JOHN R. WUNDERLICH
PART 2
PRINCIPLES OF ONCOLOGY
Chapter 5 Molecular Biology of Cancer: Cytogenetics MAZIN B. QUMSIYEH PEINING LI
Chapter 6 Molecular Biology of Cancer: The Cell Cycle MICHAEL B. KASTAN STEPHEN X. SKAPEK
Chapter 7 Molecular Biology of Cancer: Apoptosis STANLEY J. KORSMEYER SANDRA S. ZINKEL
Chapter 8 Molecular Biology of Cancer: Invasion and Metastases WILLIAM G. STETLER-STEVENSON DAVID E. KLEINER, JR.
Chapter 9 Biology of Cancer: Angiogenesis ISAIAH J. FIDLER ROBERT S. KERBEL LEE M. ELLIS
Chapter 10 Etiology of Cancer: Viruses
Section 10.1 RNA Viruses ERIC M. POESCHLA GARY L. BUCHSCHACHER, JR. FLOSSIE WONG-STAAL
Section 10.2 DNA Viruses PETER M. HOWLEY DON GANEM ELLIOTT KIEFF
Chapter 11 Etiology of Cancer: Chemical Factors STUART H. YUSPA PETER G. SHIELDS
Chapter 12 Etiology of Cancer: Physical Factors ROBERT L. ULLRICH
Chapter 13 Etiology of Cancer: Cancer Genetics ALLEN E. BALE SUZANNE J. BROWN
Chapter 14 Epidemiology of Cancer
Section 14.1 Epidemiologic Methods MARGARET A. TUCKER
Section 14.2 Descriptive Epidemiology: Cancer Statistics PHILIP COLE BRAD RODU
Section 14.3 Analytic Epidemiology: Cancer Causes PHILIP COLE BRAD RODU
Chapter 15 Principles of Cancer Management: Surgical Oncology STEVEN A. ROSENBERG
Chapter 16 Principles of Cancer Management: Radiation Therapy SAMUEL HELLMAN
Chapter 17 Principles of Cancer Management: Chemotherapy EDWARD CHU VINCENT T. DEVITA, JR.
Chapter 18 Principles of Cancer Management: Biologic Therapy STEVEN A. ROSENBERG
Chapter 19 Pharmacology of Cancer Chemotherapy
Section 19.1 Pharmacokinetics and Pharmacodynamics MARK J. RATAIN
Section 19.2 Cancer Drug Development
Section 19.2.1 Cancer Drug Development: Identification and Screening of New Agents EDWARD CHU MICHAEL R. GREVER BRUCE A. CHABNER
Section 19.2.2 Cancer Drug Development: Combinatorial Chemistry DAVID J. AUSTIN
Section 19.3 Antitumor Alkylating Agents OLIVER MICHAEL COLVIN
Section 19.4 Cisplatin and Its Analogues STEVEN W. JOHNSON JAMES P. STEVENSON PETER J. O'DWYER
Section 19.5 Antimetabolites EDWARD CHU AUGUSTO C. MOTA MIKLOS C. FOGARASI
Section 19.6 Topoisomerase Interactive Agents CLINTON F. STEWART MARK J. RATAIN
Section 19.7 Antimicrotubule Agents ERIC K. ROWINSKY ANTHONY W. TOLCHER
Section 19.8 Miscellaneous Chemotherapeutic Agents BRUCE D. CHESON
Chapter 20 Pharmacology of Cancer Biotherapeutics
Section 20.1 Interferons JOHN M. KIRKWOOD
Section 20.2 Interleukin-2 JAMES W. MIER MICHAEL B. ATKINS
Section 20.3 Hormonal Therapies CHARLES ERLICHMAN CHARLES L. LOPRINZI
Section 20.4 Differentiation Agents RAYMOND P. WARRELL, JR.
Section 20.5 Therapeutic Monoclonal Antibodies: General Principles LOUIS M. WEINER GREGORY P. ADAMS MARGARET VON MEHREN
Section 20.6 Antiangiogenesis Agents JUDAH FOLKMAN
Chapter 21 Clinical Trials in Cancer
Section 21.1 Design and Analysis of Clinical Trials
RICHARD SIMON
Section 21.2 Research Data Management DOUGLAS HAGEMAN DIANNE M. REEVES
PART 3
Chapter 22 Cancer Prevention: Preventing Tobacco-Related Cancers HOWARD K. KOH CHRISTINE KANNLER ALAN C. GELLER
Chapter 23 Cancer Prevention: Diet and Chemopreventive Agents
Section 23.1 Fat WALTER C. WILLETT
Section 23.2 Dietary Fibers PETER GREENWALD
Section 23.3 Retinoids, Carotenoids, and Micronutrients SUSAN TAYLOR MAYNE SCOTT M. LIPPMAN
Section 23.4 Naturally Occurring Dietary Anticarcinogens PETER GREENWALD
Section 23.5 Dietary Carcinogens PETER GREENWALD
Section 23.6 Aspirin and Other Nonsteroidal Antiinflammatory Drugs and the Risk of Cancer Development MICHAEL J. THUN CHARLES H. HENNEKENS
Section 23.7 Physical Activity and Body Weight GRAHAM A. COLDITZ
Chapter 24 Cancer Prevention: Role of Surgery in Cancer Prevention RICHARD M. SHERRY
Chapter 25 Cancer Screening BARBARA K. RIMER JOELLEN SCHILDKRAUT ROBERT A. HIATT
Chapter 26 Cancer Diagnosis: Molecular Pathology JOSÉ COSTA CARLOS CORDON-CARDO
Chapter 27 Cancer Diagnosis: Imaging
Section 27.1 Computed Tomography ELLIOT K. FISHMAN BRUCE A. URBAN
Section 27.2 Magnetic Resonance Imaging ARTHUR E. LI DAVID A. BLUEMKE
Section 27.3 Functional and Metabolic Imaging MARTIN G. POMPER
Section 27.4 Interventional Radiology JEAN-FRANCOIS H. GESCHWIND
Section 27.5 Ultrasound ULRIKE M. HAMPER
Section 27.6 Radionuclide Imaging E. EDMUND KIM
Chapter 28 Cancer Diagnosis: Endoscopy ROBERT C. KURTZ ROBERT J. GINSBERG
Chapter 29 Specialized Techniques in Cancer Management
Section 29.1 Laparoscopy ALAN T. LEFOR
Section 29.2 Vascular Access and Specialized Techniques of Drug Delivery STEVEN K. LIBUTTI MCDONALD K. HORNE III
Section 29.3 Isolation Perfusion H. RICHARD ALEXANDER
Section 29.4 Intensity-Modulated Radiation Therapy C. CLIFTON LING CHEN CHUI THOMAS LOSASSO CHANDRA BURMAN
MARGIE HUNT GIGAS MAGERAS HOWARD IRA AMOLS MICHAEL J. ZELEFSKY ZVI Y. FUKS STEVEN A. LEIBEL
Chapter 30 Cancer of the Head and Neck
Section 30.1 Molecular Biology of Head and Neck Tumors DAVID SIDRANSKY
Section 30.2 Tumors of the Nasal Cavity and Paranasal Sinuses, Nasopharynx, Oral Cavity, and Oropharynx STIMSON P. SCHANTZ LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.3 Tumors of the Larynx and Hypopharynx ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.4 Tumors of the Salivary Glands and Paragangliomas ROY B. SESSIONS LOUIS B. HARRISON ARLENE A. FORASTIERE
Section 30.5 Rehabilitation after Treatment for Head and Neck Cancer SUSAN D. MILLER ROY B. SESSIONS
Chapter 31 Cancer of the Lung
Section 31.1 Molecular Biology of Lung Cancer YOSHITAKA SEKIDO KWUN M. FONG JOHN D. MINNA
Section 31.2 Non–Small Cell Lung Cancer ROBERT J. GINSBERG EVERETT E. VOKES KENNETH ROSENZWEIG
Section 31.3 Small Cell Lung Cancer JOHN MURREN ELI GLATSTEIN HARVEY I. PASS
Chapter 32 Neoplasms of the Mediastinum ROBERT B. CAMERON PATRICK J. LOEHRER CHARLES R. THOMAS, JR.
Chapter 33 Cancers of the Gastrointestinal Tract
Section 33.1 Molecular Biology of Gastrointestinal Cancers ERIC R. FEARON
Section 33.2 Cancer of the Esophagus DAVID S. SCHRUMP NASSER K. ALTORKI ARLENE A. FORASTIERE BRUCE D. MINSKY
Section 33.3 Cancer of the Stomach MARTIN S. KARPEH DAVID P. KELSEN JOEL E. TEPPER
Section 33.4 Cancer of the Pancreas DOUGLAS B. EVANS JAMES L. ABBRUZZESE CHRISTOPHER G. WILLETT
Section 33.5 Cancer of the Liver and Biliary Tree YUMAN FONG NANCY KEMENY THEODORE S. LAWRENCE
Section 33.6 Cancer of the Small Intestine DANIEL G. COIT
Section 33.7 Cancer of the Colon JOHN M. SKIBBER BRUCE D. MINSKY PAULO M. HOFF
Section 33.8 Cancer of the Rectum JOHN M. SKIBBER PAULO M. HOFF BRUCE D. MINSKY
Section 33.9 Cancer of the Anal Region BRUCE D. MINSKY JOHN P. HOFFMAN DAVID P. KELSEN
Chapter 34 Cancers of the Genitourinary System
Section 34.1 Molecular Biology of Genitourinary Cancers W. MARSTON LINEHAN BERTON ZBAR FREDRICK LEACH CARLOS CORDON-CARDO WILLIAM ISAACS
Section 34.2 Cancer of the Kidney and Ureter W. MARSTON LINEHAN BERTON ZBAR SUSAN E. BATES MICHAEL J. ZELEFSKY JAMES C. YANG
Section 34.3 Cancer of the Bladder HARRY W. HERR WILLIAM U. SHIPLEY DEAN F. BAJORIN
Section 34.4 Cancer of the Prostate PETER R. CARROLL KEITH L. LEE ZVI Y. FUKS PHILIP W. KANTOFF
Section 34.5 Cancer of the Urethra and Penis HARRY W. HERR GUIDO DALBAGNI DEAN F. BAJORIN WILLIAM U. SHIPLEY
Chapter 35 Cancer of the Testis GEORGE J. BOSL DEAN F. BAJORIN JOEL SHEINFELD ROBERT J. MOTZER R. S. K. CHAGANTI
Chapter 36 Gynecologic Cancers
Section 36.1 Molecular Biology of Gynecologic Cancers SETSUKO KUKI CHAMBERS
Section 36.2 Cancer of the Cervix, Vagina, and Vulva PATRICIA J. EIFEL JONATHAN S. BEREK JAMES T. THIGPEN
Section 36.3 Cancers of the Uterine Body THOMAS W. BURKE PATRICIA J. EIFEL FRANCO M. MUGGIA
Section 36.4 Gestational Trophoblastic Diseases FRANCO M. MUGGIA PATRICIA J. EIFEL THOMAS W. BURKE
Section 36.5 Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma ROBERT F. OZOLS PETER E. SCHWARTZ PATRICIA J. EIFEL
Chapter 37 Cancer of the Breast
Section 37.1 Molecular Biology of Breast Cancer ROBERT B. DICKSON MARC E. LIPPMAN
Section 37.2 Malignant Tumors of the Breast ERIC P. WINER MONICA MORROW C. KENT OSBORNE JAY R. HARRIS
Section 37.3 Rehabilitation after Treatment for Cancer of the Breast JOSEPH J. DISA JEANNE A. PETREK
Chapter 38 Cancer of the Endocrine System
Section 38.1 Molecular Biology of Endocrine Tumors TERRY C. LAIRMORE SAMUEL A. WELLS, JR. JEFFREY F. MOLEY
Section 38.2 Thyroid Tumors DOUGLAS L. FRAKER MONICA SKARULIS VIRGINIA LIVOLSI
Section 38.3 Parathyroid Tumors DOUGLAS L. FRAKER
Section 38.4 Adrenal Tumors
JEFFREY A. NORTON HOP N. LE
Section 38.5 Pancreatic Endocrine Tumors H. RICHARD ALEXANDER ROBERT T. JENSEN
Section 38.6 Carcinoid Tumors and the Carcinoid Syndrome ROBERT T. JENSEN GERARD M. DOHERTY
Section 38.7 Multiple Endocrine Neoplasias GERARD M. DOHERTY ROBERT T. JENSEN
Chapter 39 Sarcomas of the Soft Tissue and Bone
Section 39.1 Soft Tissue Sarcoma MURRAY F. BRENNAN KALED M. ALEKTIAR ROBERT G. MAKI
Section 39.2 Sarcomas of Bone MARTIN M. MALAWER MICHAEL P. LINK SARAH S. DONALDSON
Chapter 40 Benign and Malignant Mesothelioma
Section 40.1 Molecular Biology of Mesothelioma JOSEPH R. TESTA HARVEY I. PASS MICHELE CARBONE
Section 40.2 Management of Mesothelioma KAREN H. ANTMAN HARVEY I. PASS PETER B. SCHIFF
Chapter 41 Cancer of the Skin
Section 41.1 Molecular Biology of Skin Cancer DOUGLAS E. BRASH ALLEN E. BALE
Section 41.2 Management of Skin Cancer DAVID J. LEFFELL JOHN A. CARUCCI
Section 41.3 Skin Cancer Atlas DAVID J. LEFFELL
Chapter 42 Melanoma
Section 42.1 Molecular Biology of Cutaneous Melanoma MEENHARD HERLYN KAPAETTU SATYAMOORTHY
Section 42.2 Cutaneous Melanoma MICHAEL T. LOTZE RAMSEY M. DALLAL JOHN M. KIRKWOOD JOHN C. FLICKINGER
Section 42.3 Intraocular Melanoma JOSÉ A. SAHEL ARTHUR S. POLANS MINESH P. MEHTA RICHARD M. AUCHTER DANIEL M. ALBERT
Chapter 43 Neoplasms of the Central Nervous System
Section 43.1 Molecular Biology of Central Nervous System Neoplasms DAVID N. LOUIS WEBSTER K. CAVENEE
Section 43.2 Neoplasms of the Central Nervous System VICTOR A. LEVIN STEVEN A. LEIBEL PHILIP H. GUTIN
Chapter 44 Cancers of Childhood
Section 44.1 Molecular Biology of Childhood Cancers LEE J. HELMAN DAVID MALKIN
Section 44.2 Solid Tumors of Childhood DAVID H. EBB DANIEL M. GREEN ROBERT C. SHAMBERGER
NANCY J. TARBELL
Chapter 45 Lymphomas
Section 45.1 Molecular Biology of Lymphomas RICCARDO DALLA-FAVERA GIANLUCA GAIDANO
Section 45.2 Leukemias and Lymphomas of Childhood HOWARD J. WEINSTEIN NANCY J. TARBELL
Section 45.3 Non-Hodgkin’s Lymphomas JAMES O. ARMITAGE PETER M. MAUCH NANCY LEE HARRIS PHILIP BIERMAN
Section 45.4 Cutaneous T-Cell Lymphomas LYNN D. WILSON GLENN W. JONES BARRY M. KACINSKI RICHARD L. EDELSON PETER W. HEALD
Section 45.5 Primary Central Nervous System Lymphoma LISA M. DEANGELIS JOACHIM YAHALOM
Section 45.6 Hodgkin’s Disease VOLKER DIEHL PETER M. MAUCH NANCY LEE HARRIS
Chapter 46 Leukemias
Section 46.1 Molecular Biology of Leukemias CLARA D. BLOOMFIELD MICHAEL A. CALIGIURI
Section 46.2 Acute Leukemias DAVID A. SCHEINBERG PETER MASLAK MARK WEISS
Section 46.3 Chronic Leukemias
Section 46.3.2 Chronic Leukemias: The Chronic Lymphocytic Leukemias BRUCE D. CHESON
Section 46.4 Plasma Cell Neoplasms NIKHIL C. MUNSHI GUIDO TRICOT BART BARLOGIE
Section 46.5 Myelodysplastic Syndromes HAGOP M. KANTARJIAN ELIHU ESTEY
Chapter 47 Paraneoplastic Syndromes SUSANNE M. ARNOLD ROY PATCHELL ANDREW M. LOWY KENNETH A. FOON
Chapter 48 Cancer of Unknown Primary Site FRANK A. GRECO JOHN D. HAINSWORTH
Chapter 49 Peritoneal Carcinomatosis DAVID L. BARTLETT
Chapter 50 Immunosuppression-Related Malignancies
Section 50.2 Transplantation-Related Malignancies STANLEY R. RIDDELL
Chapter 51 Oncologic Emergencies
Section 51.1 Superior Vena Cava Syndrome JOACHIM YAHALOM
Section 51.2 Spinal Cord Compression BRIAN G. FULLER JOHN D. HEISS EDWARD H. OLDFIELD
Section 51.3 Metabolic Emergencies RAYMOND P. WARRELL, JR.
Section 51.4 Urologic Emergencies McCLELLAN M. WALTHER
Chapter 52 Treatment of Metastatic Cancer
Section 52.1 Metastatic Brain Cancer PATRICK Y. WEN PETER MCLAREN BLACK JAY S. LOEFFLER
Section 52.2 Metastatic Cancer to the Lung JOE B. PUTNAM, JR.
Section 52.3 Metastatic Cancer to the Liver H. RICHARD ALEXANDER CARMEN J. ALLEGRA THEODORE S. LAWRENCE
Section 52.4 Metastatic Cancer to the Bone HOLLY K. BROWN JOHN H. HEALEY
Section 52.5 Malignant Pleural and Pericardial Effusions DAO M. NGUYEN DAVID S. SCHRUMP
Section 52.6 Malignant Ascites FRANCESCO M. MARINCOLA DOUGLAS J. SCHWARTZENTRUBER
Chapter 53 Hematopoietic Therapy
Section 53.1 Transfusion Therapy PETER L. PERROTTA EDWARD L. SNYDER
Section 53.2 Autologous Stem Cell Transplantation DENNIS L. COOPER STUART SEROPIAN
Section 53.3 Allogeneic Stem Cell Transplantation RICHARD W. CHILDS
Section 53.4 Hematopoietic Growth Factors JAMES D. GRIFFIN
Chapter 54 Infections in the Cancer Patient BRAHM H. SEGAL THOMAS J. WALSH STEVEN M. HOLLAND
Chapter 55 Adverse Effects of Treatment
Section 55.1 Nausea and Vomiting ANN M. BERGER REBECCA A. CLARK-SNOW
Section 55.2 Oral Complications ANN M. BERGER THOMAS J. KILROY
Section 55.3 Pulmonary Toxicity DIANE E. STOVER ROBERT J. KANER
Section 55.4 Cardiac Toxicity LAUREL J. STEINHERZ JOACHIM YAHALOM
Section 55.5 Hair Loss CLAUDIA A. SEIPP
Section 55.6 Gonadal Dysfunction MARVIN L. MEISTRICH RENA VASSILOPOULOU-SELLIN LARRY I. LIPSHULTZ
Section 55.7 Second Cancers FLORA E. VAN LEEUWEN LOIS B. TRAVIS
Section 55.8 Miscellaneous Toxicities RAYMOND B. WEISS
Chapter 56 Supportive Care and Quality of Life
Section 56.1 Management of Cancer Pain KATHLEEN M. FOLEY
Section 56.2 Nutritional Support J. STANLEY SMITH WILEY W. SOUBA
Section 56.3 Sexual Problems PATRICIA A. GANZ MARK S. LITWIN BETH E. MEYEROWITZ
Section 56.4 Genetic Counseling ELLEN T. MATLOFF ALLEN E. BALE
Section 56.5 Psychological Issues MARY JANE MASSIE LISA CHERTKOV ANDREW J. ROTH
Section 56.6 Community Resources BONNIE A. INDECK PHYLLIS M. SMITH
Section 56.7 Specialized Care of the Terminally Ill FREDERICK A. FLATOW SCOTT LONG
Chapter 57 Rehabilitation of the Cancer Patient LYNN GERBER JEANNE HICKS JAY SHAH
Chapter 58 Advanced Practice Nurses and Physician Assistants in Oncology Care M. TISH KNOBF SUSAN ANDERSON
Chapter 59 Ethical Issues in Oncology and Clinical Trials CHRISTOPHER DAUGHERTY MARK SIEGLER
Chapter 60 Information Systems in Oncology SUSAN MOLLOY HUBBARD
Chapter 61 Complementary, Alternative, and Unproven Methods of Cancer Treatment JEFFREY D. WHITE
PART 4
Chapter 62 Genetic Therapy
Section 62.1 Gene Therapy PATRICK HWU
Section 62.2 Molecular Therapy ALBERT B. DEISSEROTH AMANDA PSYRRI DAVID J. AUSTIN
Chapter 63 Cancer Vaccines
Section 63.1 Preventive Cancer Vaccines DOUGLAS R. LOWY JOHN T. SCHILLER
Section 63.2 Therapeutic Cancer Vaccines NICHOLAS P. RESTIFO MARIO SZNOL WILLEM W. OVERWIJK
Chapter 64 Image-Guided Surgery NICK BRYAN STEVEN K. LIBUTTI
Chapter 65 Proton Beam Radiation Therapy IRA J. SPIRO ALFRED R. SMITH ANTHONY LOMAX JAY S. LOEFFLER
CONTRIBUTING AUTHORS
Annie Laurie Howard Research Distinguished Professor Department of Gastrointestinal Medical Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas
Gregory P. Adams, PhD
Assistant Member Department of Medical Oncology Fox Chase Cancer Center Philadelphia, Pennsylvania
Daniel M. Albert, MD, MS
F. A. Davis Professor and Chair; Lorenz E. Zimmerman Professor Department of Ophthalmology and Visual Sciences University of Wisconsin Center for Health Sciences Madison, Wisconsin
Kaled M. Alektiar, MD
H. Richard Alexander, MD
Carmen J. Allegra, MD
Chief, Medicine Branch National Cancer Institute, National Institutes of Health Bethesda, Maryland
Nasser K. Altorki, BCh, MB
Professor of Cardiothoracic Surgery Weill Medical College of Cornell University New York, New York
Howard Ira Amols, PhD
Professor of Physics in Radiology Weill Medical College of Cornell University Memorial Sloan-Kettering Cancer Center New York, New York
Susan Anderson, BSN, MFA
Director, Clinical Trials Office Yale Cancer Center Yale University School of Medicine New Haven, Connecticut
Karen H. Antman, MD
Wu Professor of Medicine and Pharmacology Herbert Irving Comprehensive Cancer Center Columbia University College of Physicians and Surgeons New York, New York
James O. Armitage, MD
Professor of Medicine Dean of the College of Medicine University of Nebraska Medical Center Omaha, Nebraska
Susanne M. Arnold, MD
Assistant Professor of Medicine Department of Hematology and Oncology Lucille P. Markey Cancer Center University of Kentucky Chandler Medical Center Lexington, Kentucky
Michael B. Atkins, MD
Richard M. Auchter, MD
Clinical Assistant Professor of Human Oncology University of Wisconsin Medical School Madison, Wisconsin
David J. Austin, PhD
Assistant Professor of Chemistry Yale University School of Medicine New Haven, Connecticut
Dean F. Bajorin, MD
Professor of Medicine Weill Medical College of Cornell University Attending Physician Memorial Sloan-Kettering Cancer Center New York, New York
Allen E. Bale, MD
Associate Professor of Genetics Yale University School of Medicine New Haven, Connecticut
Bart Barlogie, MD, PhD
Professor of Medicine and Pathology Director, Arkansas Cancer Research Center University of Arkansas for Medical Sciences Little Rock, Arkansas
David L. Bartlett, MD
Susan E. Bates, MD
Jonathan S. Berek, MD
Professor and Chair of Applied Anatomy Vice Chair and Chief, Division of Gynecologic Oncology University of California, Los Angeles, UCLA School of Medicine Los Angeles, California
Ann M. Berger, RN, MSN, MD
Chief of Pain and Palliative Care Service National Institutes of Health Bethesda, Maryland
Philip Bierman, MD
Associate Professor of Medicine Department of Internal Medicine Section of Oncology/Hematology University of Nebraska Medical Center Omaha, Nebraska
Peter McLaren Black, MD, PhD
Franc D. Ingraham Professor of Neurosurgery Harvard Medical School Brigham and Women’s Hospital Children’s Hospital Boston, Massachusetts
Clara D. Bloomfield, MD
Professor of Medicine Ohio State University College of Medicine and Public Health Department of Internal Medicine Division of Hematology/Oncology The Comprehensive Cancer Center Columbus, Ohio
David A. Bluemke, MD, PhD, MSB
Associate Professor of Radiology Johns Hopkins University School of Medicine Baltimore, Maryland
George J. Bosl, MD
Chair, Department of Medicine Memorial Sloan-Kettering Cancer Center New York, New York
Douglas E. Brash, PhD
Professor of Therapeutic Radiology and Genetics Yale University School of Medicine New Haven, Connecticut
Murray F. Brennan, MD
Chair, Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York
Holly K. Brown, MD
Suzanne J. Brown, MD
Fellow in Oncology Yale Comprehensive Cancer Center Yale University School of Medicine New Haven, Connecticut
Nick Bryan, MD, PhD
Gary L. Buchschacher, Jr., MD, PhD
Department of Medicine Division of Hematology/Oncology University of California, San Diego, School of Medicine La Jolla, California
Thomas W. Burke, MD
Professor of Gynecologic Oncology The University of Texas M. D. Anderson Cancer Center Houston, Texas
Chandra Burman, PhD
Michael A. Caligiuri, MD
Professor of Medicine Ohio State University College of Medicine and Public Health Arthur James Cancer Hospital and Research Institute Columbus, Ohio
Robert B. Cameron, MD
Assistant Professor of Surgery University of California, Los Angeles, UCLA School of Medicine Los Angeles, California
Lewis C. Cantley, PhD
Professor of Cell Biology Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts
Michele Carbone, MD, PhD
Christopher L. Carpenter, MD, PhD
Assistant Professor of Medicine Harvard Medical School Beth Israel Deaconess Medical Center Boston, Massachusetts
Peter R. Carroll, MD
Professor and Chair, Department of Urology University of California, San Francisco, School of Medicine San Francisco, California
John A. Carucci, MD, PhD
Clinical Instructor of Dermatology Yale University School of Medicine New Haven, Connecticut
Webster K. Cavenee, PhD
Professor of Medicine University of California, San Diego, School of Medicine Director, Ludwig Institute for Cancer Research Center for Molecular Genetics; University of California Laboratory of Tumor Biology La Jolla, California
Bruce A. Chabner, MD
R. S. K. Chaganti, PhD
Member and William E. Snee Chair Human Genetics Memorial Sloan-Kettering Cancer Center New York, New York
Setsuko Kuki Chambers, MD
Professor of Obstetrics and Gynecology Division of Gynecologic Oncology Yale University School of Medicine New Haven, Connecticut
Lisa Chertkov, MD
Bruce D. Cheson, MD
Clinical Professor of Medicine Georgetown University School of Medicine Vincent T. Lombardi Cancer Research Center Washington, DC Head, Medicine Section Cancer Therapy Evaluation Program National Cancer Institute, National Institutes of Health Bethesda, Maryland
Richard W. Childs, MD
Senior Investigator Hematology Branch National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, Maryland
Edward Chu, MD
Chen Chui, PhD
Rebecca A. Clark-Snow, RN, BSN, OCN
Director of Clinical Services Oncology and Hematology Associates of Kansas City Kansas City, Missouri
Daniel G. Coit, MD
Chief of Gastric and Mixed Tumor Service Department of Surgery Memorial Sloan-Kettering Cancer Center New York, New York
Graham A. Colditz, MD, DrPH
Professor of Medicine Harvard Medical School Brigham and Women’s Hospital Boston, Massachusetts
Philip Cole, MD, PhD
Professor Emeritus Department of Epidemiology University of Alabama School of Medicine Birmingham,…